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Protein

Telomeric repeat-binding factor 2-interacting protein 1

Gene

Terf2ip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.3 Publications

Miscellaneous

Shares a bidirectional promoter with KARS (PubMed:14659874). This shared promoter with an essential gene complicated the task when generating knockout mice; the problem was overcome by generating conditional knockout strategies (PubMed:20339076 and PubMed:20622869;).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-171306 Packaging Of Telomere Ends
R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence

Names & Taxonomyi

Protein namesi
Recommended name:
Telomeric repeat-binding factor 2-interacting protein 1
Short name:
TERF2-interacting telomeric protein 1
Short name:
TRF2-interacting telomeric protein 1
Alternative name(s):
Repressor/activator protein 1 homolog
Short name:
RAP1 homolog
Gene namesi
Name:Terf2ip
Synonyms:Rap1
ORF Names:MNCb-0448, MNCb-0628
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1929871 Terf2ip

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus, Telomere

Pathology & Biotechi

Disruption phenotypei

Mice are viable and fertile. No major telomere dysfunction such as telomere fusions are observed. An increased telomere fragility and recombination due to defects in HDR are however present. Mice with conditional deletion in stratified epithelia display shorter telomeres and developed skin hyperpigmentation in adulthood.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001971272 – 393Telomeric repeat-binding factor 2-interacting protein 1Add BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei43PhosphoserineBy similarity1
Cross-linki111Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei151PhosphoserineCombined sources1
Modified residuei153PhosphoserineBy similarity1
Cross-linki191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei200PhosphoserineCombined sources1
Modified residuei203PhosphoserineBy similarity1
Cross-linki205Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki209Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki366Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ91VL8
MaxQBiQ91VL8
PaxDbiQ91VL8
PeptideAtlasiQ91VL8
PRIDEiQ91VL8

PTM databases

iPTMnetiQ91VL8
PhosphoSitePlusiQ91VL8

Expressioni

Gene expression databases

BgeeiENSMUSG00000033430 Expressed in 264 organ(s), highest expression level in supraoptic nucleus
GenevisibleiQ91VL8 MM

Interactioni

Subunit structurei

Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Binds to TERF2 (but not TERF1) with its C-terminus. Interacts with SLX4/BTBD12 (By similarity). Interacts with TERF2; the interaction is direct. Does not interact with TERF1. Associates with the I-kappa-B-kinase (IKK) core complex, composed of CHUK, IKBKB and IKBKG.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-153 Shelterin complex
IntActiQ91VL8, 2 interactors
MINTiQ91VL8
STRINGi10090.ENSMUSP00000052170

Structurei

3D structure databases

ProteinModelPortaliQ91VL8
SMRiQ91VL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 101BRCTAdd BLAST24
Domaini125 – 185Myb-likeAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi377 – 393Nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi232 – 297Asp/Glu-rich (acidic)Add BLAST66

Sequence similaritiesi

Belongs to the RAP1 family.Curated

Phylogenomic databases

eggNOGiENOG410IJNC Eukaryota
ENOG4111QPC LUCA
GeneTreeiENSGT00390000005351
HOGENOMiHOG000120115
HOVERGENiHBG054209
InParanoidiQ91VL8
KOiK11113
OMAiTQHSWQA
OrthoDBiEOG091G0NZ2
PhylomeDBiQ91VL8
TreeFamiTF332348

Family and domain databases

Gene3Di1.10.10.2170, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR009057 Homeobox-like_sf
IPR021661 Rap1_C
IPR038104 Rap1_C_sf
IPR015010 Rap1_Myb_dom
IPR039595 TE2IP/Rap1
PANTHERiPTHR16466 PTHR16466, 2 hits
PfamiView protein in Pfam
PF16589 BRCT_2, 1 hit
PF08914 Myb_DNA-bind_2, 1 hit
PF11626 Rap1_C, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91VL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEAMDLGKD PNGPTHSSTL FVREDGSAMS FYVRPSSAKR RLSTLILHGG
60 70 80 90 100
GTVCRVQEPG AVLLAQPGEA LAEASGDFIS TQYILDCVDR NEKLDLEAYR
110 120 130 140 150
LGLTEQASDP KPGASTEGST EPEPQPLTGR IAYTDAEDVA ILTYVKENAR
160 170 180 190 200
SPSSVTGNAL WKAMEKSSLT QHSWQSLKDR YLKHLRGQEH KYLLGNAPVS
210 220 230 240 250
PSSQKLKRKA EQDPEAADSG EPQNKRAPDL PEEECVKGEI KENGEADNKL
260 270 280 290 300
FEEAAPEFGE AVVDESPDFE IHITMCDGDP PTPEEDSETQ PDEEEEEPKV
310 320 330 340 350
STQEVGTAIK VIRQLMEKFN LDLSTVTQAL LKNSGELEAT SSFLESGRRP
360 370 380 390
DGYPIWCRQD DLDLQKDDDD TKNALVKKFG AQNVARRIEF RKK
Length:393
Mass (Da):43,353
Last modified:December 1, 2001 - v1
Checksum:i7A15CFD83733BE2D
GO

