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Protein

Prostate tumor-overexpressed gene 1 protein homolog

Gene

Ptov1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation (By similarity).By similarity

Caution

Despite sequence similarity to MED25, to date this protein has not been identified as a component of the Mediator complex.Curated

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Prostate tumor-overexpressed gene 1 protein homolog
Gene namesi
Name:Ptov1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1933946 Ptov1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003049661 – 416Prostate tumor-overexpressed gene 1 protein homologAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91VU8
PaxDbiQ91VU8
PeptideAtlasiQ91VU8
PRIDEiQ91VU8

PTM databases

iPTMnetiQ91VU8
PhosphoSitePlusiQ91VU8

Expressioni

Gene expression databases

BgeeiENSMUSG00000038502 Expressed in 305 organ(s), highest expression level in cerebral cortex
CleanExiMM_PTOV1
ExpressionAtlasiQ91VU8 baseline and differential
GenevisibleiQ91VU8 MM

Interactioni

Subunit structurei

May interact with CREBBP. Interacts with FLOT1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi220005, 1 interactor
IntActiQ91VU8, 1 interactor
MINTiQ91VU8
STRINGi10090.ENSMUSP00000035281

Structurei

3D structure databases

ProteinModelPortaliQ91VU8
SMRiQ91VU8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni184 – 416Interaction with FLOT1By similarityAdd BLAST233

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IHD9 Eukaryota
ENOG410Z0HI LUCA
GeneTreeiENSGT00520000055653
HOGENOMiHOG000115777
HOVERGENiHBG108306
InParanoidiQ91VU8
OMAiELDCLTH
OrthoDBiEOG091G04LS
PhylomeDBiQ91VU8
TreeFamiTF329598

Family and domain databases

Gene3Di2.40.290.30, 2 hits
InterProiView protein in InterPro
IPR021394 Med25_PTOV
IPR038196 PTOV_dom_sf
PfamiView protein in Pfam
PF11232 Med25, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q91VU8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRPRRAPHR SGAGGPLGGR GRPPRPLVVR AVRSRSWPGG PRGPQPPRIR
60 70 80 90 100
ARSAPPMEGA RVFGALGPIG PSSPGLTLGG LAVNEHRLSN KLLAWSGVLE
110 120 130 140 150
WQEKRRPFSD STAKLKRTLP CQAYVNQGEN LETDQWPQKL IMQLIPQQLL
160 170 180 190 200
TTLGPLFRNS QLAQFHFTNR DCDSLKGLCR IMGNGFAGCM LFPHISPCEV
210 220 230 240 250
RVLMLLYSSK KKIFMGLIPY DQSGFVNAIR QVITTRKQAV GPGGVHSGPV
260 270 280 290 300
QIVNNKFLAW SGVMEWQEPR PEPNSRSKRW LPSHVYVNQG EILRTDQWPR
310 320 330 340 350
RLFMQLIPQQ LLTTLVPLFR NSRLVQFHFT KDMETLKSLC RIMDNGFAGC
360 370 380 390 400
VHFSYKASCE VRVLMLLYSS EKKIFIGLIP HDQSNFVNGI RRVIANQQQV
410
LQRSLEQEQQ QRGMGG
Length:416
Mass (Da):46,865
Last modified:December 1, 2001 - v1
Checksum:i706671932F61141D
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LIC3A0A140LIC3_MOUSE
Prostate tumor-overexpressed gene 1...
Ptov1
73Annotation score:
A0A140LI15A0A140LI15_MOUSE
Prostate tumor-overexpressed gene 1...
Ptov1
136Annotation score:
A0A140LJ65A0A140LJ65_MOUSE
Prostate tumor-overexpressed gene 1...
Ptov1
132Annotation score:
A0A140LJ23A0A140LJ23_MOUSE
Prostate tumor-overexpressed gene 1...
Ptov1
158Annotation score:
A0A140LHX3A0A140LHX3_MOUSE
Prostate tumor-overexpressed gene 1...
Ptov1
247Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC008543 mRNA Translation: AAH08543.1
BC024632 mRNA Translation: AAH24632.1
AK003974 mRNA Translation: BAB23101.1
CCDSiCCDS21219.1
RefSeqiNP_598710.1, NM_133949.1
UniGeneiMm.42855
Mm.470511

Genome annotation databases

EnsembliENSMUST00000046575; ENSMUSP00000035281; ENSMUSG00000038502
GeneIDi84113
KEGGimmu:84113
UCSCiuc009grk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC008543 mRNA Translation: AAH08543.1
BC024632 mRNA Translation: AAH24632.1
AK003974 mRNA Translation: BAB23101.1
CCDSiCCDS21219.1
RefSeqiNP_598710.1, NM_133949.1
UniGeneiMm.42855
Mm.470511

3D structure databases

ProteinModelPortaliQ91VU8
SMRiQ91VU8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220005, 1 interactor
IntActiQ91VU8, 1 interactor
MINTiQ91VU8
STRINGi10090.ENSMUSP00000035281

PTM databases

iPTMnetiQ91VU8
PhosphoSitePlusiQ91VU8

Proteomic databases

MaxQBiQ91VU8
PaxDbiQ91VU8
PeptideAtlasiQ91VU8
PRIDEiQ91VU8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046575; ENSMUSP00000035281; ENSMUSG00000038502
GeneIDi84113
KEGGimmu:84113
UCSCiuc009grk.1 mouse

Organism-specific databases

CTDi53635
MGIiMGI:1933946 Ptov1

Phylogenomic databases

eggNOGiENOG410IHD9 Eukaryota
ENOG410Z0HI LUCA
GeneTreeiENSGT00520000055653
HOGENOMiHOG000115777
HOVERGENiHBG108306
InParanoidiQ91VU8
OMAiELDCLTH
OrthoDBiEOG091G04LS
PhylomeDBiQ91VU8
TreeFamiTF329598

Miscellaneous databases

ChiTaRSiPtov1 mouse
PROiPR:Q91VU8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038502 Expressed in 305 organ(s), highest expression level in cerebral cortex
CleanExiMM_PTOV1
ExpressionAtlasiQ91VU8 baseline and differential
GenevisibleiQ91VU8 MM

Family and domain databases

Gene3Di2.40.290.30, 2 hits
InterProiView protein in InterPro
IPR021394 Med25_PTOV
IPR038196 PTOV_dom_sf
PfamiView protein in Pfam
PF11232 Med25, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPTOV1_MOUSE
AccessioniPrimary (citable) accession number: Q91VU8
Secondary accession number(s): Q9CTC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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