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Protein

Golgin subfamily A member 4

Gene

Golga4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 4
Alternative name(s):
tGolgin-1
Gene namesi
Name:Golga4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1859646 Golga4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900601 – 2238Golgin subfamily A member 4Add BLAST2238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineBy similarity1
Modified residuei39PhosphothreonineCombined sources1
Modified residuei41PhosphoserineBy similarity1
Modified residuei93PhosphoserineBy similarity1
Modified residuei100PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ91VW5
MaxQBiQ91VW5
PaxDbiQ91VW5
PeptideAtlasiQ91VW5
PRIDEiQ91VW5

PTM databases

iPTMnetiQ91VW5
PhosphoSitePlusiQ91VW5

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in oligodendrocyte precursors, particularly at a stage just prior to myelination.1 Publication

Gene expression databases

BgeeiENSMUSG00000038708 Expressed in 313 organ(s), highest expression level in soleus muscle
CleanExiMM_GOLGA4
ExpressionAtlasiQ91VW5 baseline and differential
GenevisibleiQ91VW5 MM

Interactioni

Subunit structurei

Homodimer. Interacts with GTP-bound ARL1 and ARL3 (By similarity). Interacts with MACF1 (By similarity). Directly interacts with TBC1D23 (PubMed:29084197). Interacts with FAM91A1; this interaction may mediated by TBC1D23 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207604, 2 interactors
IntActiQ91VW5, 3 interactors
STRINGi10090.ENSMUSP00000081880

Structurei

3D structure databases

ProteinModelPortaliQ91VW5
SMRiQ91VW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2178 – 2225GRIPPROSITE-ProRule annotationAdd BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni154 – 224Interaction with MACF1By similarityAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili156 – 2161Sequence analysisAdd BLAST2006

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi335 – 1011Glu-richAdd BLAST677
Compositional biasi1855 – 2107Glu-richAdd BLAST253

Domaini

Extended rod-like protein with coiled-coil domains.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEA5 Eukaryota
ENOG410XQQG LUCA
GeneTreeiENSGT00730000111139
HOGENOMiHOG000112753
HOVERGENiHBG051754
InParanoidiQ91VW5
KOiK20283
OrthoDBiEOG091G009M
PhylomeDBiQ91VW5
TreeFamiTF325082

