UniProtKB - Q91WS0 (CISD1_MOUSE)
Protein
CDGSH iron-sulfur domain-containing protein 1
Gene
Cisd1
Organism
Mus musculus (Mouse)
Status
Functioni
Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation. May be involved in Fe-S cluster shuttling and/or in redox reactions (By similarity).By similarity1 Publication
Cofactori
[2Fe-2S] clusterBy similarityNote: Binds 1 [2Fe-2S] cluster per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 72 | Iron-sulfur (2Fe-2S)By similarity | 1 | |
Metal bindingi | 74 | Iron-sulfur (2Fe-2S)By similarity | 1 | |
Metal bindingi | 83 | Iron-sulfur (2Fe-2S)By similarity | 1 | |
Metal bindingi | 87 | Iron-sulfur (2Fe-2S); via pros nitrogenBy similarity | 1 |
GO - Molecular functioni
- 2 iron, 2 sulfur cluster binding Source: GO_Central
- identical protein binding Source: MGI
- iron ion binding Source: MGI
GO - Biological processi
- regulation of cellular respiration Source: MGI
Keywordsi
Ligand | 2Fe-2S, Iron, Iron-sulfur, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: CDGSH iron-sulfur domain-containing protein 1Alternative name(s): MitoNEET |
Gene namesi | Name:Cisd1 Synonyms:D10Ertd214e, Zcd1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1261855, Cisd1 |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane 1 Publication; Single-pass type III membrane protein 1 Publication
Mitochondrion
- cytoplasmic side of mitochondrial outer membrane Source: MGI
- mitochondrial outer membrane Source: MGI
- mitochondrion Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 14 – 31 | Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST | 18 | |
Topological domaini | 32 – 108 | CytoplasmicSequence analysisAdd BLAST | 77 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion outer membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089804 | 1 – 108 | CDGSH iron-sulfur domain-containing protein 1Add BLAST | 108 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 42 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Modified residuei | 55 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 55 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity | ||
Modified residuei | 68 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 68 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity | ||
Cross-linki | 78 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Cross-linki | 79 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Cross-linki | 89 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Modified residuei | 104 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 104 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity | ||
Cross-linki | 105 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Cross-linki | 106 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity |
Post-translational modificationi
Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.By similarity
Keywords - PTMi
Acetylation, Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q91WS0 |
jPOSTi | Q91WS0 |
MaxQBi | Q91WS0 |
PaxDbi | Q91WS0 |
PeptideAtlasi | Q91WS0 |
PRIDEi | Q91WS0 |
PTM databases
iPTMneti | Q91WS0 |
PhosphoSitePlusi | Q91WS0 |
SwissPalmi | Q91WS0 |
Expressioni
Tissue specificityi
Liver, adipose, skeletal muscle and heart (at protein level). Widely expressed. Expressed at the highest levels in the heart.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000037710, Expressed in primary oocyte and 307 other tissues |
Genevisiblei | Q91WS0, MM |
Interactioni
Subunit structurei
Homodimer.
By similarityGO - Molecular functioni
- identical protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 206706, 32 interactors |
IntActi | Q91WS0, 4 interactors |
MINTi | Q91WS0 |
STRINGi | 10090.ENSMUSP00000043559 |
Miscellaneous databases
RNActi | Q91WS0, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the CISD protein family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3461, Eukaryota |
GeneTreei | ENSGT00940000154445 |
HOGENOMi | CLU_132293_1_0_1 |
InParanoidi | Q91WS0 |
OMAi | SKDKCCK |
OrthoDBi | 1393750at2759 |
PhylomeDBi | Q91WS0 |
TreeFami | TF324661 |
Family and domain databases
Gene3Di | 3.40.5.90, 1 hit |
InterProi | View protein in InterPro IPR018967, FeS-contain_CDGSH-typ IPR042216, FeS-contain_mitoNEET_C IPR019610, FeS-contain_mitoNEET_N |
Pfami | View protein in Pfam PF10660, MitoNEET_N, 1 hit PF09360, zf-CDGSH, 1 hit |
SMARTi | View protein in SMART SM00704, ZnF_CDGSH, 1 hit |
i Sequence
Sequence statusi: Complete.
