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Protein

Hemopexin

Gene

Hpx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.

Miscellaneous

The isolated N-terminal domain binds one heme. The full-length protein also binds one heme, but at a different site. The physiological significance of this is not clear (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi79Iron (heme 1 axial ligand)By similarity1
Metal bindingi149Iron (heme 1 axial ligand)By similarity1
Metal bindingi235Iron (heme 2 axial ligand)By similarity1
Metal bindingi291Iron (heme 2 axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular iron ion homeostasis Source: InterPro
  • heme metabolic process Source: MGI
  • hemoglobin metabolic process Source: MGI
  • positive regulation of humoral immune response mediated by circulating immunoglobulin Source: MGI
  • positive regulation of immunoglobulin production Source: MGI
  • positive regulation of interferon-gamma-mediated signaling pathway Source: MGI
  • positive regulation of response to interferon-gamma Source: MGI
  • positive regulation of tyrosine phosphorylation of STAT protein Source: MGI
  • regulation of protein metabolic process Source: MGI

Keywordsi

Biological processTransport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-2168880 Scavenging of heme from plasma

Names & Taxonomyi

Protein namesi
Recommended name:
Hemopexin
Gene namesi
Name:Hpx
Synonyms:Hpxn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:105112 Hpx

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000002140724 – 460HemopexinAdd BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi50 ↔ 230By similarity
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi148 ↔ 153By similarity
Glycosylationi186N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi187 ↔ 199By similarity
Glycosylationi240N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi255 ↔ 458By similarity
Disulfide bondi364 ↔ 406By similarity
Disulfide bondi416 ↔ 433By similarity
Glycosylationi419N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ91X72
PaxDbiQ91X72
PeptideAtlasiQ91X72
PRIDEiQ91X72

PTM databases

CarbonylDBiQ91X72
iPTMnetiQ91X72
PhosphoSitePlusiQ91X72
SwissPalmiQ91X72

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiENSMUSG00000030895
CleanExiMM_HPX
ExpressionAtlasiQ91X72 baseline and differential
GenevisibleiQ91X72 MM

Interactioni

Protein-protein interaction databases

BioGridi200414, 1 interactor
IntActiQ91X72, 4 interactors
MINTiQ91X72
STRINGi10090.ENSMUSP00000033185

Structurei

3D structure databases

ProteinModelPortaliQ91X72
SMRiQ91X72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati53 – 93Hemopexin 1Add BLAST41
Repeati94 – 138Hemopexin 2Add BLAST45
Repeati139 – 183Hemopexin 3Add BLAST45
Repeati184 – 230Hemopexin 4Add BLAST47
Repeati257 – 302Hemopexin 5Add BLAST46
Repeati303 – 350Hemopexin 6Add BLAST48
Repeati355 – 394Hemopexin 7Add BLAST40
Repeati398 – 448Hemopexin 8Add BLAST51

Sequence similaritiesi

Belongs to the hemopexin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00390000009178
HOGENOMiHOG000112887
HOVERGENiHBG005956
InParanoidiQ91X72
KOiK18977
OMAiAVECHRG
OrthoDBiEOG091G052J
TreeFamiTF331201

Family and domain databases

CDDicd00094 HX, 2 hits
Gene3Di2.110.10.10, 2 hits
InterProiView protein in InterPro
IPR016358 Hemopexin
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
PfamiView protein in Pfam
PF00045 Hemopexin, 5 hits
PIRSFiPIRSF002551 Hemopexin_chordata, 1 hit
SMARTiView protein in SMART
SM00120 HX, 6 hits
SUPFAMiSSF50923 SSF50923, 2 hits
PROSITEiView protein in PROSITE
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 8 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91X72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTAVALNI LVLLGLCWSL AVASPLPTAN GRVAEVENGT KPDSDVPEHC
60 70 80 90 100
LDTWSFDAAT MDHNGTMLFF KGEFVWRGHS GTRELISARW KNPITSVDAA
110 120 130 140 150
FRGPDSVFLI KEDKVWVYPP EKKENGYPKL FQEEFPGIPY PPDAAVECHR
160 170 180 190 200
GECQSEGVLF FQGNRKWFWD FATRTQKERS WSTVGNCTAA LRWLERYYCF
210 220 230 240 250
QGNKFLRFNP VTGEVPPRYP LDARDYFVSC PGRGHGRPRN GTAHGNSTHP
260 270 280 290 300
MHSRCSPDPG LTALLSDHRG ATYAFTGSHY WRLDSSRDGW HSWPIAHHWP
310 320 330 340 350
QGPSTVDAAF SWDDKVYLIQ GTQVYVFLTK GGNNLVSGYP KRLEKELGSP
360 370 380 390 400
PGISLETIDA AFSCPGSSRL YVSSGRRLWW LDLKSGAQAT WTEVSWPHEK
410 420 430 440 450
VDGALCLDKS LGPNTCSSNG SSLYFIHGPN LYCYSSIDKL NAAKSLPQPQ
460
KVNSILGCSQ
Length:460
Mass (Da):51,318
Last modified:July 27, 2011 - v2
Checksum:i5DF86BA50CC23B48
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30N → H in AAH11246 (PubMed:15489334).Curated1
Sequence conflicti30N → H in AAH19901 (PubMed:15489334).Curated1
Sequence conflicti233R → Q in AAB49490 (Ref. 4) Curated1
Sequence conflicti453Missing in AAB49490 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145928 mRNA Translation: BAE26759.1
CH466531 Genomic DNA Translation: EDL16785.1
BC011246 mRNA Translation: AAH11246.1
BC019901 mRNA Translation: AAH19901.1
U89889 mRNA Translation: AAB49490.1
CCDSiCCDS21654.1
RefSeqiNP_059067.2, NM_017371.2
UniGeneiMm.3485

Genome annotation databases

EnsembliENSMUST00000033185; ENSMUSP00000033185; ENSMUSG00000030895
GeneIDi15458
KEGGimmu:15458
UCSCiuc009iyl.2 mouse

Similar proteinsi

Entry informationi

Entry nameiHEMO_MOUSE
AccessioniPrimary (citable) accession number: Q91X72
Secondary accession number(s): P97824, Q3UKP2, Q8WUP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: July 27, 2011
Last modified: February 28, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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