Family and domain databases

InterProiView protein in InterPro
IPR040071 GOLGA4
IPR000237 GRIP_dom
PANTHERiPTHR19327 PTHR19327, 2 hits
PfamiView protein in Pfam
PF01465 GRIP, 1 hit
SMARTiView protein in SMART
SM00755 Grip, 1 hit
PROSITEiView protein in PROSITE
PS50913 GRIP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q91VW5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFKKLKQKIS EEQQQLQQAL APAQASSSSS TPTRTRSRTS SFTDQLDDVT
60 70 80 90 100
PNRENASTQA TKSPDGVSKD ESSPSQSGDT QTFAQKLQLR VPSMESLFRS
110 120 130 140 150
PIKESLFRSS KEPLVRTSSR ESLNQLDLDC SAAAFDPPSD MESEAEDAPW
160 170 180 190 200
NSDGLSREQL LQRLRRMERS LSSYRGKYSE LVTAFQTLQR EKKKLQGILS
210 220 230 240 250
QSQDKSLRRI SELREELQMD QQAKKHLQDE FDACLEEKDQ YISVLQTQVS
260 270 280 290 300
LLKQRLQNGP MNVDAPKPLP PGELQAEVHG DTEKMEGVGE PVGGGTSAKT
310 320 330 340 350
LEMLQQRVKR QENLLQRCKE TIGSHKEQCA LLLSEKEALQ EQLDERLQEL
360 370 380 390 400
EKMKELHMAE KTKLITQLRD AKNLIEQLEQ DKGMVITETK RQMLETLELK
410 420 430 440 450
EDEIAQLRSH IKQMTTQGEE LREQKEKSER AAFEELEKAL STAQKTEDAQ
460 470 480 490 500
RRMKMEMDEQ MKAVERASEE ERLRLQHELS RVRQEAASMA KKNSEEQVAA
510 520 530 540 550
LQKLHAEELA SKEQELSRRL EARERELQEQ MRIALEKSRS EYLKLTQEKE
560 570 580 590 600
QQESLALEEL ELQKKAILTE SENKLQELGQ EAEAYRTRIL ELETSLEKSL
610 620 630 640 650
QESKTQSEHL AVHLEAEKNK HNKELTALAE QHRTEVEGLQ QQQDSLWTER
660 670 680 690 700
LQSLSQQHQA AVEELREKYQ QEKDALLKEK ESLFQAHIQD MNEKTLEKLD
710 720 730 740 750
KKQMELESVS SELSEALRAR DQLAEELSVL RGDADKMKQA LEAELEEQRR
760 770 780 790 800
HHQREVGSIS EQQELTVRRA EKALKDELSR LGALLDERDE HLRERQARVQ
810 820 830 840 850
DLEAHLQKSA GELQQALAKL DLLHSEQSAA REQAGAYEEQ LAQMQQKVLD
860 870 880 890 900
LETEKSLLTK QVVEMETHKK HVCEELDAQR AQVQQLERQR SELEEKVRSL
910 920 930 940 950
AQLQDSQLKN STVEKEQARQ SLMEKENIIL QMREEQAKEI EILKQTLSSK
960 970 980 990 1000
EESISILHEE YETKFKNQEK RMEKIKQKAK EMQETKKKLL DQEAKLKKEL
1010 1020 1030 1040 1050
ENTVLELSQK EKQFNAQILE MAQANSAGIS DTVSRLEENQ RQQIESLTGA
1060 1070 1080 1090 1100
HQRKLDDVIE AWEKKLSQQA AELRDKHAEQ MEEKEQGLGE LRQKVRIVQS
1110 1120 1130 1140 1150
EKEELTKEVA RLKEAVSGQD VALAGLQGQL EQKSAVIVSL SERESQLQSQ
1160 1170 1180 1190 1200
VEKLEADLGC SLSEKLSLQE ELAELKLLAD KSQLRVSELT GQVQAAEKEL
1210 1220 1230 1240 1250
QSCKSLHELS KKSLEDKSLN LKSLLEELAS QLDSRCERTK ALLEAKTNEL
1260 1270 1280 1290 1300
VCTSRDKADA ILARLSQCQR HTATVGEALL RRMGQVSELE AQLTQLTEEQ
1310 1320 1330 1340 1350
RTLKSSFQQV TNQLEEKEKQ IKTMKADIEG LLTEKEALQQ EGGQQRQAAS
1360 1370 1380 1390 1400
EKESCITQLK KELAENINAV TLLREELSEK KSEIASLSKQ LSDLGAQLES
1410 1420 1430 1440 1450
SISPSDKAEA ISALSKQHEE QELQLQAQLQ ELSLKVDALS KEKMSALEQV
1460 1470 1480 1490 1500
DHWSNKFSEW KKKAQSRLAQ HQSTIKDLQA QLDVKATDAR EKEEQICLLK
1510 1520 1530 1540 1550
EDLDRQNKKF ECLKGEMEVR KSKMEKKECD LETALKTQTA RVVELEDCVT
1560 1570 1580 1590 1600
QRKKEVESLN ETLKNYNQQR DTEHSGLVQR LQHLEELGEE KDNKVREAEE
1610 1620 1630 1640 1650
TVLRLREHVS SLEAELGTVK KELEHVNSSV KSRDGELKAL EDKLELESAA
1660 1670 1680 1690 1700
KVELKRKAEQ KIAAIRKQLL SQMEEKTQRY AKDTENRLSE LSAQLKEREK
1710 1720 1730 1740 1750
QVHSLEDKLK NLESSPHPEV PAVSRSMQSV AASPEQEAPD SQDCTHKACK
1760 1770 1780 1790 1800
ERLCMLQRRL SEKEKLLRRL EQGEGEARPS QPEAQHRALS GKLDCTRARQ
1810 1820 1830 1840 1850
LEDHVLIGCL PEELEEKMKC SLIVSQPMGE ETGNNTGVKQ NWASVVDSVQ
1860 1870 1880 1890 1900
KTLQEKELTC QALEQRVKEL ESDLVRERGA HRLEVEKLTL KYEKSQSSQQ
1910 1920 1930 1940 1950
EMDGENKCVE VLEDRPEENS QSHEIQSNVG TVDGLRSDLE SKLTGAERDK
1960 1970 1980 1990 2000
QKLSKEVARL QKELRALRRE HQQELDILKR ECEQEAEEKL KQEQEDLELK
2010 2020 2030 2040 2050
HTSTLKQLMR EFNTQLAQKE QELERTVQET IDKAQEVEAE LLESHQEETQ
2060 2070 2080 2090 2100
QLHRKIAEKE DDLRRTARRY EEILDAREEE MTGKVTDLQT QLEELQKKYQ
2110 2120 2130 2140 2150
QRLEQEESTK DSVTILELQT QLAQKTTLIS DSKLKEQELR EQVHNLEDRL
2160 2170 2180 2190 2200
KRYEKNACAA TVGTPYKGGN LYHTEVSLFG EPTEFEYLRK VMFEYMMGRE
2210 2220 2230
TKTMAKVITT VLKFPDDQAQ KILEREDARL MSWLRTSS
Length:2,238
Mass (Da):257,564
Last modified:July 3, 2003 - v2
Checksum:i494EA2C111F0165B
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RLV4A0A1D5RLV4_MOUSE
Golgin subfamily A member 4
Golga4
1,251Annotation score:
A0A1D5RME8A0A1D5RME8_MOUSE
Golgin subfamily A member 4
Golga4
941Annotation score:
A0A1D5RL95A0A1D5RL95_MOUSE
Golgin subfamily A member 4
Golga4
118Annotation score:
A0A1D5RLC6A0A1D5RLC6_MOUSE
Golgin subfamily A member 4
Golga4
454Annotation score:
A0A1D5RLH4A0A1D5RLH4_MOUSE
Golgin subfamily A member 4
Golga4
131Annotation score:
A0A1D5RM19A0A1D5RM19_MOUSE
Golgin subfamily A member 4
Golga4
111Annotation score:

