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Entry version 117 (02 Jun 2021)
Sequence version 1 (01 Dec 2001)
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Protein

Metal cation symporter ZIP8

Gene

Slc39a8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Electroneutral transporter of the plasma membrane mediating the cellular uptake of zinc and manganese, two divalent metal cations important for development, tissue homeostasis or immunity (PubMed:16638970, PubMed:18037372, PubMed:22563477, PubMed:24529376, PubMed:29337306).

Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation, a bicarbonate and a selenite anion or yet a metal cation and two bicarbonate anions (PubMed:16638970, PubMed:18037372, PubMed:22563477, PubMed:27166256).

May also transport iron, mercury and cobalt through membranes (PubMed:16638970, PubMed:22898811, PubMed:24529376).

Beside these endogenous cellular substrates, also imports cadmium a non-essential metal which is cytotoxic and carcinogenic (PubMed:15722412, PubMed:16638970, PubMed:17108009, PubMed:18037372, PubMed:24529376).

Through zinc import, indirectly regulates the metal-dependent transcription factor MTF1 and the expression of some metalloproteases involved in cartilage catabolism and also probably heart development (PubMed:24529376, PubMed:29337306).

Also indirectly regulates the expression of proteins involved in cell morphology and cytoskeleton organization (PubMed:29927450).

Indirectly controls innate immune function and inflammatory response by regulating zinc cellular uptake which in turn modulates the expression of genes specific of these processes (PubMed:23403290).

Protects, for instance, cells from injury and death at the onset of inflammation (By similarity).

By regulating zinc influx into monocytes also directly modulates their adhesion to endothelial cells and arteries (PubMed:30015240).

At the apical membrane of hepatocytes, reclaims manganese from the bile and regulates, through the systemic levels of the nutrient, the activity of manganese-dependent enzymes (PubMed:28481222).

Also participates in manganese reabsorption in the proximal tubule of the kidney (By similarity).

By mediating the extracellular uptake of manganese by cells of the blood-brain barrier, may also play a role in the transport of the micronutrient to the brain. Through manganese cellular uptake also participates in mitochondrial proper function (By similarity).

Finally, also probably functions intracellularly, translocating zinc from lysosome to cytosol to indirectly enhance the expression of specific genes during TCR-mediated T cell activation (By similarity).

By similarity13 Publications

Miscellaneous

The decreased expression of the channel in testis vascular endothelial cells confers the resistance to cadmium-induced testicular damage trait to some mice strains.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.84 µM for Cd2+1 Publication
  2. KM=0.62 µM for Cd2+1 Publication
  3. KM=0.48 µM for Cd2+ (measured in xenopus oocytes)1 Publication
  4. KM=0.26 µM for Zn2+ (measured in xenopus oocytes)1 Publication
  5. KM=2.2 µM for Mn2+1 Publication
  6. KM=5.9 µM for selenite/HSeO3-1 Publication
  1. Vmax=204 pmol/min/mg enzyme for the uptake of Cd2+1 Publication
  2. Vmax=92 pmol/min/mg enzyme for the uptake of Cd2+1 Publication
  3. Vmax=73.8 pmol/min/mg enzyme for the uptake of Mn2+1 Publication

pH dependencei

Optimum pH is 7.5.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-442380, Zinc influx into cells by the SLC39 gene family

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.5.4.8, the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Metal cation symporter ZIP81 Publication
Alternative name(s):
Solute carrier family 39 member 8Imported
Zrt- and Irt-like protein 81 Publication
Short name:
ZIP-81 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc39a8Imported
Synonyms:Zip81 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1914797, Slc39a8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 132ExtracellularBy similarityAdd BLAST113
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Topological domaini154 – 160CytoplasmicBy similarity7
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 191ExtracellularBy similarity10
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 367CytoplasmicBy similarityAdd BLAST155
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Topological domaini389 – 390ExtracellularBy similarity2
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Topological domaini412 – 431CytoplasmicBy similarityAdd BLAST20
Transmembranei432 – 452HelicalSequence analysisAdd BLAST21
Topological domaini453 – 462ExtracellularBy similarity10

