UniProtKB - Q91WN2 (T150A_MOUSE)

BLAST

>sp|Q91WN2|T150A_MOUSE Transmembrane protein 150A OS=Mus musculus OX=10090 GN=Tmem150a PE=2 SV=1
MTAWILLPVSLSAFSITGIWTVYAMAVMNRHVCPVENWSYNESCSPDPAEQGGPKSCCTL
DDVPLISKCGTYPPESCLFSLIGNMGAVMVALICLLRYGQLLEQSRHSWINTTALITGCT
NAAGLVVVGNFQVDHAKSLHYIGTGVAFTAGLLFVCLHCVLFYHGATTPLDMAMAYLRSV
LAVIAFITLVLSGVFFLHESSQLQHGAALCEWVFVLDILIFYGTFSYEFGTISSDTLVAA
LQPAPGRACKSSGSSSTSTHLNCAPESIAMI

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History
Entry version 108 (07 Nov 2018)
Sequence version 1 (01 Dec 2001)
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Protein

Transmembrane protein 150A

Gene

Tmem150a

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex. Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns₄P) synthesis (By similarity). May also play a role in fasting-induced catabolism (By similarity).By similarity

GO - Biological processⁱ

catabolic process Source: Ensembl
phosphatidylinositol phosphorylation Source: UniProtKB
protein localization to plasma membrane Source: UniProtKB
regulation of autophagy
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane protein 150A Alternative name(s): Transmembrane protein 150
Gene namesⁱ	Name:Tmem150a Synonyms:Tmem150
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 6

Organism-specific databases

MGIⁱ	MGI:2385244 Tmem150a

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 2	CytoplasmicCurated	2
Transmembraneⁱ	3 – 23	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	24 – 75	ExtracellularCuratedAdd BLAST	52
Transmembraneⁱ	76 – 96	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	97 – 108	CytoplasmicCuratedAdd BLAST	12
Transmembraneⁱ	109 – 129	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	130 – 140	ExtracellularCuratedAdd BLAST	11
Transmembraneⁱ	141 – 161	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	162 – 178	CytoplasmicCuratedAdd BLAST	17
Transmembraneⁱ	179 – 199	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	200 – 211	ExtracellularCuratedAdd BLAST	12
Transmembraneⁱ	212 – 232	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	233 – 271	CytoplasmicBy similarityAdd BLAST	39

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000274776	1 – 271	Transmembrane protein 150AAdd BLAST		271

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	37	N-linked (GlcNAc...) asparagineSequence analysis		1
Glycosylationⁱ	41	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q91WN2
PaxDbⁱ	Q91WN2
PRIDEⁱ	Q91WN2

PTM databases

iPTMnetⁱ	Q91WN2
PhosphoSitePlusⁱ	Q91WN2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000055912 Expressed in 231 organ(s), highest expression level in decidua
CleanExⁱ	MM_TMEM150
ExpressionAtlasⁱ	Q91WN2 baseline and differential
Genevisibleⁱ	Q91WN2 MM

Interactionⁱ

Subunit structureⁱ

Interacts (via C-terminal cytoplasmic tail) with PI4KA.By similarity

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000063977

STRINGⁱ

10090.ENSMUSP00000063977

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the DRAM/TMEM150 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4320 Eukaryota ENOG4111KNB LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110794
HOGENOMⁱ	HOG000251588
InParanoidⁱ	Q91WN2
KEGG Orthology (KO) More...KOⁱ	K21846
OMAⁱ	CEWVFVI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CJL
PhylomeDBⁱ	Q91WN2
TreeFamⁱ	TF314508

Family and domain databases

InterProⁱ	View protein in InterPro IPR019402 Frag1/DRAM/Sfk1 IPR027315 TMEM150A
PANTHERⁱ	PTHR21324:SF6 PTHR21324:SF6, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10277 Frag1, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q91WN2-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MTAWILLPVS LSAFSITGIW TVYAMAVMNR HVCPVENWSY NESCSPDPAE 
        60         70         80         90        100
QGGPKSCCTL DDVPLISKCG TYPPESCLFS LIGNMGAVMV ALICLLRYGQ 
       110        120        130        140        150
LLEQSRHSWI NTTALITGCT NAAGLVVVGN FQVDHAKSLH YIGTGVAFTA 
       160        170        180        190        200
GLLFVCLHCV LFYHGATTPL DMAMAYLRSV LAVIAFITLV LSGVFFLHES 
       210        220        230        240        250
SQLQHGAALC EWVFVLDILI FYGTFSYEFG TISSDTLVAA LQPAPGRACK 
       260        270 
SSGSSSTSTH LNCAPESIAM I

