UniProtKB - Q91X78 (ERLN1_MOUSE)
Protein
Erlin-1
Gene
Erlin1
Organism
Mus musculus (Mouse)
Status
Functioni
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (By similarity).By similarity
GO - Molecular functioni
- cholesterol binding Source: MGI
- ubiquitin protein ligase binding Source: InterPro
GO - Biological processi
- cholesterol metabolic process Source: UniProtKB-KW
- negative regulation of cholesterol biosynthetic process Source: MGI
- negative regulation of fatty acid biosynthetic process Source: MGI
- SREBP signaling pathway Source: MGI
- ubiquitin-dependent ERAD pathway Source: MGI
Keywordsi
Biological process | Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism |
Ligand | Lipid-binding |
Enzyme and pathway databases
Reactomei | R-MMU-382556, ABC-family proteins mediated transport |
Names & Taxonomyi
Protein namesi | Recommended name: Erlin-1By similarityAlternative name(s): Endoplasmic reticulum lipid raft-associated protein 1 Protein KE04 homologCurated Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1 Short name: SPFH domain-containing protein 1 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2387613, Erlin1 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass type II membrane protein By similarity
Note: Associated with lipid raft-like domains of the endoplasmic reticulum membrane.By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
- endoplasmic reticulum membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- protein-containing complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 7 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 8 – 28 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 29 – 348 | LumenalSequence analysisAdd BLAST | 320 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000002785 | 1 – 348 | Erlin-1Add BLAST | 348 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 108 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 269 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, GlycoproteinProteomic databases
EPDi | Q91X78 |
jPOSTi | Q91X78 |
MaxQBi | Q91X78 |
PaxDbi | Q91X78 |
PeptideAtlasi | Q91X78 |
PRIDEi | Q91X78 |
PTM databases
GlyConnecti | 2300, 1 N-Linked glycan (1 site) |
GlyGeni | Q91X78, 1 site |
iPTMneti | Q91X78 |
PhosphoSitePlusi | Q91X78 |
Interactioni
Subunit structurei
Forms a heteromeric complex with ERLIN2 (By similarity). In complex with ERLIN2, interacts with RNF170 (PubMed:21610068).
Interacts with AMFR and SYVN1 (By similarity).
By similarity1 PublicationGO - Molecular functioni
- ubiquitin protein ligase binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 230480, 5 interactors |
IntActi | Q91X78, 2 interactors |
STRINGi | 10090.ENSMUSP00000129684 |
Miscellaneous databases
RNActi | Q91X78, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the band 7/mec-2 family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2962, Eukaryota |
GeneTreei | ENSGT00390000014666 |
InParanoidi | Q91X78 |
OMAi | TDQIDEN |
OrthoDBi | 930534at2759 |
PhylomeDBi | Q91X78 |
TreeFami | TF313059 |
Family and domain databases
CDDi | cd03406, SPFH_like_u3, 1 hit |
InterProi | View protein in InterPro IPR001107, Band_7 IPR036013, Band_7/SPFH_dom_sf IPR033294, Erlin1/2 |
PANTHERi | PTHR15351, PTHR15351, 1 hit |
Pfami | View protein in Pfam PF01145, Band_7, 1 hit |
SMARTi | View protein in SMART SM00244, PHB, 1 hit |
SUPFAMi | SSF117892, SSF117892, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q91X78-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNMTQARLLV AAVVGLVAIL LYASIHKIEE GHLAVYYRGG ALLTSPSGPG
60 70 80 90 100
YHIMLPFITT FRSVQTTLQT DEVKNVPCGT SGGVMIYIDR IEVVNMLAPY
110 120 130 140 150
AVFDIVRNYT ADYDKTLIFN KIHHELNQFC SAHTLQEVYI ELFDQIDENL
160 170 180 190 200
KQALQKDLNT MAPGLTIQAV RVTKPKIPEA IRRNFELMEA EKTKLLIAAQ
210 220 230 240 250
KQKVVEKEAE TERKRAVIEA EKIAQVAKIR FQQKVMEKET EKRISEIEDA
260 270 280 290 300
AFLAREKAKA DAEYYAAHKY ATSNKHKLTP EYLELKKYQA IASNSKIYFG
