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Protein

snRNA-activating protein complex subunit 2

Gene

Snapc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Names & Taxonomyi

Protein namesi
Recommended name:
snRNA-activating protein complex subunit 2
Short name:
SNAPc subunit 2
Alternative name(s):
Small nuclear RNA-activating complex polypeptide 2
snRNA-activating protein complex 45 kDa subunit
Short name:
SNAPc 45 kDa subunit
Gene namesi
Name:Snapc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914861 Snapc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000720211 – 359snRNA-activating protein complex subunit 2Add BLAST359

Proteomic databases

MaxQBiQ91XA5
PaxDbiQ91XA5
PRIDEiQ91XA5

PTM databases

iPTMnetiQ91XA5
PhosphoSitePlusiQ91XA5

Expressioni

Gene expression databases

BgeeiENSMUSG00000011837 Expressed in 299 organ(s), highest expression level in neocortex
ExpressionAtlasiQ91XA5 baseline and differential
GenevisibleiQ91XA5 MM

Interactioni

Subunit structurei

Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC2 interacts with TBP and SNAPC4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000011981

Structurei

3D structure databases

ProteinModelPortaliQ91XA5
SMRiQ91XA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IX3I Eukaryota
ENOG410YPM6 LUCA
GeneTreeiENSGT00390000017407
HOGENOMiHOG000132929
HOVERGENiHBG079198
InParanoidiQ91XA5
KOiK15209
OMAiVEHMTET
OrthoDBiEOG091G0O5J
PhylomeDBiQ91XA5
TreeFamiTF336993

Family and domain databases

InterProiView protein in InterPro
IPR021281 SnAPC_su2-like
PANTHERiPTHR15132 PTHR15132, 1 hit
PfamiView protein in Pfam
PF11035 SnAPC_2_like, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q91XA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPPQRRRRV PARYVGEATG PTAWSPREMR HLLRLLQARR GQPEPDAAEL
60 70 80 90 100
AQELRGRSEA EICRFIQQLK GRVVREAIQK MQPGGREGPR HQGTPLPAPV
110 120 130 140 150
EVWMDLAEKL TGPMEEALTA AFSQVLTIAA AEPLSLLHSR PGKPTKARGK
160 170 180 190 200
ALVFLSNQDG QKDPASEGSG PVPMTAADPT REASVSDPKA SGANPETSGL
210 220 230 240 250
ASEVTVPDPD APTKSLAGSS TERDLAVDFE KIYKYLSFSS RGGHGPELSA
260 270 280 290 300
AESAVVLNLL MALPEELSHL PCTALLEHMT KTYAQLMAPQ TALPGEKRPR
310 320 330 340 350
PGTEDGGTGS TGPEEPDQAS PQASEPIEPR LAWKAVGICP LNPFLVPLGL

VSQAPSPSR
Length:359
Mass (Da):38,370
Last modified:December 1, 2001 - v1
Checksum:i1F69C9B571B00D52
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LID1A0A140LID1_MOUSE
snRNA-activating protein complex su...
Snapc2
249Annotation score:
A0A140LHV3A0A140LHV3_MOUSE
snRNA-activating protein complex su...
Snapc2
222Annotation score:
A0A140LHE1A0A140LHE1_MOUSE
snRNA-activating protein complex su...
Snapc2
55Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51A → D in BAC29039 (PubMed:16141072).Curated1
Sequence conflicti195P → T in BAC29039 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035340 mRNA Translation: BAC29039.1
AK075569 mRNA Translation: BAC35827.1
AK146218 mRNA Translation: BAE26986.1
BC011147 mRNA Translation: AAH11147.1
CCDSiCCDS22081.1
RefSeqiNP_598729.1, NM_133968.1
UniGeneiMm.28452

Genome annotation databases

EnsembliENSMUST00000011981; ENSMUSP00000011981; ENSMUSG00000011837
GeneIDi102209
KEGGimmu:102209
UCSCiuc009kto.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035340 mRNA Translation: BAC29039.1
AK075569 mRNA Translation: BAC35827.1
AK146218 mRNA Translation: BAE26986.1
BC011147 mRNA Translation: AAH11147.1
CCDSiCCDS22081.1
RefSeqiNP_598729.1, NM_133968.1
UniGeneiMm.28452

3D structure databases

ProteinModelPortaliQ91XA5
SMRiQ91XA5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000011981

PTM databases

iPTMnetiQ91XA5
PhosphoSitePlusiQ91XA5

Proteomic databases

MaxQBiQ91XA5
PaxDbiQ91XA5
PRIDEiQ91XA5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000011981; ENSMUSP00000011981; ENSMUSG00000011837
GeneIDi102209
KEGGimmu:102209
UCSCiuc009kto.1 mouse

Organism-specific databases

CTDi6618
MGIiMGI:1914861 Snapc2

Phylogenomic databases

eggNOGiENOG410IX3I Eukaryota
ENOG410YPM6 LUCA
GeneTreeiENSGT00390000017407
HOGENOMiHOG000132929
HOVERGENiHBG079198
InParanoidiQ91XA5
KOiK15209
OMAiVEHMTET
OrthoDBiEOG091G0O5J
PhylomeDBiQ91XA5
TreeFamiTF336993

Enzyme and pathway databases

ReactomeiR-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Miscellaneous databases

PROiPR:Q91XA5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000011837 Expressed in 299 organ(s), highest expression level in neocortex
ExpressionAtlasiQ91XA5 baseline and differential
GenevisibleiQ91XA5 MM

Family and domain databases

InterProiView protein in InterPro
IPR021281 SnAPC_su2-like
PANTHERiPTHR15132 PTHR15132, 1 hit
PfamiView protein in Pfam
PF11035 SnAPC_2_like, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNPC2_MOUSE
AccessioniPrimary (citable) accession number: Q91XA5
Secondary accession number(s): Q3UK17, Q8CBS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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