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Entry version 142 (02 Jun 2021)
Sequence version 1 (01 Dec 2001)
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Protein

N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)

Gene

Acy3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.1 mM for S-benzyl-N-acetyl-L-cysteine1 Publication
  2. KM=1.8 mM for N-acetyl-L-histidine1 Publication
  3. KM=1.4 mM for N-acetyl-L-tyrosine1 Publication
  4. KM=1.6 mM for N-acetyl-L-phenylalanine1 Publication
  1. Vmax=11.7 µmol/min/mg enzyme with S-benzyl-N-acetyl-L-cysteine as substrate1 Publication
  2. Vmax=5.9 µmol/min/mg enzyme with N-acetyl-L-histidine as substrate1 Publication
  3. Vmax=7.5 µmol/min/mg enzyme with N-acetyl-L-tyrosine as substrate1 Publication
  4. Vmax=7.9 µmol/min/mg enzyme with N-acetyl-L-phenylalanine as substrate1 Publication

pH dependencei

Optimum pH is 7.5 with S-benzyl-N-acetyl-L-cysteine as substrate, 7.6 with N-acetyl-L-histidine as substrate, 7.6 with N-acetyl-L-tyrosine as substrate, and 7.7 with N-acetyl-L-phenylalanine as substrate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi21Zinc1
Metal bindingi24Zinc1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei63Substrate1
Metal bindingi116Zinc1
Binding sitei177Substrate1
Binding sitei287Substrate1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.5.1.114, 3474

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5423646, Aflatoxin activation and detoxification

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) (EC:3.5.1.114)
Alternative name(s):
Acylase III
Aminoacylase III
Short name:
AAIII
Aminoacylase-3
Short name:
ACY-3
Aspartoacylase-2
Hepatitis C virus core-binding protein 1
Short name:
HCBP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Acy3
Synonyms:Aspa2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918920, Acy3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi63R → A: Abolishes activity. 1 Publication1
Mutagenesisi287Y → A: Drastically reduced activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002168761 – 318N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei317PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q91XE4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q91XE4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q91XE4

PeptideAtlas

More...
PeptideAtlasi
Q91XE4

PRoteomics IDEntifications database

More...
PRIDEi
Q91XE4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
285600

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q91XE4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q91XE4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in kidney and to a lesser extent in liver. Weakly expressed in heart, small intestine, brain, lung, testis, and stomach.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024866, Expressed in proximal tubule and 177 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q91XE4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q91XE4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Exists as a mixture of homodimers and homotetramer, both catalytically active.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
214844, 3 interactors

Database of interacting proteins

More...
DIPi
DIP-44060N

Protein interaction database and analysis system

More...
IntActi
Q91XE4, 6 interactors

Molecular INTeraction database

More...
MINTi
Q91XE4

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000050056

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q91XE4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1318
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q91XE4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q91XE4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 210Hydrolytic domainAdd BLAST210
Regioni70 – 71Substrate binding2
Regioni211 – 318Shielding domainAdd BLAST108

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QRAK, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001189

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_083292_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q91XE4

Identification of Orthologs from Complete Genome Data

More...
OMAi
AMHLCHH

Database of Orthologous Groups

More...
OrthoDBi
1074294at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q91XE4

TreeFam database of animal gene trees

More...
TreeFami
TF328708

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_00704, Aspartoacylase, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016708, Aspartoacylase
IPR007036, Aste_AspA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04952, AstE_AspA, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF018001, Aspartoacylase, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q91XE4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSLPGSREP LLRVAVTGGT HGNEMCGVYL ARYWLQNPGE LQRPSFSAMP
60 70 80 90 100
VLANPAATAA CCRYLDRDLN RSCTLTFLGS TATPDDPYEV KRARELNQLL
110 120 130 140 150
GPKGTGQAFD FTLDLHNTTA NTGVCLISES NISFNLHLCH YLQRQNPGMP
160 170 180 190 200
CRLFLYEPAG TETFSVESIS KNGICLEMGP QPQGVLRADL FSRMRALVAS
210 220 230 240 250
ILDFIELFNQ GMDLPAFEMD IYRNLGSVDF PRTADGDLAG TVHPQLQDHD
260 270 280 290 300
FEPLRPGEPI FKLFSGEDVL YEGDSIVYPV FINEAAYYEK HVAFLKSEKI
310
RVTVPALLRL TPRSTQTP
Length:318
Mass (Da):35,286
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8332731E7E9B30D2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494B9B0A0A494B9B0_MOUSE
N-acyl-aromatic-L-amino acid amidoh...
Acy3
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494BAV4A0A494BAV4_MOUSE
N-acyl-aromatic-L-amino acid amidoh...
Acy3
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti66D → G in AAN87897 (PubMed:14656720).Curated1
Sequence conflicti66D → G in AAM46090 (Ref. 4) Curated1
Sequence conflicti66D → G in BAB21963 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF356878 mRNA Translation: AAM00224.1
AF356879 mRNA Translation: AAM00225.1
AY040762 Genomic DNA Translation: AAK94771.1
AY169234 mRNA Translation: AAN87897.1
AF375479 mRNA Translation: AAM46090.1
AK002247 mRNA Translation: BAB21963.1
AK143782 mRNA Translation: BAE25538.1
BC010795 mRNA Translation: AAH10795.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS29406.1

