UniProtKB - Q91X86 (TMM98_MOUSE)
Protein
Transmembrane protein 98
Gene
Tmem98
Organism
Mus musculus (Mouse)
Status
Functioni
Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation (PubMed:25946230). The secreted form promotes differentiation of T helper 1 cells (Th1) (PubMed:25946230).1 Publication
GO - Biological processi
- negative regulation of myelination Source: UniProtKB
- negative regulation of oligodendrocyte differentiation Source: UniProtKB
- negative regulation of protein localization to nucleus Source: UniProtKB
- negative regulation of protein processing Source: UniProtKB
- T-helper 1 cell differentiation Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 98 |
Gene namesi | Name:Tmem98 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1923457, Tmem98 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Single-pass type II membrane protein By similarity
Plasma membrane
- Cell membrane By similarity; Single-pass type II membrane protein By similarity
Extracellular region or secreted
- Secreted 1 Publication
- extracellular exosome By similarity
Note: Secreted by exosomes through a non-classical pathway.By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
- endoplasmic reticulum membrane Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular space Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 3 | CytoplasmicBy similarity | 3 | |
Transmembranei | 4 – 24 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 25 – 226 | ExtracellularBy similarityAdd BLAST | 202 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000251712 | 1 – 226 | Transmembrane protein 98Add BLAST | 226 |
Proteomic databases
MaxQBi | Q91X86 |
PaxDbi | Q91X86 |
PeptideAtlasi | Q91X86 |
PRIDEi | Q91X86 |
PTM databases
iPTMneti | Q91X86 |
PhosphoSitePlusi | Q91X86 |
SwissPalmi | Q91X86 |
Expressioni
Tissue specificityi
Expressed in differentiated oligodendrocytes in early postanatal central nervous system tissues (PubMed:30249802). Expressed by CD4+ T cells, the expression increases upon activation (at protein level) (PubMed:25946230).2 Publications
Developmental stagei
In the spinal cord region, expression is initially detected in the ventral white matter at 18.5 dpc, upregulates rapidly afterward, and peaks at early postnatal stages from P4 to P7. At P15, expression starts to be detected in the gray matter of spinal cord but gradually disappears thereafter. Also observed in corpus callosum and the white matter of cerebellum at P15 stages.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000035413, Expressed in camera-type eye and 272 other tissues |
Genevisiblei | Q91X86, MM |
Interactioni
Subunit structurei
Interacts (via N-terminal region) with MYRF; the interaction inhibits MYRF self-cleavage.
1 PublicationProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000042825 |
Miscellaneous databases
RNActi | Q91X86, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 88 | Required for interaction with MYRF1 PublicationAdd BLAST | 88 |
Sequence similaritiesi
Belongs to the TMEM98 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QT8U, Eukaryota |
GeneTreei | ENSGT00390000012062 |
HOGENOMi | CLU_084317_0_0_1 |
InParanoidi | Q91X86 |
OMAi | RHRYCRP |
OrthoDBi | 1413051at2759 |
PhylomeDBi | Q91X86 |
TreeFami | TF336444 |
Family and domain databases
InterProi | View protein in InterPro IPR029668, TMEM98 |
PANTHERi | PTHR32510, PTHR32510, 1 hit |
i Sequence
Sequence statusi: Complete.
Q91X86-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METVVIVAIG VLATIFLASF AALVVVCRQR YCRPRDLLQR YDSKPIVDLI
60 70 80 90 100
GAMETQSEPS ELELDDVVIT NPHIEAILEN EDWIEDASGL MSHCIAILKI
110 120 130 140 150
CHTLTEKLVA MTMGSGAKMK TSASVSDIIV VAKRISPRVD DVVKSMYPPL
160 170 180 190 200
DPKLLDARTT ALLLSVSHLV LVTRNACHLT GGLDWIDQSL SAAEEHLEVL
210 220
REAALASEPD KSLPNPEGFL QEQSAI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK153960 mRNA Translation: BAE32282.1 AL663054 Genomic DNA No translation available. BC011208 mRNA Translation: AAH11208.1 |
CCDSi | CCDS25135.1 |
RefSeqi | NP_083813.1, NM_029537.1 |
Genome annotation databases
Ensembli | ENSMUST00000040865; ENSMUSP00000042825; ENSMUSG00000035413 |
GeneIDi | 103743 |
KEGGi | mmu:103743 |
UCSCi | uc007kmj.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK153960 mRNA Translation: BAE32282.1 AL663054 Genomic DNA No translation available. BC011208 mRNA Translation: AAH11208.1 |
CCDSi | CCDS25135.1 |
RefSeqi | NP_083813.1, NM_029537.1 |
3D structure databases
SMRi | Q91X86 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000042825 |
PTM databases
iPTMneti | Q91X86 |
PhosphoSitePlusi | Q91X86 |
SwissPalmi | Q91X86 |
Proteomic databases
MaxQBi | Q91X86 |
PaxDbi | Q91X86 |
PeptideAtlasi | Q91X86 |
PRIDEi | Q91X86 |
Protocols and materials databases
Antibodypediai | 52106, 39 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000040865; ENSMUSP00000042825; ENSMUSG00000035413 |
GeneIDi | 103743 |
KEGGi | mmu:103743 |
UCSCi | uc007kmj.1, mouse |
Organism-specific databases
CTDi | 26022 |
MGIi | MGI:1923457, Tmem98 |
Phylogenomic databases
eggNOGi | ENOG502QT8U, Eukaryota |
GeneTreei | ENSGT00390000012062 |
HOGENOMi | CLU_084317_0_0_1 |
InParanoidi | Q91X86 |
OMAi | RHRYCRP |
OrthoDBi | 1413051at2759 |
PhylomeDBi | Q91X86 |
TreeFami | TF336444 |
Miscellaneous databases
BioGRID-ORCSi | 103743, 0 hits in 17 CRISPR screens |
ChiTaRSi | Tmem98, mouse |
PROi | PR:Q91X86 |
RNActi | Q91X86, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000035413, Expressed in camera-type eye and 272 other tissues |
Genevisiblei | Q91X86, MM |
Family and domain databases
InterProi | View protein in InterPro IPR029668, TMEM98 |
PANTHERi | PTHR32510, PTHR32510, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TMM98_MOUSE | |
Accessioni | Q91X86Primary (citable) accession number: Q91X86 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families