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Protein

Neurexophilin-3

Gene

Nxph3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins.

GO - Molecular functioni

  • signaling receptor binding Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexophilin-3
Gene namesi
Name:Nxph3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1336188 Nxph3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002006623 – 252Neurexophilin-3Add BLAST230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ91VX5
PRIDEiQ91VX5

PTM databases

iPTMnetiQ91VX5
PhosphoSitePlusiQ91VX5

Expressioni

Tissue specificityi

Highest level in brain, present also in lung, kidney and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000046719 Expressed in 158 organ(s), highest expression level in brain
CleanExiMM_NXPH3
ExpressionAtlasiQ91VX5 baseline and differential
GenevisibleiQ91VX5 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91VX5, 2 interactors
STRINGi10090.ENSMUSP00000058254

Structurei

3D structure databases

ProteinModelPortaliQ91VX5
SMRiQ91VX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 75IIAdd BLAST53
Regioni76 – 157IIIAdd BLAST82
Regioni158 – 166IV (linker domain)9
Regioni167 – 252V (Cys-rich)Add BLAST86

Sequence similaritiesi

Belongs to the neurexophilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IK4V Eukaryota
ENOG410Y975 LUCA
GeneTreeiENSGT00390000015950
HOGENOMiHOG000261694
HOVERGENiHBG052706
InParanoidiQ91VX5
KOiK16658
OMAiCSRDHSQ
OrthoDBiEOG091G0GC5
PhylomeDBiQ91VX5
TreeFamiTF333047

Family and domain databases

InterProiView protein in InterPro
IPR010450 Nxph
IPR026845 NXPH/NXPE
PANTHERiPTHR17103 PTHR17103, 1 hit
PfamiView protein in Pfam
PF06312 Neurexophilin, 1 hit
PIRSFiPIRSF038019 Neurexophilin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91VX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLTRCCFVF LVQGSLYLVI CGQDDGPPGS EDPEHDDHEG QPRPRVPRKR
60 70 80 90 100
GHISPKSRPL ANSTLLGLLA PPGEVWGVLG QPPNRPKQSP LPSTKVKKIF
110 120 130 140 150
GWGDFYSNIK TVALNLLVTG KIVDHGNGTF SVHFRHNATG QGNISISLVP
160 170 180 190 200
PSKAVEFHQE QQIFIEAKAS KIFNCRMEWE KVERGRRTSL CTHDPAKICS
210 220 230 240 250
RDHAQSSATW SCSQPFKVVC VYIAFYSTDY RLVQKVCPDY NYHSDTPYYP

SG
Length:252
Mass (Da):28,183
Last modified:December 1, 2001 - v1
Checksum:iA770645706435A7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007167 mRNA Translation: AAH07167.1
CCDSiCCDS25278.1
RefSeqiNP_570928.1, NM_130858.3
UniGeneiMm.22970

Genome annotation databases

EnsembliENSMUST00000058866; ENSMUSP00000058254; ENSMUSG00000046719
GeneIDi104079
KEGGimmu:104079
UCSCiuc007lal.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007167 mRNA Translation: AAH07167.1
CCDSiCCDS25278.1
RefSeqiNP_570928.1, NM_130858.3
UniGeneiMm.22970

3D structure databases

ProteinModelPortaliQ91VX5
SMRiQ91VX5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91VX5, 2 interactors
STRINGi10090.ENSMUSP00000058254

PTM databases

iPTMnetiQ91VX5
PhosphoSitePlusiQ91VX5

Proteomic databases

PaxDbiQ91VX5
PRIDEiQ91VX5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058866; ENSMUSP00000058254; ENSMUSG00000046719
GeneIDi104079
KEGGimmu:104079
UCSCiuc007lal.1 mouse

Organism-specific databases

CTDi11248
MGIiMGI:1336188 Nxph3

Phylogenomic databases

eggNOGiENOG410IK4V Eukaryota
ENOG410Y975 LUCA
GeneTreeiENSGT00390000015950
HOGENOMiHOG000261694
HOVERGENiHBG052706
InParanoidiQ91VX5
KOiK16658
OMAiCSRDHSQ
OrthoDBiEOG091G0GC5
PhylomeDBiQ91VX5
TreeFamiTF333047

Miscellaneous databases

PROiPR:Q91VX5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046719 Expressed in 158 organ(s), highest expression level in brain
CleanExiMM_NXPH3
ExpressionAtlasiQ91VX5 baseline and differential
GenevisibleiQ91VX5 MM

Family and domain databases

InterProiView protein in InterPro
IPR010450 Nxph
IPR026845 NXPH/NXPE
PANTHERiPTHR17103 PTHR17103, 1 hit
PfamiView protein in Pfam
PF06312 Neurexophilin, 1 hit
PIRSFiPIRSF038019 Neurexophilin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNXPH3_MOUSE
AccessioniPrimary (citable) accession number: Q91VX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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