Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Eukaryotic translation initiation factor 3 subunit H

Gene

Eif3h

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.UniRule annotation1 Publication

GO - Molecular functioni

GO - Biological processi

  • translational initiation Source: UniProtKB

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-MMU-72702 Ribosomal scanning and start codon recognition

Protein family/group databases

MEROPSiM67.971

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit HUniRule annotation
Short name:
eIF3hUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 3UniRule annotation
eIF-3-gamma
eIF3 p40 subunitUniRule annotation
Gene namesi
Name:Eif3h
Synonyms:Eif3s3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1915385 Eif3h

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002139621 – 352Eukaryotic translation initiation factor 3 subunit HAdd BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphoserineBy similarity1
Modified residuei183PhosphoserineUniRule annotationBy similarity1
Modified residuei191PhosphoserineCombined sources1
Cross-linki303Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ91WK2
MaxQBiQ91WK2
PaxDbiQ91WK2
PRIDEiQ91WK2

PTM databases

iPTMnetiQ91WK2
PhosphoSitePlusiQ91WK2
SwissPalmiQ91WK2

Expressioni

Gene expression databases

BgeeiENSMUSG00000022312 Expressed in 284 organ(s), highest expression level in floor plate of midbrain
ExpressionAtlasiQ91WK2 baseline and differential
GenevisibleiQ91WK2 MM

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex may interact with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation may lead to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner (By similarity). Interacts with DHX33; the interaction is independent of RNA (PubMed:26100019).UniRule annotation2 Publications

Protein-protein interaction databases

BioGridi212675, 3 interactors
IntActiQ91WK2, 9 interactors
MINTiQ91WK2
STRINGi10090.ENSMUSP00000022925

Structurei

3D structure databases

ProteinModelPortaliQ91WK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 173MPNPROSITE-ProRule annotationAdd BLAST135

Sequence similaritiesi

Belongs to the eIF-3 subunit H family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1560 Eukaryota
ENOG410XSR9 LUCA
GeneTreeiENSGT00730000111042
HOGENOMiHOG000248787
HOVERGENiHBG000883
InParanoidiQ91WK2
KOiK03247
OMAiKFNRYQQ
OrthoDBiEOG091G0E5O
PhylomeDBiQ91WK2
TreeFamiTF101504

Family and domain databases

CDDicd08065 MPN_eIF3h, 1 hit
HAMAPiMF_03007 eIF3h, 1 hit
InterProiView protein in InterPro
IPR027524 eIF3h
IPR000555 JAMM/MPN+_dom
IPR037518 MPN
PANTHERiPTHR10410:SF3 PTHR10410:SF3, 1 hit
PfamiView protein in Pfam
PF01398 JAB, 1 hit
SMARTiView protein in SMART
SM00232 JAB_MPN, 1 hit
PROSITEiView protein in PROSITE
PS50249 MPN, 1 hit

Sequencei

Sequence statusi: Complete.

Q91WK2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASRKEGTGS TATSSGSAGG AVGKGKGKGG SGDSAVKQVQ IDGLVVLKII
60 70 80 90 100
KHYQEEGQGT EVVQGVLLGL VVEDRLEITN CFPFPQHTED DADFDEVQYQ
110 120 130 140 150
MEMMRSLRHV NIDHLHVGWY QSTYYGSFVT RALLDSQFSY QHAIEESVVL
160 170 180 190 200
IYDPIKTAQG SLSLKAYRLT PKLMEVCKEK DFSPEALKKA SITFEHMFEE
210 220 230 240 250
VPIVIKNSHL INVLMWELEK KSAVADKHEL LSLASSNHLG KSLQLLMDRV
260 270 280 290 300
DEMSQDIIKY NTYMRNTSKQ QQQKHQYQQR RQQENMQRQS RGEPPLPEED
310 320 330 340 350
LSKLFKPHQA PARMDSLLIA GQINTYCQNI KEFTAQNLGK LFMAQALQEY

NN
Length:352
Mass (Da):39,832
Last modified:December 1, 2001 - v1
Checksum:i96F5AB8E2F41F838
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014755 mRNA Translation: AAH14755.1
CCDSiCCDS27461.1
RefSeqiNP_542366.1, NM_080635.1
UniGeneiMm.289800

Genome annotation databases

EnsembliENSMUST00000022925; ENSMUSP00000022925; ENSMUSG00000022312
GeneIDi68135
KEGGimmu:68135
UCSCiuc007vrb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014755 mRNA Translation: AAH14755.1
CCDSiCCDS27461.1
RefSeqiNP_542366.1, NM_080635.1
UniGeneiMm.289800

3D structure databases

ProteinModelPortaliQ91WK2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212675, 3 interactors
IntActiQ91WK2, 9 interactors
MINTiQ91WK2
STRINGi10090.ENSMUSP00000022925

Protein family/group databases

MEROPSiM67.971

PTM databases

iPTMnetiQ91WK2
PhosphoSitePlusiQ91WK2
SwissPalmiQ91WK2

Proteomic databases

EPDiQ91WK2
MaxQBiQ91WK2
PaxDbiQ91WK2
PRIDEiQ91WK2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022925; ENSMUSP00000022925; ENSMUSG00000022312
GeneIDi68135
KEGGimmu:68135
UCSCiuc007vrb.1 mouse

Organism-specific databases

CTDi8667
MGIiMGI:1915385 Eif3h

Phylogenomic databases

eggNOGiKOG1560 Eukaryota
ENOG410XSR9 LUCA
GeneTreeiENSGT00730000111042
HOGENOMiHOG000248787
HOVERGENiHBG000883
InParanoidiQ91WK2
KOiK03247
OMAiKFNRYQQ
OrthoDBiEOG091G0E5O
PhylomeDBiQ91WK2
TreeFamiTF101504

Enzyme and pathway databases

ReactomeiR-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-MMU-72702 Ribosomal scanning and start codon recognition

Miscellaneous databases

PROiPR:Q91WK2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022312 Expressed in 284 organ(s), highest expression level in floor plate of midbrain
ExpressionAtlasiQ91WK2 baseline and differential
GenevisibleiQ91WK2 MM

Family and domain databases

CDDicd08065 MPN_eIF3h, 1 hit
HAMAPiMF_03007 eIF3h, 1 hit
InterProiView protein in InterPro
IPR027524 eIF3h
IPR000555 JAMM/MPN+_dom
IPR037518 MPN
PANTHERiPTHR10410:SF3 PTHR10410:SF3, 1 hit
PfamiView protein in Pfam
PF01398 JAB, 1 hit
SMARTiView protein in SMART
SM00232 JAB_MPN, 1 hit
PROSITEiView protein in PROSITE
PS50249 MPN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEIF3H_MOUSE
AccessioniPrimary (citable) accession number: Q91WK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again