UniProtKB - Q91WG2 (RABE2_MOUSE)
Rab GTPase-binding effector protein 2
Rabep2
Functioni
GO - Molecular functioni
- growth factor activity Source: InterPro
- GTPase activator activity Source: InterPro
GO - Biological processi
- cell projection organization Source: UniProtKB-KW
- endocytosis Source: UniProtKB-KW
- protein transport Source: UniProtKB-KW
- regulation of cilium assembly Source: MGI
Keywordsi
Biological process | Cilium biogenesis/degradation, Endocytosis, Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Rab GTPase-binding effector protein 2Alternative name(s): Rabaptin-5beta |
Gene namesi | Name:Rabep2 Synonyms:Rabpt5b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1917564, Rabep2 |
Subcellular locationi
Cytoskeleton
- centrosome By similarity
- cilium basal body By similarity
Endosome
- Early endosome By similarity
Other locations
- Cytoplasm By similarity
Cytoskeleton
- centrosome Source: MGI
- ciliary basal body Source: MGI
Cytosol
- cytosol Source: MGI
Endosome
- early endosome Source: UniProtKB-SubCell
Other locations
- intracellular membrane-bounded organelle Source: MGI
Keywords - Cellular componenti
Cell projection, Cytoplasm, Cytoskeleton, EndosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000187560 | 1 – 554 | Rab GTPase-binding effector protein 2Add BLAST | 554 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 176 | PhosphoserineBy similarity | 1 | |
Modified residuei | 180 | PhosphoserineBy similarity | 1 | |
Modified residuei | 187 | PhosphoserineBy similarity | 1 | |
Modified residuei | 191 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q91WG2 |
MaxQBi | Q91WG2 |
PaxDbi | Q91WG2 |
PeptideAtlasi | Q91WG2 |
PRIDEi | Q91WG2 |
PTM databases
iPTMneti | Q91WG2 |
PhosphoSitePlusi | Q91WG2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000030727, Expressed in lacrimal gland and 268 other tissues |
Genevisiblei | Q91WG2, MM |
Interactioni
Subunit structurei
Heterodimer with RABGEF1. The dimer binds RAB5A that has been activated by GTP-binding.
Interacts with SDCCAG8; this interaction is important for ciliogenesis regulation.
Interacts with RAB4A; this interaction may mediate VEGFR2 cell surface expression.
By similarityGO - Molecular functioni
- growth factor activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 213981, 9 interactors |
IntActi | Q91WG2, 5 interactors |
STRINGi | 10090.ENSMUSP00000102015 |
Miscellaneous databases
RNActi | Q91WG2, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 15 – 173 | Sequence analysisAdd BLAST | 159 | |
Coiled coili | 274 – 509 | Sequence analysisAdd BLAST | 236 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 96 – 100 | Poly-Gln | 5 | |
Compositional biasi | 313 – 463 | Gln-richAdd BLAST | 151 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0993, Eukaryota |
GeneTreei | ENSGT00530000063743 |
HOGENOMi | CLU_035043_0_0_1 |
InParanoidi | Q91WG2 |
OMAi | ICHTLLT |
OrthoDBi | 1369937at2759 |
PhylomeDBi | Q91WG2 |
TreeFami | TF329365 |
Family and domain databases
InterProi | View protein in InterPro IPR003914, Rabaptin IPR029882, Rabaptin-5beta IPR018514, Rabaptin_coiled-coil IPR015390, Rabaptin_Rab5-bd_dom |
PANTHERi | PTHR31179, PTHR31179, 1 hit PTHR31179:SF6, PTHR31179:SF6, 1 hit |
Pfami | View protein in Pfam PF09311, Rab5-bind, 1 hit PF03528, Rabaptin, 1 hit |
PRINTSi | PR01432, RABAPTIN |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAAPATLAL DPQPQEKQKD ASESSELSRL RAELAGALAE METMKAVAEV
60 70 80 90 100
SESTKAEAVA AVQRQCQEEV ASLQAILKDS ISSYETQIAA LKQERQQQQQ
110 120 130 140 150
DFEEKDRELG HLKQLLARAH PLDSLEKQME KAHEDSEKLR EIVLPMEQEI
160 170 180 190 200
TELKGKLQRA EELIQEIQRR PRQPASLHGS TELLPLSRNP SPPLEPLEEP
210 220 230 240 250
