Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RNA-binding motif, single-stranded-interacting protein 1

Gene

Rbms1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication.

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • mRNA 3'-UTR binding Source: GO_Central
  • poly(A) binding Source: GO_Central
  • poly(U) RNA binding Source: GO_Central
  • RNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding motif, single-stranded-interacting protein 1
Alternative name(s):
Single-stranded DNA-binding protein MSSP-1
Gene namesi
Name:Rbms1
Synonyms:Mssp, Mssp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1861774 Rbms1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817991 – 403RNA-binding motif, single-stranded-interacting protein 1Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei208PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ91W59
PeptideAtlasiQ91W59
PRIDEiQ91W59

PTM databases

iPTMnetiQ91W59
PhosphoSitePlusiQ91W59

Expressioni

Tissue specificityi

Ubiquitous. Expressed in all tissues except testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000026970 Expressed in 285 organ(s), highest expression level in pineal body
ExpressionAtlasiQ91W59 baseline and differential
GenevisibleiQ91W59 MM

Interactioni

Protein-protein interaction databases

BioGridi208206, 1 interactor
STRINGi10090.ENSMUSP00000131306

Structurei

3D structure databases

ProteinModelPortaliQ91W59
SMRiQ91W59
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 135RRM 1PROSITE-ProRule annotationAdd BLAST74
Domaini141 – 226RRM 2PROSITE-ProRule annotationAdd BLAST86

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4733 Eukaryota
ENOG410XRB5 LUCA
GeneTreeiENSGT00760000118913
HOGENOMiHOG000008467
HOVERGENiHBG053108
InParanoidiQ91W59
OMAiYTHVQTT
PhylomeDBiQ91W59
TreeFamiTF314644

Family and domain databases

CDDicd12470 RRM1_MSSP1, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR002343 Hud_Sxl_RNA
IPR034404 MSSP1_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
PRINTSiPR00961 HUDSXLRNA
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q91W59-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKVWKQQMY PQYATYYYPQ YLQAKQSLVP AHPMAPPSPS TTSSNNNSSS
60 70 80 90 100
SSNSGWDQLS KTNLYIRGLP PNTTDQDLVK LCQPYGKIVS TKAILDKATN
110 120 130 140 150
KCKGYGFVDF DSPAAAQKAV SALKANGVQA QMAKQQEQDP TNLYISNLPL
160 170 180 190 200
SMDEQELENM LKPFGQVIST RVLRDSSGAS RGVGFARMES TEKCEAVIGH
210 220 230 240 250
FNGKFIKTPP GVSAPTEPLL CKFADGGQKK RQNPNKYIPN GRPWPRDGEA
260 270 280 290 300
GMTLTYDPTT AALHNGFYPS PYSIATNRMI TQTSLTPYIA SPVSAYQVQS
310 320 330 340 350
PSWMQPQPYI LQHPGAVLTP SMEHTMSLQP ASMISPLAQQ MSHLSLGSTG
360 370 380 390 400
TYMPATSAMQ GAYLPQYTHM QTAAVPVEEA SGQQQVAVET SNDHSPYTFP

PNK
Length:403
Mass (Da):43,991
Last modified:December 1, 2001 - v1
Checksum:i68B8AC5816834726
GO
Isoform 2 (identifier: Q91W59-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Show »
Length:370
Mass (Da):40,001
Checksum:i62C4BEFC8757B700
GO
Isoform 3 (identifier: Q91W59-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.
     298-298: V → VAKETRENKYRGSAIKV

Show »
Length:386
Mass (Da):41,833
Checksum:i950F2C5A56A5C850
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PZ21E9PZ21_MOUSE
RNA-binding motif, single-stranded-...
Rbms1
417Annotation score:

Sequence cautioni

The sequence AAH16501 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158E → K in BAE22471 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0119311 – 33Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST33
Alternative sequenceiVSP_011932298V → VAKETRENKYRGSAIKV in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026582 Genomic DNA Translation: BAA77264.1
AB026569 mRNA Translation: BAA77262.1
AK135280 mRNA Translation: BAE22471.1
AK147109 mRNA Translation: BAE27681.1
AL928581, AL929012 Genomic DNA Translation: CAM20660.1
AL929012, AL928581 Genomic DNA Translation: CAM25422.1
BC016501 mRNA Translation: AAH16501.2 Different initiation.
BC056609 mRNA Translation: AAH56609.1
BC057866 mRNA Translation: AAH57866.1
CCDSiCCDS50591.1 [Q91W59-1]
RefSeqiNP_001135403.1, NM_001141931.1
NP_064692.2, NM_020296.2 [Q91W59-1]
UniGeneiMm.259667
Mm.482338

Genome annotation databases

EnsembliENSMUST00000028347; ENSMUSP00000028347; ENSMUSG00000026970 [Q91W59-1]
ENSMUST00000112509; ENSMUSP00000108128; ENSMUSG00000026970 [Q91W59-3]
GeneIDi56878
KEGGimmu:56878
UCSCiuc008juq.2 mouse [Q91W59-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026582 Genomic DNA Translation: BAA77264.1
AB026569 mRNA Translation: BAA77262.1
AK135280 mRNA Translation: BAE22471.1
AK147109 mRNA Translation: BAE27681.1
AL928581, AL929012 Genomic DNA Translation: CAM20660.1
AL929012, AL928581 Genomic DNA Translation: CAM25422.1
BC016501 mRNA Translation: AAH16501.2 Different initiation.
BC056609 mRNA Translation: AAH56609.1
BC057866 mRNA Translation: AAH57866.1
CCDSiCCDS50591.1 [Q91W59-1]
RefSeqiNP_001135403.1, NM_001141931.1
NP_064692.2, NM_020296.2 [Q91W59-1]
UniGeneiMm.259667
Mm.482338

3D structure databases

ProteinModelPortaliQ91W59
SMRiQ91W59
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208206, 1 interactor
STRINGi10090.ENSMUSP00000131306

PTM databases

iPTMnetiQ91W59
PhosphoSitePlusiQ91W59

Proteomic databases

PaxDbiQ91W59
PeptideAtlasiQ91W59
PRIDEiQ91W59

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028347; ENSMUSP00000028347; ENSMUSG00000026970 [Q91W59-1]
ENSMUST00000112509; ENSMUSP00000108128; ENSMUSG00000026970 [Q91W59-3]
GeneIDi56878
KEGGimmu:56878
UCSCiuc008juq.2 mouse [Q91W59-1]

Organism-specific databases

CTDi5937
MGIiMGI:1861774 Rbms1

Phylogenomic databases

eggNOGiKOG4733 Eukaryota
ENOG410XRB5 LUCA
GeneTreeiENSGT00760000118913
HOGENOMiHOG000008467
HOVERGENiHBG053108
InParanoidiQ91W59
OMAiYTHVQTT
PhylomeDBiQ91W59
TreeFamiTF314644

Miscellaneous databases

ChiTaRSiRbms1 mouse
PROiPR:Q91W59
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026970 Expressed in 285 organ(s), highest expression level in pineal body
ExpressionAtlasiQ91W59 baseline and differential
GenevisibleiQ91W59 MM

Family and domain databases

CDDicd12470 RRM1_MSSP1, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR002343 Hud_Sxl_RNA
IPR034404 MSSP1_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
PRINTSiPR00961 HUDSXLRNA
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRBMS1_MOUSE
AccessioniPrimary (citable) accession number: Q91W59
Secondary accession number(s): Q3UI25
, Q3UXU2, Q6PEU6, Q6PHC2, Q9WTK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again