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Protein

Spermatid perinuclear RNA-binding protein

Gene

Strbp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth (By similarity). Binds to double-stranded DNA and RNA (By similarity). Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA (By similarity). Binds also to single-stranded poly(G) RNA (By similarity). Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA.By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

  • mechanosensory behavior Source: MGI
  • multicellular organism development Source: UniProtKB-KW
  • spermatid development Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, RNA-binding
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatid perinuclear RNA-binding protein
Gene namesi
Name:Strbp
Synonyms:Spnr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:104626 Strbp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002749181 – 672Spermatid perinuclear RNA-binding proteinAdd BLAST672

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei612Asymmetric dimethylarginineCombined sources1
Modified residuei617Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ91WM1
PeptideAtlasiQ91WM1
PRIDEiQ91WM1

PTM databases

iPTMnetiQ91WM1
PhosphoSitePlusiQ91WM1

Expressioni

Tissue specificityi

Isoform 2 is expressed in spermatocytes (at protein level). Expressed in testis, thymus, ovary, liver, kidney, heart, spleen and brain. Expressed in cortex, dentate gyrus and Purkinje cell layer and granule cells of the cerebellum.2 Publications

Developmental stagei

Expressed in brain at 13.5 dpc. Expressed in brain, trigeminal ganglia and nasal epithelium at E18.5.2 Publications

Gene expression databases

BgeeiENSMUSG00000026915 Expressed in 301 organ(s), highest expression level in retrosplenial region
CleanExiMM_STRBP
ExpressionAtlasiQ91WM1 baseline and differential
GenevisibleiQ91WM1 MM

Interactioni

Subunit structurei

Interacts with EIF2AK2 (By similarity). Associates with microtubules; it is unsure whether such interaction is direct or indirect.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203463, 1 interactor
IntActiQ91WM1, 1 interactor
MINTiQ91WM1
STRINGi10090.ENSMUSP00000028279

Structurei

3D structure databases

ProteinModelPortaliQ91WM1
SMRiQ91WM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 363DZFPROSITE-ProRule annotationAdd BLAST359
Domaini387 – 453DRBM 1PROSITE-ProRule annotationAdd BLAST67
Domaini510 – 576DRBM 2PROSITE-ProRule annotationAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi584 – 587Poly-Lys4

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IN2U Eukaryota
ENOG410Z2M4 LUCA
GeneTreeiENSGT00550000074528
HOGENOMiHOG000232164
HOVERGENiHBG069915
InParanoidiQ91WM1
KOiK13200
OMAiGYITPGY
OrthoDBiEOG091G022L
PhylomeDBiQ91WM1
TreeFamiTF320194

Family and domain databases

CDDicd00048 DSRM, 2 hits
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR006561 DZF_dom
IPR030446 STRBP
PANTHERiPTHR10910:SF27 PTHR10910:SF27, 1 hit
PfamiView protein in Pfam
PF00035 dsrm, 2 hits
PF07528 DZF, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 2 hits
SM00572 DZF, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 2 hits
PS51703 DZF, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q91WM1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSIRSFAND DRHVMVKHST IYPSPEELEA VQNMVSTVEC ALKHVSDWLD
60 70 80 90 100
ETNKGTKPEG ETEVKKDEAV ENYSKDQGGR TLCGVMRIGL VAKGLLIKDD
110 120 130 140 150
MDLELVLMCK DKPTETLLNT VKDNLPIQIQ KLTEEKYQVE QCINEASIII
160 170 180 190 200
RNTKEPTLTL KVILTSPLIR DELEKKDGEN VMMKDPPDLL DRQKCLNALA
210 220 230 240 250
SLRHAKWFQA RANGLKSCVI VLRILRDLCN RVPTWAPLKG WPLELICEKS
260 270 280 290 300
IGTCNRPLGA GEALRRVMEC LASGILLPGG PGLHDPCERD PTDALSYMTT
310 320 330 340 350
QQKEDITHSA QHALRLSAFG QIYKVLEMDP LPSSKPFQKY SWSVTDKEGA
360 370 380 390 400
GSSALKRPFE DGLGDDKDPN KKMKRNLRKI LDSKAIDLMN ALMRLNQIRP
410 420 430 440 450
GLQYKLLSQS GPVHAPVFTM SVDVDGTTYE ASGPSKKTAK LHVAVKVLQA
460 470 480 490 500
MGYPTGFDAD IECISSDEKS DNESKNDTVS SNSSNNTGNS TTETSSTLEV
510 520 530 540 550
RTQGPILTAS GKNPVMELNE KRRGLKYELI SETGGSHDKR FVMEVEVDGQ
560 570 580 590 600
KFRGAGPNKK VAKASAALAA LEKLFSGPNA ANNKKKKIIP QAKGVVNTAV
610 620 630 640 650
SAAVQAVRGR GRGTLTRGAF VGATAAPGYI APGYGTPYGY STAAPAYGLP
660 670
KRMVLLPVMK FPTYPVPHYS FF
Length:672
Mass (Da):73,705
Last modified:December 1, 2001 - v1
Checksum:i94E61DE3FAE5D14B
GO
Isoform 2 (identifier: Q91WM1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     649-672: Missing.