Q91WS0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLSSNSAVR VEWIAAVTFA AGTAALGYLA YKKFYAKENR TKAMVNLQIQ
60 70 80 90 100
KDNPKVVHAF DMEDLGDKAV YCRCWRSKKF PFCDGAHIKH NEETGDNVGP
LIIKKKET
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK075907 mRNA Translation: BAC36046.1 AK131605 mRNA Translation: BAE20715.1 AK131812 mRNA Translation: BAE20814.1 AK131995 mRNA Translation: BAE20925.1 AK167898 mRNA Translation: BAE39909.1 BC013522 mRNA Translation: AAH13522.1 BC019860 mRNA Translation: AAH19860.1 BC021952 mRNA Translation: AAH21952.1 |
CCDSi | CCDS23917.1 |
RefSeqi | NP_598768.1, NM_134007.4 |
Genome annotation databases
Ensembli | ENSMUST00000045887; ENSMUSP00000043559; ENSMUSG00000037710 |
GeneIDi | 52637 |
KEGGi | mmu:52637 |
UCSCi | uc007foq.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK075907 mRNA Translation: BAC36046.1 AK131605 mRNA Translation: BAE20715.1 AK131812 mRNA Translation: BAE20814.1 AK131995 mRNA Translation: BAE20925.1 AK167898 mRNA Translation: BAE39909.1 BC013522 mRNA Translation: AAH13522.1 BC019860 mRNA Translation: AAH19860.1 BC021952 mRNA Translation: AAH21952.1 |
CCDSi | CCDS23917.1 |
RefSeqi | NP_598768.1, NM_134007.4 |
3D structure databases
SMRi | Q91WS0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 206706, 32 interactors |
IntActi | Q91WS0, 4 interactors |
MINTi | Q91WS0 |
STRINGi | 10090.ENSMUSP00000043559 |
PTM databases
iPTMneti | Q91WS0 |
PhosphoSitePlusi | Q91WS0 |
SwissPalmi | Q91WS0 |
Proteomic databases
EPDi | Q91WS0 |
jPOSTi | Q91WS0 |
MaxQBi | Q91WS0 |
PaxDbi | Q91WS0 |
PeptideAtlasi | Q91WS0 |
PRIDEi | Q91WS0 |
Protocols and materials databases
ABCDi | Q91WS0, 2 sequenced antibodies |
Antibodypediai | 45107, 236 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000045887; ENSMUSP00000043559; ENSMUSG00000037710 |
GeneIDi | 52637 |
KEGGi | mmu:52637 |
UCSCi | uc007foq.1, mouse |
Organism-specific databases
CTDi | 55847 |
MGIi | MGI:1261855, Cisd1 |
Phylogenomic databases
eggNOGi | KOG3461, Eukaryota |
GeneTreei | ENSGT00940000154445 |
HOGENOMi | CLU_132293_1_0_1 |
InParanoidi | Q91WS0 |
OMAi | SKDKCCK |
OrthoDBi | 1393750at2759 |
PhylomeDBi | Q91WS0 |
TreeFami | TF324661 |
Miscellaneous databases
BioGRID-ORCSi | 52637, 0 hits in 17 CRISPR screens |
ChiTaRSi | Cisd1, mouse |
PROi | PR:Q91WS0 |
RNActi | Q91WS0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037710, Expressed in primary oocyte and 307 other tissues |
Genevisiblei | Q91WS0, MM |
Family and domain databases
Gene3Di | 3.40.5.90, 1 hit |
InterProi | View protein in InterPro IPR018967, FeS-contain_CDGSH-typ IPR042216, FeS-contain_mitoNEET_C IPR019610, FeS-contain_mitoNEET_N |
Pfami | View protein in Pfam PF10660, MitoNEET_N, 1 hit PF09360, zf-CDGSH, 1 hit |
SMARTi | View protein in SMART SM00704, ZnF_CDGSH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CISD1_MOUSE | |
Accessioni | Q91WS0Primary (citable) accession number: Q91WS0 Secondary accession number(s): Q3V2I3, Q8WUQ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 25, 2002 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families