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Entry version 125 (12 Aug 2020)
Sequence version 2 (20 May 2008)
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Protein

Interferon-inducible protein AIM2

Gene

Aim2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8.10 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

In absence of dsDNA pyrin and HIN-20 domain can interact inducing a closed conformation; an autoinhibitory mechanism is proposed in which binding to dsDNA liberates the pyrin domain for homotypic downstream signaling interactions with PYCARD.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processApoptosis, Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-844615, The AIM2 inflammasome

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interferon-inducible protein AIM2
Alternative name(s):
Interferon-inducible protein 210
Short name:
Ifi-210
Interferon-inducible protein p210
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Aim2
Synonyms:Gm1313, Ifi210
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2686159, Aim2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4295911

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003345281 – 354Interferon-inducible protein AIM2Add BLAST354

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q91VJ1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q91VJ1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q91VJ1

PeptideAtlas

More...
PeptideAtlasi
Q91VJ1

PRoteomics IDEntifications database

More...
PRIDEi
Q91VJ1

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q91VJ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000037860, Expressed in thymus and 143 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q91VJ1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates; forms homooligomers in response to cytosolic dsDNA and the dsDNA seems to serve as oligomerization platform.

Component of the AIM2 inflammasome complex.

Interacts with PYCARD.

Interacts with IFI16 (By similarity).

Interacts with EIF2AK2/PKR (By similarity).

Interacts with PYDC5; disrupts assembly of the ALR inflammasome complex (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q91VJ1
With#Exp.IntAct
itself2EBI-6253384,EBI-6253384

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
238833, 1 interactor

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-4243, AIM2 inflammasome

Protein interaction database and analysis system

More...
IntActi
Q91VJ1, 3 interactors

Molecular INTeraction database

More...
MINTi
Q91VJ1

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000119465

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q91VJ1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1354
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q91VJ1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 87PyrinPROSITE-ProRule annotationAdd BLAST87
Domaini144 – 341HIN-200PROSITE-ProRule annotationAdd BLAST198

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The HIN-20 domain mediates dsDNA binding via electrostatic interactions.1 Publication
The pyrin domain mediates homotypic interaction with PYCARD.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HIN-200 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTQS, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013296

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020123_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q91VJ1

KEGG Orthology (KO)

More...
KOi
K12966

Identification of Orthologs from Complete Genome Data

More...
OMAi
MKCKEGD

Database of Orthologous Groups

More...
OrthoDBi
1304994at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q91VJ1

TreeFam database of animal gene trees

More...
TreeFami
TF337385

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004020, DAPIN
IPR011029, DEATH-like_dom_sf
IPR040205, HIN-200
IPR004021, HIN200/IF120x

The PANTHER Classification System

More...
PANTHERi
PTHR12200, PTHR12200, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02760, HIN, 1 hit
PF02758, PYRIN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01289, PYRIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50824, DAPIN, 1 hit
PS50834, HIN_200, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q91VJ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESEYREMLL LTGLDHITEE ELKRFKYFAL TEFQIARSTL DVADRTELAD
60 70 80 90 100
HLIQSAGAAS AVTKAINIFQ KLNYMHIANA LEEKKKEAER KLMTNTKKRG
110 120 130 140 150
TQKVENRSQA ENCSAASATR SDNDFKEQAA TEVCPQAKPQ KKQMVAEQEA
160 170 180 190 200
IREDLQKDPL VVTVLKAINP FECETQEGRQ EIFHATVATE TDFFFVKVLN
210 220 230 240 250
AQFKDKFIPK RTIKISNYLW HSNFMEVTSS SVVVDVESNH EVPNNVVKRA
260 270 280 290 300
RETPRISKLK IQPCGTIVNG LFKVQKITEE KDRVLYGIHD KTGTMEVLVL
310 320 330 340 350
GNPSKTKCEE GDKIRLTFFE VSKNGVKIQL KSGPCSFFKV IKAAKPKTDM

KSVE
Length:354
Mass (Da):40,155
Last modified:May 20, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE860C5D902AA5D35
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UZ36G3UZ36_MOUSE
Interferon-inducible protein AIM2
Aim2
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z341D3Z341_MOUSE
Interferon-inducible protein AIM2
Aim2
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH09664 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC084073 Genomic DNA No translation available.
BC009664 mRNA Translation: AAH09664.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS15529.2

