UniProtKB - Q91X17 (UROM_MOUSE)

BLAST

>sp|Q91X17|UROM_MOUSE Uromodulin OS=Mus musculus OX=10090 GN=Umod PE=1 SV=1
MGIPLTWMLLVMMVTSWFTLAEASNSTEARRCSECHNNATCTVDGVVTTCSCQTGFTGDG
LVCEDMDECATPWTHNCSNSSCVNTPGSFKCSCQDGFRLTPELSCTDVDECSEQGLSNCH
ALATCVNTEGDYLCVCPEGFTGDGWYCECSPGSCEPGLDCLPQGPDGKLVCQDPCNTYET
LTEYWRSTEYGVGYSCDAGLHGWYRFTGQGGVRMAETCVPVLRCNTAAPMWLNGSHPSSS
EGIVSRTACAHWSDQCCRWSTEIQVKACPGGFYIYNLTAPPECNLAYCTDPSSVEGTCEE
CRVDEDCISDNGRWRCQCKQDSNITDVSQLEYRLECGANDIKMSLRKCQLQSLGFMNVFM
YLNDRQCSGFSESDERDWMSIVTPARNGPCGTVLRRNETHATYSNTLYLANAIIIRDIII
RMNFECSYPLDMKVSLKTSLQPMVSALNISLGGTGKFTVRMALFQSPTYTQPHQGPSVML
STEAFLYVGTMLDGGDLSRFVLLMTNCYATPSSNSTDPVKYFIIQDSCPRTEDTTIQVTE
NGESSQARFSVQMFRFAGNYDLVYLHCEVYLCDSTSEQCKPTCSGTRFRSGNFIDQTRVL
NLGPITRQGVQASVSKAASSNLRLLSIWLLLFPSATLIFMVQ

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History
Entry version 141 (12 Sep 2018)
Sequence version 1 (01 Dec 2001)
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Protein

Uromodulin

Gene

Umod

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia.By similarity

Uromodulin, secreted form: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.2 Publications

GO - Molecular functionⁱ

calcium ion binding Source: InterPro
IgG binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chemical homeostasis
Source: MGI
Inferred from mutant phenotypeⁱ
- 17264314
excretion
Source: MGI
Inferred from mutant phenotypeⁱ
- 17264314
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: MGI
ion homeostasis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15327412
leukocyte cell-cell adhesion Source: MGI
metanephric ascending thin limb development
Source: UniProtKB
Inferred from expression patternⁱ
- 18618131
metanephric distal convoluted tubule development
Source: UniProtKB
Inferred from expression patternⁱ
- 18618131
metanephric thick ascending limb development
Source: UniProtKB
Inferred from expression patternⁱ
- 18618131
neutrophil migration Source: MGI

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-446203 Asparagine N-linked glycosylation

Reactomeⁱ

R-MMU-446203 Asparagine N-linked glycosylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Uromodulin Alternative name(s): Tamm-Horsfall urinary glycoprotein Short name: THP Cleaved into the following chain: Uromodulin, secreted form
Gene namesⁱ	Name:Umod
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:102674 Umod

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Membrane, Secreted

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice suffer significantly more frequently from urinary tract infections. They shown also spontaneous formation of calcium crystals in adult kidneys, and excessive intake of calcium and oxalate dramatically increases both the frequency and the severity of renal calcium crystal formation in mutant mice, but not in wild-type mice.2 Publications

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 24	By similarityAdd BLAST	24
ChainⁱPRO_0000041673	25 – 618	UromodulinAdd BLAST	594
ChainⁱPRO_0000407910	25 – 588	Uromodulin, secreted formAdd BLAST	564
PropeptideⁱPRO_0000041674	619 – 642	Removed in mature formSequence analysisAdd BLAST	24

