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Protein

RNA-binding protein 47

Gene

Rbm47

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: MGI

GO - Biological processi

  • cytidine to uridine editing Source: MGI
  • hematopoietic progenitor cell differentiation Source: MGI

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 47
Alternative name(s):
RNA-binding motif protein 47
Gene namesi
Name:Rbm47
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2384294 Rbm47

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003078561 – 590RNA-binding protein 47Add BLAST590

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei396Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei396Omega-N-methylarginine; alternateCombined sources1
Modified residuei407Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei407Omega-N-methylarginine; alternateCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ91WT8
PeptideAtlasiQ91WT8
PRIDEiQ91WT8

PTM databases

iPTMnetiQ91WT8
PhosphoSitePlusiQ91WT8

Expressioni

Gene expression databases

BgeeiENSMUSG00000070780 Expressed in 177 organ(s), highest expression level in epithelium of small intestine
CleanExiMM_RBM47
ExpressionAtlasiQ91WT8 baseline and differential
GenevisibleiQ91WT8 MM

Interactioni

Protein-protein interaction databases

IntActiQ91WT8, 4 interactors
MINTiQ91WT8
STRINGi10090.ENSMUSP00000092348

Structurei

3D structure databases

ProteinModelPortaliQ91WT8
SMRiQ91WT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 149RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini151 – 233RRM 2PROSITE-ProRule annotationAdd BLAST83
Domaini246 – 318RRM 3PROSITE-ProRule annotationAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi489 – 578Ala-richAdd BLAST90

Sequence similaritiesi

Belongs to the RRM RBM47 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0117 Eukaryota
ENOG410XTJ5 LUCA
GeneTreeiENSGT00550000074366
HOGENOMiHOG000186083
HOVERGENiHBG051917
InParanoidiQ91WT8
OMAiIGPNREY
OrthoDBiEOG091G0EUB
PhylomeDBiQ91WT8
TreeFamiTF314932

Family and domain databases

CDDicd12491 RRM2_RBM47, 1 hit
cd12497 RRM3_RBM47, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR006535 HnRNP_R/Q_splicing_fac
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034442 RBM47
IPR034440 RBM47_RRM2
IPR034445 RBM47_RRM3
IPR000504 RRM_dom
PANTHERiPTHR43980:SF4 PTHR43980:SF4, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
TIGRFAMsiTIGR01648 hnRNP-R-Q, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q91WT8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAEDSATAM NSDPTVGSST KVPEGVAGAP NEAALLALIE RTGYTMVQEN
60 70 80 90 100
GQRKYGGPPP GWEGPHPQRG CEVFVGKIPR DVYEDELVPV FETVGRIYEL
110 120 130 140 150
RLMMDFDGKN RGYAFVMYCH KHEAKRAVRE LNNYEIRPGR LLGVCCSVDN
160 170 180 190 200
CRLFIGGIPK MKKRGEILEE IAKVTEGVLN VIVYASAADK MKNRGFAFVE
210 220 230 240 250
YESHRAAAMA RRKLMPGRIQ LWGHQIAVDW AEPEIDVDED VMQTVKILYV
260 270 280 290 300
RNLMIETTEE TIKKSFGQFN PGCVERVKKI RDYAFVHFTS REDAVHAMNN
310 320 330 340 350
LNGTELEGSC LEVTLAKPVD KEQYSRYQKA AKGGGGSAEA VAQQPSYVYS
360 370 380 390 400
CDPYTLAYYG YPYNALIGPN RDYFVKTGSI RGRGRGAAGN RTPGPRGSYL
410 420 430 440 450
GGYSAGRGIY SRYHEGKGKQ QEKGYELVPN LEISPVNPVA IKPGTVAIPA
460 470 480 490 500
IGAQYSMFQA APAPKIIEDG KIHTMEHMIS PIAVQPDPAT AAAAAAAAAA
510 520 530 540 550
AAVIPAVSTP PPFQGRPITP VYTVAPNVQR IPTAGIYGAS YVPFAAPATA
560 570 580 590
TIATLQKNAA AAVYGGYAGY IPQAFPAALQ VPIHDVYQTY
Length:590
Mass (Da):64,062
Last modified:December 1, 2001 - v1
Checksum:iB74421B7EC014E0A
GO
Isoform 2 (identifier: Q91WT8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     377-377: T → S
     378-590: Missing.

