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Protein

Elongator complex protein 2

Gene

Elp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the ligand-dependent activation of STAT3.1 Publication
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 2
Short name:
ELP2
Alternative name(s):
STAT3-interacting protein 1
Short name:
StIP1
Gene namesi
Name:Elp2
Synonyms:Statip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1889642 Elp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512421 – 831Elongator complex protein 2Add BLAST831

Proteomic databases

EPDiQ91WG4
PaxDbiQ91WG4
PeptideAtlasiQ91WG4
PRIDEiQ91WG4

PTM databases

iPTMnetiQ91WG4
PhosphoSitePlusiQ91WG4

Expressioni

Gene expression databases

BgeeiENSMUSG00000024271 Expressed in 285 organ(s), highest expression level in saccule of membranous labyrinth
CleanExiMM_ELP2
GenevisibleiQ91WG4 MM

Interactioni

Subunit structurei

Component of the RNA polymerase II elongator complex (Elongator), which consists of ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit (By similarity). Interacts with STAT3 and JAKs.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91WG4, 1 interactor
MINTiQ91WG4
STRINGi10090.ENSMUSP00000025120

Structurei

3D structure databases

ProteinModelPortaliQ91WG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati56 – 100WD 1Add BLAST45
Repeati105 – 152WD 2Add BLAST48
Repeati158 – 200WD 3Add BLAST43
Repeati205 – 246WD 4Add BLAST42
Repeati280 – 328WD 5Add BLAST49
Repeati338 – 377WD 6Add BLAST40
Repeati385 – 424WD 7Add BLAST40
Repeati438 – 476WD 8Add BLAST39
Repeati565 – 609WD 9Add BLAST45
Repeati612 – 651WD 10Add BLAST40
Repeati667 – 706WD 11Add BLAST40
Repeati718 – 762WD 12Add BLAST45
Repeati775 – 831WD 13Add BLAST57

Sequence similaritiesi

Belongs to the WD repeat ELP2 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1063 Eukaryota
ENOG410XRF0 LUCA
GeneTreeiENSGT00390000000916
HOGENOMiHOG000200623
HOVERGENiHBG087208
InParanoidiQ91WG4
KOiK11374
OMAiQAHHLTV
OrthoDBiEOG091G02XJ
PhylomeDBiQ91WG4
TreeFamiTF105985

Family and domain databases

Gene3Di2.130.10.10, 5 hits
InterProiView protein in InterPro
IPR037289 Elp2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR44111 PTHR44111, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 6 hits
SMARTiView protein in SMART
SM00320 WD40, 10 hits
SUPFAMiSSF50978 SSF50978, 3 hits
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q91WG4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVSSVLEVSH VFCCPNRVRG ALSWNTGPGG LLAFGTSCSV VLYDPQKKVV
60 70 80 90 100
ITNLNGHTAR VNCLQWIRTE DGSPSNELVS GGSDNRVIHW ELENNQVLKS
110 120 130 140 150
VRLQGHEGPV CAVHAIYQSG PSEGEQHALI ASAASDSTVR IWSKKGSEVK
160 170 180 190 200
YLQTLSFRDG FVLSVCLAIL PGTNVPVLAC GDDDCRIHLY IQQDDQFQKA
210 220 230 240 250
LSLCGHEDWI RGVEWATFGR DLFLASCSQD CLIRIWRLYM KPASFETKDG
260 270 280 290 300
SLRLKENTFT IKDGGVRTTV AVTLETVLAG HENWVNAVHW QPSFYKDGVL
310 320 330 340 350
QQPVRLLSAS MDKTMILWAP DEESGVWLEQ VRVGEVGGNT LGFYDCQFGE
360 370 380 390 400
NGTMIIAHAF HGALHLWKQS TVNPRQWAPE IVISGHFDGV QDLMWDPEGE
410 420 430 440 450
FIITTSTDQT TRLFAPWKKK DQKDRSQVTW HEIARPQIHG YNIKCLAMID
460 470 480 490 500
RFQFVSGADE KVLRVFSAPR NFVENFSVIS RQSLSHMLCD DQDLPEGATV
510 520 530 540 550
PALGLSNKAL FQGDIASQPF EEDELISPAF GSPQVTFQPA VLNEPPTEDH
560 570 580 590 600
LLQNTLWPEI QKLYGHGYEI VCVACNNSKT LLASACKASQ KEHAAIILWS
610 620 630 640 650
TASWKQVQSL AFHTLTVTQM TFSPDDKFLL AVSRDRTWSL WKRQDATSSE
660 670 680 690 700
FDPFFSLFAF TNKITSVHSR IIWSCDWSPD NKYFFTGSRD KKVVVWGECK
710 720 730 740 750
SSHNPMEHPI RPCSSILDVG SSVTAVSVCP VLNPAQRYIV AIGLESGKIC
760 770 780 790 800
IYSWNKTNQE INDWTSCVET NPSQSHSLGI RRLCWKSCSD DDDDDDDDDT
810 820 830
EQSEEGPEWL HFASCGEDHT VKIYRVNRRA L
Length:831
Mass (Da):93,093
Last modified:December 1, 2001 - v1
Checksum:i177290C8B633FDC4
GO
Isoform 2 (identifier: Q91WG4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     175-264: Missing.

