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Protein

SH3 domain-binding glutamic acid-rich-like protein 3

Gene

Sh3bgrl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could act as a modulator of glutaredoxin biological activity.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-binding glutamic acid-rich-like protein 3
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1920973 Sh3bgrl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002207502 – 93SH3 domain-binding glutamic acid-rich-like protein 3Add BLAST92

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ91VW3
MaxQBiQ91VW3
PaxDbiQ91VW3
PeptideAtlasiQ91VW3
PRIDEiQ91VW3

PTM databases

iPTMnetiQ91VW3
PhosphoSitePlusiQ91VW3

Expressioni

Gene expression databases

BgeeiENSMUSG00000028843 Expressed in 274 organ(s), highest expression level in blood
ExpressionAtlasiQ91VW3 baseline and differential
GenevisibleiQ91VW3 MM

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi216213, 1 interactor
IntActiQ91VW3, 3 interactors
MINTiQ91VW3
STRINGi10090.ENSMUSP00000030651

Structurei

Secondary structure

193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ91VW3
SMRiQ91VW3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ91VW3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 93GlutaredoxinPROSITE-ProRule annotationAdd BLAST92

Sequence similaritiesi

Belongs to the SH3BGR family.Curated

Phylogenomic databases

eggNOGiKOG4023 Eukaryota
ENOG4111N7M LUCA
GeneTreeiENSGT00440000039098
HOGENOMiHOG000095212
HOVERGENiHBG054781
InParanoidiQ91VW3
OMAiYCGNYEM
OrthoDBiEOG091G10PC
PhylomeDBiQ91VW3
TreeFamiTF105574

Family and domain databases

CDDicd03030 GRX_SH3BGR, 1 hit
InterProiView protein in InterPro
IPR006993 Glut_rich_SH3-bd
IPR002109 Glutaredoxin
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF04908 SH3BGR, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51354 GLUTAREDOXIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q91VW3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGLRVYSTS VTGSREIKSQ QSEVTRILDG KRIQYQLVDI SQDNALRDEM
60 70 80 90
RTLAGNPKAT PPQIVNGNHY CGDYELFVEA VEQDTLQEFL KLA
Length:93
Mass (Da):10,477
Last modified:December 1, 2001 - v1
Checksum:iDB89688F0C5B82CC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I7HPY0I7HPY0_MOUSE
SH3 domain-binding glutamic acid-ri...
Sh3bgrl3
37Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003431 mRNA Translation: BAC25034.1
BC008110 mRNA Translation: AAH08110.1
CCDSiCCDS38910.1
RefSeqiNP_542126.1, NM_080559.1
UniGeneiMm.22240

Genome annotation databases

EnsembliENSMUST00000030651; ENSMUSP00000030651; ENSMUSG00000028843
GeneIDi73723
KEGGimmu:73723
UCSCiuc008vec.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003431 mRNA Translation: BAC25034.1
BC008110 mRNA Translation: AAH08110.1
CCDSiCCDS38910.1
RefSeqiNP_542126.1, NM_080559.1
UniGeneiMm.22240

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J0FNMR-A1-93[»]
1T1VX-ray1.60A/B1-93[»]
ProteinModelPortaliQ91VW3
SMRiQ91VW3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216213, 1 interactor
IntActiQ91VW3, 3 interactors
MINTiQ91VW3
STRINGi10090.ENSMUSP00000030651

PTM databases

iPTMnetiQ91VW3
PhosphoSitePlusiQ91VW3

Proteomic databases

EPDiQ91VW3
MaxQBiQ91VW3
PaxDbiQ91VW3
PeptideAtlasiQ91VW3
PRIDEiQ91VW3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030651; ENSMUSP00000030651; ENSMUSG00000028843
GeneIDi73723
KEGGimmu:73723
UCSCiuc008vec.1 mouse

Organism-specific databases

CTDi83442
MGIiMGI:1920973 Sh3bgrl3

Phylogenomic databases

eggNOGiKOG4023 Eukaryota
ENOG4111N7M LUCA
GeneTreeiENSGT00440000039098
HOGENOMiHOG000095212
HOVERGENiHBG054781
InParanoidiQ91VW3
OMAiYCGNYEM
OrthoDBiEOG091G10PC
PhylomeDBiQ91VW3
TreeFamiTF105574

Miscellaneous databases

EvolutionaryTraceiQ91VW3
PROiPR:Q91VW3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028843 Expressed in 274 organ(s), highest expression level in blood
ExpressionAtlasiQ91VW3 baseline and differential
GenevisibleiQ91VW3 MM

Family and domain databases

CDDicd03030 GRX_SH3BGR, 1 hit
InterProiView protein in InterPro
IPR006993 Glut_rich_SH3-bd
IPR002109 Glutaredoxin
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF04908 SH3BGR, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51354 GLUTAREDOXIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSH3L3_MOUSE
AccessioniPrimary (citable) accession number: Q91VW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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