Eif3h

Functionⁱ

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.UniRule annotation1 Publication

GO - Molecular functionⁱ

translation initiation factor activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

translational initiation
Source: UniProtKB
Inferred from direct assayⁱ
- 17581632

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Initiation factor
Biological process	Protein biosynthesis

Enzyme and pathway databases

Reactomeⁱ	R-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complex R-MMU-72702 Ribosomal scanning and start codon recognition

Reactomeⁱ

R-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-MMU-72702 Ribosomal scanning and start codon recognition

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	M67.971

MEROPSⁱ

M67.971

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Eukaryotic translation initiation factor 3 subunit HUniRule annotation Short name: eIF3hUniRule annotation Alternative name(s): Eukaryotic translation initiation factor 3 subunit 3UniRule annotation eIF-3-gamma eIF3 p40 subunitUniRule annotation
Gene namesⁱ	Name:Eif3h Synonyms:Eif3s3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 15

Organism-specific databases

MGIⁱ	MGI:1915385 Eif3h

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000213962	1 – 352	Eukaryotic translation initiation factor 3 subunit HAdd BLAST		352

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	3	PhosphoserineBy similarity	1
Modified residueⁱ	183	PhosphoserineUniRule annotationBy similarity	1
Modified residueⁱ	191	PhosphoserineCombined sources	1
Cross-linkⁱ	303	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q91WK2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q91WK2
PaxDbⁱ	Q91WK2
PRIDEⁱ	Q91WK2

PTM databases

iPTMnetⁱ	Q91WK2
PhosphoSitePlusⁱ	Q91WK2
SwissPalmⁱ	Q91WK2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000022312 Expressed in 284 organ(s), highest expression level in floor plate of midbrain
ExpressionAtlasⁱ	Q91WK2 baseline and differential
Genevisibleⁱ	Q91WK2 MM

Interactionⁱ

Subunit structureⁱ

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex may interact with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation may lead to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner (By similarity). Interacts with DHX33; the interaction is independent of RNA (PubMed:26100019).UniRule annotation2 Publications

Protein-protein interaction databases

BioGridⁱ	212675, 3 interactors
IntActⁱ	Q91WK2, 9 interactors
Molecular INTeraction database More...MINTⁱ	Q91WK2
STRINGⁱ	10090.ENSMUSP00000022925

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q91WK2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	39 – 173	MPNPROSITE-ProRule annotationAdd BLAST		135

Sequence similaritiesⁱ

Belongs to the eIF-3 subunit H family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG1560 Eukaryota ENOG410XSR9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111042
HOGENOMⁱ	HOG000248787
HOVERGENⁱ	HBG000883
InParanoidⁱ	Q91WK2
KEGG Orthology (KO) More...KOⁱ	K03247
OMAⁱ	KFNRYQQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0E5O
PhylomeDBⁱ	Q91WK2
TreeFamⁱ	TF101504

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08065 MPN_eIF3h, 1 hit
HAMAPⁱ	MF_03007 eIF3h, 1 hit
InterProⁱ	View protein in InterPro IPR027524 eIF3h IPR000555 JAMM/MPN+_dom IPR037518 MPN
PANTHERⁱ	PTHR10410:SF3 PTHR10410:SF3, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01398 JAB, 1 hit
SMARTⁱ	View protein in SMART SM00232 JAB_MPN, 1 hit
PROSITEⁱ	View protein in PROSITE PS50249 MPN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q91WK2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASRKEGTGS TATSSGSAGG AVGKGKGKGG SGDSAVKQVQ IDGLVVLKII 
        60         70         80         90        100
KHYQEEGQGT EVVQGVLLGL VVEDRLEITN CFPFPQHTED DADFDEVQYQ 
       110        120        130        140        150
MEMMRSLRHV NIDHLHVGWY QSTYYGSFVT RALLDSQFSY QHAIEESVVL 
       160        170        180        190        200
IYDPIKTAQG SLSLKAYRLT PKLMEVCKEK DFSPEALKKA SITFEHMFEE 
       210        220        230        240        250
VPIVIKNSHL INVLMWELEK KSAVADKHEL LSLASSNHLG KSLQLLMDRV 
       260        270        280        290        300
DEMSQDIIKY NTYMRNTSKQ QQQKHQYQQR RQQENMQRQS RGEPPLPEED 
       310        320        330        340        350
LSKLFKPHQA PARMDSLLIA GQINTYCQNI KEFTAQNLGK LFMAQALQEY 

NN

Length:352

Mass (Da):39,832

Last modified:December 1, 2001 - v1

Checksum:ⁱ96F5AB8E2F41F838

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC014755 mRNA Translation: AAH14755.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27461.1
NCBI Reference Sequences More...RefSeqⁱ	NP_542366.1, NM_080635.1
UniGeneⁱ	Mm.289800