Note: No experimental confirmation available.
Show »
Length:741
Mass (Da):82,711
Checksum:iD89DDD60090ECA89
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23S → G in BAE39871 (PubMed:16141072).Curated1
Sequence conflicti84D → E in AAG01032 (PubMed:10954736).Curated1
Sequence conflicti112A → V in BAE39871 (PubMed:16141072).Curated1
Sequence conflicti550H → N in BAE39871 (PubMed:16141072).Curated1
Sequence conflicti687G → R in BAC28716 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016534175 – 264Missing in isoform 2. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291064 mRNA Translation: AAG01032.1
AK033246 mRNA Translation: BAC28210.1
AK034457 mRNA Translation: BAC28716.1
AK050960 mRNA Translation: BAC34477.1
AK147826 mRNA Translation: BAE28163.1
AK167725 mRNA Translation: BAE39766.1
AK167853 mRNA Translation: BAE39871.1
AK168370 mRNA Translation: BAE40302.1
BC015284 mRNA Translation: AAH15284.1
BC051943 mRNA Translation: AAH51943.1
CCDSiCCDS29103.1 [Q91WG4-1]
RefSeqiNP_067423.2, NM_021448.2 [Q91WG4-1]
UniGeneiMm.25298

Genome annotation databases

EnsembliENSMUST00000025120; ENSMUSP00000025120; ENSMUSG00000024271 [Q91WG4-1]
GeneIDi58523
KEGGimmu:58523
UCSCiuc008egx.1 mouse [Q91WG4-1]
uc012baj.1 mouse [Q91WG4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291064 mRNA Translation: AAG01032.1
AK033246 mRNA Translation: BAC28210.1
AK034457 mRNA Translation: BAC28716.1
AK050960 mRNA Translation: BAC34477.1
AK147826 mRNA Translation: BAE28163.1
AK167725 mRNA Translation: BAE39766.1
AK167853 mRNA Translation: BAE39871.1
AK168370 mRNA Translation: BAE40302.1
BC015284 mRNA Translation: AAH15284.1
BC051943 mRNA Translation: AAH51943.1
CCDSiCCDS29103.1 [Q91WG4-1]
RefSeqiNP_067423.2, NM_021448.2 [Q91WG4-1]
UniGeneiMm.25298

3D structure databases

ProteinModelPortaliQ91WG4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91WG4, 1 interactor
MINTiQ91WG4
STRINGi10090.ENSMUSP00000025120

PTM databases

iPTMnetiQ91WG4
PhosphoSitePlusiQ91WG4

Proteomic databases

EPDiQ91WG4
PaxDbiQ91WG4
PeptideAtlasiQ91WG4
PRIDEiQ91WG4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025120; ENSMUSP00000025120; ENSMUSG00000024271 [Q91WG4-1]
GeneIDi58523
KEGGimmu:58523
UCSCiuc008egx.1 mouse [Q91WG4-1]
uc012baj.1 mouse [Q91WG4-2]

Organism-specific databases

CTDi55250
MGIiMGI:1889642 Elp2

Phylogenomic databases

eggNOGiKOG1063 Eukaryota
ENOG410XRF0 LUCA
GeneTreeiENSGT00390000000916
HOGENOMiHOG000200623
HOVERGENiHBG087208
InParanoidiQ91WG4
KOiK11374
OMAiQAHHLTV
OrthoDBiEOG091G02XJ
PhylomeDBiQ91WG4
TreeFamiTF105985

Miscellaneous databases

PROiPR:Q91WG4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024271 Expressed in 285 organ(s), highest expression level in saccule of membranous labyrinth
CleanExiMM_ELP2
GenevisibleiQ91WG4 MM

Family and domain databases

Gene3Di2.130.10.10, 5 hits
InterProiView protein in InterPro
IPR037289 Elp2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR44111 PTHR44111, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 6 hits
SMARTiView protein in SMART
SM00320 WD40, 10 hits
SUPFAMiSSF50978 SSF50978, 3 hits
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiELP2_MOUSE
AccessioniPrimary (citable) accession number: Q91WG4
Secondary accession number(s): Q3TIH5
, Q3TIT0, Q8CBW6, Q9ESY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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