Sequence cautioni

The sequence AAH37641 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti61T → R in strain: Czech II. 1 Publication1
Natural varianti280G → S in strain: Czech II. 1 Publication1
Natural varianti293G → E in strain: Czech II. 1 Publication1
Natural varianti638G → S in strain: Czech II. 1 Publication1
Natural varianti819K → T in strain: Czech II. 1 Publication1
Natural varianti829A → T in strain: Czech II. 1 Publication1
Natural varianti859T → A in strain: Czech II. 1 Publication1
Natural varianti2065R → S in strain: C57BL/6. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051357 mRNA Translation: AAC05573.2
BC007485 mRNA Translation: AAH07485.1
BC037641 mRNA Translation: AAH37641.1 Different initiation.
BC053000 mRNA Translation: AAH53000.1
CCDSiCCDS40801.1
PIRiT14265
RefSeqiNP_061218.2, NM_018748.3
UniGeneiMm.10409

Genome annotation databases

EnsembliENSMUST00000084820; ENSMUSP00000081880; ENSMUSG00000038708
GeneIDi54214
KEGGimmu:54214
UCSCiuc009rzs.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051357 mRNA Translation: AAC05573.2
BC007485 mRNA Translation: AAH07485.1
BC037641 mRNA Translation: AAH37641.1 Different initiation.
BC053000 mRNA Translation: AAH53000.1
CCDSiCCDS40801.1
PIRiT14265
RefSeqiNP_061218.2, NM_018748.3
UniGeneiMm.10409

3D structure databases

ProteinModelPortaliQ91VW5
SMRiQ91VW5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207604, 2 interactors
IntActiQ91VW5, 3 interactors
STRINGi10090.ENSMUSP00000081880

PTM databases

iPTMnetiQ91VW5
PhosphoSitePlusiQ91VW5

Proteomic databases

EPDiQ91VW5
MaxQBiQ91VW5
PaxDbiQ91VW5
PeptideAtlasiQ91VW5
PRIDEiQ91VW5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084820; ENSMUSP00000081880; ENSMUSG00000038708
GeneIDi54214
KEGGimmu:54214
UCSCiuc009rzs.1 mouse

Organism-specific databases

CTDi2803
MGIiMGI:1859646 Golga4

Phylogenomic databases

eggNOGiENOG410IEA5 Eukaryota
ENOG410XQQG LUCA
GeneTreeiENSGT00730000111139
HOGENOMiHOG000112753
HOVERGENiHBG051754
InParanoidiQ91VW5
KOiK20283
OrthoDBiEOG091G009M
PhylomeDBiQ91VW5
TreeFamiTF325082

Enzyme and pathway databases

ReactomeiR-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

PROiPR:Q91VW5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038708 Expressed in 313 organ(s), highest expression level in soleus muscle
CleanExiMM_GOLGA4
ExpressionAtlasiQ91VW5 baseline and differential
GenevisibleiQ91VW5 MM

Family and domain databases

InterProiView protein in InterPro
IPR040071 GOLGA4
IPR000237 GRIP_dom
PANTHERiPTHR19327 PTHR19327, 2 hits
PfamiView protein in Pfam
PF01465 GRIP, 1 hit
SMARTiView protein in SMART
SM00755 Grip, 1 hit
PROSITEiView protein in PROSITE
PS50913 GRIP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGOGA4_MOUSE
AccessioniPrimary (citable) accession number: Q91VW5
Secondary accession number(s): O70365, Q8CGH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: July 3, 2003
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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