310 320 330 340
SNIPSMFVDS SCALKYSDGR TGREDSLPPE EAREPSGESP IQNKENAG
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PUH5 | E9PUH5_MOUSE | Erlin-1 | Erlin1 | 158 | Annotation score: | ||
E9PZB0 | E9PZB0_MOUSE | Erlin-1 | Erlin1 | 69 | Annotation score: | ||
F6Z6D6 | F6Z6D6_MOUSE | Erlin-1 | Erlin1 | 59 | Annotation score: | ||
E9PVM2 | E9PVM2_MOUSE | Erlin-1 | Erlin1 | 23 | Annotation score: |
Sequence cautioni
The sequence AAH11220 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH23849 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 57 | F → S in AAH23849 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK133557 mRNA Translation: BAE21724.1 AK145990 mRNA Translation: BAE26812.1 AC124693 Genomic DNA No translation available. CH466534 Genomic DNA Translation: EDL41918.1 BC011220 mRNA Translation: AAH11220.1 Different initiation. BC023849 mRNA Translation: AAH23849.1 Different initiation. |
CCDSi | CCDS29842.2 |
RefSeqi | NP_001157831.1, NM_001164359.1 NP_001157832.1, NM_001164360.1 NP_663477.3, NM_145502.3 XP_006527061.1, XM_006526998.3 |
Genome annotation databases
Ensembli | ENSMUST00000071698; ENSMUSP00000071618; ENSMUSG00000025198 ENSMUST00000112028; ENSMUSP00000107659; ENSMUSG00000025198 ENSMUST00000170801; ENSMUSP00000129684; ENSMUSG00000025198 |
GeneIDi | 226144 |
KEGGi | mmu:226144 |
UCSCi | uc008hpd.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK133557 mRNA Translation: BAE21724.1 AK145990 mRNA Translation: BAE26812.1 AC124693 Genomic DNA No translation available. CH466534 Genomic DNA Translation: EDL41918.1 BC011220 mRNA Translation: AAH11220.1 Different initiation. BC023849 mRNA Translation: AAH23849.1 Different initiation. |
CCDSi | CCDS29842.2 |
RefSeqi | NP_001157831.1, NM_001164359.1 NP_001157832.1, NM_001164360.1 NP_663477.3, NM_145502.3 XP_006527061.1, XM_006526998.3 |
3D structure databases
SMRi | Q91X78 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 230480, 5 interactors |
IntActi | Q91X78, 2 interactors |
STRINGi | 10090.ENSMUSP00000129684 |
PTM databases
GlyConnecti | 2300, 1 N-Linked glycan (1 site) |
GlyGeni | Q91X78, 1 site |
iPTMneti | Q91X78 |
PhosphoSitePlusi | Q91X78 |
Proteomic databases
EPDi | Q91X78 |
jPOSTi | Q91X78 |
MaxQBi | Q91X78 |
PaxDbi | Q91X78 |
PeptideAtlasi | Q91X78 |
PRIDEi | Q91X78 |
Protocols and materials databases
Antibodypediai | 2279, 197 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000071698; ENSMUSP00000071618; ENSMUSG00000025198 ENSMUST00000112028; ENSMUSP00000107659; ENSMUSG00000025198 ENSMUST00000170801; ENSMUSP00000129684; ENSMUSG00000025198 |
GeneIDi | 226144 |
KEGGi | mmu:226144 |
UCSCi | uc008hpd.2, mouse |
Organism-specific databases
CTDi | 10613 |
MGIi | MGI:2387613, Erlin1 |
Phylogenomic databases
eggNOGi | KOG2962, Eukaryota |
GeneTreei | ENSGT00390000014666 |
InParanoidi | Q91X78 |
OMAi | TDQIDEN |
OrthoDBi | 930534at2759 |
PhylomeDBi | Q91X78 |
TreeFami | TF313059 |
Enzyme and pathway databases
Reactomei | R-MMU-382556, ABC-family proteins mediated transport |
Miscellaneous databases
BioGRID-ORCSi | 226144, 1 hit in 17 CRISPR screens |
ChiTaRSi | Erlin1, mouse |
PROi | PR:Q91X78 |
RNActi | Q91X78, protein |
SOURCEi | Search... |
Gene expression databases
ExpressionAtlasi | Q91X78, baseline and differential |
Family and domain databases
CDDi | cd03406, SPFH_like_u3, 1 hit |
InterProi | View protein in InterPro IPR001107, Band_7 IPR036013, Band_7/SPFH_dom_sf IPR033294, Erlin1/2 |
PANTHERi | PTHR15351, PTHR15351, 1 hit |
Pfami | View protein in Pfam PF01145, Band_7, 1 hit |
SMARTi | View protein in SMART SM00244, PHB, 1 hit |
SUPFAMi | SSF117892, SSF117892, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ERLN1_MOUSE | |
Accessioni | Q91X78Primary (citable) accession number: Q91X78 Secondary accession number(s): A0A0R4J1G5, Q3UKI9, Q8CIH7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | May 8, 2019 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families