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Protein

Transmembrane protein 150A

Gene

Tmem150a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex. Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns4P) synthesis (By similarity). May also play a role in fasting-induced catabolism (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 150A
Alternative name(s):
Transmembrane protein 150
Gene namesi
Name:Tmem150a
Synonyms:Tmem150
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2385244 Tmem150a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2CytoplasmicCurated2
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Topological domaini24 – 75ExtracellularCuratedAdd BLAST52
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 108CytoplasmicCuratedAdd BLAST12
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130 – 140ExtracellularCuratedAdd BLAST11
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 178CytoplasmicCuratedAdd BLAST17
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 211ExtracellularCuratedAdd BLAST12
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Topological domaini233 – 271CytoplasmicBy similarityAdd BLAST39

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002747761 – 271Transmembrane protein 150AAdd BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ91WN2
PaxDbiQ91WN2
PRIDEiQ91WN2

PTM databases

iPTMnetiQ91WN2
PhosphoSitePlusiQ91WN2

Expressioni

Gene expression databases

BgeeiENSMUSG00000055912 Expressed in 231 organ(s), highest expression level in decidua
CleanExiMM_TMEM150
ExpressionAtlasiQ91WN2 baseline and differential
GenevisibleiQ91WN2 MM

Interactioni

Subunit structurei

Interacts (via C-terminal cytoplasmic tail) with PI4KA.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063977

Family & Domainsi

Sequence similaritiesi

Belongs to the DRAM/TMEM150 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4320 Eukaryota
ENOG4111KNB LUCA
GeneTreeiENSGT00730000110794
HOGENOMiHOG000251588
InParanoidiQ91WN2
KOiK21846
OMAiCEWVFVI
OrthoDBiEOG091G0CJL
PhylomeDBiQ91WN2
TreeFamiTF314508

Family and domain databases

InterProiView protein in InterPro
IPR019402 Frag1/DRAM/Sfk1
IPR027315 TMEM150A
PANTHERiPTHR21324:SF6 PTHR21324:SF6, 1 hit
PfamiView protein in Pfam
PF10277 Frag1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q91WN2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAWILLPVS LSAFSITGIW TVYAMAVMNR HVCPVENWSY NESCSPDPAE
60 70 80 90 100
QGGPKSCCTL DDVPLISKCG TYPPESCLFS LIGNMGAVMV ALICLLRYGQ
110 120 130 140 150
LLEQSRHSWI NTTALITGCT NAAGLVVVGN FQVDHAKSLH YIGTGVAFTA
160 170 180 190 200
GLLFVCLHCV LFYHGATTPL DMAMAYLRSV LAVIAFITLV LSGVFFLHES
210 220 230 240 250
SQLQHGAALC EWVFVLDILI FYGTFSYEFG TISSDTLVAA LQPAPGRACK
260 270
SSGSSSTSTH LNCAPESIAM I
Length:271
Mass (Da):29,066
Last modified:December 1, 2001 - v1
Checksum:i9F74F4B8F5136202
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RNR4A0A0U1RNR4_MOUSE
Transmembrane protein 150, isoform ...
Tmem150a Tmem150, mCG_129316
174Annotation score:
A0A0U1RQ67A0A0U1RQ67_MOUSE
Transmembrane protein 150A
Tmem150a
120Annotation score:
S4R204S4R204_MOUSE
Transmembrane protein 150A
Tmem150a
168Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014685 mRNA Translation: AAH14685.1
BC028825 mRNA Translation: AAH28825.1
CCDSiCCDS20239.1
RefSeqiNP_659165.1, NM_144916.3
UniGeneiMm.491165

Genome annotation databases

EnsembliENSMUST00000069695; ENSMUSP00000063977; ENSMUSG00000055912
ENSMUST00000193693; ENSMUSP00000142022; ENSMUSG00000102455
GeneIDi232086
KEGGimmu:232086
UCSCiuc009cih.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014685 mRNA Translation: AAH14685.1
BC028825 mRNA Translation: AAH28825.1
CCDSiCCDS20239.1
RefSeqiNP_659165.1, NM_144916.3
UniGeneiMm.491165

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063977

PTM databases

iPTMnetiQ91WN2
PhosphoSitePlusiQ91WN2

Proteomic databases

MaxQBiQ91WN2
PaxDbiQ91WN2
PRIDEiQ91WN2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069695; ENSMUSP00000063977; ENSMUSG00000055912
ENSMUST00000193693; ENSMUSP00000142022; ENSMUSG00000102455
GeneIDi232086
KEGGimmu:232086
UCSCiuc009cih.1 mouse

Organism-specific databases

CTDi129303
MGIiMGI:2385244 Tmem150a

Phylogenomic databases

eggNOGiKOG4320 Eukaryota
ENOG4111KNB LUCA
GeneTreeiENSGT00730000110794
HOGENOMiHOG000251588
InParanoidiQ91WN2
KOiK21846
OMAiCEWVFVI
OrthoDBiEOG091G0CJL
PhylomeDBiQ91WN2
TreeFamiTF314508

Miscellaneous databases

ChiTaRSiTmem150a mouse
PROiPR:Q91WN2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055912 Expressed in 231 organ(s), highest expression level in decidua
CleanExiMM_TMEM150
ExpressionAtlasiQ91WN2 baseline and differential
GenevisibleiQ91WN2 MM

Family and domain databases

InterProiView protein in InterPro
IPR019402 Frag1/DRAM/Sfk1
IPR027315 TMEM150A
PANTHERiPTHR21324:SF6 PTHR21324:SF6, 1 hit
PfamiView protein in Pfam
PF10277 Frag1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT150A_MOUSE
AccessioniPrimary (citable) accession number: Q91WN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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