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Protein

Feline leukemia virus subgroup C receptor-related protein 2

Gene

Flvcr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • heme export Source: GO_Central

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Feline leukemia virus subgroup C receptor-related protein 2
Alternative name(s):
Calcium-chelate transporter
Short name:
CCT
Gene namesi
Name:Flvcr2
Synonyms:Mfsd7c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2384974 Flvcr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Transmembranei459 – 479HelicalSequence analysisAdd BLAST21
Transmembranei490 – 510HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000848471 – 551Feline leukemia virus subgroup C receptor-related protein 2Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei541PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91X85
PaxDbiQ91X85
PRIDEiQ91X85

PTM databases

iPTMnetiQ91X85
PhosphoSitePlusiQ91X85

Expressioni

Tissue specificityi

Found in the kidney and in cells implicated in rapid calcium exchange, namely the CNS, the eye, cardiomyocytes and placenta in late term.

Developmental stagei

Found in fetal chondrocytes and osteoclasts.

Interactioni

Protein-protein interaction databases

BioGridi229955, 1 interactor
STRINGi10090.ENSMUSP00000035569

Structurei

3D structure databases

ProteinModelPortaliQ91X85
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 3616
Repeati37 – 4226
Repeati43 – 4836
Repeati49 – 5446
Repeati55 – 6056
Repeati61 – 6666
Repeati67 – 7276
Repeati73 – 7886

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni31 – 788 X 6 AA tandem repeats of P-S-[VSG]-S-[VIAG]-[HDRL]Add BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi530 – 536Poly-Glu7

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2563 Eukaryota
ENOG410XSTK LUCA
HOGENOMiHOG000019717
HOVERGENiHBG051631
InParanoidiQ91X85
KOiK08220
PhylomeDBiQ91X85
TreeFamiTF314292

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q91X85-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNESLNQEE SNDRPAPESE FQMDTSYSTQ PSGSIHPSVS GHPSVSGHPS
60 70 80 90 100
VSGHPSVSIH PSVSIDPSVS VRPSSSALPS TLAQPSGLTH HSSLVREDSV
110 120 130 140 150
IKVSKRRWVV VLVFSCYSLC NAFQWIQYGS INNIFMNFYG VSAFAIDWLS
160 170 180 190 200
MCYMLTYIPL LLPVAWMLEK FGLRTIAITG SALNCLGAWV KLGSLEPHLF
210 220 230 240 250
PVTMVGQVIC SVAQVFILGM PSRIASVWFG ADEVSTACSV AVFGNQLGIA
260 270 280 290 300
IGFLVPPVLV PNIKDPEKLA YHISIMFYII GGVATFLFIL VIIVFKEKPK
310 320 330 340 350
HPPSRAQSLS YALATTDASY LSSIVRLFKN LNFVLLVITY GLNAGAFYAL
360 370 380 390 400
STLLNRMVIL HFPGEEVNAG RIGLTIVIAG MFGAMISGIW LDKSKTYKET
410 420 430 440 450
TLVVYIMTLV GMVVYTFTLN LNHLWIVFIT AGTLGFFMTG YLPLGFEFAV
460 470 480 490 500
EFTYPESEGV SSGLLNVSAQ VFGIVFTISQ GQIIDNHGTM FGNIFLCVFL
510 520 530 540 550
ALGSALTAFI KSDLRRQRAN KDAPETKVQE EEEEEEGSNT SKVPVVSEAH

L
Length:551
Mass (Da):60,107
Last modified:April 13, 2004 - v2
Checksum:i968F46696EEAE416
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0E9A0A0R4J0E9_MOUSE
Feline leukemia virus subgroup C re...
Flvcr2 BC011209, Mfsd7c, mCG_140638
551Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti426I → V in AAH11209 (PubMed:15489334).Curated1
Sequence conflicti452F → L in AAH11209 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY260574 mRNA Translation: AAP86635.1
AY260576 mRNA Translation: AAP86637.1
AY260575 mRNA Translation: AAP86636.1
BC011209 mRNA Translation: AAH11209.1
CCDSiCCDS26062.1
RefSeqiNP_663422.1, NM_145447.2
UniGeneiMm.301076

Genome annotation databases

GeneIDi217721
KEGGimmu:217721
UCSCiuc007ohe.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY260574 mRNA Translation: AAP86635.1
AY260576 mRNA Translation: AAP86637.1
AY260575 mRNA Translation: AAP86636.1
BC011209 mRNA Translation: AAH11209.1
CCDSiCCDS26062.1
RefSeqiNP_663422.1, NM_145447.2
UniGeneiMm.301076

3D structure databases

ProteinModelPortaliQ91X85
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229955, 1 interactor
STRINGi10090.ENSMUSP00000035569

PTM databases

iPTMnetiQ91X85
PhosphoSitePlusiQ91X85

Proteomic databases

MaxQBiQ91X85
PaxDbiQ91X85
PRIDEiQ91X85

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi217721
KEGGimmu:217721
UCSCiuc007ohe.1 mouse

Organism-specific databases

CTDi55640
MGIiMGI:2384974 Flvcr2

Phylogenomic databases

eggNOGiKOG2563 Eukaryota
ENOG410XSTK LUCA
HOGENOMiHOG000019717
HOVERGENiHBG051631
InParanoidiQ91X85
KOiK08220
PhylomeDBiQ91X85
TreeFamiTF314292

Miscellaneous databases

ChiTaRSiMfsd7c mouse
PROiPR:Q91X85
SOURCEiSearch...

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFLVC2_MOUSE
AccessioniPrimary (citable) accession number: Q91X85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: November 7, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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