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Protein

Protein eva-1 homolog A

Gene

Eva1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.By similarity

GO - Biological processi

Keywordsi

Biological processApoptosis, Autophagy

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein eva-1 homolog A
Alternative name(s):
Protein FAM176A
Transmembrane protein 166
Gene namesi
Name:Eva1a
Synonyms:Fam176a, Tmem166
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2385247 Eva1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002786721 – 156Protein eva-1 homolog AAdd BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110PhosphothreonineCombined sources1
Modified residuei118PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91WM6
PaxDbiQ91WM6
PRIDEiQ91WM6

PTM databases

iPTMnetiQ91WM6
PhosphoSitePlusiQ91WM6

Expressioni

Gene expression databases

BgeeiENSMUSG00000035104 Expressed in 218 organ(s), highest expression level in liver
ExpressionAtlasiQ91WM6 baseline and differential
GenevisibleiQ91WM6 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037422

Family & Domainsi

Sequence similaritiesi

Belongs to the EVA1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZJN Eukaryota
ENOG410YJR4 LUCA
GeneTreeiENSGT00900000140931
HOGENOMiHOG000294093
HOVERGENiHBG061487
InParanoidiQ91WM6
OMAiCHTDCRQ
OrthoDBiEOG091G11DT
TreeFamiTF352986

Family and domain databases

InterProiView protein in InterPro
IPR039500 EVA1_dom
IPR039501 EVA1A
PANTHERiPTHR45242 PTHR45242, 1 hit
PfamiView protein in Pfam
PF14851 FAM176, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q91WM6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLPLSPSTE PVATEPLGMA LLSSILAAWS YISENPERAA LYFVSGVCIG
60 70 80 90 100
LFLTLAALVM RISCHTDCRR GPRRRCLQDR ECSDSSDSED GSEDTASDLS
110 120 130 140 150
VRRHRRFERT LNKNVFTSAE ELERAQRLEE RERIIREIWM NGQPEVPGTR

SLNRYY
Length:156
Mass (Da):17,810
Last modified:October 3, 2012 - v2
Checksum:i1070A2E55EAA3C40
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z511D3Z511_MOUSE
Protein eva-1 homolog A
Eva1a Fam176a
155Annotation score:
D3Z4B6D3Z4B6_MOUSE
Protein eva-1 homolog A
Eva1a Fam176a
67Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25I → L in BAE26256 (PubMed:16141072).Curated1
Sequence conflicti25I → L in AAH14699 (PubMed:15489334).Curated1
Sequence conflicti25I → L in AAH27150 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145140 mRNA Translation: BAE26256.1
AC171502 Genomic DNA No translation available.
CH466523 Genomic DNA Translation: EDK99032.1
BC014699 mRNA Translation: AAH14699.1
BC027150 mRNA Translation: AAH27150.1
CCDSiCCDS20261.1
RefSeqiNP_663545.2, NM_145570.2
XP_006506025.1, XM_006505962.1
UniGeneiMm.489683

Genome annotation databases

EnsembliENSMUST00000042974; ENSMUSP00000037422; ENSMUSG00000035104
GeneIDi232146
KEGGimmu:232146
UCSCiuc009clg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145140 mRNA Translation: BAE26256.1
AC171502 Genomic DNA No translation available.
CH466523 Genomic DNA Translation: EDK99032.1
BC014699 mRNA Translation: AAH14699.1
BC027150 mRNA Translation: AAH27150.1
CCDSiCCDS20261.1
RefSeqiNP_663545.2, NM_145570.2
XP_006506025.1, XM_006505962.1
UniGeneiMm.489683

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037422

PTM databases

iPTMnetiQ91WM6
PhosphoSitePlusiQ91WM6

Proteomic databases

MaxQBiQ91WM6
PaxDbiQ91WM6
PRIDEiQ91WM6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042974; ENSMUSP00000037422; ENSMUSG00000035104
GeneIDi232146
KEGGimmu:232146
UCSCiuc009clg.2 mouse

Organism-specific databases

CTDi84141
MGIiMGI:2385247 Eva1a

Phylogenomic databases

eggNOGiENOG410IZJN Eukaryota
ENOG410YJR4 LUCA
GeneTreeiENSGT00900000140931
HOGENOMiHOG000294093
HOVERGENiHBG061487
InParanoidiQ91WM6
OMAiCHTDCRQ
OrthoDBiEOG091G11DT
TreeFamiTF352986

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

PROiPR:Q91WM6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035104 Expressed in 218 organ(s), highest expression level in liver
ExpressionAtlasiQ91WM6 baseline and differential
GenevisibleiQ91WM6 MM

Family and domain databases

InterProiView protein in InterPro
IPR039500 EVA1_dom
IPR039501 EVA1A
PANTHERiPTHR45242 PTHR45242, 1 hit
PfamiView protein in Pfam
PF14851 FAM176, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEVA1A_MOUSE
AccessioniPrimary (citable) accession number: Q91WM6
Secondary accession number(s): G3X936
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 3, 2012
Last modified: October 10, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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