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Protein

Interferon-inducible protein AIM2

Gene

Aim2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8.10 Publications

Activity regulationi

In absence of dsDNA pyrin and HIN-20 domain can interact inducing a closed conformation; an autoinhibitory mechanism is proposed in which binding to dsDNA liberates the pyrin domain for homotypic downstream signaling interactions with PYCARD.By similarity

GO - Molecular functioni

  • double-stranded DNA binding Source: UniProtKB
  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processApoptosis, Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-844615 The AIM2 inflammasome

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-inducible protein AIM2
Alternative name(s):
Interferon-inducible protein 210
Short name:
Ifi-210
Interferon-inducible protein p210
Gene namesi
Name:Aim2
Synonyms:Gm1313, Ifi210
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2686159 Aim2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003345281 – 354Interferon-inducible protein AIM2Add BLAST354

Proteomic databases

EPDiQ91VJ1
MaxQBiQ91VJ1
PaxDbiQ91VJ1
PeptideAtlasiQ91VJ1
PRIDEiQ91VJ1

PTM databases

PhosphoSitePlusiQ91VJ1

Expressioni

Gene expression databases

BgeeiENSMUSG00000037860 Expressed in 123 organ(s), highest expression level in thymus
ExpressionAtlasiQ91VJ1 baseline and differential
GenevisibleiQ91VJ1 MM

Interactioni

Subunit structurei

Self-associates; forms homooligomers in response to cytosolic dsDNA and the dsDNA seems to serve as oligomerization platform. Component of the AIM2 inflammasome complex. Interacts with PYCARD. Interacts with IFI16 (By similarity). Interacts with EIF2AK2/PKR (By similarity). Interacts with PYDC5; disrupts assembly of the ALR inflammasome complex (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-6253384,EBI-6253384

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91VJ1, 3 interactors
MINTiQ91VJ1
STRINGi10090.ENSMUSP00000119465

Structurei

Secondary structure

1354
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ91VJ1
SMRiQ91VJ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 87PyrinPROSITE-ProRule annotationAdd BLAST87
Domaini144 – 341HIN-200PROSITE-ProRule annotationAdd BLAST198

Domaini

The HIN-20 domain mediates dsDNA binding via electrostatic interactions.1 Publication
The pyrin domain mediates homotypic interaction with PYCARD.By similarity

Sequence similaritiesi

Belongs to the HIN-200 family.Curated

Phylogenomic databases

eggNOGiENOG410J5NP Eukaryota
ENOG410Y78B LUCA
GeneTreeiENSGT00390000013296
HOVERGENiHBG006122
InParanoidiQ91VJ1
KOiK12966
OMAiQEMFHAT
OrthoDBiEOG091G02W0
PhylomeDBiQ91VJ1
TreeFamiTF337385

Family and domain databases

InterProiView protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
IPR004021 HIN200/IF120x
PfamiView protein in Pfam
PF02760 HIN, 1 hit
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit
PS50834 HIN_200, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q91VJ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESEYREMLL LTGLDHITEE ELKRFKYFAL TEFQIARSTL DVADRTELAD
60 70 80 90 100
HLIQSAGAAS AVTKAINIFQ KLNYMHIANA LEEKKKEAER KLMTNTKKRG
110 120 130 140 150
TQKVENRSQA ENCSAASATR SDNDFKEQAA TEVCPQAKPQ KKQMVAEQEA
160 170 180 190 200
IREDLQKDPL VVTVLKAINP FECETQEGRQ EIFHATVATE TDFFFVKVLN
210 220 230 240 250
AQFKDKFIPK RTIKISNYLW HSNFMEVTSS SVVVDVESNH EVPNNVVKRA
260 270 280 290 300
RETPRISKLK IQPCGTIVNG LFKVQKITEE KDRVLYGIHD KTGTMEVLVL
310 320 330 340 350
GNPSKTKCEE GDKIRLTFFE VSKNGVKIQL KSGPCSFFKV IKAAKPKTDM

KSVE
Length:354
Mass (Da):40,155
Last modified:May 20, 2008 - v2
Checksum:iE860C5D902AA5D35
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UZ36G3UZ36_MOUSE
Interferon-inducible protein AIM2
Aim2
94Annotation score:
D3Z341D3Z341_MOUSE
Interferon-inducible protein AIM2
Aim2
80Annotation score:

