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Protein

PSME3-interacting protein

Gene

Fam192a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
PSME3-interacting proteinCurated
Alternative name(s):
NEFA-interacting nuclear protein NIP301 Publication
PA28G-interacting proteinBy similarity
Gene namesi
Name:Fam192aImported
Synonyms:Nip301 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1919637 Fam192a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000968481 – 254PSME3-interacting proteinAdd BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei17PhosphoserineBy similarity1
Modified residuei138N6-acetyllysineBy similarity1
Modified residuei222PhosphoserineBy similarity1
Modified residuei228PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation by CK2 stabilizes the interaction with PSME3.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ91WE2
MaxQBiQ91WE2
PaxDbiQ91WE2
PeptideAtlasiQ91WE2
PRIDEiQ91WE2

PTM databases

iPTMnetiQ91WE2
PhosphoSitePlusiQ91WE2

Expressioni

Tissue specificityi

Expressed in skeletal muscle.1 Publication

Developmental stagei

Shows relatively constant expression in both proliferating myoblasts and in differentiated myotubes, when assayed in C2C12 cell line (at protein level).1 Publication

Inductioni

Up-regulated in response to denervation-induced skeletal muscle atrophy. Induced by MYOD1.1 Publication

Gene expression databases

BgeeiENSMUSG00000031774 Expressed in 297 organ(s), highest expression level in primary oocyte
CleanExiMM_2310065K24RIK
ExpressionAtlasiQ91WE2 baseline and differential
GenevisibleiQ91WE2 MM

Interactioni

Subunit structurei

Interacts (via C-terminus) with both free and 20S proteasome-bound forms of the proteasome activator complex subunit PSME3/PA28G; the interaction is direct.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034226

Structurei

3D structure databases

SMRiQ91WE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni201 – 254Interaction with PSME3By similarityAdd BLAST54

Phylogenomic databases

eggNOGiKOG4036 Eukaryota
ENOG4111INN LUCA
GeneTreeiENSGT00500000044916
HOGENOMiHOG000045055
HOVERGENiHBG052624
InParanoidiQ91WE2
OMAiWERVRQP
OrthoDBiEOG091G0RWI
PhylomeDBiQ91WE2
TreeFamiTF314540

Family and domain databases

InterProiView protein in InterPro
IPR039845 FAM192A
IPR019331 FAM192A/Fyv6_N
PANTHERiPTHR13495 PTHR13495, 1 hit
PfamiView protein in Pfam
PF10187 Nefa_Nip30_N, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

Q91WE2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGEDDSNLV IKKRFVSEAE LDERRKRRQE EWEKVRKPED PKECPEEAYD
60 70 80 90 100
PRSLYERLQE QKDRKQQEYE EQFKFKNMVR GLDEDETNFL DEVSRQQELI
110 120 130 140 150
EKQRREEELE ELKEYRSNLN KVGISAENKE VEKKLAVKPI ETKNKFSQAK
160 170 180 190 200
LLAGAVKHKS SESGNSVKRL KPDPDPDDKA QEAPSCMSLG SSSLSGPPSI
210 220 230 240 250
HCPSAAVCIG ILPGLGAYSG SSDSESSSDS EGTINATGKI VSSIFRTNTF