Sequence cautioni

The sequence BAA95043 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti281 – 286PTPEED → HTHTQS in BAA95042 (Ref. 4) Curated6
Sequence conflicti281 – 286PTPEED → HTHTQS in BAA95043 (Ref. 4) Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041613 mRNA Translation: BAC31005.1
AK051818 mRNA Translation: BAC34781.1
AK081557 mRNA Translation: BAC38258.1
AK087729 mRNA Translation: BAC39985.1
AK084563 mRNA Translation: BAC39217.1
AK148508 mRNA Translation: BAE28592.1
AK148537 mRNA Translation: BAE28607.1
AK161452 mRNA Translation: BAE36404.1
AK165074 mRNA Translation: BAE38026.1
AC114648 Genomic DNA No translation available.
BC012270 mRNA Translation: AAH12270.1
BC017641 mRNA Translation: AAH17641.1
AB041557 mRNA Translation: BAA95042.1
AB041559 mRNA Translation: BAA95043.1 Different initiation.
CCDSiCCDS52678.1
RefSeqiNP_065609.2, NM_020584.2
UniGeneiMm.213064

Genome annotation databases

EnsembliENSMUST00000052138; ENSMUSP00000052170; ENSMUSG00000033430
GeneIDi57321
KEGGimmu:57321
UCSCiuc012gla.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041613 mRNA Translation: BAC31005.1
AK051818 mRNA Translation: BAC34781.1
AK081557 mRNA Translation: BAC38258.1
AK087729 mRNA Translation: BAC39985.1
AK084563 mRNA Translation: BAC39217.1
AK148508 mRNA Translation: BAE28592.1
AK148537 mRNA Translation: BAE28607.1
AK161452 mRNA Translation: BAE36404.1
AK165074 mRNA Translation: BAE38026.1
AC114648 Genomic DNA No translation available.
BC012270 mRNA Translation: AAH12270.1
BC017641 mRNA Translation: AAH17641.1
AB041557 mRNA Translation: BAA95042.1
AB041559 mRNA Translation: BAA95043.1 Different initiation.
CCDSiCCDS52678.1
RefSeqiNP_065609.2, NM_020584.2
UniGeneiMm.213064

3D structure databases

ProteinModelPortaliQ91VL8
SMRiQ91VL8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-153 Shelterin complex
IntActiQ91VL8, 2 interactors
MINTiQ91VL8
STRINGi10090.ENSMUSP00000052170

PTM databases

iPTMnetiQ91VL8
PhosphoSitePlusiQ91VL8

Proteomic databases

EPDiQ91VL8
MaxQBiQ91VL8
PaxDbiQ91VL8
PeptideAtlasiQ91VL8
PRIDEiQ91VL8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052138; ENSMUSP00000052170; ENSMUSG00000033430
GeneIDi57321
KEGGimmu:57321
UCSCiuc012gla.1 mouse

Organism-specific databases

CTDi54386
MGIiMGI:1929871 Terf2ip

Phylogenomic databases

eggNOGiENOG410IJNC Eukaryota
ENOG4111QPC LUCA
GeneTreeiENSGT00390000005351
HOGENOMiHOG000120115
HOVERGENiHBG054209
InParanoidiQ91VL8
KOiK11113
OMAiTQHSWQA
OrthoDBiEOG091G0NZ2
PhylomeDBiQ91VL8
TreeFamiTF332348

Enzyme and pathway databases

ReactomeiR-MMU-171306 Packaging Of Telomere Ends
R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence

Miscellaneous databases

ChiTaRSiTerf2ip mouse
PROiPR:Q91VL8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033430 Expressed in 264 organ(s), highest expression level in supraoptic nucleus
GenevisibleiQ91VL8 MM

Family and domain databases

Gene3Di1.10.10.2170, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR009057 Homeobox-like_sf
IPR021661 Rap1_C
IPR038104 Rap1_C_sf
IPR015010 Rap1_Myb_dom
IPR039595 TE2IP/Rap1
PANTHERiPTHR16466 PTHR16466, 2 hits
PfamiView protein in Pfam
PF16589 BRCT_2, 1 hit
PF08914 Myb_DNA-bind_2, 1 hit
PF11626 Rap1_C, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTE2IP_MOUSE
AccessioniPrimary (citable) accession number: Q91VL8
Secondary accession number(s): D3YWE8
, Q543F4, Q8C2Y1, Q9JJE8, Q9JJE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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