Genome annotation databases

Ensemblⁱ	ENSMUST00000022925; ENSMUSP00000022925; ENSMUSG00000022312
GeneIDⁱ	68135
KEGGⁱ	mmu:68135
UCSC genome browser More...UCSCⁱ	uc007vrb.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q91WK2	Eukaryotic translation initiation factor 3 subunit H		MOUSE		352	UniRef100_Q91WK2
LOC100037221 protein (Fragment)		XENLA		351
Putative Eukaryotic translation initiation factor 3 subunit H (Fragment)		Daphnia magna		125
Putative Eukaryotic translation initiation factor 3 subunit H (Fragment)		Daphnia magna		141

Protein	Similar proteins		Species	Score	Length	Source
Q91WK2	Eukaryotic translation initiation factor 3 subunit H	)	HUMAN		352	UniRef90_O15372
Eukaryotic translation initiation factor 3 subunit H		BOVIN		352
Eukaryotic translation initiation factor 3 subunit H		RAT		352
Eukaryotic translation initiation factor 3 subunit H		PONAB		366
Eukaryotic translation initiation factor 3 subunit H		PANTR		352
+144

Protein	Similar proteins		Species	Score	Length	Source
Q91WK2	Eukaryotic translation initiation factor 3 subunit H	)	HUMAN		352	UniRef50_O15372
Eukaryotic translation initiation factor 3 subunit H		RAT		352
Eukaryotic translation initiation factor 3 subunit H		BOVIN		352
Eukaryotic translation initiation factor 3 subunit H-A		DANRE		335
Eukaryotic translation initiation factor 3 subunit H		SALSA		344
+235

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC014755 mRNA Translation: AAH14755.1
CCDSⁱ	CCDS27461.1
RefSeqⁱ	NP_542366.1, NM_080635.1
UniGeneⁱ	Mm.289800

3D structure databases

ProteinModelPortalⁱ	Q91WK2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	212675, 3 interactors
IntActⁱ	Q91WK2, 9 interactors
MINTⁱ	Q91WK2
STRINGⁱ	10090.ENSMUSP00000022925

Protein family/group databases

MEROPSⁱ	M67.971

MEROPSⁱ

M67.971

PTM databases

iPTMnetⁱ	Q91WK2
PhosphoSitePlusⁱ	Q91WK2
SwissPalmⁱ	Q91WK2

Proteomic databases

EPDⁱ	Q91WK2
MaxQBⁱ	Q91WK2
PaxDbⁱ	Q91WK2
PRIDEⁱ	Q91WK2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000022925; ENSMUSP00000022925; ENSMUSG00000022312
GeneIDⁱ	68135
KEGGⁱ	mmu:68135
UCSCⁱ	uc007vrb.1 mouse

Organism-specific databases

CTDⁱ	8667
MGIⁱ	MGI:1915385 Eif3h

Phylogenomic databases

eggNOGⁱ	KOG1560 Eukaryota ENOG410XSR9 LUCA
GeneTreeⁱ	ENSGT00730000111042
HOGENOMⁱ	HOG000248787
HOVERGENⁱ	HBG000883
InParanoidⁱ	Q91WK2
KOⁱ	K03247
OMAⁱ	KFNRYQQ
OrthoDBⁱ	EOG091G0E5O
PhylomeDBⁱ	Q91WK2
TreeFamⁱ	TF101504

Enzyme and pathway databases

Reactomeⁱ	R-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complex R-MMU-72702 Ribosomal scanning and start codon recognition

Reactomeⁱ

R-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-MMU-72702 Ribosomal scanning and start codon recognition

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q91WK2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000022312 Expressed in 284 organ(s), highest expression level in floor plate of midbrain
ExpressionAtlasⁱ	Q91WK2 baseline and differential
Genevisibleⁱ	Q91WK2 MM

Family and domain databases

CDDⁱ	cd08065 MPN_eIF3h, 1 hit
HAMAPⁱ	MF_03007 eIF3h, 1 hit
InterProⁱ	View protein in InterPro IPR027524 eIF3h IPR000555 JAMM/MPN+_dom IPR037518 MPN
PANTHERⁱ	PTHR10410:SF3 PTHR10410:SF3, 1 hit
Pfamⁱ	View protein in Pfam PF01398 JAB, 1 hit
SMARTⁱ	View protein in SMART SM00232 JAB_MPN, 1 hit
PROSITEⁱ	View protein in PROSITE PS50249 MPN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EIF3H_MOUSE
Accessionⁱ	Q91WK2Primary (citable) accession number: Q91WK2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
	Last sequence update:	December 1, 2001
	Last modified:	September 12, 2018
	This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - Q91WK2 (EIF3H_MOUSE)

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Eukaryotic translation initiation factor 3 subunit H

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