LEAP
Length:254
Mass (Da):28,702
Last modified:December 1, 2001 - v1
Checksum:i82CC62DE8ED636EC
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RLU2A0A1D5RLU2_MOUSE
PSME3-interacting protein
Fam192a
194Annotation score:
A0A1D5RLX7A0A1D5RLX7_MOUSE
PSME3-interacting protein
Fam192a
143Annotation score:
A0A1D5RLW0A0A1D5RLW0_MOUSE
PSME3-interacting protein
Fam192a
173Annotation score:
A0A1D5RLT4A0A1D5RLT4_MOUSE
PSME3-interacting protein
Fam192a
86Annotation score:
A0A1D5RLF2A0A1D5RLF2_MOUSE
PSME3-interacting protein
Fam192a
110Annotation score:
A0A1D5RLY1A0A1D5RLY1_MOUSE
PSME3-interacting protein
Fam192a
129Annotation score:
A0A1D5RLI3A0A1D5RLI3_MOUSE
PSME3-interacting protein
Fam192a
113Annotation score:
A0A1D5RLD7A0A1D5RLD7_MOUSE
PSME3-interacting protein
Fam192a
83Annotation score:
A0A1D5RLJ3A0A1D5RLJ3_MOUSE
PSME3-interacting protein
Fam192a
90Annotation score:
A0A1D5RM30A0A1D5RM30_MOUSE
PSME3-interacting protein
Fam192a
36Annotation score:
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4E → G in BAE30543 (PubMed:16141072).Curated1
Sequence conflicti98E → D in AAH27060 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033988 mRNA Translation: BAC28539.1
AK151603 mRNA Translation: BAE30543.1
AK050704 mRNA Translation: BAC34387.1
BC016088 mRNA Translation: AAH16088.1
BC023158 mRNA Translation: AAH23158.1
BC025472 mRNA Translation: AAH25472.1
BC027060 mRNA Translation: AAH27060.1
BC040818 mRNA Translation: AAH40818.1
CCDSiCCDS40439.1
RefSeqiNP_082497.2, NM_028221.4
XP_006530603.1, XM_006530540.2
XP_006530604.1, XM_006530541.2
XP_006530605.1, XM_006530542.2
XP_011246558.1, XM_011248256.2
UniGeneiMm.250425

Genome annotation databases

EnsembliENSMUST00000034226; ENSMUSP00000034226; ENSMUSG00000031774
GeneIDi102122
KEGGimmu:102122
UCSCiuc009mwn.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033988 mRNA Translation: BAC28539.1
AK151603 mRNA Translation: BAE30543.1
AK050704 mRNA Translation: BAC34387.1
BC016088 mRNA Translation: AAH16088.1
BC023158 mRNA Translation: AAH23158.1
BC025472 mRNA Translation: AAH25472.1
BC027060 mRNA Translation: AAH27060.1
BC040818 mRNA Translation: AAH40818.1
CCDSiCCDS40439.1
RefSeqiNP_082497.2, NM_028221.4
XP_006530603.1, XM_006530540.2
XP_006530604.1, XM_006530541.2
XP_006530605.1, XM_006530542.2
XP_011246558.1, XM_011248256.2
UniGeneiMm.250425

3D structure databases

SMRiQ91WE2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034226

PTM databases

iPTMnetiQ91WE2
PhosphoSitePlusiQ91WE2

Proteomic databases

EPDiQ91WE2
MaxQBiQ91WE2
PaxDbiQ91WE2
PeptideAtlasiQ91WE2
PRIDEiQ91WE2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034226; ENSMUSP00000034226; ENSMUSG00000031774
GeneIDi102122
KEGGimmu:102122
UCSCiuc009mwn.2 mouse

Organism-specific databases

CTDi80011
MGIiMGI:1919637 Fam192a

Phylogenomic databases

eggNOGiKOG4036 Eukaryota
ENOG4111INN LUCA
GeneTreeiENSGT00500000044916
HOGENOMiHOG000045055
HOVERGENiHBG052624
InParanoidiQ91WE2
OMAiWERVRQP
OrthoDBiEOG091G0RWI
PhylomeDBiQ91WE2
TreeFamiTF314540

Miscellaneous databases

PROiPR:Q91WE2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031774 Expressed in 297 organ(s), highest expression level in primary oocyte
CleanExiMM_2310065K24RIK
ExpressionAtlasiQ91WE2 baseline and differential
GenevisibleiQ91WE2 MM

Family and domain databases

InterProiView protein in InterPro
IPR039845 FAM192A
IPR019331 FAM192A/Fyv6_N
PANTHERiPTHR13495 PTHR13495, 1 hit
PfamiView protein in Pfam
PF10187 Nefa_Nip30_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPIP30_MOUSE
AccessioniPrimary (citable) accession number: Q91WE2
Secondary accession number(s): Q3U9X3, Q8R0C9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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