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Protein

TIMELESS-interacting protein

Gene

Tipin

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.1 Publication

GO - Molecular functioni

  • DNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, DNA damage, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-5693607 Processing of DNA double-strand break ends

Names & Taxonomyi

Protein namesi
Recommended name:
TIMELESS-interacting protein
Gene namesi
Name:Tipin
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1921571 Tipin

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003052541 – 278TIMELESS-interacting proteinAdd BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei191PhosphoserineBy similarity1
Modified residuei219PhosphoserineBy similarity1
Modified residuei233PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ91WA1
MaxQBiQ91WA1
PaxDbiQ91WA1
PeptideAtlasiQ91WA1
PRIDEiQ91WA1

PTM databases

iPTMnetiQ91WA1
PhosphoSitePlusiQ91WA1

Expressioni

Tissue specificityi

Expressed in brain.1 Publication

Developmental stagei

Expression peaks between E11 and E15. At E7.5, expressed in germ cell layers. At E14.5, expressed at highest levels in thymus, liver, gastrointestinal tract, lung and the rapidly proliferating ventricular zone of the brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000032397 Expressed in 293 organ(s), highest expression level in liver
CleanExiMM_TIPIN
ExpressionAtlasiQ91WA1 baseline and differential
GenevisibleiQ91WA1 MM

Interactioni

Subunit structurei

Interacts with MCM6 and MCM7 (By similarity). Interacts with TIMELESS, which impairs TIMELESS self-association. Interacts with RPA2 and PRDX2.By similarity2 Publications

Protein-protein interaction databases

BioGridi211238, 30 interactors
IntActiQ91WA1, 28 interactors
STRINGi10090.ENSMUSP00000034964

Structurei

3D structure databases

ProteinModelPortaliQ91WA1
SMRiQ91WA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni64 – 140Interaction with TIMELESSBy similarityAdd BLAST77

Sequence similaritiesi

Belongs to the CSM3 family.Curated

Phylogenomic databases

eggNOGiKOG3004 Eukaryota
ENOG4111VXN LUCA
GeneTreeiENSGT00390000005764
HOGENOMiHOG000154594
HOVERGENiHBG061130
InParanoidiQ91WA1
KOiK10904
OMAiDILDNPC
OrthoDBiEOG091G0H5F
PhylomeDBiQ91WA1
TreeFamiTF313290

Family and domain databases

InterProiView protein in InterPro
IPR012923 Csm3
IPR040038 TIPIN/Csm3/Swi3
PANTHERiPTHR13220 PTHR13220, 1 hit
PfamiView protein in Pfam
PF07962 Swi3, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD089639 Swi3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q91WA1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLEQEENGLF EIPDYEHVED ETFPPFPPPA SPERDPADAE PEEGSGSGVP
60 70 80 90 100
VPPKRTVKRN LPKLDATRLT SERGLPALRH VFDKTKFKGK GHEAEDLKTL
110 120 130 140 150
IRHMEHWAHR LFPKLQFEDF IDRVENLGNK KEVQTCLKRI RLDLPIVHED
160 170 180 190 200
FVNNNDEVGE ANGPDVSATG FDPFLTSSSD SRKFASEPTR SLTEEQQQRI
210 220 230 240 250
ERNKQLALER RQAKLLSNSQ SLENDVTVEE NSTGEDQEES NGLNIDTADG
260 270
PHDVPFASTH EEEQCKAEET QLDHTNLD
Length:278
Mass (Da):31,498
Last modified:October 2, 2007 - v2
Checksum:i769F56BBDF2763C9
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SUT4A0A1L1SUT4_MOUSE
TIMELESS-interacting protein
Tipin
93Annotation score:
A0A1L1SUJ5A0A1L1SUJ5_MOUSE
TIMELESS-interacting protein
Tipin
111Annotation score:
A0A1L1STK1A0A1L1STK1_MOUSE
TIMELESS-interacting protein
Tipin
93Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67T → A in BAB22798 (PubMed:16141072).Curated1
Sequence conflicti265C → F in AAH16211 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003451 mRNA Translation: BAB22798.1
AK003802 mRNA Translation: BAB23004.1
AK011357 mRNA Translation: BAB27565.1
AK038111 mRNA Translation: BAC29931.1
BC016211 mRNA Translation: AAH16211.1
BK001385 mRNA Translation: DAA01364.1
CCDSiCCDS23279.1
RefSeqiNP_001311485.1, NM_001324556.1
NP_001311486.1, NM_001324557.1
NP_001311487.1, NM_001324558.1
NP_079648.1, NM_025372.4
XP_006511403.1, XM_006511340.3
UniGeneiMm.196219

Genome annotation databases

EnsembliENSMUST00000034964; ENSMUSP00000034964; ENSMUSG00000032397
ENSMUST00000216594; ENSMUSP00000149833; ENSMUSG00000032397
GeneIDi66131
KEGGimmu:66131
UCSCiuc009qbr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003451 mRNA Translation: BAB22798.1
AK003802 mRNA Translation: BAB23004.1
AK011357 mRNA Translation: BAB27565.1
AK038111 mRNA Translation: BAC29931.1
BC016211 mRNA Translation: AAH16211.1
BK001385 mRNA Translation: DAA01364.1
CCDSiCCDS23279.1
RefSeqiNP_001311485.1, NM_001324556.1
NP_001311486.1, NM_001324557.1
NP_001311487.1, NM_001324558.1
NP_079648.1, NM_025372.4
XP_006511403.1, XM_006511340.3
UniGeneiMm.196219

3D structure databases

ProteinModelPortaliQ91WA1
SMRiQ91WA1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211238, 30 interactors
IntActiQ91WA1, 28 interactors
STRINGi10090.ENSMUSP00000034964

PTM databases

iPTMnetiQ91WA1
PhosphoSitePlusiQ91WA1

Proteomic databases

EPDiQ91WA1
MaxQBiQ91WA1
PaxDbiQ91WA1
PeptideAtlasiQ91WA1
PRIDEiQ91WA1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034964; ENSMUSP00000034964; ENSMUSG00000032397
ENSMUST00000216594; ENSMUSP00000149833; ENSMUSG00000032397
GeneIDi66131
KEGGimmu:66131
UCSCiuc009qbr.1 mouse

Organism-specific databases

CTDi54962
MGIiMGI:1921571 Tipin

Phylogenomic databases

eggNOGiKOG3004 Eukaryota
ENOG4111VXN LUCA
GeneTreeiENSGT00390000005764
HOGENOMiHOG000154594
HOVERGENiHBG061130
InParanoidiQ91WA1
KOiK10904
OMAiDILDNPC
OrthoDBiEOG091G0H5F
PhylomeDBiQ91WA1
TreeFamiTF313290

Enzyme and pathway databases

ReactomeiR-MMU-5693607 Processing of DNA double-strand break ends

Miscellaneous databases

PROiPR:Q91WA1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032397 Expressed in 293 organ(s), highest expression level in liver
CleanExiMM_TIPIN
ExpressionAtlasiQ91WA1 baseline and differential
GenevisibleiQ91WA1 MM

Family and domain databases

InterProiView protein in InterPro
IPR012923 Csm3
IPR040038 TIPIN/Csm3/Swi3
PANTHERiPTHR13220 PTHR13220, 1 hit
PfamiView protein in Pfam
PF07962 Swi3, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD089639 Swi3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTIPIN_MOUSE
AccessioniPrimary (citable) accession number: Q91WA1
Secondary accession number(s): Q9CQM3, Q9D1J4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 7, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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