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Protein

Kinesin-like protein KIF18A

Gene

Kif18a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi113 – 120ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processProtein transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2132295 MHC class II antigen presentation
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-68877 Mitotic Prometaphase
R-MMU-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF18A
Gene namesi
Name:Kif18a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2446977 Kif18a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254591 – 886Kinesin-like protein KIF18AAdd BLAST886

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei674PhosphoserineBy similarity1
Cross-linki683Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei695PhosphoserineBy similarity1
Cross-linki782Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei826PhosphoserineBy similarity1
Cross-linki862Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Glycosylated.By similarity
Ubiquitinated.By similarity

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ91WD7
MaxQBiQ91WD7
PaxDbiQ91WD7
PeptideAtlasiQ91WD7
PRIDEiQ91WD7

PTM databases

iPTMnetiQ91WD7
PhosphoSitePlusiQ91WD7

Expressioni

Gene expression databases

BgeeiENSMUSG00000027115 Expressed in 191 organ(s), highest expression level in embryo
CleanExiMM_KIF18A
GenevisibleiQ91WD7 MM

Interactioni

Subunit structurei

Interacts with CENPE and ESR1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230733, 8 interactors
IntActiQ91WD7, 8 interactors
STRINGi10090.ENSMUSP00000028527

Structurei

3D structure databases

ProteinModelPortaliQ91WD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 355Kinesin motorPROSITE-ProRule annotationAdd BLAST345

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili370 – 404Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0242 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150846
HOGENOMiHOG000231436
HOVERGENiHBG052245
InParanoidiQ91WD7
KOiK10401
OMAiIEMMCSE
OrthoDBiEOG091G0438
PhylomeDBiQ91WD7
TreeFamiTF105231

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q91WD7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGTEEDLCH RMKVVVRVRP ENTKEKAVQF CKVVHVVDKH ILSFDPKQEE
60 70 80 90 100
ISFFHRKKTT NFDITKRQNK DLKFVFDAVF DETSTQMEVF EHTTKPILHS
110 120 130 140 150
FLNGYNCTVF AYGATGSGKT HTMLGSAAEP GVMYLTMLDL FKCIDEIKEE
160 170 180 190 200
KECSTAVSYL EVYNEQIRDL LTNSGPLAVR EDSQKGVVVQ GLTLHQPKSS
210 220 230 240 250
EEILQLLDNG NKNRTQHPTD VNAVSSRSHA VFQIYLRQQD KTASINQNVR
260 270 280 290 300
IAKMSLIDLA GSERASVSGA KGSRFVEGTN INKSLLALGN VINALANTKR
310 320 330 340 350
RNQHIPYRNS KLTRLLKDSL GGNCQTIMIA AVSPSSLFYD DTYNTLKYAN
360 370 380 390 400
RAKEIKSSLK SNVLNLNSHI SQYVKICNMQ KAEILMLKEK LKAYEEQKAL
410 420 430 440 450
SDRNDCAKLV HSNPEDRETE RFQEILNCLF QNREGIRQEY LKLEMLLKAN
460 470 480 490 500
ALKSSYHQQC HKQIEMMCSE DKVEKATCKR DHRLEKLKTN SCFLEKKKEE
510 520 530 540 550
VSKQFDENTN WLHRVENEMR LLGQNGDIPE ALNKELHCHH LHLQNKELKT
560 570 580 590 600
QMAHMTALAC LQEQQHKQTE AVLNALLPVL RKQYWKLKET GLSNAAFDSD
610 620 630 640 650
FKDIEHLVER KKVVAWADQT NEHSNRNDLP GISLLMTFPQ LEPIQSISCC
660 670 680 690 700
TSVSDPNVLK LTPQRRTRRK IIPSPLKVQH TQKSALSEST QLNDSFSKEL
710 720 730 740 750
QPIVYTPEDC KKAQDLFPSL TRTSSQSANV MNDNSQKALC RIESPLSRTE
760 770 780 790 800
CKQGLYSTST LCDSIRGLKN KWPEQEPLAS SKSSVHRIES SSFSTKDSMP
810 820 830 840 850
ESAGVPSYMA MTTAAKRKWK QMSSTSNASI KSDESCGFAK RIRRDNSSVK
860 870 880
PMQENRLKVG YKRNTNKTNS NMLRKFRRNT SKENVQ
Length:886
Mass (Da):100,935
Last modified:December 1, 2001 - v1
Checksum:iF611802A899AF0E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044795 mRNA Translation: BAC32095.2
AK164649 mRNA Translation: BAE37860.1
BC016095 mRNA Translation: AAH16095.1
CCDSiCCDS16507.1
RefSeqiNP_647464.1, NM_139303.1
UniGeneiMm.274086

Genome annotation databases

EnsembliENSMUST00000028527; ENSMUSP00000028527; ENSMUSG00000027115
GeneIDi228421
KEGGimmu:228421
UCSCiuc008lmb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044795 mRNA Translation: BAC32095.2
AK164649 mRNA Translation: BAE37860.1
BC016095 mRNA Translation: AAH16095.1
CCDSiCCDS16507.1
RefSeqiNP_647464.1, NM_139303.1
UniGeneiMm.274086

3D structure databases

ProteinModelPortaliQ91WD7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230733, 8 interactors
IntActiQ91WD7, 8 interactors
STRINGi10090.ENSMUSP00000028527

PTM databases

iPTMnetiQ91WD7
PhosphoSitePlusiQ91WD7

Proteomic databases

EPDiQ91WD7
MaxQBiQ91WD7
PaxDbiQ91WD7
PeptideAtlasiQ91WD7
PRIDEiQ91WD7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028527; ENSMUSP00000028527; ENSMUSG00000027115
GeneIDi228421
KEGGimmu:228421
UCSCiuc008lmb.1 mouse

Organism-specific databases

CTDi81930
MGIiMGI:2446977 Kif18a

Phylogenomic databases

eggNOGiKOG0242 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150846
HOGENOMiHOG000231436
HOVERGENiHBG052245
InParanoidiQ91WD7
KOiK10401
OMAiIEMMCSE
OrthoDBiEOG091G0438
PhylomeDBiQ91WD7
TreeFamiTF105231

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2132295 MHC class II antigen presentation
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-68877 Mitotic Prometaphase
R-MMU-983189 Kinesins

Miscellaneous databases

PROiPR:Q91WD7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027115 Expressed in 191 organ(s), highest expression level in embryo
CleanExiMM_KIF18A
GenevisibleiQ91WD7 MM

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKI18A_MOUSE
AccessioniPrimary (citable) accession number: Q91WD7
Secondary accession number(s): Q3TP77, Q8BLL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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