UniProtKB - Q91WN2 (T150A_MOUSE)
Protein
Transmembrane protein 150A
Gene
Tmem150a
Organism
Mus musculus (Mouse)
Status
Functioni
Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex. Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns4P) synthesis (By similarity). May also play a role in fasting-induced catabolism (By similarity).By similarity
GO - Biological processi
- catabolic process Source: Ensembl
- phosphatidylinositol phosphorylation Source: UniProtKB
- protein localization to plasma membrane Source: UniProtKB
- regulation of autophagy Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 150AAlternative name(s): Transmembrane protein 150 |
Gene namesi | Name:Tmem150a Synonyms:Tmem150 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2385244, Tmem150a |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Note: Localizes mainly at the plasma membrane; only a minor fraction localizes on intracellular structures.By similarity
Lysosome
- lysosome Source: GO_Central
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 2 | CytoplasmicCurated | 2 | |
Transmembranei | 3 – 23 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 24 – 75 | ExtracellularCuratedAdd BLAST | 52 | |
Transmembranei | 76 – 96 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 97 – 108 | CytoplasmicCuratedAdd BLAST | 12 | |
Transmembranei | 109 – 129 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 130 – 140 | ExtracellularCuratedAdd BLAST | 11 | |
Transmembranei | 141 – 161 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 162 – 178 | CytoplasmicCuratedAdd BLAST | 17 | |
Transmembranei | 179 – 199 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 200 – 211 | ExtracellularCuratedAdd BLAST | 12 | |
Transmembranei | 212 – 232 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 233 – 271 | CytoplasmicBy similarityAdd BLAST | 39 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000274776 | 1 – 271 | Transmembrane protein 150AAdd BLAST | 271 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 37 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 41 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q91WN2 |
MaxQBi | Q91WN2 |
PaxDbi | Q91WN2 |
PRIDEi | Q91WN2 |
PTM databases
GlyGeni | Q91WN2, 2 sites |
iPTMneti | Q91WN2 |
PhosphoSitePlusi | Q91WN2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000055912, Expressed in decidua and 249 other tissues |
ExpressionAtlasi | Q91WN2, baseline and differential |
Genevisiblei | Q91WN2, MM |
Interactioni
Subunit structurei
Interacts (via C-terminal cytoplasmic tail) with PI4KA.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000063977 |
Miscellaneous databases
RNActi | Q91WN2, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the DRAM/TMEM150 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4320, Eukaryota |
GeneTreei | ENSGT01000000214535 |
HOGENOMi | CLU_059992_1_0_1 |
InParanoidi | Q91WN2 |
OMAi | EHSHRCW |
OrthoDBi | 955528at2759 |
PhylomeDBi | Q91WN2 |
TreeFami | TF314508 |
Family and domain databases
InterProi | View protein in InterPro IPR019402, Frag1/DRAM/Sfk1 IPR027315, TMEM150A |
PANTHERi | PTHR21324:SF6, PTHR21324:SF6, 1 hit |
Pfami | View protein in Pfam PF10277, Frag1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q91WN2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTAWILLPVS LSAFSITGIW TVYAMAVMNR HVCPVENWSY NESCSPDPAE
60 70 80 90 100
QGGPKSCCTL DDVPLISKCG TYPPESCLFS LIGNMGAVMV ALICLLRYGQ
110 120 130 140 150
LLEQSRHSWI NTTALITGCT NAAGLVVVGN FQVDHAKSLH YIGTGVAFTA
160 170 180 190 200
GLLFVCLHCV LFYHGATTPL DMAMAYLRSV LAVIAFITLV LSGVFFLHES
210 220 230 240 250
SQLQHGAALC EWVFVLDILI FYGTFSYEFG TISSDTLVAA LQPAPGRACK
260 270
SSGSSSTSTH LNCAPESIAM I
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0U1RQ67 | A0A0U1RQ67_MOUSE | Transmembrane protein 150 | Tmem150a | 120 | Annotation score: | ||
A0A0U1RNR4 | A0A0U1RNR4_MOUSE | Transmembrane protein 150 | Tmem150a | 174 | Annotation score: | ||
S4R204 | S4R204_MOUSE | Transmembrane protein 150A | Tmem150a | 168 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC014685 mRNA Translation: AAH14685.1 BC028825 mRNA Translation: AAH28825.1 |
CCDSi | CCDS20239.1 |
RefSeqi | NP_659165.1, NM_144916.3 |
Genome annotation databases
Ensembli | ENSMUST00000069695; ENSMUSP00000063977; ENSMUSG00000055912 ENSMUST00000193693; ENSMUSP00000142022; ENSMUSG00000102455 |
GeneIDi | 232086 |
KEGGi | mmu:232086 |
UCSCi | uc009cih.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC014685 mRNA Translation: AAH14685.1 BC028825 mRNA Translation: AAH28825.1 |
CCDSi | CCDS20239.1 |
RefSeqi | NP_659165.1, NM_144916.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000063977 |
PTM databases
GlyGeni | Q91WN2, 2 sites |
iPTMneti | Q91WN2 |
PhosphoSitePlusi | Q91WN2 |
Proteomic databases
jPOSTi | Q91WN2 |
MaxQBi | Q91WN2 |
PaxDbi | Q91WN2 |
PRIDEi | Q91WN2 |
Protocols and materials databases
Antibodypediai | 16968, 67 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000069695; ENSMUSP00000063977; ENSMUSG00000055912 ENSMUST00000193693; ENSMUSP00000142022; ENSMUSG00000102455 |
GeneIDi | 232086 |
KEGGi | mmu:232086 |
UCSCi | uc009cih.1, mouse |
Organism-specific databases
CTDi | 129303 |
MGIi | MGI:2385244, Tmem150a |
Phylogenomic databases
eggNOGi | KOG4320, Eukaryota |
GeneTreei | ENSGT01000000214535 |
HOGENOMi | CLU_059992_1_0_1 |
InParanoidi | Q91WN2 |
OMAi | EHSHRCW |
OrthoDBi | 955528at2759 |
PhylomeDBi | Q91WN2 |
TreeFami | TF314508 |
Miscellaneous databases
BioGRID-ORCSi | 232086, 1 hit in 19 CRISPR screens |
ChiTaRSi | Tmem150a, mouse |
PROi | PR:Q91WN2 |
RNActi | Q91WN2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000055912, Expressed in decidua and 249 other tissues |
ExpressionAtlasi | Q91WN2, baseline and differential |
Genevisiblei | Q91WN2, MM |
Family and domain databases
InterProi | View protein in InterPro IPR019402, Frag1/DRAM/Sfk1 IPR027315, TMEM150A |
PANTHERi | PTHR21324:SF6, PTHR21324:SF6, 1 hit |
Pfami | View protein in Pfam PF10277, Frag1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | T150A_MOUSE | |
Accessioni | Q91WN2Primary (citable) accession number: Q91WN2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families