UniProtKB - Q91VW9 (ZKSC3_MOUSE)

BLAST

>sp|Q91VW9|ZKSC3_MOUSE Zinc finger protein with KRAB and SCAN domains 3 OS=Mus musculus OX=10090 GN=Zkscan3 PE=1 SV=1
MARESRESTTLDSHSAEDQMELLVIKVEQEESSPLAEETSWLGSPGPDRSRQRFRAFRYP
EAAGPRQALSRLRELCRQWLRPDMHSKEQILELLVLEQFLTILPGELQAWVREQHPDSGE
EVVALLEYLDRQLDDTPPQVPDDDDGQELLCSKAVLLTSAQGSESSQMEPVEPLLKQESL
GSLPSEVRVTHVGHCGEDGVTATRLTSELQGLLKMEDVAPVLSPRWTEQDSSQMNLYKDG
MQEHSGSLVSLDQDMQTKVRDLPRAEEYRDQKPEQTVCFLGEDTVPIPTGAEASEQEGKL
QAAQKSATGTRRFYCRECGKSFAQSSGLSKHKRIHTGLKPYECEECGKAFIGSSALIIHQ
RVHTGEKPYECEECGKAFSHSSDLIKHQRTHTGEKPYECDDCGKTFTQSCSLLEHHRIHT
GEKPYQCNMCPKAFRRSSHLLRHQRTHTGDKDFFVPEPYWESQSRVESHWENIETPVSYQ
CNDCERSFSRITSLIEHQKVHTGEKPFECQTCGKGFTRPSYLIQHQRRHTGKKTSVTVTP
AVHSEVGVQLSLN

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History
Entry version 143 (07 Nov 2018)
Sequence version 1 (01 Dec 2001)
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Protein

Zinc finger protein with KRAB and SCAN domains 3

Gene

Zkscan3

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	313 – 335	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	341 – 363	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	369 – 391	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	397 – 419	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	425 – 447	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	479 – 501	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	507 – 529	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

chromatin binding Source: UniProtKB
DNA binding Source: UniProtKB
DNA-binding transcription factor activity Source: UniProtKB
metal ion binding Source: UniProtKB-KW
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI
sequence-specific DNA binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

autophagy Source: UniProtKB-KW
lysosome organization Source: UniProtKB
negative regulation of autophagy Source: UniProtKB
negative regulation of cellular senescence Source: UniProtKB
negative regulation of transcription, DNA-templated Source: UniProtKB
negative regulation of transcription by RNA polymerase II Source: MGI
positive regulation of transcription, DNA-templated Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Autophagy, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein with KRAB and SCAN domains 3 Alternative name(s): SCAN-KRAB-zinc finger protein Zinc finger protein 306 Zinc finger protein 307 Zinc finger protein 47 homolog Short name: Zf47 Short name: Zfp-47
Gene namesⁱ	Name:Zkscan3 Synonyms:Skz1, Zfp306, Zfp307, Zfp47
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:1919989 Zkscan3

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000394861	1 – 553	Zinc finger protein with KRAB and SCAN domains 3Add BLAST		553

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	33	PhosphoserineCombined sources	1
Modified residueⁱ	44	PhosphoserineCombined sources	1
Modified residueⁱ	136	PhosphothreonineCombined sources	1
Cross-linkⁱ	176	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	206	PhosphothreonineBy similarity	1
Modified residueⁱ	223	PhosphoserineCombined sources	1
Modified residueⁱ	448	PhosphothreonineBy similarity	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q91VW9
PaxDbⁱ	Q91VW9
PRIDEⁱ	Q91VW9

PTM databases

iPTMnetⁱ	Q91VW9
PhosphoSitePlusⁱ	Q91VW9

Expressionⁱ

Tissue specificityⁱ

Expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.1 Publication

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000068424

STRINGⁱ

10090.ENSMUSP00000068424

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q91VW9
SMRⁱ	Q91VW9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	51 – 133	SCAN boxPROSITE-ProRule annotationAdd BLAST		83
Domainⁱ	213 – 273	KRABAdd BLAST		61