NCBI Reference Sequences

More...
RefSeqi
NP_001013801.2, NM_001013779.2
XP_006496982.1, XM_006496919.2
XP_006496989.1, XM_006496926.1
XP_011237133.1, XM_011238831.2
XP_011237137.1, XM_011238835.1
XP_011237144.1, XM_011238842.1
XP_017176969.1, XM_017321480.1
XP_017176971.1, XM_017321482.1
XP_017176972.1, XM_017321483.1
XP_017176975.1, XM_017321486.1
XP_017176976.1, XM_017321487.1
XP_017176977.1, XM_017321488.1
XP_017176981.1, XM_017321492.1
XP_017176983.1, XM_017321494.1
XP_017176985.1, XM_017321496.1
XP_017176987.1, XM_017321498.1
XP_017176990.1, XM_017321501.1
XP_017176994.1, XM_017321505.1
XP_017176996.1, XM_017321507.1
XP_017176999.1, XM_017321510.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000147604; ENSMUSP00000119465; ENSMUSG00000037860
ENSMUST00000166137; ENSMUSP00000132253; ENSMUSG00000037860

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
383619

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:383619

UCSC genome browser

More...
UCSCi
uc011wws.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084073 Genomic DNA No translation available.
BC009664 mRNA Translation: AAH09664.1 Different initiation.
CCDSiCCDS15529.2
RefSeqiNP_001013801.2, NM_001013779.2
XP_006496982.1, XM_006496919.2
XP_006496989.1, XM_006496926.1
XP_011237133.1, XM_011238831.2
XP_011237137.1, XM_011238835.1
XP_011237144.1, XM_011238842.1
XP_017176969.1, XM_017321480.1
XP_017176971.1, XM_017321482.1
XP_017176972.1, XM_017321483.1
XP_017176975.1, XM_017321486.1
XP_017176976.1, XM_017321487.1
XP_017176977.1, XM_017321488.1
XP_017176981.1, XM_017321492.1
XP_017176983.1, XM_017321494.1
XP_017176985.1, XM_017321496.1
XP_017176987.1, XM_017321498.1
XP_017176990.1, XM_017321501.1
XP_017176994.1, XM_017321505.1
XP_017176996.1, XM_017321507.1
XP_017176999.1, XM_017321510.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N00NMR-A1-95[»]
4JBMX-ray2.22A/B158-349[»]
SMRiQ91VJ1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi238833, 1 interactor
ComplexPortaliCPX-4243, AIM2 inflammasome
IntActiQ91VJ1, 3 interactors
MINTiQ91VJ1
STRINGi10090.ENSMUSP00000119465

Chemistry databases

ChEMBLiCHEMBL4295911

PTM databases

PhosphoSitePlusiQ91VJ1

Proteomic databases

EPDiQ91VJ1
MaxQBiQ91VJ1
PaxDbiQ91VJ1
PeptideAtlasiQ91VJ1
PRIDEiQ91VJ1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34257, 593 antibodies

Genome annotation databases

EnsembliENSMUST00000147604; ENSMUSP00000119465; ENSMUSG00000037860
ENSMUST00000166137; ENSMUSP00000132253; ENSMUSG00000037860
GeneIDi383619
KEGGimmu:383619
UCSCiuc011wws.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9447
MGIiMGI:2686159, Aim2

Phylogenomic databases

eggNOGiENOG502QTQS, Eukaryota
GeneTreeiENSGT00390000013296
HOGENOMiCLU_020123_2_0_1
InParanoidiQ91VJ1
KOiK12966
OMAiMKCKEGD
OrthoDBi1304994at2759
PhylomeDBiQ91VJ1
TreeFamiTF337385

Enzyme and pathway databases

ReactomeiR-MMU-844615, The AIM2 inflammasome

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
383619, 1 hit in 19 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Aim2, mouse

Protein Ontology

More...
PROi
PR:Q91VJ1
RNActiQ91VJ1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000037860, Expressed in thymus and 143 other tissues
GenevisibleiQ91VJ1, MM

Family and domain databases

InterProiView protein in InterPro
IPR004020, DAPIN
IPR011029, DEATH-like_dom_sf
IPR040205, HIN-200
IPR004021, HIN200/IF120x
PANTHERiPTHR12200, PTHR12200, 1 hit
PfamiView protein in Pfam
PF02760, HIN, 1 hit
PF02758, PYRIN, 1 hit
SMARTiView protein in SMART
SM01289, PYRIN, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50824, DAPIN, 1 hit
PS50834, HIN_200, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAIM2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91VJ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: August 12, 2020
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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