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Protein

CXXC-type zinc finger protein 5

Gene

Cxxc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis (By similarity). Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri251 – 292CXXC-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
CXXC-type zinc finger protein 5
Gene namesi
Name:Cxxc5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1914643 Cxxc5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175491 – 317CXXC-type zinc finger protein 5Add BLAST317

Proteomic databases

MaxQBiQ91WA4
PaxDbiQ91WA4
PeptideAtlasiQ91WA4
PRIDEiQ91WA4

PTM databases

iPTMnetiQ91WA4
PhosphoSitePlusiQ91WA4

Expressioni

Developmental stagei

Expressed in dorsal pallium and in and around the developing choroid plexus at 10.5 and 12.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000046668 Expressed in 279 organ(s), highest expression level in retina
CleanExiMM_CXXC5
GenevisibleiQ91WA4 MM

Interactioni

Subunit structurei

Interacts with DVL1. Interacts with RBPJ.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212157, 8 interactors
IntActiQ91WA4, 7 interactors
MINTiQ91WA4

Structurei

3D structure databases

ProteinModelPortaliQ91WA4
SMRiQ91WA4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi252 – 257Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 18Poly-Ser5

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri251 – 292CXXC-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGNJ Eukaryota
ENOG4110UND LUCA
GeneTreeiENSGT00910000144072
HOGENOMiHOG000112118
HOVERGENiHBG095668
InParanoidiQ91WA4
KOiK22760
OMAiPMQNELA
OrthoDBiEOG091G0FYR
PhylomeDBiQ91WA4
TreeFamiTF326617

Family and domain databases

InterProiView protein in InterPro
IPR002857 Znf_CXXC
PfamiView protein in Pfam
PF02008 zf-CXXC, 1 hit
PROSITEiView protein in PROSITE
PS51058 ZF_CXXC, 1 hit

Sequencei

Sequence statusi: Complete.

Q91WA4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSLGGGSQD AGGSSSSSNT NSSSGSGQKA GGTDKSTAVA ATTAPTSVAD
60 70 80 90 100
DAPPPERRNK SGIISEPLNK SLRRSRPLSH YSSFGSSGGG GSMMGVESAD
110 120 130 140 150
KAAAAAASLL ANGHDLAAAM AVDKSNPTSK HKSGAVASLL SKAERATELA
160 170 180 190 200
AEGQLTLQQF AQSTEMLKRV VQEHLPLMSE AGAGLPDMEA VAGAEALNGQ
210 220 230 240 250
SDFPYLGAFP INPGLFIMTP AGVFLAESAL HMAGLAEYPM QGELASAISS
260 270 280 290 300
GKKKRKRCGM CAPCRRRINC EQCSSCRNRK TGHQICKFRK CEELKKKPSA
310
ALEKVMLPSG AAFRWFQ
Length:317
Mass (Da):32,812
Last modified:December 1, 2001 - v1
Checksum:i215B73C8BA2AE031
GO

Sequence cautioni

The sequence BAC25113 differs from that shown. Reason: Frameshift at position 245.Curated
The sequence BAC25458 differs from that shown. Reason: Frameshift at position 245.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10D → G in BAE21439 (PubMed:16141072).Curated1
Sequence conflicti105A → G in BAC25458 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005364 mRNA Translation: BAC25113.1 Frameshift.
AK015150 mRNA Translation: BAC25458.1 Frameshift.
AK132950 mRNA Translation: BAE21439.1
BC016207 mRNA Translation: AAH16207.1
BC089314 mRNA Translation: AAH89314.1
CCDSiCCDS29150.1
RefSeqiNP_598448.1, NM_133687.2
XP_006526239.1, XM_006526176.3
XP_006526240.1, XM_006526177.3
XP_006526241.1, XM_006526178.3
XP_006526243.1, XM_006526180.2
XP_006526244.1, XM_006526181.3
UniGeneiMm.94560

Genome annotation databases

EnsembliENSMUST00000060722; ENSMUSP00000054307; ENSMUSG00000046668
GeneIDi67393
KEGGimmu:67393
UCSCiuc008emx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005364 mRNA Translation: BAC25113.1 Frameshift.
AK015150 mRNA Translation: BAC25458.1 Frameshift.
AK132950 mRNA Translation: BAE21439.1
BC016207 mRNA Translation: AAH16207.1
BC089314 mRNA Translation: AAH89314.1
CCDSiCCDS29150.1
RefSeqiNP_598448.1, NM_133687.2
XP_006526239.1, XM_006526176.3
XP_006526240.1, XM_006526177.3
XP_006526241.1, XM_006526178.3
XP_006526243.1, XM_006526180.2
XP_006526244.1, XM_006526181.3
UniGeneiMm.94560

3D structure databases

ProteinModelPortaliQ91WA4
SMRiQ91WA4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212157, 8 interactors
IntActiQ91WA4, 7 interactors
MINTiQ91WA4

PTM databases

iPTMnetiQ91WA4
PhosphoSitePlusiQ91WA4

Proteomic databases

MaxQBiQ91WA4
PaxDbiQ91WA4
PeptideAtlasiQ91WA4
PRIDEiQ91WA4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060722; ENSMUSP00000054307; ENSMUSG00000046668
GeneIDi67393
KEGGimmu:67393
UCSCiuc008emx.1 mouse

Organism-specific databases

CTDi51523
MGIiMGI:1914643 Cxxc5

Phylogenomic databases

eggNOGiENOG410IGNJ Eukaryota
ENOG4110UND LUCA
GeneTreeiENSGT00910000144072
HOGENOMiHOG000112118
HOVERGENiHBG095668
InParanoidiQ91WA4
KOiK22760
OMAiPMQNELA
OrthoDBiEOG091G0FYR
PhylomeDBiQ91WA4
TreeFamiTF326617

Miscellaneous databases

ChiTaRSiCxxc5 mouse
PROiPR:Q91WA4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046668 Expressed in 279 organ(s), highest expression level in retina
CleanExiMM_CXXC5
GenevisibleiQ91WA4 MM

Family and domain databases

InterProiView protein in InterPro
IPR002857 Znf_CXXC
PfamiView protein in Pfam
PF02008 zf-CXXC, 1 hit
PROSITEiView protein in PROSITE
PS51058 ZF_CXXC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXXC5_MOUSE
AccessioniPrimary (citable) accession number: Q91WA4
Secondary accession number(s): Q3V0R4, Q8CES6, Q8CF49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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