Note: No experimental confirmation available.
Show »
Length:377
Mass (Da):42,188
Checksum:i1AE05F744CF48BF2
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YXZ5D3YXZ5_MOUSE
RNA-binding protein 47
Rbm47
521Annotation score:
D3Z113D3Z113_MOUSE
RNA-binding protein 47
Rbm47
158Annotation score:
D3Z5E3D3Z5E3_MOUSE
RNA-binding protein 47
Rbm47
13Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti557K → E in BAC29127 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028840377T → S in isoform 2. 1 Publication1
Alternative sequenceiVSP_028841378 – 590Missing in isoform 2. 1 PublicationAdd BLAST213

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035620 mRNA Translation: BAC29127.1
AK085733 mRNA Translation: BAC39524.1
AK142584 mRNA Translation: BAE25115.1
AK170082 mRNA Translation: BAE41553.1
BC013481 mRNA Translation: AAH13481.1
BC034195 mRNA Translation: AAH34195.1
BC112902 mRNA Translation: AAI12903.1
CCDSiCCDS19313.1 [Q91WT8-1]
RefSeqiNP_001120854.1, NM_001127382.2 [Q91WT8-1]
NP_001278155.1, NM_001291226.1
NP_620704.1, NM_139065.3 [Q91WT8-1]
NP_848541.2, NM_178446.4 [Q91WT8-1]
XP_006504019.1, XM_006503956.2 [Q91WT8-1]
UniGeneiMm.36863
Mm.400185
Mm.426431

Genome annotation databases

EnsembliENSMUST00000094757; ENSMUSP00000092349; ENSMUSG00000070780 [Q91WT8-1]
ENSMUST00000113724; ENSMUSP00000109353; ENSMUSG00000070780 [Q91WT8-1]
ENSMUST00000113726; ENSMUSP00000109355; ENSMUSG00000070780 [Q91WT8-1]
ENSMUST00000167950; ENSMUSP00000128016; ENSMUSG00000070780 [Q91WT8-1]
ENSMUST00000200775; ENSMUSP00000144325; ENSMUSG00000070780 [Q91WT8-1]
ENSMUST00000201544; ENSMUSP00000144122; ENSMUSG00000070780 [Q91WT8-1]
GeneIDi245945
KEGGimmu:245945
UCSCiuc008xok.3 mouse [Q91WT8-1]
uc008xop.3 mouse [Q91WT8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035620 mRNA Translation: BAC29127.1
AK085733 mRNA Translation: BAC39524.1
AK142584 mRNA Translation: BAE25115.1
AK170082 mRNA Translation: BAE41553.1
BC013481 mRNA Translation: AAH13481.1
BC034195 mRNA Translation: AAH34195.1
BC112902 mRNA Translation: AAI12903.1
CCDSiCCDS19313.1 [Q91WT8-1]
RefSeqiNP_001120854.1, NM_001127382.2 [Q91WT8-1]
NP_001278155.1, NM_001291226.1
NP_620704.1, NM_139065.3 [Q91WT8-1]
NP_848541.2, NM_178446.4 [Q91WT8-1]
XP_006504019.1, XM_006503956.2 [Q91WT8-1]
UniGeneiMm.36863
Mm.400185
Mm.426431

3D structure databases

ProteinModelPortaliQ91WT8
SMRiQ91WT8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91WT8, 4 interactors
MINTiQ91WT8
STRINGi10090.ENSMUSP00000092348

PTM databases

iPTMnetiQ91WT8
PhosphoSitePlusiQ91WT8

Proteomic databases

PaxDbiQ91WT8
PeptideAtlasiQ91WT8
PRIDEiQ91WT8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094757; ENSMUSP00000092349; ENSMUSG00000070780 [Q91WT8-1]
ENSMUST00000113724; ENSMUSP00000109353; ENSMUSG00000070780 [Q91WT8-1]
ENSMUST00000113726; ENSMUSP00000109355; ENSMUSG00000070780 [Q91WT8-1]
ENSMUST00000167950; ENSMUSP00000128016; ENSMUSG00000070780 [Q91WT8-1]
ENSMUST00000200775; ENSMUSP00000144325; ENSMUSG00000070780 [Q91WT8-1]
ENSMUST00000201544; ENSMUSP00000144122; ENSMUSG00000070780 [Q91WT8-1]
GeneIDi245945
KEGGimmu:245945
UCSCiuc008xok.3 mouse [Q91WT8-1]
uc008xop.3 mouse [Q91WT8-2]

Organism-specific databases

CTDi54502
MGIiMGI:2384294 Rbm47

Phylogenomic databases

eggNOGiKOG0117 Eukaryota
ENOG410XTJ5 LUCA
GeneTreeiENSGT00550000074366
HOGENOMiHOG000186083
HOVERGENiHBG051917
InParanoidiQ91WT8
OMAiIGPNREY
OrthoDBiEOG091G0EUB
PhylomeDBiQ91WT8
TreeFamiTF314932

Miscellaneous databases

PROiPR:Q91WT8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070780 Expressed in 177 organ(s), highest expression level in epithelium of small intestine
CleanExiMM_RBM47
ExpressionAtlasiQ91WT8 baseline and differential
GenevisibleiQ91WT8 MM

Family and domain databases

CDDicd12491 RRM2_RBM47, 1 hit
cd12497 RRM3_RBM47, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR006535 HnRNP_R/Q_splicing_fac
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034442 RBM47
IPR034440 RBM47_RRM2
IPR034445 RBM47_RRM3
IPR000504 RRM_dom
PANTHERiPTHR43980:SF4 PTHR43980:SF4, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
TIGRFAMsiTIGR01648 hnRNP-R-Q, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRBM47_MOUSE
AccessioniPrimary (citable) accession number: Q91WT8
Secondary accession number(s): Q3UQC7, Q8BZE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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