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Protein

Mitochondrial glycine transporter

Gene

Slc25a38

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glycine transporterUniRule annotation
Alternative name(s):
Solute carrier family 25 member 38UniRule annotation
Gene namesi
Name:Slc25a38UniRule annotation
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2384782 Slc25a38

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei51 – 76Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei109 – 135Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei147 – 172Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei200 – 223Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei241 – 267Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei296 – 314Helical; Name=6UniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002918031 – 326Mitochondrial glycine transporterAdd BLAST326

Proteomic databases

MaxQBiQ91XD8
PaxDbiQ91XD8
PRIDEiQ91XD8

PTM databases

iPTMnetiQ91XD8
PhosphoSitePlusiQ91XD8

Expressioni

Gene expression databases

BgeeiENSMUSG00000032519
CleanExiMM_SLC25A38
ExpressionAtlasiQ91XD8 baseline and differential
GenevisibleiQ91XD8 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035106

Structurei

3D structure databases

ProteinModelPortaliQ91XD8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati45 – 134Solcar 1UniRule annotationAdd BLAST90
Repeati141 – 225Solcar 2UniRule annotationAdd BLAST85
Repeati237 – 321Solcar 3UniRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0766 Eukaryota
ENOG410XRMK LUCA
GeneTreeiENSGT00550000075117
HOGENOMiHOG000006978
HOVERGENiHBG054682
InParanoidiQ91XD8
KOiK15118
OMAiTVYEQMM
OrthoDBiEOG091G0IR1
PhylomeDBiQ91XD8
TreeFamiTF332793

Family and domain databases

Gene3Di1.50.40.10, 2 hits
HAMAPiMF_03064 SLC25A38, 1 hit
InterProiView protein in InterPro
IPR030847 Hem25/SLC25A38
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q91XD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVSAEPRSL SVAGAGLASP VIEKARSALL QSQDVEDTVE TLMLHPVIKA
60 70 80 90 100
FLCGSISGTC STLLFQPLDL LKTRLQALQP SDLGPRRVGM LAVFLKVVRT
110 120 130 140 150
ESLLGLWKGM SPSIVRCVPG VGIYFGTLYS SKQYFLRGHP PTALESVILG
160 170 180 190 200
MGSRSVAGVC MSPITVIKTR YESGTYSYES IYAALRSIYC SEGHRGLFRG
210 220 230 240 250
LTATLLRDAP FSGLYLMFYS QTRTAVLHGT AQLDAALIPL INFSCGIFAG
260 270 280 290 300
VLASLVTQPA DVIKTHMQLS PVKFQWIGQA ATLIFKNHGL RGFFHGSVPR
310 320
ALRRTLMAAM AWTVYEEMMA RMGLKS
Length:326
Mass (Da):35,390
Last modified:December 1, 2001 - v1
Checksum:i9C895EBD7A87A9F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078385 mRNA Translation: BAC37246.1
BC010801 mRNA Translation: AAH10801.1
CCDSiCCDS23622.1
RefSeqiNP_659042.1, NM_144793.1
UniGeneiMm.236656

Genome annotation databases

EnsembliENSMUST00000035106; ENSMUSP00000035106; ENSMUSG00000032519
GeneIDi208638
KEGGimmu:208638
UCSCiuc009scc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiS2538_MOUSE
AccessioniPrimary (citable) accession number: Q91XD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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