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Protein

Stromal membrane-associated protein 1

Gene

Smap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri33 – 56C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • clathrin binding Source: MGI
  • GTPase activator activity Source: MGI
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Stromal membrane-associated protein 1
Gene namesi
Name:Smap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2138261 Smap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi61R → Q: Loss of GTPase activation. 1 Publication1
Mutagenesisi192 – 196LLGLD → AAAAA: Loss of interaction with clathrin heavy chains. 1 Publication5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002358391 – 440Stromal membrane-associated protein 1Add BLAST440

Proteomic databases

EPDiQ91VZ6
MaxQBiQ91VZ6
PaxDbiQ91VZ6
PeptideAtlasiQ91VZ6
PRIDEiQ91VZ6

PTM databases

iPTMnetiQ91VZ6
PhosphoSitePlusiQ91VZ6

Expressioni

Tissue specificityi

Detected in adult brain, lung, heart, liver, ovary and bone marrow. Detected in stromal cells of the red pulp of adult spleen.1 Publication

Developmental stagei

Detected in stromal cells of fetal liver at 10.5 days. Expression was maximal after 14 days of development and decreased thereafter. Detected at low levels after 18 days.1 Publication

Gene expression databases

BgeeiENSMUSG00000026155 Expressed in 289 organ(s), highest expression level in blood
CleanExiMM_SMAP1
ExpressionAtlasiQ91VZ6 baseline and differential
GenevisibleiQ91VZ6 MM

Interactioni

Subunit structurei

Interacts with ARF6. Interacts with clathrin heavy chains via the clathrin box-like motif.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Smap2Q7TN294EBI-8317690,EBI-11358641

GO - Molecular functioni

Protein-protein interaction databases

BioGridi221043, 11 interactors
ELMiQ91VZ6
IntActiQ91VZ6, 14 interactors
MINTiQ91VZ6
STRINGi10090.ENSMUSP00000027339

Structurei

3D structure databases

ProteinModelPortaliQ91VZ6
SMRiQ91VZ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 143Arf-GAPPROSITE-ProRule annotationAdd BLAST126

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi192 – 196Interaction with clathrin heavy chains5

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri33 – 56C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0703 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00900000140892
HOGENOMiHOG000230583
HOVERGENiHBG055260
InParanoidiQ91VZ6
KOiK12486
OMAiNNGWSGM
OrthoDBiEOG091G0E7F
PhylomeDBiQ91VZ6
TreeFamiTF313876

Family and domain databases

Gene3Di3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SUPFAMiSSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q91VZ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATRSCREKA QKLNEQHQLI LSKLLREEDN KYCADCEAKG PRWASWNIGV
60 70 80 90 100
FICIRCAGIH RNLGVHISRV KSVNLDQWTP EQIQCMQDMG NTKARLLYEA
110 120 130 140 150
NLPENFRRPQ TDQAVEFFIR DKYEKKKYYD KNAIAITNKE KEKKKDEKKR
160 170 180 190 200
EKEPEKPAKP LTTEKLPKKE EQQLEPKKST SPKNAAEPTI DLLGLDGPAE
210 220 230 240 250
APVTNGNPAT APALSDDLDI FGPMISNPLP AAVMPPAQGT ASVPAPATLS
260 270 280 290 300
TVTSGDLDLF TEQTTKSEEV AKKQLSKDSI LSLYGTGAQQ STPGVFMGPT
310 320 330 340 350
NIPFTSQAPT AFQGFPSMGV PVPAAPGLIG NMMGQNTGMM VGMPMHNGFM
360 370 380 390 400
GNAQTGVMPL PQNVVGPQGG MVGQMGAPQS KFGLPQAQQP QWNLSQMNQQ
410 420 430 440
MAAMNLSSAN ASAGFGQPPS TTAGWSGSSS GQTLSTQLWK
Length:440
Mass (Da):47,660
Last modified:December 1, 2001 - v1
Checksum:iE1852548BAFBC229
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YVX4D3YVX4_MOUSE
Stromal membrane-associated protein...
Smap1 mCG_7897
355Annotation score:

Sequence cautioni

The sequence AAI00538 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC006946 mRNA Translation: AAH06946.1
BC080286 mRNA Translation: AAH80286.1
BC100537 mRNA Translation: AAI00538.1 Sequence problems.
CCDSiCCDS14851.1
RefSeqiNP_001277612.1, NM_001290683.1
NP_082810.1, NM_028534.3
UniGeneiMm.329963

Genome annotation databases

EnsembliENSMUST00000027339; ENSMUSP00000027339; ENSMUSG00000026155
GeneIDi98366
KEGGimmu:98366
UCSCiuc007amg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC006946 mRNA Translation: AAH06946.1
BC080286 mRNA Translation: AAH80286.1
BC100537 mRNA Translation: AAI00538.1 Sequence problems.
CCDSiCCDS14851.1
RefSeqiNP_001277612.1, NM_001290683.1
NP_082810.1, NM_028534.3
UniGeneiMm.329963

3D structure databases

ProteinModelPortaliQ91VZ6
SMRiQ91VZ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221043, 11 interactors
ELMiQ91VZ6
IntActiQ91VZ6, 14 interactors
MINTiQ91VZ6
STRINGi10090.ENSMUSP00000027339

PTM databases

iPTMnetiQ91VZ6
PhosphoSitePlusiQ91VZ6

Proteomic databases

EPDiQ91VZ6
MaxQBiQ91VZ6
PaxDbiQ91VZ6
PeptideAtlasiQ91VZ6
PRIDEiQ91VZ6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027339; ENSMUSP00000027339; ENSMUSG00000026155
GeneIDi98366
KEGGimmu:98366
UCSCiuc007amg.2 mouse

Organism-specific databases

CTDi60682
MGIiMGI:2138261 Smap1

Phylogenomic databases

eggNOGiKOG0703 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00900000140892
HOGENOMiHOG000230583
HOVERGENiHBG055260
InParanoidiQ91VZ6
KOiK12486
OMAiNNGWSGM
OrthoDBiEOG091G0E7F
PhylomeDBiQ91VZ6
TreeFamiTF313876

Miscellaneous databases

PROiPR:Q91VZ6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026155 Expressed in 289 organ(s), highest expression level in blood
CleanExiMM_SMAP1
ExpressionAtlasiQ91VZ6 baseline and differential
GenevisibleiQ91VZ6 MM

Family and domain databases

Gene3Di3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SUPFAMiSSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSMAP1_MOUSE
AccessioniPrimary (citable) accession number: Q91VZ6
Secondary accession number(s): Q497I6, Q68EF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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