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Entry version 140 (17 Jun 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Actin-histidine N-methyltransferase

Gene

Setd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein-histidine N-methyltransferase that specifically mediates methylation of actin at 'His-73' (PubMed:30626964). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964).1 Publication

Caution

Was initially reported to have histone methyltransferase activity and methylate 'Lys-4' and 'Lys-36' of histone H3 (H3K4me and H3K36me) (PubMed:21832073). However, this conclusion was based on mass spectrometry data wherin mass shifts were inconsistent with a bona fide methylation event and the histone methyltransferase activity could not be confirmed (PubMed:30626964).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei75S-adenosyl-L-methionineBy similarity1
Binding sitei254S-adenosyl-L-methionineBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Methyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3214841 PKMTs methylate histone lysines

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Actin-histidine N-methyltransferaseCurated (EC:2.1.1.851 Publication)
Alternative name(s):
Endothelial differentiation inhibitory protein D101 Publication
SET domain-containing protein 3Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Setd3Imported
Synonyms:D12Ertd771eImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1289184 Setd3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable, but females display severely decreased litter sizes due to primary maternal dystocia (delayed parturition) that is refractory to ecbolic induction agents (PubMed:30626964). Cells show complete loss of actin histidine methylation (PubMed:30626964).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002541761 – 594Actin-histidine N-methyltransferaseAdd BLAST594

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by GSK3B, which is required for recognition by the SCF(FBXW7) complex and subsequent degradation.By similarity
Ubiquitinated by the SCF(FBXW7) complex following phosphorylation by GSK3B, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q91WC0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q91WC0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q91WC0

PeptideAtlas

More...
PeptideAtlasi
Q91WC0

PRoteomics IDEntifications database

More...
PRIDEi
Q91WC0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q91WC0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q91WC0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Prominently expressed in the heart and skeletal muscles and is also detected weakly in the stomach, small intestine, and colon.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000056770 Expressed in zone of skin and 28 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q91WC0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q91WC0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MYOD1.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
206736, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q91WC0, 6 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000066413

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q91WC0 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q91WC0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini94 – 314SETPROSITE-ProRule annotationAdd BLAST221

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni104 – 106S-adenosyl-L-methionine bindingBy similarity3
Regioni275 – 279S-adenosyl-L-methionine bindingBy similarity5
Regioni325 – 327S-adenosyl-L-methionine bindingBy similarity3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SET domain specifically recognizes and binds actin, suggesting that it does not accommodate substrates diverging from actin.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1337 Eukaryota
ENOG410Y7DR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153577

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_028272_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q91WC0

KEGG Orthology (KO)

More...
KOi
K19199

Identification of Orthologs from Complete Genome Data

More...
OMAi
KWALCTV

Database of Orthologous Groups

More...
OrthoDBi
489371at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q91WC0

TreeFam database of animal gene trees

More...
TreeFami
TF354226

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.1420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015353 Rubisco_LSMT_subst-bd
IPR036464 Rubisco_LSMT_subst-bd_sf
IPR001214 SET_dom
IPR025785 SETD3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09273 Rubis-subs-bind, 1 hit
PF00856 SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81822 SSF81822, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51565 SAM_MT85_SETD3, 1 hit
PS50280 SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q91WC0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKKSRVKTQ KSGTGATATV SPKEILNLTS ELLQKCSSPA PSPGKEWEEY
60 70 80 90 100
TQIRALVEKI RKKQKGLSVT FDGKREDYFP DLMKWASENG ASVEGFEMVN
110 120 130 140 150
FKEEGFGLRA TRDIKAEELF LWVPRKLLMT VESAKNSVLG PLYSQDRILQ
160 170 180 190 200
AMGNIALAFH LLCERASPNS FWQPYIQTLP SEYDTPLYFE EEEVRCLQST
210 220 230 240 250
QAIHDVFSQY KNTARQYAYF YKVIQTHPHA NKLPLKESFT YEDYRWAVSS
260 270 280 290 300
VMTRQNQIPT EDGSRVTLAL IPLWDMCNHT NGLITTGYNL EDDRCECVAL
310 320 330 340 350
QDFQAGDQIY IFYGTRSNAE FVIHSGFFFD NNSHDRVKIK LGVSKSDRLY
360 370 380 390 400
AMKAEVLARA GIPTSSVFAL HSTEPPISAQ LLAFLRVFCM TEEELKEHLL
410 420 430 440 450
GDSAIDRIFT LGNAEFPVSW DNEVKLWTFL EDRASLLLKT YKTTIEEDKI
460 470 480 490 500
VLKNPDLSVR ATMAIKLRLG EKEILEKAVK SAAVNREYYR KHMEERAPLP
510 520 530 540 550
RYEESDLGLL EGGVGDSRLP LVLRKLEEEA GVQESLSLTE TVSKVKAAEN
560 570 580 590
GLVNGENLIP NGTRSENESL SPEESENVTG EESSGSMAKV KERL
Length:594
Mass (Da):67,176
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67DA47889A5C9F55
GO
Isoform 2 (identifier: Q91WC0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.
     226-283: Missing.

Show »
Length:408
Mass (Da):46,072
Checksum:i051A8DA6EA0643BA
GO
Isoform 3 (identifier: Q91WC0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-351: Missing.

Show »
Length:243
Mass (Da):27,001
Checksum:iC3FD156DC6D07D43
GO
Isoform 4 (identifier: Q91WC0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.
     284-290: ITTGYNL → VKISSWG
     291-594: Missing.

