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Protein

Cdc42 effector protein 1

Gene

Cdc42ep1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts (By similarity).By similarity

GO - Molecular functioni

  • GTP-Rho binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell shape

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42 effector protein 1
Alternative name(s):
Binder of Rho GTPases 5
Gene namesi
Name:Cdc42ep1
Synonyms:Borg5, Cep1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1929763 Cdc42ep1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126581 – 409Cdc42 effector protein 1Add BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineBy similarity1
Modified residuei27PhosphoserineBy similarity1
Modified residuei34PhosphothreonineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei53Omega-N-methylarginineCombined sources1
Modified residuei65PhosphoserineBy similarity1
Modified residuei77PhosphoserineBy similarity1
Modified residuei101PhosphoserineBy similarity1
Modified residuei113PhosphoserineBy similarity1
Modified residuei121PhosphoserineCombined sources1
Modified residuei139PhosphoserineCombined sources1
Modified residuei191PhosphoserineBy similarity1
Modified residuei205PhosphoserineBy similarity1
Modified residuei207PhosphoserineCombined sources1
Modified residuei210PhosphoserineBy similarity1
Modified residuei312PhosphoserineBy similarity1
Modified residuei332PhosphoserineBy similarity1
Modified residuei368PhosphoserineCombined sources1
Modified residuei371PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ91W92
PaxDbiQ91W92
PeptideAtlasiQ91W92
PRIDEiQ91W92

PTM databases

iPTMnetiQ91W92
PhosphoSitePlusiQ91W92

Expressioni

Gene expression databases

CleanExiMM_CDC42EP1

Interactioni

Subunit structurei

Interacts with RHOQ and CDC42, in a GTP-dependent manner.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91W92, 1 interactor
MINTiQ91W92
STRINGi10090.ENSMUSP00000060930

Structurei

3D structure databases

ProteinModelPortaliQ91W92
SMRiQ91W92
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 52CRIBPROSITE-ProRule annotationAdd BLAST15
Repeati235 – 24117
Repeati242 – 24827
Repeati255 – 26137

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 2843 X 7 AA tandem repeats of [PT]-[AT]-A-[ENT]-[PT]-[PTS]-[AG]Add BLAST50

Domaini

The CRIB domain mediates interaction with CDC42.By similarity

Sequence similaritiesi

Belongs to the BORG/CEP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IGPN Eukaryota
ENOG4111PPX LUCA
HOGENOMiHOG000095252
HOVERGENiHBG080906
InParanoidiQ91W92
PhylomeDBiQ91W92
TreeFamiTF331725

Family and domain databases

InterProiView protein in InterPro
IPR029273 Cdc42_effect
IPR000095 CRIB_dom
PfamiView protein in Pfam
PF14957 BORG_CEP, 1 hit
PF00786 PBD, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q91W92-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGPQGGTGA PTMSLGKLSP VGWVSSSHGK RRLTADMISP PLGDFRHTMH
60 70 80 90 100
VGRGGDVFGD TSFLSNHGGR SGNTHRSPRS FLARKLQQVR RVGVPPRRMA
110 120 130 140 150
SPAAPSPAPP PISPIIKNAI SLPQLNQATY DSLVMGKLSF DSTPASSTDG
160 170 180 190 200
HSGYGLESGF CTISRLPRVE KHSNRDRDRD PDHSQDREQS SFPSEPTPNP
210 220 230 240 250
ELRRSDSLLS FRFDLDLGPS LLSELLGVMS LSEAPAAETP VPTANPPAPA
260 270 280 290 300
ANPAPTAKPP AHAITTLDAV TSLPASAVTS LPAPAAASSP SRGHFPNGVT
310 320 330 340 350
SVLGPAAEAK PSPVGEGPQV PSNMTFDRHG ASWGASRASW GASRASRHYT
360 370 380 390 400
EMDARRELAG VLPQVHGSWE SLNEDWSTPP ASVRAPVPTS VQVNAFEFAD

AEEDDEVKV
Length:409
Mass (Da):43,096
Last modified:December 1, 2001 - v1
Checksum:i1794FD0850171F0E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0S1A0A0R4J0S1_MOUSE
Cdc42 effector protein 1
Cdc42ep1
409Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti286A → V in BAB25335 (PubMed:16141072).Curated1
Sequence conflicti325T → A in BAB25335 (PubMed:16141072).Curated1
Sequence conflicti378T → A in BAB25335 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007896 mRNA Translation: BAB25335.1
BC016250 mRNA Translation: AAH16250.1
BC083130 mRNA Translation: AAH83130.1
CCDSiCCDS27624.1
RefSeqiNP_081495.1, NM_027219.3
UniGeneiMm.307488

Genome annotation databases

GeneIDi104445
KEGGimmu:104445
UCSCiuc007wrl.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007896 mRNA Translation: BAB25335.1
BC016250 mRNA Translation: AAH16250.1
BC083130 mRNA Translation: AAH83130.1
CCDSiCCDS27624.1
RefSeqiNP_081495.1, NM_027219.3
UniGeneiMm.307488

3D structure databases

ProteinModelPortaliQ91W92
SMRiQ91W92
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91W92, 1 interactor
MINTiQ91W92
STRINGi10090.ENSMUSP00000060930

PTM databases

iPTMnetiQ91W92
PhosphoSitePlusiQ91W92

Proteomic databases

MaxQBiQ91W92
PaxDbiQ91W92
PeptideAtlasiQ91W92
PRIDEiQ91W92

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi104445
KEGGimmu:104445
UCSCiuc007wrl.1 mouse

Organism-specific databases

CTDi11135
MGIiMGI:1929763 Cdc42ep1

Phylogenomic databases

eggNOGiENOG410IGPN Eukaryota
ENOG4111PPX LUCA
HOGENOMiHOG000095252
HOVERGENiHBG080906
InParanoidiQ91W92
PhylomeDBiQ91W92
TreeFamiTF331725

Miscellaneous databases

ChiTaRSiCdc42ep1 mouse
PROiPR:Q91W92
SOURCEiSearch...

Gene expression databases

CleanExiMM_CDC42EP1

Family and domain databases

InterProiView protein in InterPro
IPR029273 Cdc42_effect
IPR000095 CRIB_dom
PfamiView protein in Pfam
PF14957 BORG_CEP, 1 hit
PF00786 PBD, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBORG5_MOUSE
AccessioniPrimary (citable) accession number: Q91W92
Secondary accession number(s): Q9D8M1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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