SGDAGPAAEA FAHNCDDSAS ISSFSLGGAA GSASLRGPQG LSPEQEETAS
260 270 280 290 300
LVSTGTLVPE GIFLPPPGYQ LVPDSQWEQL QVEGRQLQKE LESVSRERDE
310 320 330 340 350
LQEGLRRSNE DCAKQMQVLL AQVQNSEQLL RTLQGTVSQA QERVQLQMAE
360 370 380 390 400
LATSHKCLSQ EVKRLNEENQ GLRAEQLPSS ALQGSEQRED QDEALPSSIQ
410 420 430 440 450
ELHLLVQNTR QQARARQQAQ EHEAERLRIE IVKLREALDE ETAAKASLER
460 470 480 490 500
QLRVQREETD VLEASLCSLR IETERVQQEQ RKAQLTDLLS EQRAKTLRLQ
510 520 530 540 550
AELETSEQVQ RDFVRLSQAL QVRLERIRQA ETLQQVRSIL DEAPLRDIRD
IKDS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RCU7 | D6RCU7_MOUSE | Rab GTPase-binding effector protein... | Rabep2 | 92 | Annotation score: | ||
D6RGR2 | D6RGR2_MOUSE | Rab GTPase-binding effector protein... | Rabep2 | 60 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010460 | 1 – 43 | Missing in isoform 2. 1 PublicationAdd BLAST | 43 | |
Alternative sequenceiVSP_010461 | 483 – 554 | AQLTD…DIKDS → VSGAGGLA in isoform 3. 1 PublicationAdd BLAST | 72 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK144836 mRNA Translation: BAE26090.1 BC004088 mRNA Translation: AAH04088.1 BC015287 mRNA Translation: AAH15287.1 |
CCDSi | CCDS21829.2 [Q91WG2-3] |
RefSeqi | NP_085043.2, NM_030566.2 [Q91WG2-3] |
Genome annotation databases
Ensembli | ENSMUST00000106405; ENSMUSP00000102013; ENSMUSG00000030727 [Q91WG2-1] ENSMUST00000106407; ENSMUSP00000102015; ENSMUSG00000030727 [Q91WG2-3] |
GeneIDi | 70314 |
KEGGi | mmu:70314 |
UCSCi | uc009jrd.1, mouse [Q91WG2-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK144836 mRNA Translation: BAE26090.1 BC004088 mRNA Translation: AAH04088.1 BC015287 mRNA Translation: AAH15287.1 |
CCDSi | CCDS21829.2 [Q91WG2-3] |
RefSeqi | NP_085043.2, NM_030566.2 [Q91WG2-3] |
3D structure databases
SMRi | Q91WG2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 213981, 9 interactors |
IntActi | Q91WG2, 5 interactors |
STRINGi | 10090.ENSMUSP00000102015 |
PTM databases
iPTMneti | Q91WG2 |
PhosphoSitePlusi | Q91WG2 |
Proteomic databases
EPDi | Q91WG2 |
MaxQBi | Q91WG2 |
PaxDbi | Q91WG2 |
PeptideAtlasi | Q91WG2 |
PRIDEi | Q91WG2 |
Protocols and materials databases
Antibodypediai | 26625, 115 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000106405; ENSMUSP00000102013; ENSMUSG00000030727 [Q91WG2-1] ENSMUST00000106407; ENSMUSP00000102015; ENSMUSG00000030727 [Q91WG2-3] |
GeneIDi | 70314 |
KEGGi | mmu:70314 |
UCSCi | uc009jrd.1, mouse [Q91WG2-3] |
Organism-specific databases
CTDi | 79874 |
MGIi | MGI:1917564, Rabep2 |
Phylogenomic databases
eggNOGi | KOG0993, Eukaryota |
GeneTreei | ENSGT00530000063743 |
HOGENOMi | CLU_035043_0_0_1 |
InParanoidi | Q91WG2 |
OMAi | ICHTLLT |
OrthoDBi | 1369937at2759 |
PhylomeDBi | Q91WG2 |
TreeFami | TF329365 |
Miscellaneous databases
BioGRID-ORCSi | 70314, 2 hits in 18 CRISPR screens |
ChiTaRSi | Rabep2, mouse |
PROi | PR:Q91WG2 |
RNActi | Q91WG2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030727, Expressed in lacrimal gland and 268 other tissues |
Genevisiblei | Q91WG2, MM |
Family and domain databases
InterProi | View protein in InterPro IPR003914, Rabaptin IPR029882, Rabaptin-5beta IPR018514, Rabaptin_coiled-coil IPR015390, Rabaptin_Rab5-bd_dom |
PANTHERi | PTHR31179, PTHR31179, 1 hit PTHR31179:SF6, PTHR31179:SF6, 1 hit |
Pfami | View protein in Pfam PF09311, Rab5-bind, 1 hit PF03528, Rabaptin, 1 hit |
PRINTSi | PR01432, RABAPTIN |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RABE2_MOUSE | |
Accessioni | Q91WG2Primary (citable) accession number: Q91WG2 Secondary accession number(s): Q3UMK8, Q99KN3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2004 |
Last sequence update: | September 2, 2008 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families