Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutathione peroxidase 6

Gene

Gpx6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase

Enzyme and pathway databases

ReactomeiR-MMU-3299685 Detoxification of Reactive Oxygen Species

Protein family/group databases

PeroxiBasei3719 MmGPx06

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase 6 (EC:1.11.1.9)
Short name:
GPx-6
Short name:
GSHPx-6
Gene namesi
Name:Gpx6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1922762 Gpx6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001308220 – 221Glutathione peroxidase 6Add BLAST202

Proteomic databases

MaxQBiQ91WR8
PaxDbiQ91WR8
PRIDEiQ91WR8

Expressioni

Gene expression databases

BgeeiENSMUSG00000004341
CleanExiMM_GPX6
GenevisibleiQ91WR8 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004453

Structurei

3D structure databases

ProteinModelPortaliQ91WR8
SMRiQ91WR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1651 Eukaryota
COG0386 LUCA
GeneTreeiENSGT00760000119230
HOGENOMiHOG000277055
HOVERGENiHBG004333
InParanoidiQ91WR8
KOiK00432
OMAiSQLFWEP
OrthoDBiEOG091G10LN
TreeFamiTF105318

Family and domain databases

CDDicd00340 GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR000889 Glutathione_peroxidase
IPR029759 GPX_AS
IPR029760 GPX_CS
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11592 PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255 GSHPx, 1 hit
PIRSFiPIRSF000303 Glutathion_perox, 1 hit
PRINTSiPR01011 GLUTPROXDASE
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00460 GLUTATHIONE_PEROXID_1, 1 hit
PS00763 GLUTATHIONE_PEROXID_2, 1 hit
PS51355 GLUTATHIONE_PEROXID_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91WR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQKLWGSCL FSLFMAALAQ ETLNPQKSKV DCNKGVTGTV YEYGANTIDG
60 70 80 90 100
GEFVNFQQYA GKHILFVNVA SFCGLTATYP ELNTLQEELK PFNVTVLGFP
110 120 130 140 150
CNQFGKQEPG KNSEILLGLK YVRPGGGYVP NFQLFEKGDV NGDNEQKVFS
160 170 180 190 200
FLKNSCPPTS ELFGSPEHLF WDPMKVHDIR WNFEKFLVGP DGVPVMRWFH
210 220
HTPVRIVQSD IMEYLNQTST Q
Length:221
Mass (Da):24,903
Last modified:October 3, 2012 - v2
Checksum:i39577A18B4C99BCA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52E → G in AAH13526 (PubMed:15489334).Curated1
Sequence conflicti176V → I in AAH13526 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124460 Genomic DNA No translation available.
BC013526 mRNA Translation: AAH13526.1
CCDSiCCDS26271.1
RefSeqiNP_663426.2, NM_145451.3
UniGeneiMm.46195

Genome annotation databases

EnsembliENSMUST00000004453; ENSMUSP00000004453; ENSMUSG00000004341
GeneIDi75512
KEGGimmu:75512
UCSCiuc007pqa.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGPX6_MOUSE
AccessioniPrimary (citable) accession number: Q91WR8
Secondary accession number(s): F2Z3U8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: October 3, 2012
Last modified: February 28, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health