UniProtKB - Q91WK2 (EIF3H_MOUSE)
Eukaryotic translation initiation factor 3 subunit H
Eif3h
Functioni
GO - Molecular functioni
- isopeptidase activity Source: InterPro
- metallopeptidase activity Source: GO_Central
- translation initiation factor activity Source: UniProtKB-UniRule
- ubiquitinyl hydrolase activity Source: MGI
GO - Biological processi
- formation of cytoplasmic translation initiation complex Source: UniProtKB-UniRule
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
- translational initiation Source: UniProtKB
Keywordsi
Molecular function | Initiation factor |
Biological process | Protein biosynthesis |
Enzyme and pathway databases
Reactomei | R-MMU-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-MMU-72649, Translation initiation complex formation R-MMU-72689, Formation of a pool of free 40S subunits R-MMU-72695, Formation of the ternary complex, and subsequently, the 43S complex R-MMU-72702, Ribosomal scanning and start codon recognition R-MMU-72706, GTP hydrolysis and joining of the 60S ribosomal subunit |
Protein family/group databases
MEROPSi | M67.971 |
Names & Taxonomyi
Protein namesi | Recommended name: Eukaryotic translation initiation factor 3 subunit HUniRule annotationShort name: eIF3hUniRule annotation Alternative name(s): Eukaryotic translation initiation factor 3 subunit 3UniRule annotation eIF-3-gamma eIF3 p40 subunitUniRule annotation |
Gene namesi | Name:Eif3h Synonyms:Eif3s3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1915385, Eif3h |
Subcellular locationi
Other locations
- Cytoplasm UniRule annotation
Cytosol
- cytosol Source: GO_Central
Other locations
- eukaryotic 43S preinitiation complex Source: GO_Central
- eukaryotic 48S preinitiation complex Source: UniProtKB-UniRule
- eukaryotic translation initiation factor 3 complex Source: UniProtKB
- eukaryotic translation initiation factor 3 complex, eIF3m Source: MGI
- polysomal ribosome Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213962 | 1 – 352 | Eukaryotic translation initiation factor 3 subunit HAdd BLAST | 352 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 3 | PhosphoserineBy similarity | 1 | |
Modified residuei | 183 | PhosphoserineUniRule annotationBy similarity | 1 | |
Modified residuei | 191 | PhosphoserineCombined sources | 1 | |
Cross-linki | 303 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q91WK2 |
jPOSTi | Q91WK2 |
MaxQBi | Q91WK2 |
PaxDbi | Q91WK2 |
PRIDEi | Q91WK2 |
PTM databases
iPTMneti | Q91WK2 |
PhosphoSitePlusi | Q91WK2 |
SwissPalmi | Q91WK2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000022312, Expressed in floor plate of midbrain and 301 other tissues |
ExpressionAtlasi | Q91WK2, baseline and differential |
Genevisiblei | Q91WK2, MM |
Interactioni
Subunit structurei
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex may interact with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation may lead to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner (By similarity).
Interacts with DHX33; the interaction is independent of RNA (PubMed:26100019).
UniRule annotation2 PublicationsProtein-protein interaction databases
BioGRIDi | 212675, 33 interactors |
IntActi | Q91WK2, 9 interactors |
MINTi | Q91WK2 |
STRINGi | 10090.ENSMUSP00000022925 |
Miscellaneous databases
RNActi | Q91WK2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 173 | MPNPROSITE-ProRule annotationAdd BLAST | 135 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1560, Eukaryota |
GeneTreei | ENSGT00730000111042 |
HOGENOMi | CLU_044094_0_0_1 |
InParanoidi | Q91WK2 |
OMAi | KFNRYQQ |
OrthoDBi | 976469at2759 |
PhylomeDBi | Q91WK2 |
TreeFami | TF101504 |
Family and domain databases
CDDi | cd08065, MPN_eIF3h, 1 hit |
