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Protein

Pleckstrin homology domain-containing family F member 2

Gene

Plekhf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport (By similarity). Enhances cellular sensitivity to TNF-induced apoptosis.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri152 – 212FYVE-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • phosphatidylinositol binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family F member 2
Short name:
PH domain-containing family F member 2
Gene namesi
Name:Plekhf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1919051 Plekhf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002516011 – 249Pleckstrin homology domain-containing family F member 2Add BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Modified residuei44N6-acetyllysineBy similarity1
Modified residuei239PhosphoserineCombined sources1
Modified residuei248PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ91WB4
MaxQBiQ91WB4
PaxDbiQ91WB4
PeptideAtlasiQ91WB4
PRIDEiQ91WB4

PTM databases

iPTMnetiQ91WB4
PhosphoSitePlusiQ91WB4

Expressioni

Tissue specificityi

Expressed in brain, stomach and thymus, as well as in kidney, spleen, and skeletal muscle. Also expressed in peripheral blood mononuclear cells and dendritic cells.1 Publication

Inductioni

Up-regulated by TNF, bacterial lipopolysaccharides (LPS) and phorbol myristate acetate (PMA) (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000049969 Expressed in 188 organ(s), highest expression level in embryonic stem cell
ExpressionAtlasiQ91WB4 baseline and differential
GenevisibleiQ91WB4 MM

Interactioni

Subunit structurei

May interact with EEA1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054745

Structurei

3D structure databases

ProteinModelPortaliQ91WB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 131PHPROSITE-ProRule annotationAdd BLAST97

Domaini

The PH and FYVE domains may be important for TNF-induced localization to the endoplasmic reticulum and for enhanced cellular sensitivity to TNF-induced apoptosis. The FYVE domain is important for binding to the endosomal membrane (By similarity).By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri152 – 212FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1729 Eukaryota
ENOG410XPJK LUCA
GeneTreeiENSGT00920000148981
HOGENOMiHOG000231519
HOVERGENiHBG059973
InParanoidiQ91WB4
OMAiGEHAAVW
OrthoDBiEOG091G0OVV
PhylomeDBiQ91WB4
TreeFamiTF315235

Family and domain databases

CDDicd01218 PH_Phafin2-like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037871 PH_Phafin
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50178 ZF_FYVE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q91WB4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDRLANSEA NTRRISIVES CFGAAGQPLT IPGRVLIGEG VLTKLCRKKP
60 70 80 90 100
KARQFFLFND ILVYGNIVIQ KKKYNKQHII PLENVTIDSI KDEGELRNGW
110 120 130 140 150
LIKTPTKSFA VYAATATEKS EWMNHINKCV TDLLSKSGKT PSNEHAAVWV
160 170 180 190 200
PDSEATVCMR CQKAKFTPVN RRHHCRKCGF VVCGPCSEKR FLLPSQSSKP
210 220 230 240
VRICDFCYDL LSTGDMAACQ PTRSDSYSQS LKSPLNDASD DDDDDDSSD
Length:249
Mass (Da):27,755
Last modified:December 1, 2001 - v1
Checksum:iA2609E652CF21E98
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8Y5N8A8Y5N8_MOUSE
Pleckstrin homology domain-containi...
Plekhf2
197Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033666 mRNA Translation: BAC28417.1
AK154634 mRNA Translation: BAE32730.1
BC016134 mRNA Translation: AAH16134.1
BC039276 mRNA Translation: AAH39276.1
CCDSiCCDS17962.1
RefSeqiNP_780384.1, NM_175175.4
UniGeneiMm.34351

Genome annotation databases

EnsembliENSMUST00000054776; ENSMUSP00000054745; ENSMUSG00000049969
GeneIDi71801
KEGGimmu:71801
UCSCiuc008ryw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033666 mRNA Translation: BAC28417.1
AK154634 mRNA Translation: BAE32730.1
BC016134 mRNA Translation: AAH16134.1
BC039276 mRNA Translation: AAH39276.1
CCDSiCCDS17962.1
RefSeqiNP_780384.1, NM_175175.4
UniGeneiMm.34351

3D structure databases

ProteinModelPortaliQ91WB4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054745

PTM databases

iPTMnetiQ91WB4
PhosphoSitePlusiQ91WB4

Proteomic databases

EPDiQ91WB4
MaxQBiQ91WB4
PaxDbiQ91WB4
PeptideAtlasiQ91WB4
PRIDEiQ91WB4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054776; ENSMUSP00000054745; ENSMUSG00000049969
GeneIDi71801
KEGGimmu:71801
UCSCiuc008ryw.2 mouse

Organism-specific databases

CTDi79666
MGIiMGI:1919051 Plekhf2

Phylogenomic databases

eggNOGiKOG1729 Eukaryota
ENOG410XPJK LUCA
GeneTreeiENSGT00920000148981
HOGENOMiHOG000231519
HOVERGENiHBG059973
InParanoidiQ91WB4
OMAiGEHAAVW
OrthoDBiEOG091G0OVV
PhylomeDBiQ91WB4
TreeFamiTF315235

Miscellaneous databases

PROiPR:Q91WB4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049969 Expressed in 188 organ(s), highest expression level in embryonic stem cell
ExpressionAtlasiQ91WB4 baseline and differential
GenevisibleiQ91WB4 MM

Family and domain databases

CDDicd01218 PH_Phafin2-like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037871 PH_Phafin
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50178 ZF_FYVE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPKHF2_MOUSE
AccessioniPrimary (citable) accession number: Q91WB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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