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	313 – 335	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	341 – 363	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	369 – 391	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	397 – 419	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	425 – 447	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	479 – 501	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	507 – 529	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
HOGENOMⁱ	HOG000234619
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q91VW9
KEGG Orthology (KO) More...KOⁱ	K09229
PhylomeDBⁱ	Q91VW9
TreeFamⁱ	TF350830

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07765 KRAB_A-box, 1 hit cd07936 SCAN, 1 hit
Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR003309 SCAN_dom IPR038269 SCAN_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF02023 SCAN, 1 hit PF00096 zf-C2H2, 7 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 7 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

Q91VW9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MARESRESTT LDSHSAEDQM ELLVIKVEQE ESSPLAEETS WLGSPGPDRS 
        60         70         80         90        100
RQRFRAFRYP EAAGPRQALS RLRELCRQWL RPDMHSKEQI LELLVLEQFL 
       110        120        130        140        150
TILPGELQAW VREQHPDSGE EVVALLEYLD RQLDDTPPQV PDDDDGQELL 
       160        170        180        190        200
CSKAVLLTSA QGSESSQMEP VEPLLKQESL GSLPSEVRVT HVGHCGEDGV 
       210        220        230        240        250
TATRLTSELQ GLLKMEDVAP VLSPRWTEQD SSQMNLYKDG MQEHSGSLVS 
       260        270        280        290        300
LDQDMQTKVR DLPRAEEYRD QKPEQTVCFL GEDTVPIPTG AEASEQEGKL 
       310        320        330        340        350
QAAQKSATGT RRFYCRECGK SFAQSSGLSK HKRIHTGLKP YECEECGKAF 
       360        370        380        390        400
IGSSALIIHQ RVHTGEKPYE CEECGKAFSH SSDLIKHQRT HTGEKPYECD 
       410        420        430        440        450
DCGKTFTQSC SLLEHHRIHT GEKPYQCNMC PKAFRRSSHL LRHQRTHTGD 
       460        470        480        490        500
KDFFVPEPYW ESQSRVESHW ENIETPVSYQ CNDCERSFSR ITSLIEHQKV 
       510        520        530        540        550
HTGEKPFECQ TCGKGFTRPS YLIQHQRRHT GKKTSVTVTP AVHSEVGVQL 

SLN

Length:553

Mass (Da):62,642

Last modified:December 1, 2001 - v1

Checksum:ⁱ53B41483D21AC3C8

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0R4J1L3	A0A0R4J1L3_MOUSE	Zinc finger protein with KRAB and S... Zinc finger protein with KRAB and SCAN domains 3	Zkscan3	553	Annotation score:
A0A286YD32	A0A286YD32_MOUSE	Zinc finger protein with KRAB and S... Zinc finger protein with KRAB and SCAN domains 3	Zkscan3	386	Annotation score:
D3YTV4	D3YTV4_MOUSE	Zinc finger protein with KRAB and S... Zinc finger protein with KRAB and SCAN domains 3	Zkscan3	257	Annotation score:
Q5RJ53	Q5RJ53_MOUSE	Zinc finger protein with KRAB and S... Zinc finger protein with KRAB and SCAN domains 3	Zkscan3	298	Annotation score:
A0A286YDF9	A0A286YDF9_MOUSE	Zinc finger protein with KRAB and S... Zinc finger protein with KRAB and SCAN domains 3	Zkscan3	281	Annotation score:

