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Protein

Vacuolar protein sorting-associated protein 11 homolog

Gene

Vps11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes. Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri822 – 861RING-typePROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAutophagy, Protein transport, Transport
LigandMetal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 11 homolog
Gene namesi
Name:Vps11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1918982 Vps11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000559032 – 941Vacuolar protein sorting-associated protein 11 homologAdd BLAST940

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei813PhosphoserineBy similarity1
Modified residuei904Omega-N-methylarginineCombined sources1
Modified residuei924PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ91W86
MaxQBiQ91W86
PaxDbiQ91W86
PeptideAtlasiQ91W86
PRIDEiQ91W86

PTM databases

iPTMnetiQ91W86
PhosphoSitePlusiQ91W86
SwissPalmiQ91W86

Expressioni

Gene expression databases

BgeeiENSMUSG00000032127 Expressed in 264 organ(s), highest expression level in dorsal pancreas
CleanExiMM_VPS11
ExpressionAtlasiQ91W86 baseline and differential
GenevisibleiQ91W86 MM

Interactioni

Subunit structurei

Core component of at least two putative endosomal tethering complexes, the homotypic fusion and vacuole protein sorting (HOPS) complex and the class C core vacuole/endosome tethering (CORVET) complex. Their common core is composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, which in HOPS further associates with VPS39 and VPS41 and in CORVET with VPS8 and TGFBRAP1 (PubMed:25266290). Interacts with RAB5C (PubMed:25266290). Interacts with TGFBRAP1, MON1B, STX7, STX17, ECPAS, EZR, RDX, MSN (By similarity). Associates with adaptor protein complex 3 (AP-3) and clathrin:AP-3 complexes (PubMed:21411634).By similarity1 Publication2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
VIPAS39Q9H9C13EBI-2527812,EBI-749080From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi214887, 10 interactors
IntActiQ91W86, 3 interactors
STRINGi10090.ENSMUSP00000034644

Structurei

3D structure databases

ProteinModelPortaliQ91W86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati411 – 561CHCR 1Add BLAST151
Repeati572 – 736CHCR 2Add BLAST165

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili772 – 813Sequence analysisAdd BLAST42

Sequence similaritiesi

Belongs to the VPS11 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri822 – 861RING-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2114 Eukaryota
ENOG410XRNZ LUCA
GeneTreeiENSGT00390000015058
HOGENOMiHOG000216424
HOVERGENiHBG055822
InParanoidiQ91W86
KOiK20179
OMAiCQMHNFK
OrthoDBiEOG091G04NG
TreeFamiTF300479