Keywords - Cellular componenti

Cell membrane, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

The homozygous knockout of Slc39a8 is embryonic lethal by E16.5. Hearts exhibit hypertrabeculation and non-compaction phenotypes including excessive trabeculae and thin compact myocardium. These phenotypes are evident at E12.5 and prominent at E14.5, and embryos that survive until E16.5 display an even stronger phenotype. Ventricular septal defects are also observed. Some E14.5 embryos exhibit body edema, suggesting that cardiac muscle function is compromised. Hearts display increased cardiomyocyte proliferation (PubMed:29337306). This is associated with decreased expression of metalloproteases and impaired degradation of the extracellular matrix leading to its aberrant accumulation in heart (PubMed:29337306). In mice homozygous for an hypomorphic allele of the gene, resulting in significant decreased expression of the protein, hematopoiesis and the development of multiple organs are affected from very early embryogenesis (PubMed:22563477). Conditional knockout of the gene at the level of the whole organism decreases manganese levels in tissues but has no effect on zinc and iron (PubMed:28481222). Conditional liver-specific knockout of the gene results in decreased systemic tissue manganese levels coupled to increased manganese in bile but has no effect on zinc or iron levels (PubMed:28481222).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031270820 – 462Metal cation symporter ZIP8Sequence analysisAdd BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated (PubMed:16638970). N-glycosylation is not required for proper iron and zinc transport (By similarity).By similarity1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q91W10

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q91W10

PeptideAtlas

More...
PeptideAtlasi
Q91W10

PRoteomics IDEntifications database

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PRIDEi
Q91W10

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
256685 [Q91W10-1]
256686 [Q91W10-2]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q91W10

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the developing heart by cardiac endothelial cells with a peak of expression at E12.5 and a decline to low levels in adult heart.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in monocytes upon adhesion and recruitment to arteries (PubMed:30015240). Up-regulated by the proinflammatory cytokine interleukin-1 beta/IL1B (PubMed:24529376).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000053897, Expressed in brain blood vessel and 296 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q91W10, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000080640

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q91W10, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi345 – 350XEXPHE-motifBy similarity6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2693, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158926

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_015114_13_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q91W10

Identification of Orthologs from Complete Genome Data

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OMAi
TAIVCEE

Database of Orthologous Groups

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OrthoDBi
657777at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q91W10

TreeFam database of animal gene trees

More...
TreeFami
TF318470

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003689, ZIP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02535, Zip, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q91W10-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPGRAVAGL LLLAATSLGH PSEGPELAFS EDVLSVFGAN RSLSAAQLGR
60 70 80 90 100
LLERLGAASQ QGALDLGQLH FNQCLSAEDI FSLHGFSNVT QITSSNFSAI
110 120 130 140 150
CPAILQQLNF HPCEDLRKHN AKPSLSEVWG YGFLSVTIIN LASLLGLILT
160 170 180 190 200
PLIKKSYFPK ILTYFVGLAI GTLFSNAIFQ LIPEAFGFNP KIDNYVEKAV
210 220 230 240 250
AVFGGFYMLF FVERTLKMLL KTYGQNDHTH FRNDDFGSKE KTHQPKTLPL
260 270 280 290 300
PAVNGVTCYA NPAVTEPNGH IHFDTVSVVS LQDGKTEPSS CTCLKGPKLS
310 320 330 340 350
EIGTIAWMIT LCDALHNFID GLAIGASCTL SLLQGLSTSI AILCEEFPHE
360 370 380 390 400
LGDFVILLNA GMSTRQALLF NFLSACSCYV GLAFGILVGN NFAPNIIFAL
410 420 430 440 450
AGGMFLYISL ADMFPEMNDM LREKVTGRQT DFTFFMIQNA GMLTGFTAIL
460
LITLYAGDIE LQ
Length:462
Mass (Da):50,082
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i52EBA157C295411C
GO
Isoform 2 (identifier: Q91W10-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     283-341: DGKTEPSSCT...LLQGLSTSIA → VCPADCTFLL...LSLWMLRPTK
     342-462: Missing.

