UniProtKB - Q91X56 (S1PR5_MOUSE)
Protein
Sphingosine 1-phosphate receptor 5
Gene
S1pr5
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. S1P activation on O4-positive pre-oligodendrocytes induces process retraction via a Rho kinase/collapsin response-mediated protein signaling pathway. The S1P-induced survival of mature oligodendrocytes is mediated through a pertussis toxin-sensitive, Akt-dependent pathway. S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. These effects depend on the developmental stage of the cell.By similarity1 Publication
GO - Molecular functioni
- G protein-coupled receptor activity Source: MGI
- sphingosine-1-phosphate receptor activity Source: InterPro
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
- G protein-coupled receptor signaling pathway Source: MGI
- regulation of metabolic process Source: GO_Central
- regulation of neuron differentiation Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-418594, G alpha (i) signalling events R-MMU-419408, Lysosphingolipid and LPA receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Sphingosine 1-phosphate receptor 5Short name: S1P receptor 5 Short name: S1P5 Alternative name(s): Endothelial differentiation G-protein-coupled receptor 8 Lysophospholipid receptor B4 Sphingosine 1-phosphate receptor Edg-8 Short name: S1P receptor Edg-8 |
Gene namesi | Name:S1pr5 Synonyms:Edg8, Lpb4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2150641, S1pr5 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- integral component of membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 41 | ExtracellularBy similarityAdd BLAST | 41 | |
Transmembranei | 42 – 62 | Helical; Name=1By similarityAdd BLAST | 21 | |
Topological domaini | 63 – 68 | CytoplasmicBy similarity | 6 | |
Transmembranei | 69 – 89 | Helical; Name=2By similarityAdd BLAST | 21 | |
Topological domaini | 90 – 111 | ExtracellularBy similarityAdd BLAST | 22 | |
Transmembranei | 112 – 132 | Helical; Name=3By similarityAdd BLAST | 21 | |
Topological domaini | 133 – 151 | CytoplasmicBy similarityAdd BLAST | 19 | |
Transmembranei | 152 – 172 | Helical; Name=4By similarityAdd BLAST | 21 | |
Topological domaini | 173 – 192 | ExtracellularBy similarityAdd BLAST | 20 | |
Transmembranei | 193 – 213 | Helical; Name=5By similarityAdd BLAST | 21 | |
Topological domaini | 214 – 253 | CytoplasmicBy similarityAdd BLAST | 40 | |
Transmembranei | 254 – 274 | Helical; Name=6By similarityAdd BLAST | 21 | |
Topological domaini | 275 – 288 | ExtracellularBy similarityAdd BLAST | 14 | |
Transmembranei | 289 – 309 | Helical; Name=7By similarityAdd BLAST | 21 | |
Topological domaini | 310 – 400 | CytoplasmicBy similarityAdd BLAST | 91 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069437 | 1 – 400 | Sphingosine 1-phosphate receptor 5Add BLAST | 400 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 20 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 324 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 340 | PhosphoserineCombined sources | 1 | |
Modified residuei | 342 | PhosphoserineBy similarity | 1 | |
Modified residuei | 384 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
PaxDbi | Q91X56 |
PRIDEi | Q91X56 |
PTM databases
GlyGeni | Q91X56, 1 site |
iPTMneti | Q91X56 |
PhosphoSitePlusi | Q91X56 |
Expressioni
Tissue specificityi
Expressed in spleen and brain. In the CNS expression is restricted to oligodendrocytes.2 Publications
Developmental stagei
Expressed in 7-day and 17-day embryos, but not in 11-day and 15-day embryos, implying its role in mammalian development. In oligodendrocytes, expressed throughout development from the immature stages to the mature myelin-froming cell.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000045087, Expressed in lumbar subsegment of spinal cord and 156 other tissues |