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.130.10.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000547 Clathrin_H-chain/VPS_repeat
IPR011990 TPR-like_helical_dom_sf
IPR016528 VPS11
IPR024763 VPS11_C
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR23323:SF24 PTHR23323:SF24, 1 hit
PfamiView protein in Pfam
PF00637 Clathrin, 1 hit
PF12451 VPS11_C, 1 hit
PIRSFiPIRSF007860 VPS11, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50236 CHCR, 2 hits
PS50089 ZF_RING_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q91W86-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAYLQWRRF VFFEKELVKE PLGNDGAAPG AAPVSGSAAS KFLCLPPGIT
60 70 80 90 100
VCDSGRGSLV FGDMEGQIWF LPRSLQLTGF QAYKLRVTHL YQLKQHNILA
110 120 130 140 150
SVGEDEEGIN PLVKIWNLEK RDGGNPLCTR IFPAIPGTEP TVVSCLTVHE
160 170 180 190 200
NLNFMAIGFT DGSVTLNKGD ITRDRHSKTQ ILHKGNYPVT GLAFRQAGKT
210 220 230 240 250
THLFVVTTEN VQSYIVSGKD YPRVELDTHG CGLRCSALSD PSQDLQFIVA
260 270 280 290 300
GDECVYLYQP DERGPCFAFE GHKLIVHWFR GYLVIVSRDR KVSPKSEFTS
310 320 330 340 350
RDSQNSDKQI LNIYDLCNKF IAYSAGFEDI VDVLAEWGSL YVLTRDGRVH
360 370 380 390 400
ALQEKDTQTK LEMLFKKNLF EMAINLAKSQ HLDSDGLAQI FMQYGDHLYS
410 420 430 440 450
KGNHDGAVQQ YIRTIGKLEP SYVIRKFLDA QRIHNLTAYL QTLHRQSLAN
460 470 480 490 500
ADHTTLLLNC YTKLKDSSKL EEFIKTKSES EVHFDVETAI KVLRQAGYYS
510 520 530 540 550
HALYLAENHA HHEWYLKIQL EDIKNYQEAL RYIGKLPFEQ AESNMKRYGK
560 570 580 590 600
TLMHHIPEQT TQLLKGLCTD YRPSLEGRGD REALSCRASS EEFIPIFANN
610 620 630 640 650
PRELKAFLEH MSEVQPDSPQ GIYDTLLELR LQNWAHEKDP QAKEKLHAEA
660 670 680 690 700
ISLLKSGRFC DVFDKALVLC QMHDFQDGVL YLYEQGKLFQ QIMHYHMQHE
710 720 730 740 750
QYRQVIAVCE RHGEQEPSLW EQALSYFARK EEDCKEYVAA VLRHIENKSL
760 770 780 790 800
MPPLLVVQTL AHNSTATLSI IRDYLVQKLQ KQSQQIAQDE LRVRRYREET
810 820 830 840 850
TRIRQEIQEL KASPKIFQKT KCSICNSALE LPSVHFLCGH SFHQHCFESY
860 870 880 890 900
SESDADCPTC LPENRKVMDM IRAQEQKRDL HDQFQHQLKC SNDSFSVIAD
910 920 930 940
YFGRGVFNKL TLLTDPPTAR LTPSLEAGLQ RDLLMHSRRG T
Length:941
Mass (Da):107,719
Last modified:July 27, 2011 - v3
Checksum:iDB96F07E92C9E534
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SRH3A0A1L1SRH3_MOUSE
Vacuolar protein sorting-associated...
Vps11
407Annotation score:
A0A1L1SV27A0A1L1SV27_MOUSE
Vacuolar protein sorting-associated...
Vps11
249Annotation score:
A0A1L1SQ62A0A1L1SQ62_MOUSE
Vacuolar protein sorting-associated...
Vps11
49Annotation score:
A0A1L1STI8A0A1L1STI8_MOUSE
Vacuolar protein sorting-associated...
Vps11
120Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → HAS in AAH16258 (PubMed:15489334).Curated1
Sequence conflicti28A → T in AAH16258 (PubMed:15489334).Curated1
Sequence conflicti34V → T in AAH16258 (PubMed:15489334).Curated1
Sequence conflicti37 – 38SA → PT in AAH16258 (PubMed:15489334).Curated2
Sequence conflicti132F → L in AAH16258 (PubMed:15489334).Curated1
Sequence conflicti186N → S in AAH16258 (PubMed:15489334).Curated1
Sequence conflicti276V → A in AAH16258 (PubMed:15489334).Curated1
Sequence conflicti326G → V in AAH16258 (PubMed:15489334).Curated1
Sequence conflicti330I → V in AAH16258 (PubMed:15489334).Curated1
Sequence conflicti551T → I in AAH16258 (PubMed:15489334).Curated1
Sequence conflicti583 – 584AL → FP in AAH16258 (PubMed:15489334).Curated2
Sequence conflicti589S → N in AAH16258 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004695 mRNA Translation: BAB23481.1
BC029004 mRNA Translation: AAH29004.1
BC016258 mRNA Translation: AAH16258.1
CCDSiCCDS40599.1
RefSeqiNP_082165.1, NM_027889.1
UniGeneiMm.295013

Genome annotation databases

EnsembliENSMUST00000034644; ENSMUSP00000034644; ENSMUSG00000032127
GeneIDi71732
KEGGimmu:71732
UCSCiuc009pdc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004695 mRNA Translation: BAB23481.1
BC029004 mRNA Translation: AAH29004.1
BC016258 mRNA Translation: AAH16258.1
CCDSiCCDS40599.1
RefSeqiNP_082165.1, NM_027889.1
UniGeneiMm.295013

3D structure databases

ProteinModelPortaliQ91W86
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214887, 10 interactors
IntActiQ91W86, 3 interactors
STRINGi10090.ENSMUSP00000034644

PTM databases

iPTMnetiQ91W86
PhosphoSitePlusiQ91W86
SwissPalmiQ91W86

Proteomic databases

EPDiQ91W86
MaxQBiQ91W86
PaxDbiQ91W86
PeptideAtlasiQ91W86
PRIDEiQ91W86

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034644; ENSMUSP00000034644; ENSMUSG00000032127
GeneIDi71732
KEGGimmu:71732
UCSCiuc009pdc.2 mouse

Organism-specific databases

CTDi55823
MGIiMGI:1918982 Vps11

Phylogenomic databases

eggNOGiKOG2114 Eukaryota
ENOG410XRNZ LUCA
GeneTreeiENSGT00390000015058
HOGENOMiHOG000216424
HOVERGENiHBG055822
InParanoidiQ91W86
KOiK20179
OMAiCQMHNFK
OrthoDBiEOG091G04NG
TreeFamiTF300479

Miscellaneous databases

PROiPR:Q91W86
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032127 Expressed in 264 organ(s), highest expression level in dorsal pancreas
CleanExiMM_VPS11
ExpressionAtlasiQ91W86 baseline and differential
GenevisibleiQ91W86 MM

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.130.10.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000547 Clathrin_H-chain/VPS_repeat
IPR011990 TPR-like_helical_dom_sf
IPR016528 VPS11
IPR024763 VPS11_C
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR23323:SF24 PTHR23323:SF24, 1 hit
PfamiView protein in Pfam
PF00637 Clathrin, 1 hit
PF12451 VPS11_C, 1 hit
PIRSFiPIRSF007860 VPS11, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50236 CHCR, 2 hits
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVPS11_MOUSE
AccessioniPrimary (citable) accession number: Q91W86
Secondary accession number(s): Q5FWZ1, Q9DBX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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