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Protein

Polyphosphoinositide phosphatase

Gene

Fig4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.2 Publications

GO - Molecular functioni

GO - Biological processi

  • locomotory behavior Source: MGI
  • myelin assembly Source: MGI
  • negative regulation of myelination Source: MGI
  • neuron development Source: MGI
  • phosphatidylinositol metabolic process Source: MGI
  • pigmentation Source: MGI
  • positive regulation of neuron projection development Source: MGI
  • vacuole organization Source: MGI

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-MMU-1660514 Synthesis of PIPs at the Golgi membrane
R-MMU-1660516 Synthesis of PIPs at the early endosome membrane
R-MMU-1660517 Synthesis of PIPs at the late endosome membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Polyphosphoinositide phosphatase (EC:3.1.3.-)
Alternative name(s):
Phosphatidylinositol 3,5-bisphosphate 5-phosphatase
SAC domain-containing protein 3
Gene namesi
Name:Fig4
Synonyms:Kiaa0274, Sac3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2143585 Fig4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Fig4 are the cause of the pale tremor phenotype which is a multi-organ disorder with neuronal degeneration in the central nervous system, peripheral neuronopathy and diluted pigmentation. At postnatal day three (P3), affected homozygotes have diluted pigmentation and reduced size. Intentional tremor develops during the second week after birth, and abnormal limb postures are evident by the third week. There is impaired motor coordination, muscle weakness and "swimming" gait. There is progressive loss of mobility, reduction in body weight and juvenile lethality.1 Publication

Keywords - Diseasei

Neurodegeneration, Neuropathy

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002097441 – 907Polyphosphoinositide phosphataseAdd BLAST907

Proteomic databases

EPDiQ91WF7
MaxQBiQ91WF7
PaxDbiQ91WF7
PRIDEiQ91WF7

PTM databases

iPTMnetiQ91WF7
PhosphoSitePlusiQ91WF7

Expressioni

Tissue specificityi

Wide-spread.1 Publication

Gene expression databases

BgeeiENSMUSG00000038417 Expressed in 266 organ(s), highest expression level in heart left ventricle
CleanExiMM_FIG4
GenevisibleiQ91WF7 MM

Interactioni

Subunit structurei

Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and WIPI1. VAC14 nucleates the assembly of the complex and serves as a scaffold.1 Publication

Protein-protein interaction databases

IntActiQ91WF7, 1 interactor
STRINGi10090.ENSMUSP00000039598

Structurei

3D structure databases

ProteinModelPortaliQ91WF7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini154 – 547SACPROSITE-ProRule annotationAdd BLAST394

Phylogenomic databases

eggNOGiKOG1888 Eukaryota
COG5329 LUCA
GeneTreeiENSGT00550000074943
HOGENOMiHOG000168063
InParanoidiQ91WF7
OMAiKRKCCAH
OrthoDBiEOG091G01F4
PhylomeDBiQ91WF7
TreeFamiTF105702

Family and domain databases

InterProiView protein in InterPro
IPR002013 SAC_dom
PfamiView protein in Pfam
PF02383 Syja_N, 1 hit
PROSITEiView protein in PROSITE
PS50275 SAC, 1 hit

Sequencei

Sequence statusi: Complete.

