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Protein

Protein FAM3C

Gene

Fam3c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.3 Publications

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM3C
Alternative name(s):
Interleukin-like EMT inducer
Gene namesi
Name:Fam3c
Synonyms:D6Wsu176e, Ilei
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107892 Fam3c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000000875325 – 227Protein FAM3CAdd BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 86By similarity
Disulfide bondi64 ↔ 221By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ91VU0
MaxQBiQ91VU0
PaxDbiQ91VU0
PRIDEiQ91VU0
TopDownProteomicsiQ91VU0

PTM databases

PhosphoSitePlusiQ91VU0

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in the retina. Up-regulated in mammary epithelial cells and hepatocytes undergoing epithelial to mesenchymal transition (at protein level).3 Publications

Developmental stagei

Expressed at E15.5 in the nonsensory epithelium of the inner ear and at lower levels in the vestibule of the inner ear, the brain and hair follicles. Expressed in the ganglion cell layer of the retina and in the ciliary body at E15.5. At later stages, retinal expression becomes restricted to the ganglion cell layer.2 Publications

Inductioni

By TGF-beta in epithelial cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000029672 Expressed in 285 organ(s), highest expression level in cumulus cell
ExpressionAtlasiQ91VU0 baseline and differential
GenevisibleiQ91VU0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127709

Structurei

Secondary structure

1227
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ91VU0
SMRiQ91VU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEGC Eukaryota
ENOG4111I9K LUCA
GeneTreeiENSGT00530000063020
HOVERGENiHBG051544
InParanoidiQ91VU0
PhylomeDBiQ91VU0
TreeFamiTF353414

Family and domain databases

CDDicd13940 ILEI_FAM3C, 1 hit
InterProiView protein in InterPro
IPR039220 FAM3
IPR039219 FAM3C
IPR039477 ILEI/PANDER_dom
IPR039475 ILEI_FAM3C
PANTHERiPTHR14592 PTHR14592, 1 hit
PTHR14592:SF10 PTHR14592:SF10, 1 hit
PfamiView protein in Pfam
PF15711 ILEI, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q91VU0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVAGAAKLV VAVAVFLLTF YVISQVFEIK MDASLGNLFA RSALDSAIRS
60 70 80 90 100
TKPPRYKCGI SKACPEKHFA FKMASGAANV VGPKICLEDN VLMSGVKNNV
110 120 130 140 150
GRGINIALVN GKTGEVIDTK FFDMWGGDVA PFIEFLKTIQ DGTVVLMATY
160 170 180 190 200
DDGATKLTDE ARRLIAELGS TSITSLGFRD NWVFCGGKGI KTKSPFEQHI
210 220
KNNKETNKYE GWPEVVEMEG CIPQKQD
Length:227
Mass (Da):24,753
Last modified:December 1, 2001 - v1
Checksum:i9195280B92838CF4
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E911G5E911_MOUSE
DNA segment, Chr 6, Wayne State Uni...
Fam3c D6Wsu176e, mCG_9383
247Annotation score:
G3X9I1G3X9I1_MOUSE
DNA segment, Chr 6, Wayne State Uni...
Fam3c D6Wsu176e, mCG_9383
197Annotation score:
E9Q8C5E9Q8C5_MOUSE
Protein FAM3C
Fam3c
99Annotation score:
E9Q6F0E9Q6F0_MOUSE
Protein FAM3C
Fam3c
110Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43A → T in AAH55853 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424275 mRNA Translation: AAR84605.1
AK004059 mRNA Translation: BAB23146.1
AK154498 mRNA Translation: BAE32629.1
AK170887 mRNA Translation: BAE42094.1
CH466533 Genomic DNA Translation: EDL13845.1
BC009086 mRNA Translation: AAH09086.1
BC055853 mRNA Translation: AAH55853.1
CCDSiCCDS39436.1
RefSeqiNP_613053.3, NM_138587.4
XP_006505165.1, XM_006505102.3
XP_006505166.1, XM_006505103.3
UniGeneiMm.490307

Genome annotation databases

EnsembliENSMUST00000165576; ENSMUSP00000127709; ENSMUSG00000029672
GeneIDi27999
KEGGimmu:27999
UCSCiuc009bay.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424275 mRNA Translation: AAR84605.1
AK004059 mRNA Translation: BAB23146.1
AK154498 mRNA Translation: BAE32629.1
AK170887 mRNA Translation: BAE42094.1
CH466533 Genomic DNA Translation: EDL13845.1
BC009086 mRNA Translation: AAH09086.1
BC055853 mRNA Translation: AAH55853.1
CCDSiCCDS39436.1
RefSeqiNP_613053.3, NM_138587.4
XP_006505165.1, XM_006505102.3
XP_006505166.1, XM_006505103.3
UniGeneiMm.490307

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC3X-ray2.00A/B55-227[»]
5LC4X-ray1.84A/B/C/D55-227[»]
ProteinModelPortaliQ91VU0
SMRiQ91VU0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127709

PTM databases

PhosphoSitePlusiQ91VU0

Proteomic databases

EPDiQ91VU0
MaxQBiQ91VU0
PaxDbiQ91VU0
PRIDEiQ91VU0
TopDownProteomicsiQ91VU0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000165576; ENSMUSP00000127709; ENSMUSG00000029672
GeneIDi27999
KEGGimmu:27999
UCSCiuc009bay.1 mouse

Organism-specific databases

CTDi10447
MGIiMGI:107892 Fam3c

Phylogenomic databases

eggNOGiENOG410IEGC Eukaryota
ENOG4111I9K LUCA
GeneTreeiENSGT00530000063020
HOVERGENiHBG051544
InParanoidiQ91VU0
PhylomeDBiQ91VU0
TreeFamiTF353414

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation

Miscellaneous databases

ChiTaRSiFam3c mouse
PROiPR:Q91VU0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029672 Expressed in 285 organ(s), highest expression level in cumulus cell
ExpressionAtlasiQ91VU0 baseline and differential
GenevisibleiQ91VU0 MM

Family and domain databases

CDDicd13940 ILEI_FAM3C, 1 hit
InterProiView protein in InterPro
IPR039220 FAM3
IPR039219 FAM3C
IPR039477 ILEI/PANDER_dom
IPR039475 ILEI_FAM3C
PANTHERiPTHR14592 PTHR14592, 1 hit
PTHR14592:SF10 PTHR14592:SF10, 1 hit
PfamiView protein in Pfam
PF15711 ILEI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFAM3C_MOUSE
AccessioniPrimary (citable) accession number: Q91VU0
Secondary accession number(s): Q53YY7, Q7TML1, Q9CTB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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