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	25	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	32 ↔ 41	PROSITE-ProRule annotation
Disulfide bondⁱ	35 ↔ 50	PROSITE-ProRule annotation
Glycosylationⁱ	38	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	52 ↔ 63	PROSITE-ProRule annotation
Disulfide bondⁱ	69 ↔ 82	PROSITE-ProRule annotation
Glycosylationⁱ	76	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	77 ↔ 91	PROSITE-ProRule annotation
Glycosylationⁱ	79	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	93 ↔ 105	PROSITE-ProRule annotation
Disulfide bondⁱ	111 ↔ 125	PROSITE-ProRule annotation
Disulfide bondⁱ	119 ↔ 134	PROSITE-ProRule annotation
Disulfide bondⁱ	136 ↔ 147	PROSITE-ProRule annotation
Glycosylationⁱ	233	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	276	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	298 ↔ 307	By similarity
Disulfide bondⁱ	301 ↔ 316	By similarity
Disulfide bondⁱ	318 ↔ 348	By similarity
Glycosylationⁱ	323	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	336 ↔ 426	By similarity
Disulfide bondⁱ	367 ↔ 390	By similarity
Glycosylationⁱ	397	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	448	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	507 ↔ 567	PROSITE-ProRule annotation
Glycosylationⁱ	514	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	528 ↔ 583	By similarity
Disulfide bondⁱ	572 ↔ 579	By similarity
Lipidationⁱ	618	GPI-anchor amidated alanineSequence analysis	1

Post-translational modificationⁱ

Proteolytically cleaved at a conserved C-terminal proteolytic cleavage site to generate the secreted form found in urine (PubMed:18375198). This cleavage is catalyzed by HPN (PubMed:26673890).2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	588 – 589	Cleavage2 Publications		2

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q91X17
PaxDbⁱ	Q91X17
PRIDEⁱ	Q91X17

PTM databases

iPTMnetⁱ	Q91X17
PhosphoSitePlusⁱ	Q91X17

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000030963 Expressed in 67 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	MM_UMOD
ExpressionAtlasⁱ	Q91X17 baseline and differential
Genevisibleⁱ	Q91X17 MM

Interactionⁱ

Subunit structureⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000033263

STRINGⁱ

10090.ENSMUSP00000033263

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q91X17
SMRⁱ	Q91X17
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	28 – 64	EGF-like 1PROSITE-ProRule annotationAdd BLAST	37
Domainⁱ	65 – 106	EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST	42
Domainⁱ	107 – 148	EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST	42
Domainⁱ	335 – 590	ZPPROSITE-ProRule annotationAdd BLAST	256

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	431 – 454	Important for secretion and polymerization into filamentsBy similarityAdd BLAST	24
Regionⁱ	587 – 590	Essential for cleavage by HPNBy similarity	4
Regionⁱ	599 – 608	Regulates polymerization into filamentsBy similarity	10

Domainⁱ

The ZP domain mediates polymerization, leading to the formation of long filaments.2 Publications

Keywords - Domainⁱ

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IVSV Eukaryota ENOG410YDU6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063244
HOGENOMⁱ	HOG000293303
HOVERGENⁱ	HBG004349
InParanoidⁱ	Q91X17
KEGG Orthology (KO) More...KOⁱ	K18274
OMAⁱ	GPCGTVM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06RJ
PhylomeDBⁱ	Q91X17
TreeFamⁱ	TF330284

Family and domain databases

InterProⁱ	View protein in InterPro IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR018097 EGF_Ca-bd_CS IPR024731 EGF_dom IPR009030 Growth_fac_rcpt_cys_sf IPR001507 ZP_dom IPR017977 ZP_dom_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12947 EGF_3, 1 hit PF07645 EGF_CA, 1 hit PF00100 Zona_pellucida, 1 hit
PRINTSⁱ	PR00023 ZPELLUCIDA
SMARTⁱ	View protein in SMART SM00181 EGF, 3 hits SM00179 EGF_CA, 2 hits SM00241 ZP, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit
PROSITEⁱ	View protein in PROSITE PS00010 ASX_HYDROXYL, 2 hits PS01186 EGF_2, 3 hits PS50026 EGF_3, 3 hits PS01187 EGF_CA, 2 hits PS00682 ZP_1, 1 hit PS51034 ZP_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q91X17-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MGIPLTWMLL VMMVTSWFTL AEASNSTEAR RCSECHNNAT CTVDGVVTTC 
        60         70         80         90        100
SCQTGFTGDG LVCEDMDECA TPWTHNCSNS SCVNTPGSFK CSCQDGFRLT 
       110        120        130        140        150
PELSCTDVDE CSEQGLSNCH ALATCVNTEG DYLCVCPEGF TGDGWYCECS 
       160        170        180        190        200
PGSCEPGLDC LPQGPDGKLV CQDPCNTYET LTEYWRSTEY GVGYSCDAGL 
       210        220        230        240        250
HGWYRFTGQG GVRMAETCVP VLRCNTAAPM WLNGSHPSSS EGIVSRTACA 
       260        270        280        290        300
HWSDQCCRWS TEIQVKACPG GFYIYNLTAP PECNLAYCTD PSSVEGTCEE 
       310        320        330        340        350
CRVDEDCISD NGRWRCQCKQ DSNITDVSQL EYRLECGAND IKMSLRKCQL 
       360        370        380        390        400
QSLGFMNVFM YLNDRQCSGF SESDERDWMS IVTPARNGPC GTVLRRNETH 
       410        420        430        440        450
ATYSNTLYLA NAIIIRDIII RMNFECSYPL DMKVSLKTSL QPMVSALNIS 
       460        470        480        490        500
LGGTGKFTVR MALFQSPTYT QPHQGPSVML STEAFLYVGT MLDGGDLSRF 
       510        520        530        540        550
VLLMTNCYAT PSSNSTDPVK YFIIQDSCPR TEDTTIQVTE NGESSQARFS 
       560        570        580        590        600
VQMFRFAGNY DLVYLHCEVY LCDSTSEQCK PTCSGTRFRS GNFIDQTRVL 
       610        620        630        640 
NLGPITRQGV QASVSKAASS NLRLLSIWLL LFPSATLIFM VQ

