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Protein

Tuberoinfundibular peptide of 39 residues

Gene

Pth2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action of PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.3 Publications

Miscellaneous

The N-terminal truncation of tuberoinfundibular peptide of 39 residues [TIP39(7-39)] reverses PTH2R/PTHR1 binding selectivity, then is a highly potent and selective antagonist for PTHR1.

GO - Molecular functioni

  • signaling receptor binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-MMU-373080 Class B/2 (Secretin family receptors)
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Tuberoinfundibular peptide of 39 residues
Short name:
TIP39
Alternative name(s):
Parathyroid hormone 2
Gene namesi
Name:Pth2
Synonyms:Tip39, Tipf39
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2152297 Pth2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
PropeptideiPRO_000004594431 – 59By similarityAdd BLAST29
PeptideiPRO_000004594562 – 100Tuberoinfundibular peptide of 39 residuesAdd BLAST39

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ91W27
PRIDEiQ91W27

PTM databases

PhosphoSitePlusiQ91W27

Expressioni

Tissue specificityi

Expressed in testis and, less abundantly, in liver and kidney. Expressed in seminiferous tubuli and several brain regions, including nucleus ruber, caudal paralemniscal nucleus, nucleus centralis pontis, and nucleus subparafascicularis thalami. Expressed in neurons of cerebral cortex and subcortical areas. Expressed in Purkinje cells of cerebellum.3 Publications

Gene expression databases

BgeeiENSMUSG00000038300 Expressed in 26 organ(s), highest expression level in testis
CleanExiMM_PTH2
ExpressionAtlasiQ91W27 baseline and differential
GenevisibleiQ91W27 MM

Interactioni

Subunit structurei

Ligand of high affinity for the PTH2 receptor (PTH2R).

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041047

Family & Domainsi

Sequence similaritiesi

Belongs to the parathyroid hormone family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J15Z Eukaryota
ENOG410Y2YH LUCA
GeneTreeiENSGT00410000026259
HOGENOMiHOG000154591
HOVERGENiHBG094047
InParanoidiQ91W27
OrthoDBiEOG091G16L2
PhylomeDBiQ91W27
TreeFamiTF353520

Family and domain databases

InterProiView protein in InterPro
IPR029396 TIP39
PANTHERiPTHR28585 PTHR28585, 1 hit
PfamiView protein in Pfam
PF14980 TIP39, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q91W27-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METCQMSRSP RERLLLLLLL LLLVPWGTGP ASGVALPLAG VFSLRAPGRA
60 70 80 90 100
WAGLGSPLSR RSLALADDAA FRERARLLAA LERRRWLDSY MQKLLLLDAP
Length:100
Mass (Da):11,022
Last modified:December 1, 2001 - v1
Checksum:iDC778742E13E0243
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GR43A0A1B0GR43_MOUSE
Tuberoinfundibular peptide of 39 re...
Pth2 Tifp39, mCG_142424
113Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92Q → H (PubMed:12559132).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399674 mRNA Translation: AAK84862.1
AY048587 mRNA Translation: AAL06596.1
CCDSiCCDS21233.1
RefSeqiNP_444486.1, NM_053256.2
XP_006540625.1, XM_006540562.1
XP_006540626.1, XM_006540563.2
XP_006540627.1, XM_006540564.3
XP_006540628.1, XM_006540565.3
XP_017177420.1, XM_017321931.1
UniGeneiMm.207078

Genome annotation databases

EnsembliENSMUST00000042754; ENSMUSP00000041047; ENSMUSG00000038300
GeneIDi114640
KEGGimmu:114640
UCSCiuc009gtz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399674 mRNA Translation: AAK84862.1
AY048587 mRNA Translation: AAL06596.1
CCDSiCCDS21233.1
RefSeqiNP_444486.1, NM_053256.2
XP_006540625.1, XM_006540562.1
XP_006540626.1, XM_006540563.2
XP_006540627.1, XM_006540564.3
XP_006540628.1, XM_006540565.3
XP_017177420.1, XM_017321931.1
UniGeneiMm.207078

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041047

PTM databases

PhosphoSitePlusiQ91W27

Proteomic databases

PaxDbiQ91W27
PRIDEiQ91W27

Protocols and materials databases

DNASUi114640
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042754; ENSMUSP00000041047; ENSMUSG00000038300
GeneIDi114640
KEGGimmu:114640
UCSCiuc009gtz.1 mouse

Organism-specific databases

CTDi113091
MGIiMGI:2152297 Pth2

Phylogenomic databases

eggNOGiENOG410J15Z Eukaryota
ENOG410Y2YH LUCA
GeneTreeiENSGT00410000026259
HOGENOMiHOG000154591
HOVERGENiHBG094047
InParanoidiQ91W27
OrthoDBiEOG091G16L2
PhylomeDBiQ91W27
TreeFamiTF353520

Enzyme and pathway databases

ReactomeiR-MMU-373080 Class B/2 (Secretin family receptors)
R-MMU-418555 G alpha (s) signalling events

Miscellaneous databases

PROiPR:Q91W27
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038300 Expressed in 26 organ(s), highest expression level in testis
CleanExiMM_PTH2
ExpressionAtlasiQ91W27 baseline and differential
GenevisibleiQ91W27 MM

Family and domain databases

InterProiView protein in InterPro
IPR029396 TIP39
PANTHERiPTHR28585 PTHR28585, 1 hit
PfamiView protein in Pfam
PF14980 TIP39, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTIP39_MOUSE
AccessioniPrimary (citable) accession number: Q91W27
Secondary accession number(s): Q91ZA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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