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Protein

Cytohesin-interacting protein

Gene

Cytip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cytohesin-interacting protein
Alternative name(s):
Cytohesin-binding protein HE
Short name:
Cbp HE
Pleckstrin homology Sec7 and coiled-coil domains-binding protein
Gene namesi
Name:Cytip
Synonyms:Pscdbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2183535 Cytip

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000970621 – 359Cytohesin-interacting proteinAdd BLAST359

Proteomic databases

EPDiQ91VY6
MaxQBiQ91VY6
PaxDbiQ91VY6
PRIDEiQ91VY6

PTM databases

iPTMnetiQ91VY6
PhosphoSitePlusiQ91VY6

Expressioni

Gene expression databases

BgeeiENSMUSG00000026832 Expressed in 144 organ(s), highest expression level in spleen
GenevisibleiQ91VY6 MM

Interactioni

Subunit structurei

Interacts with CYTH1 and SNX27.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028175

Structurei

3D structure databases

ProteinModelPortaliQ91VY6
SMRiQ91VY6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 166PDZPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 188Interaction with CYTH1By similarityAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili165 – 188Sequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi241 – 323Ser-richAdd BLAST83

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410ITA8 Eukaryota
ENOG4111KMM LUCA
GeneTreeiENSGT00530000063734
HOGENOMiHOG000231871
HOVERGENiHBG053061
InParanoidiQ91VY6
OMAiEGFTHKQ
OrthoDBiEOG091G0NRM
PhylomeDBiQ91VY6
TreeFamiTF316315

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit

Sequencei

Sequence statusi: Complete.

Q91VY6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLQRFLQRQ GSNGNLEYCA DSAYGSYSVL TGQLTMEDNR RIQVLADTVA
60 70 80 90 100
TLPRGRKQLA LARSSSLGDF SWSQRKVVTV EKQDNGTFGF EIQTYRLQNQ
110 120 130 140 150
NICSSEVCTM ICKVQEDSPA HCAGLQVGDI FANVNGVSTE GFTHKQVVDL
160 170 180 190 200
IRSSGNLLTI ETLNGTMIHR RAELEAKLQT LKQTLKKKWV ELRSLHLQEQ
210 220 230 240 250
RLLHGDTANS PNLENMDLDE SSLFGNLLGP SPALLDRHRL SSESSCKSWL
260 270 280 290 300
SSLTVDSEDG YRSSMSEDSI RGAFSRQTST DDECFHSKDG DEILRNASSR
310 320 330 340 350
RNRSISVTSS GSFSPLWESN YSSVFGTLPR KSRRGSVRKQ ILKFIPGLHR

AVEEEESRF
Length:359
Mass (Da):40,143
Last modified:December 1, 2001 - v1
Checksum:i4C922BC8B96B11F7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6F → Q in AAF04842 (PubMed:12909129).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK089364 mRNA Translation: BAC40855.1
AK152784 mRNA Translation: BAE31493.1
AK157859 mRNA Translation: BAE34237.1
AK169575 mRNA Translation: BAE41236.1
AK170544 mRNA Translation: BAE41869.1
AK171467 mRNA Translation: BAE42473.1
AK172071 mRNA Translation: BAE42810.1
AL928564 Genomic DNA No translation available.
BC007144 mRNA Translation: AAH07144.1
AF374273 mRNA Translation: AAL87039.1
AF192525 mRNA Translation: AAF04842.1
CCDSiCCDS16048.1
RefSeqiNP_631939.1, NM_139200.4
XP_006498075.1, XM_006498012.3
XP_006498076.1, XM_006498013.3
UniGeneiMm.273905
Mm.473610

Genome annotation databases

EnsembliENSMUST00000028175; ENSMUSP00000028175; ENSMUSG00000026832
GeneIDi227929
KEGGimmu:227929
UCSCiuc008jsi.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK089364 mRNA Translation: BAC40855.1
AK152784 mRNA Translation: BAE31493.1
AK157859 mRNA Translation: BAE34237.1
AK169575 mRNA Translation: BAE41236.1
AK170544 mRNA Translation: BAE41869.1
AK171467 mRNA Translation: BAE42473.1
AK172071 mRNA Translation: BAE42810.1
AL928564 Genomic DNA No translation available.
BC007144 mRNA Translation: AAH07144.1
AF374273 mRNA Translation: AAL87039.1
AF192525 mRNA Translation: AAF04842.1
CCDSiCCDS16048.1
RefSeqiNP_631939.1, NM_139200.4
XP_006498075.1, XM_006498012.3
XP_006498076.1, XM_006498013.3
UniGeneiMm.273905
Mm.473610

3D structure databases

ProteinModelPortaliQ91VY6
SMRiQ91VY6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028175

PTM databases

iPTMnetiQ91VY6
PhosphoSitePlusiQ91VY6

Proteomic databases

EPDiQ91VY6
MaxQBiQ91VY6
PaxDbiQ91VY6
PRIDEiQ91VY6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028175; ENSMUSP00000028175; ENSMUSG00000026832
GeneIDi227929
KEGGimmu:227929
UCSCiuc008jsi.1 mouse

Organism-specific databases

CTDi9595
MGIiMGI:2183535 Cytip

Phylogenomic databases

eggNOGiENOG410ITA8 Eukaryota
ENOG4111KMM LUCA
GeneTreeiENSGT00530000063734
HOGENOMiHOG000231871
HOVERGENiHBG053061
InParanoidiQ91VY6
OMAiEGFTHKQ
OrthoDBiEOG091G0NRM
PhylomeDBiQ91VY6
TreeFamiTF316315

Miscellaneous databases

ChiTaRSiCytip mouse
PROiPR:Q91VY6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026832 Expressed in 144 organ(s), highest expression level in spleen
GenevisibleiQ91VY6 MM

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYTIP_MOUSE
AccessioniPrimary (citable) accession number: Q91VY6
Secondary accession number(s): A2AS77
, Q3TZH1, Q8R4T4, Q9QZA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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