Length:642

Mass (Da):70,845

Last modified:December 1, 2001 - v1

Checksum:ⁱ31B1461B4DCAE927

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A140LI10	A0A140LI10_MOUSE	Uromodulin Uromodulin	Umod	187	Annotation score:
A0A140LJ95	A0A140LJ95_MOUSE	Uromodulin Uromodulin	Umod	87	Annotation score:
A0A140LJ15	A0A140LJ15_MOUSE	Uromodulin Uromodulin	Umod	77	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	22	E → G in AAA73896 (PubMed:7873609).Curated	1
Sequence conflictⁱ	102 – 104	ELS → GLG in AAA73896 (PubMed:7873609).Curated	3
Sequence conflictⁱ	138	E → K in AAA73896 (PubMed:7873609).Curated	1
Sequence conflictⁱ	152	G → S in AAA73896 (PubMed:7873609).Curated	1
Sequence conflictⁱ	200	L → Q in AAA73896 (PubMed:7873609).Curated	1
Sequence conflictⁱ	223	R → A in AAA73896 (PubMed:7873609).Curated	1
Sequence conflictⁱ	255	Q → H in AAA73896 (PubMed:7873609).Curated	1
Sequence conflictⁱ	279	A → E in AAA73896 (PubMed:7873609).Curated	1
Sequence conflictⁱ	340	D → G in BAE38225 (PubMed:16141072).Curated	1
Sequence conflictⁱ	473	H → Y in AAA73896 (PubMed:7873609).Curated	1
Sequence conflictⁱ	590	S → C in AAA73896 (PubMed:7873609).Curated	1
Sequence conflictⁱ	606	T → TRQ in AAA73896 (PubMed:7873609).Curated	1
Sequence conflictⁱ	616 – 617	Missing in AAA73896 (PubMed:7873609).Curated	2
Sequence conflictⁱ	633	P → L in AAA73896 (PubMed:7873609).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L33406 mRNA Translation: AAA73896.1 AK085460 mRNA Translation: BAC39452.1 AK144065 mRNA Translation: BAE25681.1 AK164688 mRNA Translation: BAE37877.1 AK165507 mRNA Translation: BAE38225.1 BC012973 mRNA Translation: AAH12973.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21780.1
PIRⁱ	S52111
NCBI Reference Sequences More...RefSeqⁱ	NP_001265534.1, NM_001278605.1 NP_033496.1, NM_009470.5
UniGeneⁱ	Mm.10826

Genome annotation databases

Ensemblⁱ	ENSMUST00000033263; ENSMUSP00000033263; ENSMUSG00000030963 ENSMUST00000209095; ENSMUSP00000146652; ENSMUSG00000030963
GeneIDⁱ	22242
KEGGⁱ	mmu:22242
UCSC genome browser More...UCSCⁱ	uc009jlb.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q91X17	Uromodulin (Fragment)		MOUSE		87	UniRef100_Q91X17
Tamm-Horsfall protein (Fragment)		MOUSE		205
Uromodulin (Fragment)		MOUSE		187

