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Protein

Zinc finger protein 24

Gene

Znf24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri251 – 273C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
  • DNA-binding transcription factor activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 24Imported
Alternative name(s):
Hypomyelinated CNS protein1 Publication
Zinc finger protein 191By similarity
Zinc finger protein ZF-121 Publication
Gene namesi
Name:Znf24By similarity
Synonyms:Hmcns1 Publication, Zfp191By similarity, Zfp24Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1929704 Zfp24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

According to PubMed:20080941, most mice die by postnatal day 25 (P25) due to myelination defects. Brains and spinal cords isolated from P14 mice appear to be smaller than those from wild-type mice and to lack white matter. Mutant oligodendrocytes arrest at a late stage of differentiation. Expression of genes expressed specifically in mature myelinating oligodendrocytes is down-regulated. According to PubMed:17064688, embryos are severely retarded in development and die at approximately 7.5 days post-fertilization (E7.5). One possible explanation for the different phenotypes described is that the two null alleles are not identical. In the mutants described by PubMed:20080941, the PGK-neo cassette used for positive selection of embryonic stem (ES) cells has been removed, whereas it remains in the allele described by PubMed:17064688.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473531 – 368Zinc finger protein 24Add BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki22Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei132PhosphoserineBy similarity1
Modified residuei142PhosphoserineBy similarity1
Cross-linki147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki177Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki236Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei274PhosphoserineBy similarity1
Cross-linki277Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki286Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei292PhosphoserineBy similarity1
Modified residuei335PhosphotyrosineBy similarity1
Cross-linki361Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki367Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Sumoylated.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ91VN1
MaxQBiQ91VN1
PaxDbiQ91VN1
PeptideAtlasiQ91VN1
PRIDEiQ91VN1

PTM databases

iPTMnetiQ91VN1
PhosphoSitePlusiQ91VN1

Expressioni

Tissue specificityi

Widely expressed with highest levels in heart, brain, liver, skeletal muscle, kidney and testis and very low levels in spleen and lung.2 Publications

Developmental stagei

In the embryo, barely detectable at day 17, peaks at day 11 and remains constant thereafter. Detected early during embryogenesis in ectodermal, endodermal, mesodermal and extraembryonic tissues. Expressed in the developing central nervous system. In the developing central nervous system (CNS), mainly expressed in progenitors.2 Publications

Gene expression databases

BgeeiENSMUSG00000051469 Expressed in 352 organ(s), highest expression level in optic fissure
CleanExiMM_ZFP191
ExpressionAtlasiQ91VN1 baseline and differential
GenevisibleiQ91VN1 MM

Interactioni

Protein-protein interaction databases

BioGridi208519, 1 interactor
IntActiQ91VN1, 1 interactor
STRINGi10090.ENSMUSP00000064637

Structurei

3D structure databases

ProteinModelPortaliQ91VN1
SMRiQ91VN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 134SCAN boxPROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni251 – 301Necessary and sufficient for nuclear localizationBy similarityAdd BLAST51

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri251 – 273C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ91VN1
KOiK09230
OMAiTWNHLPD
OrthoDBiEOG091G09O3
PhylomeDBiQ91VN1
TreeFamiTF338304

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q91VN1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAQSVEEDS ILIIPNPDEE EKILRVKLEE DPDGEEGSSI SWNHLPDPEV
60 70 80 90 100
FRQRFRQFGY QDSPGPREAV SQLRELCRLW LRPETHTKEQ ILELVVLEQF
110 120 130 140 150
VAILPKELQT WVREHHPENG EEAVAVLEDL ESELDDPGQP VSLRRQKREV
160 170 180 190 200
LVEEITSQED AQGLPSSELD AVENQLKWAS WELHSLRHCD DDATTENGAL
210 220 230 240 250
APKQEMASAG ESHEGPGTLN IGVPQLFKYG ETCFPKGRFE RKRNPSRKKQ
260 270 280 290 300
HICDECGKHF SQGSALILHQ RIHSGEKPYG CVECGKAFSR SSILVQHQRV
310 320 330 340 350
HTGEKPYKCL ECGKAFSQNS GLINHQRIHT GEKPYECVQC GKSYSQSSNL
360
FRHQRRHNAE KLLNVVKV
Length:368
Mass (Da):41,919
Last modified:December 1, 2001 - v1
Checksum:i344974009D2A5469
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YVP1D3YVP1_MOUSE
Zinc finger protein 24
Zfp24 Zfp191
39Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91I → M in AAD37421 (PubMed:10542327).Curated1
Sequence conflicti366Missing in AAD37421 (PubMed:10542327).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF149093 mRNA Translation: AAD37421.1
AY052495 Genomic DNA Translation: AAL13429.1
AY832930 mRNA Translation: AAV91152.1
AK146726 mRNA Translation: BAE27389.1
CH466557 Genomic DNA Translation: EDK96990.1
CH466557 Genomic DNA Translation: EDK96991.1
BC011345 mRNA Translation: AAH11345.1
BC054832 mRNA Translation: AAH54832.1
CCDSiCCDS29098.1
RefSeqiNP_067534.2, NM_021559.2
XP_006526199.1, XM_006526136.3
XP_006526200.1, XM_006526137.3
UniGeneiMm.417427
Mm.486596

Genome annotation databases

EnsembliENSMUST00000066497; ENSMUSP00000064637; ENSMUSG00000051469
ENSMUST00000153337; ENSMUSP00000122579; ENSMUSG00000051469
GeneIDi59057
KEGGimmu:59057
UCSCiuc008egm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF149093 mRNA Translation: AAD37421.1
AY052495 Genomic DNA Translation: AAL13429.1
AY832930 mRNA Translation: AAV91152.1
AK146726 mRNA Translation: BAE27389.1
CH466557 Genomic DNA Translation: EDK96990.1
CH466557 Genomic DNA Translation: EDK96991.1
BC011345 mRNA Translation: AAH11345.1
BC054832 mRNA Translation: AAH54832.1
CCDSiCCDS29098.1
RefSeqiNP_067534.2, NM_021559.2
XP_006526199.1, XM_006526136.3
XP_006526200.1, XM_006526137.3
UniGeneiMm.417427
Mm.486596

3D structure databases

ProteinModelPortaliQ91VN1
SMRiQ91VN1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208519, 1 interactor
IntActiQ91VN1, 1 interactor
STRINGi10090.ENSMUSP00000064637

PTM databases

iPTMnetiQ91VN1
PhosphoSitePlusiQ91VN1

Proteomic databases

EPDiQ91VN1
MaxQBiQ91VN1
PaxDbiQ91VN1
PeptideAtlasiQ91VN1
PRIDEiQ91VN1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066497; ENSMUSP00000064637; ENSMUSG00000051469
ENSMUST00000153337; ENSMUSP00000122579; ENSMUSG00000051469
GeneIDi59057
KEGGimmu:59057
UCSCiuc008egm.1 mouse

Organism-specific databases

CTDi59057
MGIiMGI:1929704 Zfp24

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ91VN1
KOiK09230
OMAiTWNHLPD
OrthoDBiEOG091G09O3
PhylomeDBiQ91VN1
TreeFamiTF338304

Miscellaneous databases

PROiPR:Q91VN1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051469 Expressed in 352 organ(s), highest expression level in optic fissure
CleanExiMM_ZFP191
ExpressionAtlasiQ91VN1 baseline and differential
GenevisibleiQ91VN1 MM

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZNF24_MOUSE
AccessioniPrimary (citable) accession number: Q91VN1
Secondary accession number(s): Q5MDG8, Q9WUQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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