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Protein

Kinesin light chain 3

Gene

Klc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.

GO - Molecular functioni

  • kinesin binding Source: MGI
  • microtubule binding Source: MGI
  • microtubule motor activity Source: InterPro

GO - Biological processi

  • axo-dendritic transport Source: MGI
  • intraciliary transport Source: MGI

Keywordsi

Molecular functionMotor protein

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-5625970 RHO GTPases activate KTN1
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin light chain 3
Gene namesi
Name:Klc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1277971 Klc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002307861 – 508Kinesin light chain 3Add BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173PhosphoserineCombined sources1
Modified residuei467PhosphoserineCombined sources1
Modified residuei502PhosphothreonineBy similarity1
Modified residuei506PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ91W40
MaxQBiQ91W40
PaxDbiQ91W40
PRIDEiQ91W40

PTM databases

iPTMnetiQ91W40
PhosphoSitePlusiQ91W40

Expressioni

Tissue specificityi

Expressed in postmeiotic male germ cells (at protein level). Expressed in spleen, intestine, brain, ovary, testis, spermatocytes and spermatids.1 Publication

Gene expression databases

BgeeiENSMUSG00000040714 Expressed in 175 organ(s), highest expression level in retina
CleanExiMM_KLC3
ExpressionAtlasiQ91W40 baseline and differential
GenevisibleiQ91W40 MM

Interactioni

Subunit structurei

Oligomer composed of two heavy chains and two light chains (By similarity). Associates with microtubulin in an ATP-dependent manner (By similarity). Interacts with KIF5C. Interacts with ODF1 (By similarity). Interacts with LRGUK (PubMed:28003339).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231327, 19 interactors
DIPiDIP-48703N
IntActiQ91W40, 18 interactors
MINTiQ91W40
STRINGi10090.ENSMUSP00000038091

Structurei

3D structure databases

ProteinModelPortaliQ91W40
SMRiQ91W40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati207 – 240TPR 1Add BLAST34
Repeati249 – 282TPR 2Add BLAST34
Repeati291 – 324TPR 3Add BLAST34
Repeati333 – 366TPR 4Add BLAST34
Repeati375 – 408TPR 5Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili88 – 150Sequence analysisAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi181 – 184Poly-Glu4
Compositional biasi190 – 196Poly-Ala7

Domaini

The heptad repeat (HR) motif is sufficient for interaction with kinesin heavy (KHL) chains and ODF1. The TPR region is involved in mitochondrial binding (By similarity).By similarity

Sequence similaritiesi

Belongs to the kinesin light chain family.Curated

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1840 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00390000006393
HOGENOMiHOG000261663
HOVERGENiHBG006217
InParanoidiQ91W40
KOiK10407
OMAiCHPDVAT
OrthoDBiEOG091G05DM
PhylomeDBiQ91W40
TreeFamiTF314010

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR002151 Kinesin_light
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PRINTSiPR00381 KINESINLIGHT
SMARTiView protein in SMART
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 4 hits
PS50293 TPR_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q91W40-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVQVAAPGS TGLGPERLNP EELVRQTRQV VQGLEALRAE HHSLAGHLAE
60 70 80 90 100
ALAGPGPVAG VELLEEKQQV VNHSLEAIEL GLGEAQVLLA LSAHVSVLEA
110 120 130 140 150
EKQRLRAQAR RLAQENTWLR EELEETQRRL RASEEAVAQL EEEKSHLQFL
160 170 180 190 200
GQLRQYDPPE ESQRPESPPR RDSLASLFPS EEEEKKGPEA AGAAAAQQGG
210 220 230 240 250
YEIPARLRTL HNLVIQYAGQ GRYEVAVPLC RQALEDLERS SGHCHPDVAT
260 270 280 290 300
MLNILALVYR DQNKYKEATE LLHDALQIRE QTLGPEHPAV AATLNNLAVL
310 320 330 340 350
YGKRGRYREA EPLCQRALEI REKVLGADHP DVAKQLNNLA LLCQNQGKFQ
360 370 380 390 400
DVERHYARAL SIYEALGGPQ DPNVAKTKNN LASAYLKQNK YQQAEELYKE
410 420 430 440 450
ILSQEALPAP LGAPQGGTAG DTQQQVLRRS SSFSKLRESI RRGSEKLVSR
460 470 480 490 500
LRGEGMAGAA GMKRAMSLNM LNVDGPRAAR TQLSQLSTRH LSEAPRTLSI

STQDLSPR
Length:508
Mass (Da):56,006
Last modified:December 1, 2001 - v1
Checksum:i7F6F11CB943792C2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z710D3Z710_MOUSE
Kinesin light chain 3
Klc3
505Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti313L → P in BAE34354 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK158094 mRNA Translation: BAE34354.1
BC017147 mRNA Translation: AAH17147.1
CCDSiCCDS20901.1
RefSeqiNP_001272967.1, NM_001286038.1
NP_001272968.1, NM_001286039.1
NP_666294.1, NM_146182.4
UniGeneiMm.213403

Genome annotation databases

EnsembliENSMUST00000047170; ENSMUSP00000038091; ENSMUSG00000040714
ENSMUST00000108458; ENSMUSP00000104098; ENSMUSG00000040714
ENSMUST00000108459; ENSMUSP00000104099; ENSMUSG00000040714
GeneIDi232943
KEGGimmu:232943
UCSCiuc009fls.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK158094 mRNA Translation: BAE34354.1
BC017147 mRNA Translation: AAH17147.1
CCDSiCCDS20901.1
RefSeqiNP_001272967.1, NM_001286038.1
NP_001272968.1, NM_001286039.1
NP_666294.1, NM_146182.4
UniGeneiMm.213403

3D structure databases

ProteinModelPortaliQ91W40
SMRiQ91W40
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231327, 19 interactors
DIPiDIP-48703N
IntActiQ91W40, 18 interactors
MINTiQ91W40
STRINGi10090.ENSMUSP00000038091

PTM databases

iPTMnetiQ91W40
PhosphoSitePlusiQ91W40

Proteomic databases

EPDiQ91W40
MaxQBiQ91W40
PaxDbiQ91W40
PRIDEiQ91W40

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047170; ENSMUSP00000038091; ENSMUSG00000040714
ENSMUST00000108458; ENSMUSP00000104098; ENSMUSG00000040714
ENSMUST00000108459; ENSMUSP00000104099; ENSMUSG00000040714
GeneIDi232943
KEGGimmu:232943
UCSCiuc009fls.2 mouse

Organism-specific databases

CTDi147700
MGIiMGI:1277971 Klc3

Phylogenomic databases

eggNOGiKOG1840 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00390000006393
HOGENOMiHOG000261663
HOVERGENiHBG006217
InParanoidiQ91W40
KOiK10407
OMAiCHPDVAT
OrthoDBiEOG091G05DM
PhylomeDBiQ91W40
TreeFamiTF314010

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-5625970 RHO GTPases activate KTN1
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Miscellaneous databases

PROiPR:Q91W40
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040714 Expressed in 175 organ(s), highest expression level in retina
CleanExiMM_KLC3
ExpressionAtlasiQ91W40 baseline and differential
GenevisibleiQ91W40 MM

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR002151 Kinesin_light
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PRINTSiPR00381 KINESINLIGHT
SMARTiView protein in SMART
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 4 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKLC3_MOUSE
AccessioniPrimary (citable) accession number: Q91W40
Secondary accession number(s): Q3TZ56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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