NCBI Reference Sequences

More...
RefSeqi
NP_001289408.1, NM_001302479.1
NP_001289409.1, NM_001302480.1
NP_001289410.1, NM_001302481.1
NP_001289411.1, NM_001302482.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000054030; ENSMUSP00000050056; ENSMUSG00000024866
ENSMUST00000235612; ENSMUSP00000158093; ENSMUSG00000024866
ENSMUST00000236510; ENSMUSP00000158512; ENSMUSG00000024866

Database of genes from NCBI RefSeq genomes

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GeneIDi
71670

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:71670

UCSC genome browser

More...
UCSCi
uc008fxx.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF356878 mRNA Translation: AAM00224.1
AF356879 mRNA Translation: AAM00225.1
AY040762 Genomic DNA Translation: AAK94771.1
AY169234 mRNA Translation: AAN87897.1
AF375479 mRNA Translation: AAM46090.1
AK002247 mRNA Translation: BAB21963.1
AK143782 mRNA Translation: BAE25538.1
BC010795 mRNA Translation: AAH10795.1
CCDSiCCDS29406.1
RefSeqiNP_001289408.1, NM_001302479.1
NP_001289409.1, NM_001302480.1
NP_001289410.1, NM_001302481.1
NP_001289411.1, NM_001302482.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NFZX-ray2.15A1-318[»]
3NH4X-ray2.00A1-318[»]
3NH5X-ray2.09A1-318[»]
3NH8X-ray2.80A1-318[»]
SMRiQ91XE4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi214844, 3 interactors
DIPiDIP-44060N
IntActiQ91XE4, 6 interactors
MINTiQ91XE4
STRINGi10090.ENSMUSP00000050056

PTM databases

iPTMnetiQ91XE4
PhosphoSitePlusiQ91XE4

Proteomic databases

jPOSTiQ91XE4
MaxQBiQ91XE4
PaxDbiQ91XE4
PeptideAtlasiQ91XE4
PRIDEiQ91XE4
ProteomicsDBi285600

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
30490, 277 antibodies

The DNASU plasmid repository

More...
DNASUi
71670

Genome annotation databases

EnsembliENSMUST00000054030; ENSMUSP00000050056; ENSMUSG00000024866
ENSMUST00000235612; ENSMUSP00000158093; ENSMUSG00000024866
ENSMUST00000236510; ENSMUSP00000158512; ENSMUSG00000024866
GeneIDi71670
KEGGimmu:71670
UCSCiuc008fxx.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
91703
MGIiMGI:1918920, Acy3

Phylogenomic databases

eggNOGiENOG502QRAK, Eukaryota
GeneTreeiENSGT00390000001189
HOGENOMiCLU_083292_0_0_1
InParanoidiQ91XE4
OMAiAMHLCHH
OrthoDBi1074294at2759
PhylomeDBiQ91XE4
TreeFamiTF328708

Enzyme and pathway databases

BRENDAi3.5.1.114, 3474
ReactomeiR-MMU-5423646, Aflatoxin activation and detoxification

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
71670, 2 hits in 52 CRISPR screens
EvolutionaryTraceiQ91XE4

Protein Ontology

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PROi
PR:Q91XE4
RNActiQ91XE4, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000024866, Expressed in proximal tubule and 177 other tissues
ExpressionAtlasiQ91XE4, baseline and differential
GenevisibleiQ91XE4, MM

Family and domain databases

HAMAPiMF_00704, Aspartoacylase, 1 hit
InterProiView protein in InterPro
IPR016708, Aspartoacylase
IPR007036, Aste_AspA
PfamiView protein in Pfam
PF04952, AstE_AspA, 1 hit
PIRSFiPIRSF018001, Aspartoacylase, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACY3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91XE4
Secondary accession number(s): Q3UP59, Q9DD17
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: December 1, 2001
Last modified: June 2, 2021
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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