Tipin

Functionⁱ

Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.1 Publication

GO - Molecular functionⁱ

DNA binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle phase transition Source: BHF-UCL
cell division Source: UniProtKB-KW
DNA damage checkpoint
Source: MGI
Inferred from mutant phenotypeⁱ
- 17141802
DNA replication checkpoint Source: UniProtKB
intra-S DNA damage checkpoint Source: UniProtKB
positive regulation of cell proliferation Source: UniProtKB
regulation of nuclear cell cycle DNA replication Source: GO_Central
replication fork arrest Source: GO_Central
replication fork protection Source: GO_Central
response to UV
Source: MGI
Inferred from mutant phenotypeⁱ
- 17141802

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division, DNA damage, Mitosis

Biological process

Cell cycle, Cell division, DNA damage, Mitosis

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5693607 Processing of DNA double-strand break ends

Reactomeⁱ

R-MMU-5693607 Processing of DNA double-strand break ends

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: TIMELESS-interacting protein
Gene namesⁱ	Name:Tipin
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:1921571 Tipin

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000305254	1 – 278	TIMELESS-interacting proteinAdd BLAST		278

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	191	PhosphoserineBy similarity	1
Modified residueⁱ	219	PhosphoserineBy similarity	1
Modified residueⁱ	233	PhosphothreonineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q91WA1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q91WA1
PaxDbⁱ	Q91WA1
PeptideAtlas More...PeptideAtlasⁱ	Q91WA1
PRIDEⁱ	Q91WA1

PTM databases

iPTMnetⁱ	Q91WA1
PhosphoSitePlusⁱ	Q91WA1

Expressionⁱ

Tissue specificityⁱ

Expressed in brain.1 Publication

Developmental stageⁱ

Expression peaks between E11 and E15. At E7.5, expressed in germ cell layers. At E14.5, expressed at highest levels in thymus, liver, gastrointestinal tract, lung and the rapidly proliferating ventricular zone of the brain.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000032397
CleanExⁱ	MM_TIPIN
ExpressionAtlasⁱ	Q91WA1 baseline and differential
Genevisibleⁱ	Q91WA1 MM

Interactionⁱ

Subunit structureⁱ

Interacts with MCM6 and MCM7 (By similarity). Interacts with TIMELESS, which impairs TIMELESS self-association. Interacts with RPA2 and PRDX2.By similarity2 Publications

Protein-protein interaction databases

BioGridⁱ	211238, 30 interactors
IntActⁱ	Q91WA1, 28 interactors
STRINGⁱ	10090.ENSMUSP00000034964

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q91WA1
SMRⁱ	Q91WA1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	64 – 140	Interaction with TIMELESSBy similarityAdd BLAST		77

Sequence similaritiesⁱ

Belongs to the CSM3 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3004 Eukaryota ENOG4111VXN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005764
HOGENOMⁱ	HOG000154594
HOVERGENⁱ	HBG061130
InParanoidⁱ	Q91WA1
KEGG Orthology (KO) More...KOⁱ	K10904
OMAⁱ	MLEPQEN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0H5F
PhylomeDBⁱ	Q91WA1
TreeFamⁱ	TF313290

Family and domain databases

InterProⁱ	View protein in InterPro IPR012923 Csm3
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07962 Swi3, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD089639 Swi3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q91WA1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLEQEENGLF EIPDYEHVED ETFPPFPPPA SPERDPADAE PEEGSGSGVP 
        60         70         80         90        100
VPPKRTVKRN LPKLDATRLT SERGLPALRH VFDKTKFKGK GHEAEDLKTL 
       110        120        130        140        150
IRHMEHWAHR LFPKLQFEDF IDRVENLGNK KEVQTCLKRI RLDLPIVHED 
       160        170        180        190        200
FVNNNDEVGE ANGPDVSATG FDPFLTSSSD SRKFASEPTR SLTEEQQQRI 
       210        220        230        240        250
ERNKQLALER RQAKLLSNSQ SLENDVTVEE NSTGEDQEES NGLNIDTADG 
       260        270 
PHDVPFASTH EEEQCKAEET QLDHTNLD

Length:278

Mass (Da):31,498

Last modified:October 2, 2007 - v2

Checksum:ⁱ769F56BBDF2763C9

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	67	T → A in BAB22798 (PubMed:16141072).Curated		1
Sequence conflictⁱ	265	C → F in AAH16211 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK003451 mRNA Translation: BAB22798.1 AK003802 mRNA Translation: BAB23004.1 AK011357 mRNA Translation: BAB27565.1 AK038111 mRNA Translation: BAC29931.1 BC016211 mRNA Translation: AAH16211.1 BK001385 mRNA Translation: DAA01364.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23279.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001311485.1, NM_001324556.1 NP_001311486.1, NM_001324557.1 NP_001311487.1, NM_001324558.1 NP_079648.1, NM_025372.4 XP_006511403.1, XM_006511340.3
UniGeneⁱ	Mm.196219

Genome annotation databases

Ensemblⁱ	ENSMUST00000034964; ENSMUSP00000034964; ENSMUSG00000032397 ENSMUST00000216594; ENSMUSP00000149833; ENSMUSG00000032397
GeneIDⁱ	66131
KEGGⁱ	mmu:66131
UCSC genome browser More...UCSCⁱ	uc009qbr.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q91WA1	Putative Timeless-interacting, mRNA protein (Fragment)		Daphnia magna		131
TIMELESS-interacting protein (Fragment)		MOUSE		111
UPI000A317340		MUSCR		278
TIMELESS-interacting protein (Fragment)		MOUSE		93
TIMELESS-interacting protein (Fragment)		MOUSE		93

Protein	Similar proteins		Species	Score	Length
Q91WA1	Putative Timeless-interacting, mRNA protein (Fragment)		Daphnia magna		131
TIMELESS-interacting protein (Fragment)		MOUSE		111
UPI000A317340		MUSCR		278
UPI0003F07BF1		ELEED		287
Uncharacterized protein (Fragment)		AILME		278
+108

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK003451 mRNA Translation: BAB22798.1 AK003802 mRNA Translation: BAB23004.1 AK011357 mRNA Translation: BAB27565.1 AK038111 mRNA Translation: BAC29931.1 BC016211 mRNA Translation: AAH16211.1 BK001385 mRNA Translation: DAA01364.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23279.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001311485.1, NM_001324556.1 NP_001311486.1, NM_001324557.1 NP_001311487.1, NM_001324558.1 NP_079648.1, NM_025372.4 XP_006511403.1, XM_006511340.3
UniGeneⁱ	Mm.196219

3D structure databases

ProteinModelPortalⁱ	Q91WA1
SMRⁱ	Q91WA1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	211238, 30 interactors
IntActⁱ	Q91WA1, 28 interactors
STRINGⁱ	10090.ENSMUSP00000034964

PTM databases

iPTMnetⁱ	Q91WA1
PhosphoSitePlusⁱ	Q91WA1

Proteomic databases

EPDⁱ	Q91WA1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q91WA1
PaxDbⁱ	Q91WA1
PeptideAtlas More...PeptideAtlasⁱ	Q91WA1
PRIDEⁱ	Q91WA1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000034964; ENSMUSP00000034964; ENSMUSG00000032397 ENSMUST00000216594; ENSMUSP00000149833; ENSMUSG00000032397
GeneIDⁱ	66131
KEGGⁱ	mmu:66131
UCSC genome browser More...UCSCⁱ	uc009qbr.1 mouse

Organism-specific databases

CTDⁱ	54962
MGIⁱ	MGI:1921571 Tipin

Phylogenomic databases

eggNOGⁱ	KOG3004 Eukaryota ENOG4111VXN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005764
HOGENOMⁱ	HOG000154594
HOVERGENⁱ	HBG061130
InParanoidⁱ	Q91WA1
KEGG Orthology (KO) More...KOⁱ	K10904
OMAⁱ	MLEPQEN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0H5F
PhylomeDBⁱ	Q91WA1
TreeFamⁱ	TF313290

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5693607 Processing of DNA double-strand break ends

Reactomeⁱ

R-MMU-5693607 Processing of DNA double-strand break ends

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q91WA1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000032397
CleanExⁱ	MM_TIPIN
ExpressionAtlasⁱ	Q91WA1 baseline and differential
Genevisibleⁱ	Q91WA1 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR012923 Csm3
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07962 Swi3, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD089639 Swi3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TIPIN_MOUSE
Accessionⁱ	Q91WA1Primary (citable) accession number: Q91WA1 Secondary accession number(s): Q9CQM3, Q9D1J4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
	Last sequence update:	October 2, 2007
	Last modified:	October 25, 2017
	This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q91WA1 (TIPIN_MOUSE)

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TIMELESS-interacting protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