HAMAPi | MF_03007, eIF3h, 1 hit |
InterProi | View protein in InterPro IPR027524, eIF3h IPR000555, JAMM/MPN+_dom IPR037518, MPN |
PANTHERi | PTHR10410:SF3, PTHR10410:SF3, 1 hit |
Pfami | View protein in Pfam PF01398, JAB, 1 hit |
SMARTi | View protein in SMART SM00232, JAB_MPN, 1 hit |
PROSITEi | View protein in PROSITE PS50249, MPN, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MASRKEGTGS TATSSGSAGG AVGKGKGKGG SGDSAVKQVQ IDGLVVLKII
60 70 80 90 100
KHYQEEGQGT EVVQGVLLGL VVEDRLEITN CFPFPQHTED DADFDEVQYQ
110 120 130 140 150
MEMMRSLRHV NIDHLHVGWY QSTYYGSFVT RALLDSQFSY QHAIEESVVL
160 170 180 190 200
IYDPIKTAQG SLSLKAYRLT PKLMEVCKEK DFSPEALKKA SITFEHMFEE
210 220 230 240 250
VPIVIKNSHL INVLMWELEK KSAVADKHEL LSLASSNHLG KSLQLLMDRV
260 270 280 290 300
DEMSQDIIKY NTYMRNTSKQ QQQKHQYQQR RQQENMQRQS RGEPPLPEED
310 320 330 340 350
LSKLFKPHQA PARMDSLLIA GQINTYCQNI KEFTAQNLGK LFMAQALQEY
NN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC014755 mRNA Translation: AAH14755.1 |
CCDSi | CCDS27461.1 |
RefSeqi | NP_542366.1, NM_080635.1 |
Genome annotation databases
Ensembli | ENSMUST00000022925; ENSMUSP00000022925; ENSMUSG00000022312 |
GeneIDi | 68135 |
KEGGi | mmu:68135 |
UCSCi | uc007vrb.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC014755 mRNA Translation: AAH14755.1 |
CCDSi | CCDS27461.1 |
RefSeqi | NP_542366.1, NM_080635.1 |
3D structure databases
SMRi | Q91WK2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 212675, 33 interactors |
IntActi | Q91WK2, 9 interactors |
MINTi | Q91WK2 |
STRINGi | 10090.ENSMUSP00000022925 |
Protein family/group databases
MEROPSi | M67.971 |
PTM databases
iPTMneti | Q91WK2 |
PhosphoSitePlusi | Q91WK2 |
SwissPalmi | Q91WK2 |
Proteomic databases
EPDi | Q91WK2 |
jPOSTi | Q91WK2 |
MaxQBi | Q91WK2 |
PaxDbi | Q91WK2 |
PRIDEi | Q91WK2 |
Protocols and materials databases
Antibodypediai | 13577, 282 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000022925; ENSMUSP00000022925; ENSMUSG00000022312 |
GeneIDi | 68135 |
KEGGi | mmu:68135 |
UCSCi | uc007vrb.1, mouse |
Organism-specific databases
CTDi | 8667 |
MGIi | MGI:1915385, Eif3h |
Phylogenomic databases
eggNOGi | KOG1560, Eukaryota |
GeneTreei | ENSGT00730000111042 |
HOGENOMi | CLU_044094_0_0_1 |
InParanoidi | Q91WK2 |
OMAi | KFNRYQQ |
OrthoDBi | 976469at2759 |
PhylomeDBi | Q91WK2 |
TreeFami | TF101504 |
Enzyme and pathway databases
Reactomei | R-MMU-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-MMU-72649, Translation initiation complex formation R-MMU-72689, Formation of a pool of free 40S subunits R-MMU-72695, Formation of the ternary complex, and subsequently, the 43S complex R-MMU-72702, Ribosomal scanning and start codon recognition R-MMU-72706, GTP hydrolysis and joining of the 60S ribosomal subunit |
Miscellaneous databases
BioGRID-ORCSi | 68135, 8 hits in 18 CRISPR screens |
ChiTaRSi | Eif3h, mouse |
PROi | PR:Q91WK2 |
RNActi | Q91WK2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022312, Expressed in floor plate of midbrain and 301 other tissues |
ExpressionAtlasi | Q91WK2, baseline and differential |
Genevisiblei | Q91WK2, MM |
Family and domain databases
CDDi | cd08065, MPN_eIF3h, 1 hit |
HAMAPi | MF_03007, eIF3h, 1 hit |
InterProi | View protein in InterPro IPR027524, eIF3h IPR000555, JAMM/MPN+_dom IPR037518, MPN |
PANTHERi | PTHR10410:SF3, PTHR10410:SF3, 1 hit |
Pfami | View protein in Pfam PF01398, JAB, 1 hit |
SMARTi | View protein in SMART SM00232, JAB_MPN, 1 hit |
PROSITEi | View protein in PROSITE PS50249, MPN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EIF3H_MOUSE | |
Accessioni | Q91WK2Primary (citable) accession number: Q91WK2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Translation initiation factors
List of translation initiation factor entries