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Protein

Guanine nucleotide exchange factor MSS4

Gene

Rabif

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi23ZincPROSITE-ProRule annotation1
Metal bindingi26ZincPROSITE-ProRule annotation1
Metal bindingi94ZincPROSITE-ProRule annotation1
Metal bindingi97ZincPROSITE-ProRule annotation1

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: GO_Central
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processProtein transport, Transport
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide exchange factor MSS4
Alternative name(s):
Rab-interacting factor
Gene namesi
Name:Rabif
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2138605 Rabif

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001741751 – 123Guanine nucleotide exchange factor MSS4Add BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ91X96
MaxQBiQ91X96
PaxDbiQ91X96
PeptideAtlasiQ91X96
PRIDEiQ91X96

PTM databases

PhosphoSitePlusiQ91X96

Expressioni

Gene expression databases

BgeeiENSMUSG00000042229 Expressed in 272 organ(s), highest expression level in cerebellum
CleanExiMM_RABIF
GenevisibleiQ91X96 MM

Interactioni

Subunit structurei

Interacts with RAB8A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ91X96
IntActiQ91X96, 1 interactor
STRINGi10090.ENSMUSP00000038335

Structurei

3D structure databases

ProteinModelPortaliQ91X96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 123MSS4PROSITE-ProRule annotationAdd BLAST115

Sequence similaritiesi

Belongs to the DSS4/MSS4 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4113 Eukaryota
ENOG4111UFA LUCA
GeneTreeiENSGT00390000016889
HOGENOMiHOG000007903
HOVERGENiHBG006402
InParanoidiQ91X96
KOiK19952
OMAiHWLVNDM
OrthoDBiEOG091G0XXM
PhylomeDBiQ91X96
TreeFamiTF314029

Family and domain databases

CDDicd00246 RabGEF, 1 hit
Gene3Di2.170.150.10, 1 hit
InterProiView protein in InterPro
IPR007515 Mss4
IPR011057 Mss4-like_sf
IPR011323 Mss4/transl-control_tumour
PANTHERiPTHR13276 PTHR13276, 1 hit
PfamiView protein in Pfam
PF04421 Mss4, 1 hit
SUPFAMiSSF51316 SSF51316, 1 hit
PROSITEiView protein in PROSITE
PS51796 MSS4, 1 hit

Sequencei

Sequence statusi: Complete.

Q91X96-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPCELQNEL VSAEGRNRKA VLCQRCGSRV LQPGTALFSR RQLFLPSMRK
60 70 80 90 100
KPDLADGSNP DGDLLQEHWL VNDMFTFENV GFTKDVGNIK FLVCADCEIG
110 120
PIGWHCLDDK NSFYVALERV SHE
Length:123
Mass (Da):13,915
Last modified:December 1, 2001 - v1
Checksum:i73F3AEEC0DBE8B02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK087547 mRNA Translation: BAC39922.1
AK133528 mRNA Translation: BAE21707.1
AK155054 mRNA Translation: BAE33016.1
AK158129 mRNA Translation: BAE34373.1
AK165748 mRNA Translation: BAE38365.1
BC011166 mRNA Translation: AAH11166.1
BC024808 mRNA Translation: AAH24808.1
CCDSiCCDS15310.1
RefSeqiNP_663485.1, NM_145510.1
UniGeneiMm.198119

Genome annotation databases

EnsembliENSMUST00000047978; ENSMUSP00000038335; ENSMUSG00000042229
GeneIDi98710
KEGGimmu:98710
UCSCiuc007csc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK087547 mRNA Translation: BAC39922.1
AK133528 mRNA Translation: BAE21707.1
AK155054 mRNA Translation: BAE33016.1
AK158129 mRNA Translation: BAE34373.1
AK165748 mRNA Translation: BAE38365.1
BC011166 mRNA Translation: AAH11166.1
BC024808 mRNA Translation: AAH24808.1
CCDSiCCDS15310.1
RefSeqiNP_663485.1, NM_145510.1
UniGeneiMm.198119

3D structure databases

ProteinModelPortaliQ91X96
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ91X96
IntActiQ91X96, 1 interactor
STRINGi10090.ENSMUSP00000038335

PTM databases

PhosphoSitePlusiQ91X96

Proteomic databases

EPDiQ91X96
MaxQBiQ91X96
PaxDbiQ91X96
PeptideAtlasiQ91X96
PRIDEiQ91X96

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047978; ENSMUSP00000038335; ENSMUSG00000042229
GeneIDi98710
KEGGimmu:98710
UCSCiuc007csc.1 mouse

Organism-specific databases

CTDi5877
MGIiMGI:2138605 Rabif

Phylogenomic databases

eggNOGiKOG4113 Eukaryota
ENOG4111UFA LUCA
GeneTreeiENSGT00390000016889
HOGENOMiHOG000007903
HOVERGENiHBG006402
InParanoidiQ91X96
KOiK19952
OMAiHWLVNDM
OrthoDBiEOG091G0XXM
PhylomeDBiQ91X96
TreeFamiTF314029

Miscellaneous databases

ChiTaRSiRabif mouse
PROiPR:Q91X96
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042229 Expressed in 272 organ(s), highest expression level in cerebellum
CleanExiMM_RABIF
GenevisibleiQ91X96 MM

Family and domain databases

CDDicd00246 RabGEF, 1 hit
Gene3Di2.170.150.10, 1 hit
InterProiView protein in InterPro
IPR007515 Mss4
IPR011057 Mss4-like_sf
IPR011323 Mss4/transl-control_tumour
PANTHERiPTHR13276 PTHR13276, 1 hit
PfamiView protein in Pfam
PF04421 Mss4, 1 hit
SUPFAMiSSF51316 SSF51316, 1 hit
PROSITEiView protein in PROSITE
PS51796 MSS4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMSS4_MOUSE
AccessioniPrimary (citable) accession number: Q91X96
Secondary accession number(s): Q3U2X4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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