UniProtKB - Q91WD9 (SEGN_MOUSE)
Protein
Secretagogin
Gene
Scgn
Organism
Mus musculus (Mouse)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 25 – 36 | 1PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 71 – 82 | 2PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 118 – 129 | 3PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 162 – 173 | 4PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 210 – 221 | 5PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 254 – 265 | 6PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: GO_Central
GO - Biological processi
- regulation of cytosolic calcium ion concentration Source: GO_Central
- regulation of long-term synaptic potentiation Source: GO_Central
- regulation of presynaptic cytosolic calcium ion concentration Source: GO_Central
Keywordsi
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Secretagogin |
Gene namesi | Name:Scgn |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2384873, Scgn |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Other locations
- Cytoplasm
- secretory vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Note: Predominantly cytoplasmic. A small proportion is associated with secretory granules and membrane fractions (By similarity).By similarity
Cytosol
- cytosol Source: GO_Central
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Nucleus
- nucleus Source: GO_Central
Other locations
- dendrite Source: GO_Central
- neuron projection Source: GO_Central
- synapse Source: GO_Central
- terminal bouton Source: GO_Central
- transport vesicle membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Cytoplasmic vesicle, Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000073637 | 1 – 276 | SecretagoginAdd BLAST | 276 |
Proteomic databases
MaxQBi | Q91WD9 |
PaxDbi | Q91WD9 |
PeptideAtlasi | Q91WD9 |
PRIDEi | Q91WD9 |
PTM databases
iPTMneti | Q91WD9 |
PhosphoSitePlusi | Q91WD9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000021337, Expressed in islet of Langerhans and 102 other tissues |
Genevisiblei | Q91WD9, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000021770 |
Miscellaneous databases
RNActi | Q91WD9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 47 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 58 – 93 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 105 – 140 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 149 – 184 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 197 – 232 | EF-hand 5PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 240 – 276 | EF-hand 6PROSITE-ProRule annotationAdd BLAST | 37 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0027, Eukaryota |
GeneTreei | ENSGT00950000183108 |
HOGENOMi | CLU_054826_1_1_1 |
InParanoidi | Q91WD9 |
OMAi | HCDINRD |
OrthoDBi | 979297at2759 |
PhylomeDBi | Q91WD9 |
TreeFami | TF325083 |
Family and domain databases
CDDi | cd16178, EFh_HEF_SCGN, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR035798, EFh_SCGN |
Pfami | View protein in Pfam PF13202, EF-hand_5, 1 hit PF13499, EF-hand_7, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 5 hits |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 4 hits PS50222, EF_HAND_2, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q91WD9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDNARRKTPA RLDAACFWQI WQRFDKEEKG YIRETELDAF FDHLLAKSGT
60 70 80 90 100
EDTLMEENVQ KVKEQLMTSH NVSKEGRILM KELASMFLSE DENFLLFFRL
110 120 130 140 150
ETPLDNSVEF MQIWRKYDAD SSGFISAAEL CNFLRDLFLH HKKNISEAEL
160 170 180 190 200
EEYTSTMMKI FDKNKDGRLD LNDLARILAL QENFLLQFKM DASSTEERKR
210 220 230 240 250
DFEKIFAHYD VSKTGALEGP EVDGFVKDMM ELVQPSISGV DLDKFREILL
260 270
RHCDVNKDGK IQKSELALCL GLKINP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A286YD29 | A0A286YD29_MOUSE | Secretagogin | Scgn | 119 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC016093 mRNA Translation: AAH16093.1 |
CCDSi | CCDS26375.1 |
RefSeqi | NP_663374.1, NM_145399.1 |
Genome annotation databases
Ensembli | ENSMUST00000021770; ENSMUSP00000021770; ENSMUSG00000021337 |
GeneIDi | 214189 |
KEGGi | mmu:214189 |
UCSCi | uc007pvk.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC016093 mRNA Translation: AAH16093.1 |
CCDSi | CCDS26375.1 |
RefSeqi | NP_663374.1, NM_145399.1 |
3D structure databases
SMRi | Q91WD9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000021770 |
PTM databases
iPTMneti | Q91WD9 |
PhosphoSitePlusi | Q91WD9 |
Proteomic databases
MaxQBi | Q91WD9 |
PaxDbi | Q91WD9 |
PeptideAtlasi | Q91WD9 |
PRIDEi | Q91WD9 |
Protocols and materials databases
Antibodypediai | 1357, 324 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000021770; ENSMUSP00000021770; ENSMUSG00000021337 |
GeneIDi | 214189 |
KEGGi | mmu:214189 |
UCSCi | uc007pvk.1, mouse |
Organism-specific databases
CTDi | 10590 |
MGIi | MGI:2384873, Scgn |
Phylogenomic databases
eggNOGi | KOG0027, Eukaryota |
GeneTreei | ENSGT00950000183108 |
HOGENOMi | CLU_054826_1_1_1 |
InParanoidi | Q91WD9 |
OMAi | HCDINRD |
OrthoDBi | 979297at2759 |
PhylomeDBi | Q91WD9 |
TreeFami | TF325083 |
Miscellaneous databases
BioGRID-ORCSi | 214189, 2 hits in 17 CRISPR screens |
PROi | PR:Q91WD9 |
RNActi | Q91WD9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021337, Expressed in islet of Langerhans and 102 other tissues |
Genevisiblei | Q91WD9, MM |
Family and domain databases
CDDi | cd16178, EFh_HEF_SCGN, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR035798, EFh_SCGN |
Pfami | View protein in Pfam PF13202, EF-hand_5, 1 hit PF13499, EF-hand_7, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 5 hits |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 4 hits PS50222, EF_HAND_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SEGN_MOUSE | |
Accessioni | Q91WD9Primary (citable) accession number: Q91WD9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 22, 2003 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot