UniProtKB - Q91W98 (S15A4_MOUSE)

BLAST

>sp|Q91W98|S15A4_MOUSE Solute carrier family 15 member 4 OS=Mus musculus OX=10090 GN=Slc15a4 PE=1 SV=1
MEGERAPLLGSRRPAVSAASAVFAGRRAACGAVLLAELLERAAFYGVTANLVLFLNGAPF
DWEGAQASQALLLFMGLTYLGSPFGGWLADARLGRARAILLSLALYLLGLLAFPLLAAPR
SRSFLCGDPRPELVRNCSAPFPNGSASCPENAARRCAPATFAGLVLVGLGVATVKANITP
FGADQVKDRGPEATRRFFNWFYWSINLGAILSLGGIAYIQQNVSFFTGYLIPTVCVAIAF
LVFLCGQSVFITKPPDGSAFTDMFRILTYSCCSQRGGQRRSGEGLGVFQQSSKHSLFDSC
KMSRGGPFTEDKVEDVKALVKIVPVFLALIPYWTVYFQMQTTYALQSLHLKIPEISSITT
THHTLPAAWLTMFDAVLILLLIPLKDKLVDPVLRRHGLLPSSLKRIAVGMFFVMCSAFAA
GILESKRLDLVKEKTINQTIGGVVYHAADLPIWWQIPQYVLIGISEIFASIAGLEFAYSA
APKSMQSAIMGLFFFFSGIGSFVGSGLLALVSLKAIGWMSSHTDFGNINSCHLHYYFFLL
AAIQGATLLLFLIVSVKYDRQRARTDGGPASTRT

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History
Entry version 111 (07 Nov 2018)
Sequence version 1 (01 Dec 2001)
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Protein

Solute carrier family 15 member 4

Gene

Slc15a4

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity).By similarity

GO - Molecular functionⁱ

L-histidine transmembrane transporter activity Source: MGI
oligopeptide transmembrane transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
peptide:proton symporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
peptide transmembrane transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

histidine transport Source: MGI
protein transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Peptide transport, Protein transport, Symport, Transport

Biological process

Peptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-MMU-427975 Proton/oligopeptide cotransporters R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-427975 Proton/oligopeptide cotransporters
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Solute carrier family 15 member 4 Alternative name(s): Peptide transporter 4 Peptide/histidine transporter 1
Gene namesⁱ	Name:Slc15a4
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:2140796 Slc15a4

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	42 – 62	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	69 – 89	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	98 – 118	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	161 – 181	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	197 – 217	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	225 – 245	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	319 – 339	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	364 – 384	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	406 – 426	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	460 – 480	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	491 – 511	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	536 – 556	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000338600	1 – 574	Solute carrier family 15 member 4Add BLAST		574

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	281	PhosphoserineCombined sources		1
Modified residueⁱ	299	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q91W98
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q91W98
PaxDbⁱ	Q91W98
PeptideAtlas More...PeptideAtlasⁱ	Q91W98
PRIDEⁱ	Q91W98

PTM databases

iPTMnetⁱ	Q91W98
PhosphoSitePlusⁱ	Q91W98
SwissPalmⁱ	Q91W98

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000029416 Expressed in 268 organ(s), highest expression level in bone marrow macrophage
ExpressionAtlasⁱ	Q91W98 baseline and differential
Genevisibleⁱ	Q91W98 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000031367

STRINGⁱ

10090.ENSMUSP00000031367

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q91W98
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the PTR2/POT transporter (TC 2.A.17) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1237 Eukaryota COG3104 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062961
HOGENOMⁱ	HOG000143436
HOVERGENⁱ	HBG108431
InParanoidⁱ	Q91W98
KEGG Orthology (KO) More...KOⁱ	K14638
OMAⁱ	WLLHNQG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GF9
PhylomeDBⁱ	Q91W98
TreeFamⁱ	TF330897

Family and domain databases

InterProⁱ	View protein in InterPro IPR036259 MFS_trans_sf IPR000109 POT_fam IPR018456 PTR2_symporter_CS
PANTHERⁱ	PTHR11654 PTHR11654, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00854 PTR2, 1 hit
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
PROSITEⁱ	View protein in PROSITE PS01023 PTR2_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show all Align All

Q91W98-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEGERAPLLG SRRPAVSAAS AVFAGRRAAC GAVLLAELLE RAAFYGVTAN 
        60         70         80         90        100
LVLFLNGAPF DWEGAQASQA LLLFMGLTYL GSPFGGWLAD ARLGRARAIL 
       110        120        130        140        150
LSLALYLLGL LAFPLLAAPR SRSFLCGDPR PELVRNCSAP FPNGSASCPE 
       160        170        180        190        200
NAARRCAPAT FAGLVLVGLG VATVKANITP FGADQVKDRG PEATRRFFNW 
       210        220        230        240        250
FYWSINLGAI LSLGGIAYIQ QNVSFFTGYL IPTVCVAIAF LVFLCGQSVF 
       260        270        280        290        300
ITKPPDGSAF TDMFRILTYS CCSQRGGQRR SGEGLGVFQQ SSKHSLFDSC 
       310        320        330        340        350
KMSRGGPFTE DKVEDVKALV KIVPVFLALI PYWTVYFQMQ TTYALQSLHL 
       360        370        380        390        400
KIPEISSITT THHTLPAAWL TMFDAVLILL LIPLKDKLVD PVLRRHGLLP 
       410        420        430        440        450
SSLKRIAVGM FFVMCSAFAA GILESKRLDL VKEKTINQTI GGVVYHAADL 
       460        470        480        490        500
PIWWQIPQYV LIGISEIFAS IAGLEFAYSA APKSMQSAIM GLFFFFSGIG 
       510        520        530        540        550
SFVGSGLLAL VSLKAIGWMS SHTDFGNINS CHLHYYFFLL AAIQGATLLL 
       560        570 
FLIVSVKYDR QRARTDGGPA STRT

Length:574

Mass (Da):62,256

Last modified:December 1, 2001 - v1

Checksum:ⁱ9AE338C1AF56AD05

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RDC2	D6RDC2_MOUSE	Solute carrier family 15 member 4 Solute carrier family 15 member 4	Slc15a4	296	Annotation score:
F6QFB4	F6QFB4_MOUSE	Solute carrier family 15 member 4 Solute carrier family 15 member 4	Slc15a4	246	Annotation score:
F7AZ26	F7AZ26_MOUSE	Solute carrier family 15 member 4 Solute carrier family 15 member 4	Slc15a4	127	Annotation score:
D3Z5E9	D3Z5E9_MOUSE	Solute carrier family 15 member 4 Solute carrier family 15 member 4	Slc15a4	105	Annotation score:
D3Z4X0	D3Z4X0_MOUSE	Solute carrier family 15 member 4 Solute carrier family 15 member 4	Slc15a4	81	Annotation score:
A0A0G2JDS1	A0A0G2JDS1_MOUSE	Solute carrier family 15 member 4 Solute carrier family 15 member 4	Slc15a4	169	Annotation score:

Sequence cautionⁱ

The sequence AAK95566 differs from that shown. Reason: Frameshift at positions 209, 233, 235, 242 and 262.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	218	Y → I in AAK95566 (Ref. 1) Curated	1
Sequence conflictⁱ	254	P → L in AAK95566 (Ref. 1) Curated	1
Sequence conflictⁱ	258	S → G in AAK95566 (Ref. 1) Curated	1
Sequence conflictⁱ	347	S → N in AAK95566 (Ref. 1) Curated	1
Sequence conflictⁱ	427	R → K in AAK95566 (Ref. 1) Curated	1
Sequence conflictⁱ	445	Y → F in AAK95566 (Ref. 1) Curated	1
Sequence conflictⁱ	457	P → L in AAK95566 (Ref. 1) Curated	1
Sequence conflictⁱ	473 – 474	GL → RQ in AAK95566 (Ref. 1) Curated	2
Sequence conflictⁱ	498	G → C in AAK95566 (Ref. 1) Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY050630 mRNA Translation: AAK95566.1 Frameshift. BC016233 mRNA Translation: AAH16233.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19688.1
NCBI Reference Sequences More...RefSeqⁱ	NP_598656.1, NM_133895.1
UniGeneⁱ	Mm.28506

Genome annotation databases

Ensemblⁱ	ENSMUST00000031367; ENSMUSP00000031367; ENSMUSG00000029416
GeneIDⁱ	100561
KEGGⁱ	mmu:100561
UCSC genome browser More...UCSCⁱ	uc008zsb.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q91W98	Solute carrier family 15 member 4 (Fragment)		MOUSE		81	UniRef100_Q91W98

Protein	Similar proteins		Species	Score	Length	Source
Q91W98	Solute carrier family 15 member 4		RAT		572	UniRef90_O09014
Solute carrier family 15 member 4 (Fragment)		MOUSE		81
UPI0004ED6BDA		NANGA		577
UPI000A316DA7		MUSCR		574
UPI00038C635E		MICOH		572
+2

Protein	Similar proteins		Species	Score	Length	Source
Q91W98	Solute carrier family 15 member 3		HUMAN		581	UniRef50_Q8IY34
Solute carrier family 15 member 4		RAT		572
Solute carrier family 15 member 4		XENLA		569
Solute carrier family 15 member 3		MOUSE		578
Solute carrier family 15 member 3		CALJA		582
+162

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY050630 mRNA Translation: AAK95566.1 Frameshift. BC016233 mRNA Translation: AAH16233.1
CCDSⁱ	CCDS19688.1
RefSeqⁱ	NP_598656.1, NM_133895.1
UniGeneⁱ	Mm.28506

3D structure databases

ProteinModelPortalⁱ	Q91W98
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000031367

STRINGⁱ

10090.ENSMUSP00000031367

PTM databases

iPTMnetⁱ	Q91W98
PhosphoSitePlusⁱ	Q91W98
SwissPalmⁱ	Q91W98

Proteomic databases

EPDⁱ	Q91W98
MaxQBⁱ	Q91W98
PaxDbⁱ	Q91W98
PeptideAtlasⁱ	Q91W98
PRIDEⁱ	Q91W98

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000031367; ENSMUSP00000031367; ENSMUSG00000029416
GeneIDⁱ	100561
KEGGⁱ	mmu:100561
UCSCⁱ	uc008zsb.1 mouse

Organism-specific databases

CTDⁱ	121260
MGIⁱ	MGI:2140796 Slc15a4

Phylogenomic databases

eggNOGⁱ	KOG1237 Eukaryota COG3104 LUCA
GeneTreeⁱ	ENSGT00530000062961
HOGENOMⁱ	HOG000143436
HOVERGENⁱ	HBG108431
InParanoidⁱ	Q91W98
KOⁱ	K14638
OMAⁱ	WLLHNQG
OrthoDBⁱ	EOG091G0GF9
PhylomeDBⁱ	Q91W98
TreeFamⁱ	TF330897

Enzyme and pathway databases

Reactomeⁱ	R-MMU-427975 Proton/oligopeptide cotransporters R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-427975 Proton/oligopeptide cotransporters
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q91W98
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000029416 Expressed in 268 organ(s), highest expression level in bone marrow macrophage
ExpressionAtlasⁱ	Q91W98 baseline and differential
Genevisibleⁱ	Q91W98 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR036259 MFS_trans_sf IPR000109 POT_fam IPR018456 PTR2_symporter_CS
PANTHERⁱ	PTHR11654 PTHR11654, 1 hit
Pfamⁱ	View protein in Pfam PF00854 PTR2, 1 hit
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
PROSITEⁱ	View protein in PROSITE PS01023 PTR2_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S15A4_MOUSE
Accessionⁱ	Q91W98Primary (citable) accession number: Q91W98 Secondary accession number(s): Q7TPL5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q91W98 (S15A4_MOUSE)

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Solute carrier family 15 member 4

Slc15a4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