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Protein

Inorganic pyrophosphatase 2, mitochondrial

Gene

Ppa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes inorganic pyrophosphate. This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function.By similarity

Catalytic activityi

Diphosphate + H2O = 2 phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi159Magnesium 1By similarity1
Metal bindingi164Magnesium 1By similarity1
Metal bindingi164Magnesium 2By similarity1
Metal bindingi196Magnesium 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-379726 Mitochondrial tRNA aminoacylation
R-MMU-71737 Pyrophosphate hydrolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphatase 2, mitochondrial (EC:3.6.1.1)
Alternative name(s):
Pyrophosphate phospho-hydrolase 2
Short name:
PPase 2
Gene namesi
Name:Ppa2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1922026 Ppa2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionBy similarityAdd BLAST27
ChainiPRO_000002541228 – 330Inorganic pyrophosphatase 2, mitochondrialAdd BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei211N6-succinyllysineCombined sources1
Modified residuei219N6-acetyllysineCombined sources1
Modified residuei254N6-succinyllysineCombined sources1
Modified residuei256N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ91VM9
PaxDbiQ91VM9
PeptideAtlasiQ91VM9
PRIDEiQ91VM9

2D gel databases

REPRODUCTION-2DPAGEiQ91VM9

PTM databases

iPTMnetiQ91VM9
PhosphoSitePlusiQ91VM9
SwissPalmiQ91VM9

Expressioni

Gene expression databases

BgeeiENSMUSG00000028013
CleanExiMM_PPA2
ExpressionAtlasiQ91VM9 baseline and differential
GenevisibleiQ91VM9 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi217012, 2 interactors
IntActiQ91VM9, 3 interactors
MINTiQ91VM9
STRINGi10090.ENSMUSP00000029644

Structurei

3D structure databases

ProteinModelPortaliQ91VM9
SMRiQ91VM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1626 Eukaryota
COG0221 LUCA
GeneTreeiENSGT00390000017004
HOGENOMiHOG000195569
HOVERGENiHBG000491
InParanoidiQ91VM9
KOiK01507
OMAiIVDKWHY
OrthoDBiEOG091G0KFV
PhylomeDBiQ91VM9
TreeFamiTF300887

Family and domain databases

CDDicd00412 pyrophosphatase, 1 hit
Gene3Di3.90.80.10, 1 hit
InterProiView protein in InterPro
IPR008162 Pyrophosphatase
IPR036649 Pyrophosphatase_sf
PANTHERiPTHR10286 PTHR10286, 1 hit
PfamiView protein in Pfam
PF00719 Pyrophosphatase, 1 hit
SUPFAMiSSF50324 SSF50324, 1 hit
PROSITEiView protein in PROSITE
PS00387 PPASE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91VM9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRALLPLLSV GRGWRVGAAA RPPRRVMSLY RTEELGHPRS QDYRLFFKHV
60 70 80 90 100
AGHYISPFHD IPLKADCKEE HDIPRKKARN DEYENLFNMV VEIPRWTNAK
110 120 130 140 150
MEIATEEPLN PIKQDIKNGK LRYTPNIFPH KGYIWNYGAL PQTWEDPHLR
160 170 180 190 200
DKSTDCCGDN DPIDVCEIGS KVLSRGDVVH VKILGTLALI DQSETDWKII
210 220 230 240 250
AINVNDPEAE KFHDIDDVKK FKPGYLEATL NWFRLYKVPD GKPENKFAFN
260 270 280 290 300
GEFKNKAFAL DVINSAHERW KEMVMKKCDK GAISCVNVHI CDSPFHCTME
310 320 330
EARSLVESVP TPSMNKESNV EEEVWHFLRN
Length:330
Mass (Da):38,115
Last modified:December 1, 2001 - v1
Checksum:i8AFD61FA561D7268
GO
Isoform 2 (identifier: Q91VM9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.
     127-170: IFPHKGYIWN...DPIDVCEIGS → MLDADAPQNC...FQAIETLSQM

Note: No experimental confirmation available.
Show »
Length:204
Mass (Da):23,274
Checksum:i27E5DA9D3A368CC9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti225 – 227YLE → HLQ in BAC41194 (PubMed:16141072).Curated3
Sequence conflicti254K → T in BAC41194 (PubMed:16141072).Curated1
Sequence conflicti321Missing in BAC41194 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0116531 – 126Missing in isoform 2. 1 PublicationAdd BLAST126
Alternative sequenceiVSP_011654127 – 170IFPHK…CEIGS → MLDADAPQNCQSWEGKDKQI PGPHRPNSQACLVKFQAIET LSQM in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003660 mRNA Translation: BAB22922.1
AK090384 mRNA Translation: BAC41194.1
AK143475 mRNA Translation: BAE25392.1
BC011417 mRNA Translation: AAH11417.1
CCDSiCCDS17850.1 [Q91VM9-1]
RefSeqiNP_001280570.1, NM_001293641.1
NP_666253.1, NM_146141.2 [Q91VM9-1]
UniGeneiMm.210305

Genome annotation databases

EnsembliENSMUST00000029644; ENSMUSP00000029644; ENSMUSG00000028013 [Q91VM9-1]
GeneIDi74776
KEGGimmu:74776
UCSCiuc008rkm.2 mouse [Q91VM9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiIPYR2_MOUSE
AccessioniPrimary (citable) accession number: Q91VM9
Secondary accession number(s): Q3UPK3, Q8BTG5, Q9D1E3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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