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Protein

Cysteine-rich with EGF-like domain protein 1

Gene

Creld1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich with EGF-like domain protein 1
Gene namesi
Name:Creld1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2152539 Creld1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 362ExtracellularSequence analysisAdd BLAST333
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Topological domaini384CytoplasmicSequence analysis1
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Topological domaini406 – 420ExtracellularSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000004278230 – 420Cysteine-rich with EGF-like domain protein 1Add BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi155 ↔ 169PROSITE-ProRule annotation
Disulfide bondi163 ↔ 181PROSITE-ProRule annotation
Disulfide bondi183 ↔ 192PROSITE-ProRule annotation
Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi309 ↔ 321PROSITE-ProRule annotation
Disulfide bondi314 ↔ 330PROSITE-ProRule annotation
Disulfide bondi332 ↔ 343PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ91XD7
PaxDbiQ91XD7
PRIDEiQ91XD7

PTM databases

PhosphoSitePlusiQ91XD7

Expressioni

Gene expression databases

BgeeiENSMUSG00000030284 Expressed in 252 organ(s), highest expression level in dorsal root ganglion
CleanExiMM_CRELD1
ExpressionAtlasiQ91XD7 baseline and differential
GenevisibleiQ91XD7 MM

Interactioni

Protein-protein interaction databases

IntActiQ91XD7, 2 interactors
MINTiQ91XD7
STRINGi10090.ENSMUSP00000032422

Structurei

3D structure databases

ProteinModelPortaliQ91XD7
SMRiQ91XD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 193EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Repeati208 – 255FU 1Add BLAST48
Repeati268 – 315FU 2Add BLAST48
Domaini305 – 342EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST38

Sequence similaritiesi

Belongs to the CRELD family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4260 Eukaryota
ENOG41107X2 LUCA
GeneTreeiENSGT00680000100014
HOGENOMiHOG000004778
HOVERGENiHBG081344
InParanoidiQ91XD7
OMAiFHRQQEA
OrthoDBiEOG091G09AA
PhylomeDBiQ91XD7
TreeFamiTF316507

Family and domain databases

CDDicd00064 FU, 1 hit
InterProiView protein in InterPro
IPR021852 DUF3456
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR006212 Furin_repeat
IPR009030 Growth_fac_rcpt_cys_sf
IPR002049 Laminin_EGF
PfamiView protein in Pfam
PF11938 DUF3456, 1 hit
PF07645 EGF_CA, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 2 hits
SM00261 FU, 2 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91XD7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPLPPRGLV PSLLWCLSLF LSLPGPVWLQ PSPPPHPSPR AEPHPCHTCR
60 70 80 90 100
ALVDNFNKGL ERTIRDNFGG GNTAWEEEKL SKYKDSETRL VEVLEGVCSR
110 120 130 140 150
SDFECHRLLE LSEELVENWW FHRQQEAPDL FQWLCSDSLK LCCPSGTFGP
160 170 180 190 200
SCLPCPGGTE RPCGGYGQCE GEGTRGGSGH CDCQAGYGGE ACGQCGLGYF
210 220 230 240 250
EAERNSSHLV CSACFGPCAR CTGPEESHCL QCKKGWALHH LKCVDIDECG
260 270 280 290 300
TEQATCGADQ FCVNTEGSYE CRDCAKACLG CMGAGPGRCK KCSRGYQQVG
310 320 330 340 350
SKCLDVDECE TVVCPGENEK CENTEGGYRC VCAEGYRQED GICVKEQVPE
360 370 380 390 400
SAGFFAEMTE DEMVVLQQMF FGVIICALAT LAAKGDLVFT AIFIGAVAAM
410 420
TGYWLSERSD RVLEGFIKGR
Length:420
Mass (Da):45,718
Last modified:December 1, 2001 - v1
Checksum:i4066BF2D739D3179
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050160 mRNA Translation: BAC34101.1
AK050455 mRNA Translation: BAC34266.1
AK155777 mRNA Translation: BAE33433.1
BC010804 mRNA Translation: AAH10804.1
BC023893 mRNA Translation: AAH23893.1
BC025932 mRNA Translation: AAH25932.1
BC029065 mRNA Translation: AAH29065.1
CCDSiCCDS20423.1
RefSeqiNP_598691.1, NM_133930.2
UniGeneiMm.41593

Genome annotation databases

EnsembliENSMUST00000032422; ENSMUSP00000032422; ENSMUSG00000030284
GeneIDi171508
KEGGimmu:171508
UCSCiuc009dgo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050160 mRNA Translation: BAC34101.1
AK050455 mRNA Translation: BAC34266.1
AK155777 mRNA Translation: BAE33433.1
BC010804 mRNA Translation: AAH10804.1
BC023893 mRNA Translation: AAH23893.1
BC025932 mRNA Translation: AAH25932.1
BC029065 mRNA Translation: AAH29065.1
CCDSiCCDS20423.1
RefSeqiNP_598691.1, NM_133930.2
UniGeneiMm.41593

3D structure databases

ProteinModelPortaliQ91XD7
SMRiQ91XD7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91XD7, 2 interactors
MINTiQ91XD7
STRINGi10090.ENSMUSP00000032422

PTM databases

PhosphoSitePlusiQ91XD7

Proteomic databases

MaxQBiQ91XD7
PaxDbiQ91XD7
PRIDEiQ91XD7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032422; ENSMUSP00000032422; ENSMUSG00000030284
GeneIDi171508
KEGGimmu:171508
UCSCiuc009dgo.1 mouse

Organism-specific databases

CTDi78987
MGIiMGI:2152539 Creld1

Phylogenomic databases

eggNOGiKOG4260 Eukaryota
ENOG41107X2 LUCA
GeneTreeiENSGT00680000100014
HOGENOMiHOG000004778
HOVERGENiHBG081344
InParanoidiQ91XD7
OMAiFHRQQEA
OrthoDBiEOG091G09AA
PhylomeDBiQ91XD7
TreeFamiTF316507

Miscellaneous databases

PROiPR:Q91XD7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030284 Expressed in 252 organ(s), highest expression level in dorsal root ganglion
CleanExiMM_CRELD1
ExpressionAtlasiQ91XD7 baseline and differential
GenevisibleiQ91XD7 MM

Family and domain databases

CDDicd00064 FU, 1 hit
InterProiView protein in InterPro
IPR021852 DUF3456
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR006212 Furin_repeat
IPR009030 Growth_fac_rcpt_cys_sf
IPR002049 Laminin_EGF
PfamiView protein in Pfam
PF11938 DUF3456, 1 hit
PF07645 EGF_CA, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 2 hits
SM00261 FU, 2 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCREL1_MOUSE
AccessioniPrimary (citable) accession number: Q91XD7
Secondary accession number(s): Q8BGJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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