Show »
Length:162
Mass (Da):18,731
Checksum:iE282E87B51F209C4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z420F2Z420_MOUSE
Protein-histidine N-methyltransfera...
Setd3
290Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z438F2Z438_MOUSE
Protein-histidine N-methyltransfera...
Setd3
155Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCY6D6RCY6_MOUSE
Actin-histidine N-methyltransferase
Setd3
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti321F → S in AAS82953 (PubMed:16008511).Curated1
Sequence conflicti321F → S in BAB27964 (PubMed:16141072).Curated1
Sequence conflicti460R → Q in BAC27215 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0211941 – 351Missing in isoform 3. 1 PublicationAdd BLAST351
Alternative sequenceiVSP_0211951 – 128Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST128
Alternative sequenceiVSP_021196226 – 283Missing in isoform 2. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_021197284 – 290ITTGYNL → VKISSWG in isoform 4. 1 Publication7
Alternative sequenceiVSP_021198291 – 594Missing in isoform 4. 1 PublicationAdd BLAST304

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY513271 mRNA Translation: AAS82953.1
AK011993 mRNA Translation: BAB27964.1
AK029403 mRNA Translation: BAC26435.1
AK031017 mRNA Translation: BAC27215.1
AK031371 mRNA Translation: BAC27371.1
AK146777 mRNA Translation: BAE27425.1
AK166570 mRNA Translation: BAE38861.1
BC016123 mRNA Translation: AAH16123.1
BC019973 mRNA Translation: AAH19973.1
BC057968 mRNA Translation: AAH57968.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS26159.1 [Q91WC0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_082538.2, NM_028262.3 [Q91WC0-1]
XP_006516144.3, XM_006516081.3 [Q91WC0-2]
XP_006516146.1, XM_006516083.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000071095; ENSMUSP00000066413; ENSMUSG00000056770 [Q91WC0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
52690

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:52690

UCSC genome browser

More...
UCSCi
uc007ozj.2 mouse [Q91WC0-1]
uc007ozk.2 mouse [Q91WC0-2]
uc007ozl.2 mouse [Q91WC0-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY513271 mRNA Translation: AAS82953.1
AK011993 mRNA Translation: BAB27964.1
AK029403 mRNA Translation: BAC26435.1
AK031017 mRNA Translation: BAC27215.1
AK031371 mRNA Translation: BAC27371.1
AK146777 mRNA Translation: BAE27425.1
AK166570 mRNA Translation: BAE38861.1
BC016123 mRNA Translation: AAH16123.1
BC019973 mRNA Translation: AAH19973.1
BC057968 mRNA Translation: AAH57968.1
CCDSiCCDS26159.1 [Q91WC0-1]
RefSeqiNP_082538.2, NM_028262.3 [Q91WC0-1]
XP_006516144.3, XM_006516081.3 [Q91WC0-2]
XP_006516146.1, XM_006516083.3

3D structure databases

SMRiQ91WC0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi206736, 6 interactors
IntActiQ91WC0, 6 interactors
STRINGi10090.ENSMUSP00000066413

PTM databases

iPTMnetiQ91WC0
PhosphoSitePlusiQ91WC0

Proteomic databases

EPDiQ91WC0
jPOSTiQ91WC0
PaxDbiQ91WC0
PeptideAtlasiQ91WC0
PRIDEiQ91WC0

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
147 151 antibodies

The DNASU plasmid repository

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DNASUi
52690

Genome annotation databases

EnsembliENSMUST00000071095; ENSMUSP00000066413; ENSMUSG00000056770 [Q91WC0-1]
GeneIDi52690
KEGGimmu:52690
UCSCiuc007ozj.2 mouse [Q91WC0-1]
uc007ozk.2 mouse [Q91WC0-2]
uc007ozl.2 mouse [Q91WC0-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84193
MGIiMGI:1289184 Setd3

Phylogenomic databases

eggNOGiKOG1337 Eukaryota
ENOG410Y7DR LUCA
GeneTreeiENSGT00940000153577
HOGENOMiCLU_028272_0_0_1
InParanoidiQ91WC0
KOiK19199
OMAiKWALCTV
OrthoDBi489371at2759
PhylomeDBiQ91WC0
TreeFamiTF354226

Enzyme and pathway databases

ReactomeiR-MMU-3214841 PKMTs methylate histone lysines

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
52690 0 hits in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Setd3 mouse

Protein Ontology

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PROi
PR:Q91WC0
RNActiQ91WC0 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000056770 Expressed in zone of skin and 28 other tissues
ExpressionAtlasiQ91WC0 baseline and differential
GenevisibleiQ91WC0 MM

Family and domain databases

Gene3Di3.90.1420.10, 1 hit
InterProiView protein in InterPro
IPR015353 Rubisco_LSMT_subst-bd
IPR036464 Rubisco_LSMT_subst-bd_sf
IPR001214 SET_dom
IPR025785 SETD3
PfamiView protein in Pfam
PF09273 Rubis-subs-bind, 1 hit
PF00856 SET, 1 hit
SUPFAMiSSF81822 SSF81822, 1 hit
PROSITEiView protein in PROSITE
PS51565 SAM_MT85_SETD3, 1 hit
PS50280 SET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSETD3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91WC0
Secondary accession number(s): Q6PEN3
, Q8CD86, Q8CDX8, Q9CZZ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: June 17, 2020
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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