Sequence cautionⁱ

The sequence AAG00602 differs from that shown. Reason: Frameshift at positions 421 and 432.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	32	S → A in BAC27333 (PubMed:16141072).Curated	1
Sequence conflictⁱ	32	S → A in BAE20446 (PubMed:16141072).Curated	1
Sequence conflictⁱ	62	A → T in AAG00602 (PubMed:11342224).Curated	1
Sequence conflictⁱ	67	Q → R in BAE20446 (PubMed:16141072).Curated	1
Sequence conflictⁱ	538	V → M in AAG00602 (PubMed:11342224).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF291722 mRNA Translation: AAG00602.1 Frameshift. AK028902 mRNA Translation: BAE20446.1 AK031286 mRNA Translation: BAC27333.1 CH466561 Genomic DNA Translation: EDL32657.1 CH466561 Genomic DNA Translation: EDL32658.1 CH466561 Genomic DNA Translation: EDL32661.1 BC007473 mRNA Translation: AAH07473.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS26274.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001139250.1, NM_001145778.1 NP_076174.3, NM_023685.4 XP_006516852.1, XM_006516789.3 XP_006516853.1, XM_006516790.3
UniGeneⁱ	Mm.296071

Genome annotation databases

GeneIDⁱ	72739
KEGGⁱ	mmu:72739
UCSC genome browser More...UCSCⁱ	uc007pqg.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q91VW9	Uncharacterized protein (Fragment)		MOUSE		288	UniRef100_Q91VW9
Zinc finger protein with KRAB and SCAN domains 3		MOUSE		386
UPI0003D717B5		MOUSE		299

Protein	Similar proteins		Species	Score	Length	Source
Q91VW9	Uncharacterized protein (Fragment)		MOUSE		288	UniRef90_Q91VW9
Zinc finger with KRAB and SCAN domains 3		RAT		554
Zinc finger protein with KRAB and SCAN domain 3		CRIGR		553
UPI00042A9E0C		PERMB		553
UPI000A3194AA		MUSCR		553
+7

Protein	Similar proteins		Species	Score	Length	Source
Q91VW9	Zinc finger protein with KRAB and SCAN domains 3		HUMAN		538	UniRef50_Q9BRR0
Uncharacterized protein		CHLSB		538
Uncharacterized protein		MANLE		538
Uncharacterized protein		CERAT		538
Uncharacterized protein		RHIRO		538
+252

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF291722 mRNA Translation: AAG00602.1 Frameshift. AK028902 mRNA Translation: BAE20446.1 AK031286 mRNA Translation: BAC27333.1 CH466561 Genomic DNA Translation: EDL32657.1 CH466561 Genomic DNA Translation: EDL32658.1 CH466561 Genomic DNA Translation: EDL32661.1 BC007473 mRNA Translation: AAH07473.1
CCDSⁱ	CCDS26274.1
RefSeqⁱ	NP_001139250.1, NM_001145778.1 NP_076174.3, NM_023685.4 XP_006516852.1, XM_006516789.3 XP_006516853.1, XM_006516790.3
UniGeneⁱ	Mm.296071

3D structure databases

ProteinModelPortalⁱ	Q91VW9
SMRⁱ	Q91VW9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000068424

STRINGⁱ

10090.ENSMUSP00000068424

PTM databases

iPTMnetⁱ	Q91VW9
PhosphoSitePlusⁱ	Q91VW9

Proteomic databases

MaxQBⁱ	Q91VW9
PaxDbⁱ	Q91VW9
PRIDEⁱ	Q91VW9

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	72739
KEGGⁱ	mmu:72739
UCSCⁱ	uc007pqg.2 mouse

Organism-specific databases

CTDⁱ	80317
MGIⁱ	MGI:1919989 Zkscan3

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
HOGENOMⁱ	HOG000234619
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q91VW9
KOⁱ	K09229
PhylomeDBⁱ	Q91VW9
TreeFamⁱ	TF350830

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q91VW9
SOURCEⁱ	Search...

Family and domain databases

CDDⁱ	cd07765 KRAB_A-box, 1 hit cd07936 SCAN, 1 hit
Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR003309 SCAN_dom IPR038269 SCAN_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF02023 SCAN, 1 hit PF00096 zf-C2H2, 7 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 7 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 7 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZKSC3_MOUSE
Accessionⁱ	Q91VW9Primary (citable) accession number: Q91VW9 Secondary accession number(s): Q3V3Z2, Q8CD81, Q9ESY5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 15, 2010
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q91VW9 (ZKSC3_MOUSE)

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Zinc finger protein with KRAB and SCAN domains 3

Zkscan3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