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Protein

Protein BRICK1

Gene

Brk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BRICK1
Short name:
BRK1
Gene namesi
Name:Brk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1915406 Brk1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002836472 – 75Protein BRICK1Add BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ91VR8
MaxQBiQ91VR8
PaxDbiQ91VR8
PeptideAtlasiQ91VR8
PRIDEiQ91VR8

PTM databases

iPTMnetiQ91VR8
PhosphoSitePlusiQ91VR8

Expressioni

Gene expression databases

BgeeiENSMUSG00000033940 Expressed in 293 organ(s), highest expression level in ear
CleanExiMM_6720456B07RIK
GenevisibleiQ91VR8 MM

Interactioni

Subunit structurei

Homotrimer when in free form. Directly interacts with WASF2. Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterodimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi221634, 1 interactor
IntActiQ91VR8, 3 interactors
MINTiQ91VR8
STRINGi10090.ENSMUSP00000041644

Structurei

3D structure databases

ProteinModelPortaliQ91VR8
SMRiQ91VR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili41 – 72Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the BRK1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J0X8 Eukaryota
ENOG4111UHX LUCA
GeneTreeiENSGT00390000011082
HOGENOMiHOG000290240
HOVERGENiHBG107432
InParanoidiQ91VR8
KOiK05752
OMAiEACVTQG
OrthoDBiEOG091G172W
PhylomeDBiQ91VR8
TreeFamiTF324876

Family and domain databases

InterProiView protein in InterPro
IPR033378 BRICK1
PANTHERiPTHR33668 PTHR33668, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD593487 PD593487, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91VR8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGQEDPVQR EIHQDWANRE YIEIITSSIK KISDFLNSFD MSCRSRLATL
60 70
NEKLTALERR IEYIEARVTK GETLT
Length:75
Mass (Da):8,761
Last modified:December 1, 2001 - v1
Checksum:i637B43D779A36587
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71G → D in BAE38874 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020128 mRNA Translation: BAC25616.1
AK150689 mRNA Translation: BAE29768.1
AK163236 mRNA Translation: BAE37248.1
AK166585 mRNA Translation: BAE38874.1
BC010582 mRNA Translation: AAH10582.1
CCDSiCCDS39595.1
RefSeqiNP_598698.1, NM_133937.1
UniGeneiMm.485793

Genome annotation databases

EnsembliENSMUST00000035725; ENSMUSP00000041644; ENSMUSG00000033940
GeneIDi101314
KEGGimmu:101314
UCSCiuc009dgz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020128 mRNA Translation: BAC25616.1
AK150689 mRNA Translation: BAE29768.1
AK163236 mRNA Translation: BAE37248.1
AK166585 mRNA Translation: BAE38874.1
BC010582 mRNA Translation: AAH10582.1
CCDSiCCDS39595.1
RefSeqiNP_598698.1, NM_133937.1
UniGeneiMm.485793

3D structure databases

ProteinModelPortaliQ91VR8
SMRiQ91VR8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221634, 1 interactor
IntActiQ91VR8, 3 interactors
MINTiQ91VR8
STRINGi10090.ENSMUSP00000041644

PTM databases

iPTMnetiQ91VR8
PhosphoSitePlusiQ91VR8

Proteomic databases

EPDiQ91VR8
MaxQBiQ91VR8
PaxDbiQ91VR8
PeptideAtlasiQ91VR8
PRIDEiQ91VR8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035725; ENSMUSP00000041644; ENSMUSG00000033940
GeneIDi101314
KEGGimmu:101314
UCSCiuc009dgz.1 mouse

Organism-specific databases

CTDi55845
MGIiMGI:1915406 Brk1

Phylogenomic databases

eggNOGiENOG410J0X8 Eukaryota
ENOG4111UHX LUCA
GeneTreeiENSGT00390000011082
HOGENOMiHOG000290240
HOVERGENiHBG107432
InParanoidiQ91VR8
KOiK05752
OMAiEACVTQG
OrthoDBiEOG091G172W
PhylomeDBiQ91VR8
TreeFamiTF324876

Enzyme and pathway databases

ReactomeiR-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs

Miscellaneous databases

ChiTaRSiBrk1 mouse
PROiPR:Q91VR8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033940 Expressed in 293 organ(s), highest expression level in ear
CleanExiMM_6720456B07RIK
GenevisibleiQ91VR8 MM

Family and domain databases

InterProiView protein in InterPro
IPR033378 BRICK1
PANTHERiPTHR33668 PTHR33668, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD593487 PD593487, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBRK1_MOUSE
AccessioniPrimary (citable) accession number: Q91VR8
Secondary accession number(s): Q3TLB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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