Note: No experimental confirmation available.
Show »
Length:648
Mass (Da):70,814
Checksum:i33EFDF7D54659AD4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2BH83A2BH83_MOUSE
Spermatid perinuclear RNA-binding p...
Strbp
128Annotation score:
A2BH82A2BH82_MOUSE
Spermatid perinuclear RNA-binding p...
Strbp
167Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022938649 – 672Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84692 mRNA Translation: CAA59167.1
BC014710 mRNA Translation: AAH14710.1
CCDSiCCDS38118.1 [Q91WM1-1]
PIRiA57284
RefSeqiNP_033287.2, NM_009261.3 [Q91WM1-1]
XP_011237348.1, XM_011239046.2 [Q91WM1-1]
XP_011237349.1, XM_011239047.2 [Q91WM1-2]
XP_017172309.1, XM_017316820.1 [Q91WM1-1]
XP_017172310.1, XM_017316821.1
XP_017172311.1, XM_017316822.1
XP_017172312.1, XM_017316823.1 [Q91WM1-1]
UniGeneiMm.237095
Mm.477856

Genome annotation databases

EnsembliENSMUST00000028279; ENSMUSP00000028279; ENSMUSG00000026915 [Q91WM1-1]
ENSMUST00000072186; ENSMUSP00000072047; ENSMUSG00000026915 [Q91WM1-1]
ENSMUST00000183690; ENSMUSP00000139145; ENSMUSG00000026915 [Q91WM1-2]
GeneIDi20744
KEGGimmu:20744
UCSCiuc008jnc.2 mouse [Q91WM1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84692 mRNA Translation: CAA59167.1
BC014710 mRNA Translation: AAH14710.1
CCDSiCCDS38118.1 [Q91WM1-1]
PIRiA57284
RefSeqiNP_033287.2, NM_009261.3 [Q91WM1-1]
XP_011237348.1, XM_011239046.2 [Q91WM1-1]
XP_011237349.1, XM_011239047.2 [Q91WM1-2]
XP_017172309.1, XM_017316820.1 [Q91WM1-1]
XP_017172310.1, XM_017316821.1
XP_017172311.1, XM_017316822.1
XP_017172312.1, XM_017316823.1 [Q91WM1-1]
UniGeneiMm.237095
Mm.477856

3D structure databases

ProteinModelPortaliQ91WM1
SMRiQ91WM1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203463, 1 interactor
IntActiQ91WM1, 1 interactor
MINTiQ91WM1
STRINGi10090.ENSMUSP00000028279

PTM databases

iPTMnetiQ91WM1
PhosphoSitePlusiQ91WM1

Proteomic databases

PaxDbiQ91WM1
PeptideAtlasiQ91WM1
PRIDEiQ91WM1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028279; ENSMUSP00000028279; ENSMUSG00000026915 [Q91WM1-1]
ENSMUST00000072186; ENSMUSP00000072047; ENSMUSG00000026915 [Q91WM1-1]
ENSMUST00000183690; ENSMUSP00000139145; ENSMUSG00000026915 [Q91WM1-2]
GeneIDi20744
KEGGimmu:20744
UCSCiuc008jnc.2 mouse [Q91WM1-1]

Organism-specific databases

CTDi55342
MGIiMGI:104626 Strbp

Phylogenomic databases

eggNOGiENOG410IN2U Eukaryota
ENOG410Z2M4 LUCA
GeneTreeiENSGT00550000074528
HOGENOMiHOG000232164
HOVERGENiHBG069915
InParanoidiQ91WM1
KOiK13200
OMAiGYITPGY
OrthoDBiEOG091G022L
PhylomeDBiQ91WM1
TreeFamiTF320194

Miscellaneous databases

PROiPR:Q91WM1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026915 Expressed in 301 organ(s), highest expression level in retrosplenial region
CleanExiMM_STRBP
ExpressionAtlasiQ91WM1 baseline and differential
GenevisibleiQ91WM1 MM

Family and domain databases

CDDicd00048 DSRM, 2 hits
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR006561 DZF_dom
IPR030446 STRBP
PANTHERiPTHR10910:SF27 PTHR10910:SF27, 1 hit
PfamiView protein in Pfam
PF00035 dsrm, 2 hits
PF07528 DZF, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 2 hits
SM00572 DZF, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 2 hits
PS51703 DZF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTRBP_MOUSE
AccessioniPrimary (citable) accession number: Q91WM1
Secondary accession number(s): Q62262
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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