UniProtKB - Q91VN6 (DDX41_MOUSE)
Protein
Probable ATP-dependent RNA helicase DDX41
Gene
Ddx41
Organism
Mus musculus (Mouse)
Status
Functioni
Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing.By similarity
Catalytic activityi
- EC:3.6.4.13
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 225 – 232 | ATPPROSITE-ProRule annotation | 8 | |
Zinc fingeri | 580 – 597 | CCHC-typeAdd BLAST | 18 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- RNA binding Source: GO_Central
- RNA helicase activity Source: GO_Central
GO - Biological processi
- cell differentiation Source: UniProtKB
- cell population proliferation Source: UniProtKB
- cellular response to interferon-beta Source: MGI
- defense response to virus Source: MGI
- mRNA splicing, via spliceosome Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | Helicase, Hydrolase, RNA-binding |
Biological process | mRNA processing, mRNA splicing |
Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-1834941, STING mediated induction of host immune responses R-MMU-3134975, Regulation of innate immune responses to cytosolic DNA |
Names & Taxonomyi
Protein namesi | Recommended name: Probable ATP-dependent RNA helicase DDX41 (EC:3.6.4.13)Alternative name(s): DEAD box protein 41 |
Gene namesi | Name:Ddx41 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1920185, Ddx41 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
Nucleus
- catalytic step 2 spliceosome Source: MGI
- nucleus Source: MGI
- spliceosomal complex Source: GO_Central
Keywords - Cellular componenti
Nucleus, SpliceosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054971 | 1 – 622 | Probable ATP-dependent RNA helicase DDX41Add BLAST | 622 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 4 | PhosphoserineBy similarity | 1 | |
Modified residuei | 21 | PhosphoserineCombined sources | 1 | |
Modified residuei | 23 | PhosphoserineCombined sources | 1 | |
Modified residuei | 33 | PhosphotyrosineCombined sources | 1 | |
Cross-linki | 416 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 442 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q91VN6 |
jPOSTi | Q91VN6 |
MaxQBi | Q91VN6 |
PaxDbi | Q91VN6 |
PeptideAtlasi | Q91VN6 |
PRIDEi | Q91VN6 |
PTM databases
iPTMneti | Q91VN6 |
PhosphoSitePlusi | Q91VN6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000021494, Expressed in forelimb bud and 253 other tissues |
Genevisiblei | Q91VN6, MM |
Interactioni
Subunit structurei
Identified in the spliceosome C complex (By similarity).
Interacts with ERCC6 (By similarity).
By similarityBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 215656, 18 interactors |
IntActi | Q91VN6, 6 interactors |
MINTi | Q91VN6 |
STRINGi | 10090.ENSMUSP00000021956 |
Miscellaneous databases
RNActi | Q91VN6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 212 – 396 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 185 | |
Domaini | 407 – 567 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 161 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 181 – 209 | Q motifPROSITE-ProRule annotationAdd BLAST | 29 | |
Motifi | 344 – 347 | DEAD boxPROSITE-ProRule annotation | 4 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 580 – 597 | CCHC-typeAdd BLAST | 18 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG0341, Eukaryota |
GeneTreei | ENSGT00940000156333 |
HOGENOMi | CLU_003041_16_5_1 |
InParanoidi | Q91VN6 |
OrthoDBi | 447398at2759 |
TreeFami | TF300340 |
Family and domain databases
CDDi | cd17951, DEADc_DDX41, 1 hit |
InterProi | View protein in InterPro IPR011545, DEAD/DEAH_box_helicase_dom IPR044113, DEADc_DDX41 IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR014014, RNA_helicase_DEAD_Q_motif |