Q91WF7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTAAAPIIS SVQKLVLYET RARYFLVGSN HAETKYRVLK IDRTEPKDLV
60 70 80 90 100
VIDDRHVYTQ QEVRELLGRL DLGNRTKMSQ KGSSGLFRAV SAFGVVGFVR
110 120 130 140 150
FLEGYYIVLI TKRRKMADIG GHAIYKIEDT SMIYIPNDSV RISHPDEARY
160 170 180 190 200
LRIFQNVDLS SNFYFSYSYD LSHSLQYNLT VLRMPLEMLK SETSKACQES
210 220 230 240 250
FDIFEDEGLI TQGGSGVFGI SSEPYMKYVW NGELLDIIKN TVHRDWLLYI
260 270 280 290 300
IHGFCGQSKL LIYGRPVYVT LIARRSSRFA GTRFLKRGAN CEGDVANEVE
310 320 330 340 350
TEQILCDASV MSFTAGSYSS YVQVRGSVPL FWSQDISTMM PKPPITLDQA
360 370 380 390 400
DPFAHVAALH FDQMLQRFGS PIIILNLVKE REKRKHERIL SEELVAAVTY
410 420 430 440 450
LNQFLPPEHT IVYIPWDMAK YTKSKLCNVL DRLNVIAESV VKKTGFFVNR
460 470 480 490 500
PDSYCSILRP DEKWNELGGH VIPTGRLQTG ILRTNCVDCL DRTNTAQFMV
510 520 530 540 550
GKCALAYQLY SLGLIDKPNL QFDTDAVRLF EELYEDHGDT LSLQYGGSQL
560 570 580 590 600
VHRVKTYRKI APWTQHSKDI MQTLSRYYSN AFSDADRQDS INLFLGVFHP
610 620 630 640 650
TEGKPHLWEL PTDFYLHHKN TMSLLPPRRS YTYWWTPEVV KHLPLPYDEV
660 670 680 690 700
ICAANLKKLM VKKFHRWEEE IDIHNEFFRP YELSSFDDTF CLAMTSSARD
710 720 730 740 750
FMPKTVGIDP SPFTVRKPDE TGKSVLGNKN TREEAVLQRK TAASAPPPPS
760 770 780 790 800
EEAVSSSSED DSGTDREDEG SISQRSTPVK MTDTGDSAKA TENVVQPMKE
810 820 830 840 850
VYGVSLSSSL SEEDHSIYAR FVQLGQSQHK QDRGNQQLCS RCSDGVIKLT
860 870 880 890 900
PISAFSQDNI YEVQPPRVDR KSTEIFQAHI QASQGIMQPL GKEDTAMYRE

YIRNRYL
Length:907
Mass (Da):103,447
Last modified:December 1, 2001 - v1
Checksum:i3C31A28BE60F2292
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC015295 mRNA Translation: AAH15295.1
BC031887 mRNA Translation: AAH31887.1
AK172926 mRNA Translation: BAD32204.1
CCDSiCCDS23803.1
RefSeqiNP_598760.1, NM_133999.1
UniGeneiMm.277242

Genome annotation databases

EnsembliENSMUST00000043814; ENSMUSP00000039598; ENSMUSG00000038417
GeneIDi103199
KEGGimmu:103199
UCSCiuc007exk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC015295 mRNA Translation: AAH15295.1
BC031887 mRNA Translation: AAH31887.1
AK172926 mRNA Translation: BAD32204.1
CCDSiCCDS23803.1
RefSeqiNP_598760.1, NM_133999.1
UniGeneiMm.277242

3D structure databases

ProteinModelPortaliQ91WF7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91WF7, 1 interactor
STRINGi10090.ENSMUSP00000039598

PTM databases

iPTMnetiQ91WF7
PhosphoSitePlusiQ91WF7

Proteomic databases

EPDiQ91WF7
MaxQBiQ91WF7
PaxDbiQ91WF7
PRIDEiQ91WF7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043814; ENSMUSP00000039598; ENSMUSG00000038417
GeneIDi103199
KEGGimmu:103199
UCSCiuc007exk.1 mouse

Organism-specific databases

CTDi9896
MGIiMGI:2143585 Fig4
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1888 Eukaryota
COG5329 LUCA
GeneTreeiENSGT00550000074943
HOGENOMiHOG000168063
InParanoidiQ91WF7
OMAiKRKCCAH
OrthoDBiEOG091G01F4
PhylomeDBiQ91WF7
TreeFamiTF105702

Enzyme and pathway databases

ReactomeiR-MMU-1660514 Synthesis of PIPs at the Golgi membrane
R-MMU-1660516 Synthesis of PIPs at the early endosome membrane
R-MMU-1660517 Synthesis of PIPs at the late endosome membrane

Miscellaneous databases

PROiPR:Q91WF7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038417 Expressed in 266 organ(s), highest expression level in heart left ventricle
CleanExiMM_FIG4
GenevisibleiQ91WF7 MM

Family and domain databases

InterProiView protein in InterPro
IPR002013 SAC_dom
PfamiView protein in Pfam
PF02383 Syja_N, 1 hit
PROSITEiView protein in PROSITE
PS50275 SAC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFIG4_MOUSE
AccessioniPrimary (citable) accession number: Q91WF7
Secondary accession number(s): Q6A092
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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