Show »
Length:341
Mass (Da):37,465
Checksum:i90633BFE59004E51
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti94S → R in BAC40727 (PubMed:16141072).Curated1
Sequence conflicti98S → C in BAC40727 (PubMed:16141072).Curated1
Sequence conflicti104I → M in BAC40727 (PubMed:16141072).Curated1
Sequence conflicti108L → V in BAC40727 (PubMed:16141072).Curated1
Sequence conflicti113C → W in BAC40727 (PubMed:16141072).Curated1
Sequence conflicti116L → V in BAC40727 (PubMed:16141072).Curated1
Sequence conflicti316H → Y in BAB30465 (PubMed:16141072).Curated1
Sequence conflicti371N → S in BAB29610 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_029886283 – 341DGKTE…STSIA → VCPADCTFLLIFCVIFTIKV AGNAGSQYFKCSHVKPAHLH RRSHFTFFLLSLWMLRPTK in isoform 2. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_029887342 – 462Missing in isoform 2. 1 PublicationAdd BLAST121

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK014895 mRNA Translation: BAB29610.1
AK016853 mRNA Translation: BAB30465.1
AK085740 mRNA Translation: BAC39526.1
AK089060 mRNA Translation: BAC40727.1
BC006731 mRNA Translation: AAH06731.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS17859.1 [Q91W10-1]

NCBI Reference Sequences

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RefSeqi
NP_001128621.1, NM_001135149.1 [Q91W10-1]
NP_001128622.1, NM_001135150.1 [Q91W10-1]
NP_080504.3, NM_026228.5 [Q91W10-1]
XP_006501997.1, XM_006501934.2 [Q91W10-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000029810; ENSMUSP00000029810; ENSMUSG00000053897 [Q91W10-1]
ENSMUST00000081978; ENSMUSP00000080640; ENSMUSG00000053897 [Q91W10-1]
ENSMUST00000167390; ENSMUSP00000128245; ENSMUSG00000053897 [Q91W10-1]
ENSMUST00000180196; ENSMUSP00000136634; ENSMUSG00000053897 [Q91W10-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
67547

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:67547

UCSC genome browser

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UCSCi
uc008rlz.3, mouse [Q91W10-1]
uc008rma.2, mouse [Q91W10-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014895 mRNA Translation: BAB29610.1
AK016853 mRNA Translation: BAB30465.1
AK085740 mRNA Translation: BAC39526.1
AK089060 mRNA Translation: BAC40727.1
BC006731 mRNA Translation: AAH06731.1
CCDSiCCDS17859.1 [Q91W10-1]
RefSeqiNP_001128621.1, NM_001135149.1 [Q91W10-1]
NP_001128622.1, NM_001135150.1 [Q91W10-1]
NP_080504.3, NM_026228.5 [Q91W10-1]
XP_006501997.1, XM_006501934.2 [Q91W10-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080640

Protein family/group databases

TCDBi2.A.5.4.8, the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

PTM databases

PhosphoSitePlusiQ91W10

Proteomic databases

EPDiQ91W10
PaxDbiQ91W10
PeptideAtlasiQ91W10
PRIDEiQ91W10
ProteomicsDBi256685 [Q91W10-1]
256686 [Q91W10-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
45037, 166 antibodies

The DNASU plasmid repository

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DNASUi
67547

Genome annotation databases

EnsembliENSMUST00000029810; ENSMUSP00000029810; ENSMUSG00000053897 [Q91W10-1]
ENSMUST00000081978; ENSMUSP00000080640; ENSMUSG00000053897 [Q91W10-1]
ENSMUST00000167390; ENSMUSP00000128245; ENSMUSG00000053897 [Q91W10-1]
ENSMUST00000180196; ENSMUSP00000136634; ENSMUSG00000053897 [Q91W10-1]
GeneIDi67547
KEGGimmu:67547
UCSCiuc008rlz.3, mouse [Q91W10-1]
uc008rma.2, mouse [Q91W10-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64116
MGIiMGI:1914797, Slc39a8

Phylogenomic databases

eggNOGiKOG2693, Eukaryota
GeneTreeiENSGT00940000158926
HOGENOMiCLU_015114_13_0_1
InParanoidiQ91W10
OMAiTAIVCEE
OrthoDBi657777at2759
PhylomeDBiQ91W10
TreeFamiTF318470

Enzyme and pathway databases

ReactomeiR-MMU-442380, Zinc influx into cells by the SLC39 gene family

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
67547, 1 hit in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Slc39a8, mouse

Protein Ontology

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PROi
PR:Q91W10
RNActiQ91W10, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000053897, Expressed in brain blood vessel and 296 other tissues
GenevisibleiQ91W10, MM

Family and domain databases

InterProiView protein in InterPro
IPR003689, ZIP
PfamiView protein in Pfam
PF02535, Zip, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS39A8_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91W10
Secondary accession number(s): Q8BTQ3
, Q8BUD6, Q9D426, Q9D5V4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 1, 2001
Last modified: June 2, 2021
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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