Length:271

Mass (Da):29,066

Last modified:December 1, 2001 - v1

Checksum:ⁱ9F74F4B8F5136202

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0U1RNR4	A0A0U1RNR4_MOUSE	Transmembrane protein 150, isoform ... Transmembrane protein 150, isoform CRA_b (Transmembrane protein 150A)	Tmem150a Tmem150, mCG_129316	174	Annotation score:
A0A0U1RQ67	A0A0U1RQ67_MOUSE	Transmembrane protein 150A Transmembrane protein 150A	Tmem150a	120	Annotation score:
S4R204	S4R204_MOUSE	Transmembrane protein 150A Transmembrane protein 150A	Tmem150a	168	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC014685 mRNA Translation: AAH14685.1 BC028825 mRNA Translation: AAH28825.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS20239.1
NCBI Reference Sequences More...RefSeqⁱ	NP_659165.1, NM_144916.3
UniGeneⁱ	Mm.491165

Genome annotation databases

Ensemblⁱ	ENSMUST00000069695; ENSMUSP00000063977; ENSMUSG00000055912 ENSMUST00000193693; ENSMUSP00000142022; ENSMUSG00000102455
GeneIDⁱ	232086
KEGGⁱ	mmu:232086
UCSC genome browser More...UCSCⁱ	uc009cih.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q91WN2	Transmembrane protein 150A (Fragment)		MOUSE		120	UniRef100_Q91WN2

Protein	Similar proteins		Species	Score	Length	Source
Q91WN2	Transmembrane protein 150A		RAT		271	UniRef90_Q9QZE9
Transmembrane protein 150A		MYOBR		271
Transmembrane protein 150A (Fragment)		MOUSE		120
transmembrane protein 150A		MESAU		271
Transmembrane protein 150A		MYOLU		268
+7

Protein	Similar proteins		Species	Score	Length	Source
Q91WN2	Transmembrane protein 150A		RAT		271	UniRef50_Q9QZE9
Transmembrane protein 150A		XENTR		271
Transmembrane protein 150A		XENLA		271
Transmembrane protein 150A (Fragment)		MOUSE		120
Transmembrane protein 150A		MYOBR		271
+82

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC014685 mRNA Translation: AAH14685.1 BC028825 mRNA Translation: AAH28825.1
CCDSⁱ	CCDS20239.1
RefSeqⁱ	NP_659165.1, NM_144916.3
UniGeneⁱ	Mm.491165

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000063977

STRINGⁱ

10090.ENSMUSP00000063977

PTM databases

iPTMnetⁱ	Q91WN2
PhosphoSitePlusⁱ	Q91WN2

Proteomic databases

MaxQBⁱ	Q91WN2
PaxDbⁱ	Q91WN2
PRIDEⁱ	Q91WN2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000069695; ENSMUSP00000063977; ENSMUSG00000055912 ENSMUST00000193693; ENSMUSP00000142022; ENSMUSG00000102455
GeneIDⁱ	232086
KEGGⁱ	mmu:232086
UCSCⁱ	uc009cih.1 mouse

Organism-specific databases

CTDⁱ	129303
MGIⁱ	MGI:2385244 Tmem150a

Phylogenomic databases

eggNOGⁱ	KOG4320 Eukaryota ENOG4111KNB LUCA
GeneTreeⁱ	ENSGT00730000110794
HOGENOMⁱ	HOG000251588
InParanoidⁱ	Q91WN2
KOⁱ	K21846
OMAⁱ	CEWVFVI
OrthoDBⁱ	EOG091G0CJL
PhylomeDBⁱ	Q91WN2
TreeFamⁱ	TF314508

Miscellaneous databases

ChiTaRSⁱ	Tmem150a mouse
Protein Ontology More...PROⁱ	PR:Q91WN2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000055912 Expressed in 231 organ(s), highest expression level in decidua
CleanExⁱ	MM_TMEM150
ExpressionAtlasⁱ	Q91WN2 baseline and differential
Genevisibleⁱ	Q91WN2 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR019402 Frag1/DRAM/Sfk1 IPR027315 TMEM150A
PANTHERⁱ	PTHR21324:SF6 PTHR21324:SF6, 1 hit
Pfamⁱ	View protein in Pfam PF10277 Frag1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	T150A_MOUSE
Accessionⁱ	Q91WN2Primary (citable) accession number: Q91WN2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q91WN2 (T150A_MOUSE)

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Transmembrane protein 150A

Tmem150a

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Lysosome

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