Sequence cautioni

The sequence AAH09664 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084073 Genomic DNA No translation available.
BC009664 mRNA Translation: AAH09664.1 Different initiation.
CCDSiCCDS15529.2
RefSeqiNP_001013801.2, NM_001013779.2
XP_006496982.1, XM_006496919.2
XP_006496989.1, XM_006496926.1
XP_011237133.1, XM_011238831.2
XP_011237137.1, XM_011238835.1
XP_011237144.1, XM_011238842.1
XP_017176969.1, XM_017321480.1
XP_017176971.1, XM_017321482.1
XP_017176972.1, XM_017321483.1
XP_017176975.1, XM_017321486.1
XP_017176976.1, XM_017321487.1
XP_017176977.1, XM_017321488.1
XP_017176981.1, XM_017321492.1
XP_017176983.1, XM_017321494.1
XP_017176985.1, XM_017321496.1
XP_017176987.1, XM_017321498.1
XP_017176990.1, XM_017321501.1
XP_017176994.1, XM_017321505.1
XP_017176996.1, XM_017321507.1
XP_017176999.1, XM_017321510.1
UniGeneiMm.131453

Genome annotation databases

EnsembliENSMUST00000147604; ENSMUSP00000119465; ENSMUSG00000037860
ENSMUST00000166137; ENSMUSP00000132253; ENSMUSG00000037860
GeneIDi383619
KEGGimmu:383619
UCSCiuc011wws.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084073 Genomic DNA No translation available.
BC009664 mRNA Translation: AAH09664.1 Different initiation.
CCDSiCCDS15529.2
RefSeqiNP_001013801.2, NM_001013779.2
XP_006496982.1, XM_006496919.2
XP_006496989.1, XM_006496926.1
XP_011237133.1, XM_011238831.2
XP_011237137.1, XM_011238835.1
XP_011237144.1, XM_011238842.1
XP_017176969.1, XM_017321480.1
XP_017176971.1, XM_017321482.1
XP_017176972.1, XM_017321483.1
XP_017176975.1, XM_017321486.1
XP_017176976.1, XM_017321487.1
XP_017176977.1, XM_017321488.1
XP_017176981.1, XM_017321492.1
XP_017176983.1, XM_017321494.1
XP_017176985.1, XM_017321496.1
XP_017176987.1, XM_017321498.1
XP_017176990.1, XM_017321501.1
XP_017176994.1, XM_017321505.1
XP_017176996.1, XM_017321507.1
XP_017176999.1, XM_017321510.1
UniGeneiMm.131453

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N00NMR-A1-95[»]
4JBMX-ray2.22A/B158-349[»]
ProteinModelPortaliQ91VJ1
SMRiQ91VJ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91VJ1, 3 interactors
MINTiQ91VJ1
STRINGi10090.ENSMUSP00000119465

PTM databases

PhosphoSitePlusiQ91VJ1

Proteomic databases

EPDiQ91VJ1
MaxQBiQ91VJ1
PaxDbiQ91VJ1
PeptideAtlasiQ91VJ1
PRIDEiQ91VJ1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000147604; ENSMUSP00000119465; ENSMUSG00000037860
ENSMUST00000166137; ENSMUSP00000132253; ENSMUSG00000037860
GeneIDi383619
KEGGimmu:383619
UCSCiuc011wws.1 mouse

Organism-specific databases

CTDi9447
MGIiMGI:2686159 Aim2

Phylogenomic databases

eggNOGiENOG410J5NP Eukaryota
ENOG410Y78B LUCA
GeneTreeiENSGT00390000013296
HOVERGENiHBG006122
InParanoidiQ91VJ1
KOiK12966
OMAiQEMFHAT
OrthoDBiEOG091G02W0
PhylomeDBiQ91VJ1
TreeFamiTF337385

Enzyme and pathway databases

ReactomeiR-MMU-844615 The AIM2 inflammasome

Miscellaneous databases

PROiPR:Q91VJ1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037860 Expressed in 123 organ(s), highest expression level in thymus
ExpressionAtlasiQ91VJ1 baseline and differential
GenevisibleiQ91VJ1 MM

Family and domain databases

InterProiView protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
IPR004021 HIN200/IF120x
PfamiView protein in Pfam
PF02760 HIN, 1 hit
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit
PS50834 HIN_200, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAIM2_MOUSE
AccessioniPrimary (citable) accession number: Q91VJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 7, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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