Protein	Similar proteins		Species	Score	Length	Source
Q91X17	Uromodulin (Fragment)		MOUSE		87	UniRef90_Q91X17
UPI000A309ECF		MUSPA		644
UPI000A3168E5		MUSCR		642
Tamm-Horsfall protein (Fragment)		MOUSE		205
Uromodulin (Fragment)		MOUSE		187

Protein	Similar proteins		Species	Score	Length	Source
Q91X17	Uromodulin		RAT		644	UniRef50_Q91X17
Uromodulin (Fragment)		MOUSE		87
Uncharacterized protein		MANLE		610
Uncharacterized protein		RABIT		652
uromodulin		TURTR		602
+61

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L33406 mRNA Translation: AAA73896.1 AK085460 mRNA Translation: BAC39452.1 AK144065 mRNA Translation: BAE25681.1 AK164688 mRNA Translation: BAE37877.1 AK165507 mRNA Translation: BAE38225.1 BC012973 mRNA Translation: AAH12973.1
CCDSⁱ	CCDS21780.1
PIRⁱ	S52111
RefSeqⁱ	NP_001265534.1, NM_001278605.1 NP_033496.1, NM_009470.5
UniGeneⁱ	Mm.10826

3D structure databases

ProteinModelPortalⁱ	Q91X17
SMRⁱ	Q91X17
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000033263

STRINGⁱ

10090.ENSMUSP00000033263

PTM databases

iPTMnetⁱ	Q91X17
PhosphoSitePlusⁱ	Q91X17

Proteomic databases

MaxQBⁱ	Q91X17
PaxDbⁱ	Q91X17
PRIDEⁱ	Q91X17

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000033263; ENSMUSP00000033263; ENSMUSG00000030963 ENSMUST00000209095; ENSMUSP00000146652; ENSMUSG00000030963
GeneIDⁱ	22242
KEGGⁱ	mmu:22242
UCSCⁱ	uc009jlb.2 mouse

Organism-specific databases

CTDⁱ	7369
MGIⁱ	MGI:102674 Umod

Phylogenomic databases

eggNOGⁱ	ENOG410IVSV Eukaryota ENOG410YDU6 LUCA
GeneTreeⁱ	ENSGT00530000063244
HOGENOMⁱ	HOG000293303
HOVERGENⁱ	HBG004349
InParanoidⁱ	Q91X17
KOⁱ	K18274
OMAⁱ	GPCGTVM
OrthoDBⁱ	EOG091G06RJ
PhylomeDBⁱ	Q91X17
TreeFamⁱ	TF330284

Enzyme and pathway databases

Reactomeⁱ	R-MMU-446203 Asparagine N-linked glycosylation

Reactomeⁱ

R-MMU-446203 Asparagine N-linked glycosylation

Miscellaneous databases

ChiTaRSⁱ	Umod mouse
Protein Ontology More...PROⁱ	PR:Q91X17
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030963 Expressed in 67 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	MM_UMOD
ExpressionAtlasⁱ	Q91X17 baseline and differential
Genevisibleⁱ	Q91X17 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR018097 EGF_Ca-bd_CS IPR024731 EGF_dom IPR009030 Growth_fac_rcpt_cys_sf IPR001507 ZP_dom IPR017977 ZP_dom_CS
Pfamⁱ	View protein in Pfam PF12947 EGF_3, 1 hit PF07645 EGF_CA, 1 hit PF00100 Zona_pellucida, 1 hit
PRINTSⁱ	PR00023 ZPELLUCIDA
SMARTⁱ	View protein in SMART SM00181 EGF, 3 hits SM00179 EGF_CA, 2 hits SM00241 ZP, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit
PROSITEⁱ	View protein in PROSITE PS00010 ASX_HYDROXYL, 2 hits PS01186 EGF_2, 3 hits PS50026 EGF_3, 3 hits PS01187 EGF_CA, 2 hits PS00682 ZP_1, 1 hit PS51034 ZP_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UROM_MOUSE
Accessionⁱ	Q91X17Primary (citable) accession number: Q91X17 Secondary accession number(s): Q3TN64, Q3TP60, Q62285
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
	Last sequence update:	December 1, 2001
	Last modified:	September 12, 2018
	This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q91X17 (UROM_MOUSE)

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Uromodulin

Umod

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Plasma membrane

Cytoskeleton

Extracellular region or secreted

Golgi apparatus

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