UniProtKB - Q91VK1 (BZW2_MOUSE)
Protein
Basic leucine zipper and W2 domain-containing protein 2
Gene
Bzw2
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in neuronal differentiation.By similarity
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- nervous system development Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Neurogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Basic leucine zipper and W2 domain-containing protein 2 |
Gene namesi | Name:Bzw2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914162, Bzw2 |
Subcellular locationi
Other locations
- cytoplasm Source: MGI
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000254620 | 1 – 419 | Basic leucine zipper and W2 domain-containing protein 2Add BLAST | 419 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 117 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 412 | PhosphoserineCombined sources | 1 | |
Modified residuei | 414 | PhosphoserineBy similarity | 1 | |
Modified residuei | 419 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q91VK1 |
jPOSTi | Q91VK1 |
MaxQBi | Q91VK1 |
PaxDbi | Q91VK1 |
PeptideAtlasi | Q91VK1 |
PRIDEi | Q91VK1 |
PTM databases
iPTMneti | Q91VK1 |
PhosphoSitePlusi | Q91VK1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000020547, Expressed in cerebral cortex and 289 other tissues |
ExpressionAtlasi | Q91VK1, baseline and differential |
Genevisiblei | Q91VK1, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 211804, 7 interactors |
IntActi | Q91VK1, 2 interactors |
STRINGi | 10090.ENSMUSP00000020856 |
Miscellaneous databases
RNActi | Q91VK1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 248 – 415 | W2PROSITE-ProRule annotationAdd BLAST | 168 |
Sequence similaritiesi
Belongs to the BZW family.Curated
Phylogenomic databases
eggNOGi | KOG2297, Eukaryota |
GeneTreei | ENSGT00390000012561 |
HOGENOMi | CLU_032849_0_1_1 |
InParanoidi | Q91VK1 |
OMAi | EPFCNGP |
OrthoDBi | 653740at2759 |
PhylomeDBi | Q91VK1 |
TreeFami | TF324313 |
Family and domain databases
CDDi | cd11560, W2_eIF5C_like, 1 hit |
Gene3Di | 1.25.40.180, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR016021, MIF4-like_sf IPR043510, W2_BZW1/2 IPR003307, W2_domain |
Pfami | View protein in Pfam PF02020, W2, 1 hit |
SMARTi | View protein in SMART SM00515, eIF5C, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51363, W2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q91VK1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNKHQKPVLT GQRFKTRKRD EKEKFEPTVF RDTLVQGLNE AGDDLEAVAK
60 70 80 90 100
FLDSTGSRLD YRRYADTLFD ILVAGSMLAP GGTRIDDGDK TKMTNHCVFS
110 120 130 140 150
ANEDHETIRN YAQVFNKLIR RYKYLEKAFE DEMKKLLLFL KAFSEAEQTK
160 170 180 190 200
LAMLSGILLG NGTLPATILT SLFTDSLVKE GIAASFAVKL FKAWMAEKDA
210 220 230 240 250
NSVTSSLRKA NLDKRLLELF PVNRQSVDHF AKYFTDAGLK ELSDFLRVQQ
260 270 280 290 300
SLGTRKELQK ELQERLSQEC PIKEVVLYVK EEMKRNDLPE TAVIGLLWTC
310 320 330 340 350
IMNAVEWNKK EELVAEQALK HLKQYAPLLA VFSSQGQSEL VLLQKVQEYC
360 370 380 390 400
YDNIHFMKAF QKIVVLFYKA DVLSEEAILK WYKEAHAAKG KSVFLDQMKK
410
FVEWLQNAEE ESESEGEES
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1Y7VJ43 | A0A1Y7VJ43_MOUSE | Basic leucine zipper and W2 domain-... | Bzw2 | 208 | Annotation score: | ||
A0A1Y7VIU9 | A0A1Y7VIU9_MOUSE | Basic leucine zipper and W2 domain-... | Bzw2 | 177 | Annotation score: | ||
A0A1Y7VKZ4 | A0A1Y7VKZ4_MOUSE | Basic leucine zipper and W2 domain-... | Bzw2 | 200 | Annotation score: | ||
A0A1Y7VM24 | A0A1Y7VM24_MOUSE | Basic leucine zipper and W2 domain-... | Bzw2 | 74 | Annotation score: | ||
A0A1Y7VM47 | A0A1Y7VM47_MOUSE | Basic leucine zipper and W2 domain-... | Bzw2 | 113 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 69 | F → L in BAB27495 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 326 | A → R in BAB27495 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK011253 mRNA Translation: BAB27495.1 AK160544 mRNA Translation: BAE35861.1 BC013060 mRNA Translation: AAH13060.1 |
CCDSi | CCDS25884.1 |
RefSeqi | NP_080116.2, NM_025840.3 |
Genome annotation databases
Ensembli | ENSMUST00000020856; ENSMUSP00000020856; ENSMUSG00000020547 |
GeneIDi | 66912 |
KEGGi | mmu:66912 |
UCSCi | uc007njp.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK011253 mRNA Translation: BAB27495.1 AK160544 mRNA Translation: BAE35861.1 BC013060 mRNA Translation: AAH13060.1 |
CCDSi | CCDS25884.1 |
RefSeqi | NP_080116.2, NM_025840.3 |
3D structure databases
SMRi | Q91VK1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 211804, 7 interactors |
IntActi | Q91VK1, 2 interactors |
STRINGi | 10090.ENSMUSP00000020856 |
PTM databases
iPTMneti | Q91VK1 |
PhosphoSitePlusi | Q91VK1 |
Proteomic databases
EPDi | Q91VK1 |
jPOSTi | Q91VK1 |
MaxQBi | Q91VK1 |
PaxDbi | Q91VK1 |
PeptideAtlasi | Q91VK1 |
PRIDEi | Q91VK1 |
Protocols and materials databases
Antibodypediai | 11817, 98 antibodies |
DNASUi | 66912 |
Genome annotation databases
Ensembli | ENSMUST00000020856; ENSMUSP00000020856; ENSMUSG00000020547 |
GeneIDi | 66912 |
KEGGi | mmu:66912 |
UCSCi | uc007njp.2, mouse |
Organism-specific databases
CTDi | 28969 |
MGIi | MGI:1914162, Bzw2 |
Phylogenomic databases
eggNOGi | KOG2297, Eukaryota |
GeneTreei | ENSGT00390000012561 |
HOGENOMi | CLU_032849_0_1_1 |
InParanoidi | Q91VK1 |
OMAi | EPFCNGP |
OrthoDBi | 653740at2759 |
PhylomeDBi | Q91VK1 |
TreeFami | TF324313 |
Miscellaneous databases
BioGRID-ORCSi | 66912, 3 hits in 17 CRISPR screens |
ChiTaRSi | Bzw2, mouse |
PROi | PR:Q91VK1 |
RNActi | Q91VK1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020547, Expressed in cerebral cortex and 289 other tissues |
ExpressionAtlasi | Q91VK1, baseline and differential |
Genevisiblei | Q91VK1, MM |
Family and domain databases
CDDi | cd11560, W2_eIF5C_like, 1 hit |
Gene3Di | 1.25.40.180, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR016021, MIF4-like_sf IPR043510, W2_BZW1/2 IPR003307, W2_domain |
Pfami | View protein in Pfam PF02020, W2, 1 hit |
SMARTi | View protein in SMART SM00515, eIF5C, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51363, W2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BZW2_MOUSE | |
Accessioni | Q91VK1Primary (citable) accession number: Q91VK1 Secondary accession number(s): Q9D0N4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families