Pfami | View protein in Pfam PF00270, DEAD, 1 hit PF00271, Helicase_C, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51195, Q_MOTIF, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q91VN6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEDSEPERKR ARADEATAGG SRSEDEDEDD EDYVPYVPLR QRRQLLLQKL
60 70 80 90 100
LQRRRKGATE EEQQDSGSEP RGDEDDIPLG PQSNVSLLDQ HQHLKEKAEA
110 120 130 140 150
RKESAKEKQL KEEEKILESV AEGRALMSVK EMAKGITYDD PIKTSWTPPR
160 170 180 190 200
YVLSMSEERH ERVRKKYHIL VEGDGIPPPI KSFKEMKFPA AILRGLKKKG
210 220 230 240 250
ILHPTPIQIQ GIPTILSGRD MIGIAFTGSG KTLVFTLPVI MFCLEQEKRL
260 270 280 290 300
PFSKREGPYG LIICPSRELA RQTHGILEYY CRLLQEDSSP LLRCALCIGG
310 320 330 340 350
MSVKEQMETI RHGVHMMVAT PGRLMDLLQK KMVSLDICRY LALDEADRMI
360 370 380 390 400
DMGFEGDIRT IFSYFKGQRQ TLLFSATMPK KIQNFAKSAL VKPVTINVGR
410 420 430 440 450
AGAASLDVIQ EVEYVKEEAK MVYLLECLQK TPPPVLIFAE KKADVDAIHE
460 470 480 490 500
YLLLKGVEAV AIHGGKDQEE RTKAIEAFRE GKKDVLVATD VASKGLDFPA
510 520 530 540 550
IQHVINYDMP EEIENYVHRI GRTGRSGNTG IATTFINKAC DESVLMDLKA
560 570 580 590 600
LLLEAKQKVP PVLQVLHCGD ESMLDIGGER GCAFCGGLGH RITDCPKLEA
610 620
MQTKQVSNIG RKDYLAHSSM DF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1S6GWJ4 | A0A1S6GWJ4_MOUSE | RNA helicase | Ddx41 | 633 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 562 | V → G in AAH11308 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK156957 mRNA Translation: BAE33914.1 BC011308 mRNA Translation: AAH11308.1 |
CCDSi | CCDS26549.1 |
RefSeqi | NP_598820.2, NM_134059.2 |
Genome annotation databases
Ensembli | ENSMUST00000021956; ENSMUSP00000021956; ENSMUSG00000021494 |
GeneIDi | 72935 |
KEGGi | mmu:72935 |
UCSCi | uc007qro.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK156957 mRNA Translation: BAE33914.1 BC011308 mRNA Translation: AAH11308.1 |
CCDSi | CCDS26549.1 |
RefSeqi | NP_598820.2, NM_134059.2 |
3D structure databases
SMRi | Q91VN6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 215656, 18 interactors |
IntActi | Q91VN6, 6 interactors |
MINTi | Q91VN6 |
STRINGi | 10090.ENSMUSP00000021956 |
PTM databases
iPTMneti | Q91VN6 |
PhosphoSitePlusi | Q91VN6 |
Proteomic databases
EPDi | Q91VN6 |
jPOSTi | Q91VN6 |
MaxQBi | Q91VN6 |
PaxDbi | Q91VN6 |
PeptideAtlasi | Q91VN6 |
PRIDEi | Q91VN6 |
Protocols and materials databases
Antibodypediai | 17469, 288 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000021956; ENSMUSP00000021956; ENSMUSG00000021494 |
GeneIDi | 72935 |
KEGGi | mmu:72935 |
UCSCi | uc007qro.2, mouse |
Organism-specific databases
CTDi | 51428 |
MGIi | MGI:1920185, Ddx41 |
Phylogenomic databases
eggNOGi | KOG0341, Eukaryota |
GeneTreei | ENSGT00940000156333 |
HOGENOMi | CLU_003041_16_5_1 |
InParanoidi | Q91VN6 |
OrthoDBi | 447398at2759 |
TreeFami | TF300340 |
Enzyme and pathway databases
Reactomei | R-MMU-1834941, STING mediated induction of host immune responses R-MMU-3134975, Regulation of innate immune responses to cytosolic DNA |
Miscellaneous databases
BioGRID-ORCSi | 72935, 10 hits in 18 CRISPR screens |
ChiTaRSi | Ddx41, mouse |
PROi | PR:Q91VN6 |
RNActi | Q91VN6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021494, Expressed in forelimb bud and 253 other tissues |
Genevisiblei | Q91VN6, MM |
Family and domain databases
CDDi | cd17951, DEADc_DDX41, 1 hit |
InterProi | View protein in InterPro IPR011545, DEAD/DEAH_box_helicase_dom IPR044113, DEADc_DDX41 IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR014014, RNA_helicase_DEAD_Q_motif |
Pfami | View protein in Pfam PF00270, DEAD, 1 hit PF00271, Helicase_C, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51195, Q_MOTIF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DDX41_MOUSE | |
Accessioni | Q91VN6Primary (citable) accession number: Q91VN6 Secondary accession number(s): Q3U0E0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2005 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 155 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families