Genevisiblei | Q91X56, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 220483, 1 interactor |
STRINGi | 10090.ENSMUSP00000113843 |
Miscellaneous databases
RNActi | Q91X56, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QSWN, Eukaryota |
GeneTreei | ENSGT00970000193365 |
HOGENOMi | CLU_047979_1_0_1 |
InParanoidi | Q91X56 |
OMAi | MVTMRPY |
OrthoDBi | 981486at2759 |
PhylomeDBi | Q91X56 |
TreeFami | TF330052 |
Family and domain databases
InterProi | View protein in InterPro IPR005386, EDG8_S1P_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR004061, S1P_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01561, EDG8RECEPTOR PR00237, GPCRRHODOPSN PR01523, S1PRECEPTOR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q91X56-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPGLLRPAP VSEVIVLHYN YTGKLRGARY QPGAGLRADA AVCLAVCAFI
60 70 80 90 100
VLENLAVLLV LVRHPRFHAP MFLLLGSLTL SDLLAGAAYA TNILLSGPLT
110 120 130 140 150
LRLSPALWFA REGGVFVALA ASVLSLLAIA LERHLTMARR GPAPAASRAR
160 170 180 190 200
TLAMAVAAWG ASLLLGLLPA LGWNCLGRLE TCSTVLPLYA KAYVLFCVLA
210 220 230 240 250
FLGILAAICA LYARIYCQVR ANARRLRAGP GSRRATSSSR SRHTPRSLAL
260 270 280 290 300
LRTLSVVLLA FVACWGPLFL LLLLDVACPA RACPVLLQAD PFLGLAMANS
310 320 330 340 350
LLNPIIYTFT NRDLRHALLR LLCCGRGPCN QDSSNSLQRS PSAAGPSGGG
360 370 380 390 400
LRRCLPPTLD RSSSPSEHLS PQQDGVDTSC STGSPGVATA NRSLVPTATD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC012232 mRNA Translation: AAH12232.1 AF327535 mRNA Translation: AAK15485.1 AK081126 mRNA Translation: BAC38142.1 |
CCDSi | CCDS22898.1 |
RefSeqi | NP_444420.1, NM_053190.2 |
Genome annotation databases
Ensembli | ENSMUST00000122088; ENSMUSP00000113843; ENSMUSG00000045087 |
GeneIDi | 94226 |
KEGGi | mmu:94226 |
UCSCi | uc009oks.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC012232 mRNA Translation: AAH12232.1 AF327535 mRNA Translation: AAK15485.1 AK081126 mRNA Translation: BAC38142.1 |
CCDSi | CCDS22898.1 |
RefSeqi | NP_444420.1, NM_053190.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 220483, 1 interactor |
STRINGi | 10090.ENSMUSP00000113843 |
Chemistry databases
GuidetoPHARMACOLOGYi | 279 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q91X56, 1 site |
iPTMneti | Q91X56 |
PhosphoSitePlusi | Q91X56 |
Proteomic databases
PaxDbi | Q91X56 |
PRIDEi | Q91X56 |
Protocols and materials databases
Antibodypediai | 12897, 388 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000122088; ENSMUSP00000113843; ENSMUSG00000045087 |
GeneIDi | 94226 |
KEGGi | mmu:94226 |
UCSCi | uc009oks.2, mouse |
Organism-specific databases
CTDi | 53637 |
MGIi | MGI:2150641, S1pr5 |
Phylogenomic databases
eggNOGi | ENOG502QSWN, Eukaryota |
GeneTreei | ENSGT00970000193365 |
HOGENOMi | CLU_047979_1_0_1 |
InParanoidi | Q91X56 |
OMAi | MVTMRPY |
OrthoDBi | 981486at2759 |
PhylomeDBi | Q91X56 |
TreeFami | TF330052 |
Enzyme and pathway databases
Reactomei | R-MMU-418594, G alpha (i) signalling events R-MMU-419408, Lysosphingolipid and LPA receptors |
Miscellaneous databases
BioGRID-ORCSi | 94226, 1 hit in 18 CRISPR screens |
PROi | PR:Q91X56 |
RNActi | Q91X56, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000045087, Expressed in lumbar subsegment of spinal cord and 156 other tissues |
Genevisiblei | Q91X56, MM |
Family and domain databases
InterProi | View protein in InterPro IPR005386, EDG8_S1P_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR004061, S1P_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01561, EDG8RECEPTOR PR00237, GPCRRHODOPSN PR01523, S1PRECEPTOR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S1PR5_MOUSE | |
Accessioni | Q91X56Primary (citable) accession number: Q91X56 Secondary accession number(s): Q99MN8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 12, 2005 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries